Earlier it hurt a lot to see WordGirl mocking Tobey who is often somewhat of an Friendly Enemy and reducing him to an inability to move out of despair and a few others. Not to mention the Butcher's frantic and confused pleading to know where WordGirl is when Miss Power is taunting him, saying that WordGirl isn't mean like Miss Power.
Despite being treated as a joke villain (like everyone else) what happened to Doctor Two-Brains is pretty sad. An intellectual Nice Guy driven to evil and insanity by placing something on his head, voiced by Tom Kenny? Two-Brains is basically a science-y Ice King on a show with a younger target audience.