- Resident EvilIntroducing
- Resident Evil 2Introducing
- Resident Evil 3: NemesisIntroducing
- Resident Evil Gun Survivor Introducing
- Resident Evil: Code: VeronicaIntroducing
- Resident Evil 0Introducing
- Resident Evil OutbreakIntroducing
- Resident Evil: The Umbrella ChroniclesIntroducing
- Resident Evil: DegenerationIntroducing
- Resident Evil 5Introducing
- Resident Evil: The Darkside ChroniclesIntroducing
- Resident Evil: RevelationsIntroducing
- Resident Evil: Operation Raccoon CityIntroducing
- Resident Evil 6Introducing
- Resident Evil: DamnationIntroducing
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Voiced by: Rino Romano
"A little rough, don't you think?"Luis is a smooth-talking cad who shows up mysteriously to aid Leon from time to time before running off. He claims to have been a policeman in Madrid before later admitting that he was also once a researcher for Los Illuminados. He does his best to help Leon and Ashley.
- The Atoner: He goes well out of his way to help Leon and Ashley because of the responsibility he feels for the situation at hand.
- Badass: The fight with numerous Ganados in the cabin shows him perfectly capable of holding his own with Leon.
- The Casanova: He claims to be "quite the ladies' man."
- Dashing Hispanic: He's a charming Spaniard with both intelligence and skills with a gun.
- Fire-Forged Friends: With Leon over the course of the game, making his death hit him all the more harder.
- Handsome Lech:Luis: "I see the president has equipped his daughter with ballistics, too."
- Heel–Face Turn: Although he is unusual in that his happens before the beginning of the story proper.
- Hot Scientist
- Impaled with Extreme Prejudice: By Saddler's Plaga tentacle.
- Obfuscating Stupidity: He acts like a sleaze, but as the notes, medication, and the laser he created attest, he's a genius. Even Ada calls him "brilliant."
- Sacrificial Lion
- Smoking Is Cool: The first thing he asks for when Leon finds him is a smoke.
- Unkempt Beauty: Long greasy hair never looked so good.
- Video Game Cruelty Punishment: During the Hold the Line segment in the cabin, you can shoot him instead; willingly or via stray bullets. Do it enough times, and Luis will get angry and kill Leon, resulting in a Non Standard Game Over.
Voiced by: Carolyn Lawrence
"I'm never turning into one of them! Never!"The president's daughter that Leon must rescue in 4. A twenty-year-old university student who was abducted and taken to Europe for ransom and to be implanted with Las Plasgas as part of Saddler's plan.
- Armor Is Useless: Averted. You can shoot the trap she was in with a rocket launcher and not kill her with it, also conveniently preventing any game overs due to a misfire. Later, when you unlock an alternate costume that is a literal suit of armor, she is both too heavy to be captured by mooks and invulnerable. Thus, having her stand in the center of a mob while shooting enemies around her works exceptionally well.
- Bare Your Midriff: Her first bonus outfit.
- Bodyguard Crush: On Leon.
- The Chick: While most of the time she's pretty much a Distressed Damsel, there's a few times in which she makes herself useful, piggybacking over locked gates to unbar them, helping out whenever there's more than one winch to turn, etc. She also drives a massive truck through a tunnel so Leon can focus on shooting up the Ganados trying to halt their progress.
- Coy, Girlish Flirt Pose: Her menu picture in her playable area shows her standing like this.
- Developers' Foresight: A minor example. When you play with the default outfit, Ashley won't let you look under her skirt if she's above you (she'll close her legs and admonish you for trying). Playing with either of the unlockable, pants equipped outfits, and she doesn't respond if you try the same thing. Leon will also fall to one knee after catching her in his arms when she jumps down from a ledge that's too high for her to safely land if she's wearing the armor and will stand up clutching his back in pain.
- Distressed Damsel: She sticks with you for a couple of chapters when you first find her before traps in the castle separate you. The next two times you find her, she winds up kidnapped again by the end of the chapter.
- Gameplay and Story Segregation:
- The PS2 version runs cutscenes off of movie files so everyone has their default outfits, while all other editions use the game engine to show what's actually worn.
- When she's kidnapped by flying monsters, Leon just goes on looking for her. But if a mook carries her into a different game zone, it's instant Game Over, even if Leon is on his heels.
- Leon has to protect her from deadly encounters and traps with alarming frequency in spite of Saddler's Evil Plan requiring her to be sent home alive and infected. Even villains who should absolutely know better than to risk killing her (like Salazar) will still occasionally try to.
- Hair of Gold, Heart of Gold: She's actually a sweet girl when things settle down, comparing to her blonde predecessor Alexia, she's really nice in comparison.
- Improvised Weapon User: She can use candles/lanterns in the rooms when you play her.
- Kill It with Fire: One of her few attacks is to throw candles at enemies.
- Nigh-Invulnerability: Her second alternate outfit is a suit of armor. Not only does it make her impervious to any and all kind of damage (Even from rocket launchers), but it's also so heavy that it also protects her from being kidnapped, making the segments with her much easier.
- Gag Boobs: Resulting in Luis's Lampshading. note
- Further lampshaded with the trophy for rescuing her."Secure the Ballistics"
- Further lampshaded with the trophy for rescuing her.
- The Load: Averted. She actually does make herself useful on occasion, and when she's alone she can fend for herself if need be (well, when the player controls her, of course, her AI isn't quite that smart). And quite often Leon can tell her to hide in a dumpster where she can't be discovered, which makes escorting her a lot easier.
- Panty Shot: Allegedly, the panties have a rather detailed graphic...
- Sensual Spandex: Her white pop star outfit.
- Stone Wall: Armor Ashley is completely invincible to any form of attack. It is a perfectly viable strategy to use Armor Ashley to lure enemies away from Leon as he snipes them from a distance... with a rocket. Ashley will be perfectly fine.
- Sweater Girl: Her sleeveless sweater (even though she is wearing a full sweater around her neck).
- Video Game Caring Potential/Video Game Cruelty Potential: Depends on your take on Escort Missions.
- Wrestler in All of Us: No kidding! Do it right, and you can have her performing Leon's suplex move on enemies!
- Ashley uses the same controls as Leon, but since she never finds any weapons in her chapter, you're not supposed to be able to fight. If you manage to hit a monk with one of the doors, though, you can run up and use one of the context-sensitive melee commands. Sadly, said ability only works in the original Nintendo GameCube release.
- Your Princess Is in Another Castle: Try and count how many times she's been rescued, only to be kidnapped again. Granted, the circumstances are out of Leon's control, ranging from an ambush to Mind Control.
Voiced by: Sally Saffioti
"May I remind you that you're still on duty?"Leon's Mission Control in Resident Evil 4, Degeneration, Damnation, and 6.
- Ambiguously Brown: She's Caucasian, or at least American according to The Other Wiki, but she has a nice tone of olive skin. This supports the theory that she is either tanned, or has Latino/Mediterranean ancestry. Not that it subtracts any points of her beauty at all.
- Beautiful All Along: Normally, she dresses and looks rather plain (not that Leon minds), but once she tidies up a little, well...
- Consummate Professional: Even people she's worked with for years know next to nothing about her personal life. The closest thing we get to hint is an anecdote in a file of her telling off her mother for calling her at work about her personal life, insisting her work is her number one priority.
- Friendship Moment: In 6, when Leon asks Hunnigan to fake his and Helena's deaths so they can chase Simmons to China, she barely hesitates. In fact, the reason they know where he's going is because she already put a tail on him. They're accusing a respected superior of a crime they themselves are the prime suspects in, without any evidence to back them up, and she believes them immediately.
- The Glasses Gotta Go
- He Knows About Timed Hits: "I'm sending you a playing manual!"
- Last Name Basis: Almost always referred to as Hunnigan.
- Meganekko: Wears glasses all the time. It led to a lot of Wild Mass Guessing that she was an established character in disguise.
- Mission Control: Acts as Leon's mission control on both 4 and 6.
- Multi-Ethnic Name: She's Ambiguously Brown, but "Ingrid" is Germanic and "Hunnigan" is an Irish surname.
Voiced by: Paul Mercier
"Got a selection of good things on sale, stranger!"A strange pirate-merchant guy introduced in RE4. Clad in a black, hooded coat and purple neckerchief, the Merchant would be available at some point during the level to sell and buy items. He's a mysterious and quirky fellow and gained quite the fanbase as a result.
- British Accents: For whatever reason, he's voiced with a Cornish/rural accent, commonly thought of as "that pirate talk".
- Catch Phrase: "Wot're ye buyin'?" and "Wot're ye sellin'?"
- Everyone Calls Him The Merchant
- Glowing Eyes of Doom: Subverted. He's a good guy.
- Video Game Cruelty Potential: You can show your "appreciation" towards the Merchant's high prices by slashing him with your knife or shooting him, which will kill him on the spot. On Normal, he'll respawn in the next area but on Professional, he'll stay dead for the rest of the game, so do so at your own risk.
- We Buy Anything: "I'll buy it fer a high price."
- We Sell Everything: Well, everything you need to survive a zombie-infested Spanish town. Except ammo, despite occasionally being shown with crates of the stuff, and obviously having enough to completely restock a weapon each time whenever Leon has its capacity increased.
- What Happened to the Mouse?: Only shows up in 4, and the last time you see him is before the final battle with Saddler. And after Ada activates the bombs to destroy the island, it's unknown whether or not he escaped. The odds are he did, since he has a habit of showing up in (often dangerous) places in seemingly impossible ways before you do, he probably had a ticket out of there somehow.
- Zombie Infectee: Appears to have the pale skin and red eyes as the Las Plagas, but isn't Brainwashed and Crazy, and is indeed willing to help out Leon... for a price, of course.
Voiced by: Michael GoughThe true mastermind behind the events of Resident Evil 4. He had Krauser capture the president's daughter in order to infect her with Las Plagas and then return her to the White House (after collecting ransom, of course), where she would presumably attack and spread Las Plagas throughout the United States. His plans were foiled by Leon and his crew.
- America Saves the Day: Saddler references this trope before fighting Leon and promises to subvert it. This, of course, is ultimately played straight.
- Big Bad: This is the man behind both Mendez and Salazar.
- Catch and Return: If you pump enough bullets into him during the Separate Ways boss fight, he fires them back at Ada by forcing them out his finger.
- Combat Tentacles: These are most prominent during his boss fight in Separate Ways. He also kills Luis with a tentacle from between his legs, in a move that fans affectionately call the "Wangpale."
- Deadpan Snarker: Conversations between Saddler and Leon can best be described as snark-offs.
- Eyes Do Not Belong There: He's got an eye in his mouth that only pops out when he's taken a lot of damage. He also has eyes on the legs that grow out of his face in One-Winged Angel mode.
- Faux Affably Evil: All the way. When Leon makes quips at his expense, Saddler always responds with a good-natured chuckle before telling him in a conversational tone how he's going to kill him, and never lets on that Leon is anything more than a source of amusement for him. Even when Leon manages to rescue Ashley at the Island after being cured of Las Plagas via chemo, Saddler's only reaction is to express amusement at him for managing to foil his plans before transforming.
- Flash Step: He's quite fond of using this during his boss fight with Ada. Unlike Wesker, he doesn't use it to dodge bullets.
- Good Hair, Evil Hair: Slicked back hair, sterotypical for a villain.
- Hive Mind: Using supersonic waves from his staff, he can control anyone or anything who hosts a Plaga, with a few possible exceptions.
- Idiot Ball: The entire plot of Resident Evil 4 makes considerably more sense on every possible level if you assume that receiving his master Plaga turned Saddler into a delusional psychopath who's unwilling to admit that he could possibly be wrong or be defeated. And as part of his research, Saddler had Luis build a machine in the research building that could kill Las Plagas without damaging the host under certain conditions. Knowing full well that the machine was still operational and that it was very near where he was holding Ashley, Saddler made no effort to destroy the machine. Lo and behold, Ashley and Leon found it and used it to get rid of their parasites.
- Interim Villain: Unlike other antagonists in the series, he is not connected to Umbrella. Albert Wesker takes the role as main villain in Resident Evil 5.
- In the Hood: Wears a hood for most of the game.
- Last Name Basis: no one calls him Osmund.
- No, You:Saddler: Perhaps you are disillusioned with overconfidence just because you killed my small-time subordinate?Leon: Saddler, you're small-time.
- One-Winged Angel: As noted above, he has legs that grow out of his face.
- Phallic Weapon: See Combat Tentacles above.
- Properly Paranoid: He never really trusted Krauser, who was indeed working for Wesker.
- Religion of Evil: Whether or not Saddler actually believes in the religion of Los Illuminados is unclear, but he is their leader and is at least using them as a cover for his own goals.
- Sinister Minister: Sinister Pope, more like. The Head Honcho of the Los Illuminados cult.
- Smug Snake: He brushes off every defeat Leon hands him with condescending arrogance. His Villainous Breakdown mentioned below is basically him making a frowny face for about a second before resuming his usual smarmy tone and going One-Winged Angel.
- Softspoken Sadist: He almost never raises his voice and speaks in a polite, soft tone, even when faced with defeat.
- Super Speed: In human form, Saddler can move very quickly. He almost seems to hover along the ground as he does so.
- Villain Ball: His persistence in keeping Ashley for ransom. Had he just quietly returned her, or allowed Leon to rescue her before he could get to the bottom of things, nobody would've known she was infected until it was too late.
- Villainous Breakdown: Saddler tries to keep a normal appearance throughout the game. Once he discovers that Leon found a way to remove his Plaga, and Ashley probably did too, Saddler goes mad and mutates into a mass of legs and tentacles.
- Villainous Friendship: One of the papers the player can find at the Island indicates that he was rather disheartened when both Bitores Mendez and Ramon Salazar were both slain by Leon.
- Why Don't Ya Just Shoot Him?: Despite his many, many opportunities to kill Leon, Saddler never gives up hope that Leon will succumb to Las Plagas and, in turn, his mind control. This comes back to bite him in the end.
Voiced by: Rene MujicaThe eighth castellan of the Salazar family castle and a high-ranking member of Los Illuminados, Salazar played a huge part in Saddler's plans by excavating fossilized Las Plagas and donating them to his cause. His goal was to create a world without sin: after all, if people have no free will, how can they do evil? He causes Leon a lot of trouble when Leon and Ashley wander into his castle.
- Body Horror: Due to a genetic defect, he's the size of a child, but he's already got gray, stringy hair and wrinkled skin that makes him look like a dying old man.
- Bratty Half-Pint: A twisted version. He's a grown man with a midget body, and his tantrums is that of a little spoiled brat.
- Butt Monkey: To Leon. You can tell Leon enjoys trolling the guy.
- Compensating for Something: Giant mecha Salazar GO!!!
- Death Trap: His castle is chock full of them, from spiked pits to closing walls.
- Depraved Dwarf: He's short, but he's also a monster willing to destroy the world.
- Devour the Dragon: He absorbs the second Verdugo when going One-Winged Angel.
- Giggling Villain: He has this obnoxious little giggle that he busts out whenever he thinks he has the situation under control. Fortunately, as you progress, he finds less and less reason to laugh.
- Hannibal Lecture: Subverted. Just as Salazar prepares to deliver a presumably well-rehearsed lecture on the nature of terrorism, Leon delivers a brilliant, wordless Shut Up, Hannibal! using violence, which leaves Salazar whimpering like a sick puppy, only less adorable and more pathetic.
- I'm Melting: His final fate.
- Impaled Palm: Leon's aforementioned Shut Up, Hannibal! moment involves him flinging his knife at Salazar and nailing his left hand to the wall.
- Knight Templar: He wanted to rid the world of sin. However, his method of doing so is to sap people's will by allowing the Los Illuminados cult to plant Las Plagas into them.
- Mister Big: He's not ultimately in charge of the operation, but he's got loads of guys working for him, and is constantly flanked by two massive bodyguards.
- The Napoleon: Not only is he short, he wears a Napoleon-esque outfit (including the Cool Hat). The fact that he spent money on a giant robotic statue of himself also suggests a Napoleon complex.
- One-Winged Angel: Some sort of... plant thing?
- Praetorian Guard: The two Verdugo that follow him around serve this purpose. The first one is sent to fight Leon but the second one is a subversion because it's merely absorbed to help fuel Ramon's fusion with the Queen Plaga.
- Psychopathic Manchild: Oh so much.
- The Walls Are Closing In: Pulls this trick on Leon. Twice.
- Trap Door: Leading into a spike pit. Ramon Salazar: Part Napoleon Boneparte, part Vlad the Impaler.
- Trap-Door Fail: He tries to kill Leon by having him fall into a pit of spikes. It fails of course.
- Villainous Breakdown: The first major villain of the game, Mendez, ends up nearly killing Leon every time they meet. In contrast, Leon always has a cool head when talking down Salazar, despite Salazar's efforts, and that drives him insane.Salazar: I've sent my right hand to dispose of you.Salazar: Say whatever you please. DIE YOU WORM! (breaks the camera)
- Younger Than They Look: "It may come as a surprise, but I am only twenty years old!"
- Older Than They Look: Salazar somehow manages to look like both a preteen boy and a withered old man, so his age is a surprise if you make an assumption either way.
Voiced by: Jim Ward
"Been a long time, comrade."An antagonist in 4, he literally shows up in the last section of the game, though he's one of the causes of the whole mess: He's the one who originally kidnapped Ashley. Also a playable character Darkside Chronicles, which serves as his Start of Darkness, showing the actual mission he worked with Leon and why he hooked up with Wesker.
- Blade Below the Shoulder: In addition to increased speed and endurance, the infection also mutates his left arm into a gigantic metal blade which you can use in the Mercenaries minigame.
- Blood Knight: He enjoys the thrill of the battle, and acts like he's having a ball during his duel with Leon in 4.
- Career-Ending Injury: Which leads to his Start of Darkness.
- Compensating for Something: Implied by Ada.
- Dirty Coward: Played with in Darkside Chronicles. In the last few missions, Krauser essentially breaks under the strain, scrambling with fear from the giant viral monsters attacking him and Leon, even (mentally) desperately begging Leon to save his ass when he thought the odds were too great. Despite all this, and an extremely injured arm, he fights competently and professionally and never really lets any of this show, so really closer to Cowardly Lion.
- Disney Death: Played straight and subverted. You would think beating the tar out of him with Leon and having a stone tower explode and collapse on him would be enough to kill Krauser. It doesn't, but Ada later manages to put him down for good anyways.
- Empowered Badass Normal: Darkside Chronicles shows us that he was pretty badass before getting infected.
- Evil Counterpart: For Leon. Both are Knife Nuts, worked for the US government, and even served on the same mission in Darkside Chronicles. Ironically, Krauser falls to the dark side because he liked his work with SOCOM so much, so when he all but loses one arm and faces an end to his military career, he turns to Wesker.
- Face–Heel Turn: Ends up turning to Wesker (and presumably faking his own death). One of the major factors in his allying himself with Wesker was because of deep anger about feeling used by the United States Military, especially when they didn't even request for him to join up with the organization to stop bioweapon threats, yet they allowed Leon to join, and later their firing him because the Javier mission had him injured in his arm with it not fully recovering. That would probably explain why Krauser, despite swearing an oath to his native country, was perfectly willing to undergo a mission to kidnap the President's daughter.
- Foil: To Leon:
- Both are blond guys, except Leon is good and he's not.
- Krauser has a nasty scar, and Leon has a perfect face.
- Leon, while not short, he's a bit above average height (5'10"), Krauser towers him at 6 ft.
- Leon has long-ish hair, Krauser has a buzzcut.
- Both were working for the government, but Krauser turned to evil.
- Both are very good with the knife.
- Both have Icy Blue Eyes, the difference however is that Leon is compassionate individual, but fairly snarky, Krauser is very serious.
- Good Eyes, Evil Eyes
- Good Scars, Evil Scars: The giant scar on his face is supposed to make him look more intimidating. When he puts war paint on his face, it lessens the appearance of it.
- Green-Eyed Monster: Has shades of this when he learns about Leon's being ordered to join the secret organization to stop bioweapons, despite the fact that Krauser, at least in his viewpoint, would have willingly joined up to aid the government to get rid of the bioweapons, and yet was not even given that chance.
- Last Name Basis: Everybody refers to him as "Krauser", making his first name, Jack, hard to find.
- Lightning Bruiser: Of the Mercenaries, he's got the largest health bar, his bow is extremely powerful, his physical attacks will demolish just about anyone, and he can run at a pretty good pace.
- Nerves of Steel: Played with, see Dirty Coward.
- Nice Hat: A raspberry beret.
- The Paragon Always Rebels: The bio for Krauser in Darkside Chronicles noted that he had a long and outstanding service in the military prior to his ultimate fall.
- Psycho Supporter: By Resident Evil 4, he is very much loyal to Wesker, presumably because of his healing his arm so he can be a soldier again.
- Remember the New Guy: "I died in the crash 2 years ago... Is that what they told you?" What crash? What mission? Who are you?
- Rival Turned Evil: Darkside Chronicles lays out the rather tragic story. Leon and Krauser only knew each other for the one mission, but they earned each other's respect and friendship and from Leon's point of view, parted as friends. In reality, because of a combination of the insane stress of the mission, fear of rejection by the government after major injury, and subsequent fascination for power with which he could liberate himself from others' control, Krauser sought after organic weaponry to augment himself immediately after that mission, breaking all bonds with Leon and the US government (although the fact that the US government fired him because of his injury was probably a huge factor in that last part of his viewpoint).
- Shell-Shocked Veteran: Similar to Gray Fox, Jack Krauser feels he is useless outside of the battlefield, and that being a soldier is his calling, to the extent that he often underwent mercenary missions even when he was off-duty from SOCOM. This is a large part of the reason why he ultimately turned to Wesker's help after the US Government fired him due to his arm injury never really recovering.
- Stab the Scorpion: In Darkside Chronicles, he stabs a snake that's about to strike Leon.
- Warrior Poet: He develops into a rather cynical philosopher over the course of The Darkside Chronicles.
- You Have Outlived Your Usefulness: Inverted. Even after death, he still served some use to Wesker with the latter autopsing his body and retrieving the Dominance Plaga to gain his plans.
Voiced by: Jesse Corti
"You carry the same blood as us, it seems."Another member of Los Illuminados and the village chief, Mendez personally led the hunt for both Leon and Ashley as they tried escaping from the clutches of the Plagas.
- Authority Equals Asskicking: He's the village chief, and every time he runs into Leon, he comes within a hair's breadth of killing him.
- Bald of Evil: Not a hair on his head.
- Beware the Quiet Ones: He only speaks to Leon once in the entire game.
- Expy: Clearly resembles Rasputin.
- Also looks a lot like the T-103/Mr. X, leading to some early speculation that he was one.
- Half the Man He Used to Be: When half of his health is depleted during his Boss Fight, his upper body rips away from his legs, forcing him to climb on the rafters to attack you.
- Handicapped Badass: Has a red Glass Eye in his left eye socket. It does little to slow him down.
- Chekhov's Gun: The glass eye serves as a key out of the village.
- Knight of Cerebus: He is a very serious threat to Leon.
- Large and in Charge: Serves as a contrast to Salazar's Mister Big.
- Lightning Bruiser: Pre-One-Winged Angel, at least. When Leon first enters the barn, Mendez practically Flash Steps across his line of sight, then appears behind him.
- Implacable Man: Has shades of this pre-One-Winged Angel, as Leon's completely unable to overpower the giant village chief when they encounter each other.
- Neck Lift: Has a habit of doing this to Leon whenever they meet.
- Neck Snap: He will do this to Leon if you fail the Quick Time Event before his Boss Fight.
- One-Winged Angel: Resembles some manner of monstrous praying mantis.
- Pragmatic Villainy: After Leon is infected with a Plaga, Mendez almost strangles him to death, but when he sees the tell tale red eyes of a Plaga host, he spares him. It doesn't last long.
- Starter Villain: He's the first major bad guy Leon encounters, and the serves as the main boss of the village section of the game.
Leon's evac personnel. A good deal of Leon's story involves him attempting to get extraction from him, and Mike even gives missile assistance late in the game.
- American Accents: He sounds like he's from New York, given how he pronounces bar.
- Badass: He's basically essential in the small part he's around in.
- Flat Character: Sadly, he only gets a couple of lines.
- Escort Mission: Inverted. By all accounts, he is escorting you.
- Gatling Good: His helicopter's armed with one.
- The Cavalry
- I Need a Freaking Drink: He and Leon agree they both need a drink after the game. Too bad his helicopter is immediately blown up after that, and him with it.
- Talking Is a Free Action: Averted. Pausing to talk to Leon about bars was his fatal mistake.
- Too Powerful to Live: Osmund Saddler shoots him down once he kills enough of his militia.
Las Plagas and Hosts
Behavior-altering macroparasitic organisms that infest other life forms and compel them to form hive-like social structures, existing only to spread and to defend the group. First unearthed centuries ago in a remote part of Europe, implicitly somewhere near Spain, they became the centerpiece of a mad cult, Los Illuminados, before being sealed away by the Castellan of the region. Generations later, Ramon Salazar, eight of his line, unearthed them from the depths of his castle and revived the cult, which made plans to spread itself to the United States of America.Although that plan was thwarted by Leon Kennedy, samples of the plagas were recovered and joined the T-Virus and its derivatives on the bio-terror black market. Tricell would later develop and deploy genetically upgraded Type 2 and Type 3 Plagas in the African country of Kijuju, and derivatives of the Type 2 Plaga would be used as bio-weapons in the Eastern Slav Civil War incident.The hosts of Las Plagas are referred to as Ganados (literally "The Herd" or "The Cattle") in Europe and as Majini (literally "Wicked People") in Africa.
- An Axe to Grind: Handaxes are among the many weapons commonly carried by Plaga hosts.
- The Executioner Majini carries an enormous executioner's axe/sledgehammer hybrid as a melee weapon.
- Attack Its Weak Point: Exposed Plagas are generally the only way to quickly take down their hosts.
- Garradors cannot be killed any other way, due to being covered in thick armor.
- Duvalias can only be harmed by attacking the "tail" made from their host body's shredded upper torso that they drag behind them.
- Big Creepy-Crawlies: On a technical level, the Plagas themselves, which as macroparasites are much larger than the viruses that were used in earlier games. The more mature Plagas look sort of like bugs and other creepy crawlies; centipedes, worms, spiders, leeches, and other squiggly things you'd find under a rock.
- The Novistadors are Plaga-based insect hosts which look something like a locust, something like a mantis, and something more like something out of an entemophobe's nightmare. They're giant flying bugs that can turn invisible and melt your face off with Hollywood Acid to eat your brains.
- Body Horror:
- Averted with most general Plaga hosts; it's the fact you can't tell that they're infected that makes them scary.
- Played straight when Plagas expose themselves in response to damage.
- The Marshland Majini, the members of the Ndipaya and Sodibaya tribes infected with the experimental Type 3 Plagas, play it straight, with corpse-green skin, flayed-looking arms, hearts that have swollen until they visibly burst through the chest, and cheeks that rot away to expose a permanent rictus snarl of teeth.
- Ndesu's body is covered in crudely-stitched gashes, from which huge leech-like Plagas burst forth after it takes enough damage.
- Regeneradors and Iron Maidens have mutated into barely human monsters with triple-jawed, otherwise featureless faces.
- U3 has a tentacle in lieu of an arm, an oversized lolling tongue, a lower jaw that's crudely broken into mandibles, and has mutated into a vaguely tauric body configuration.
- Chainsaw Good: Both the Spain and Kijuju outbreaks have special Plaga hosts who carry chainsaws as weapons (Dr. Salvador and the Bella Sisters in Spain, the Chainsaw Men in Kijuju). These mini-boss characters can soak up a disproportionately high amount of damage and dish out a One-Hit Kill attack.
- Combat Tentacles: The "Plaga Type 1 A" from the European outbreak and the "Cephalo" Type 2 from the African outbreak both wield a strange combination of this and Epic Flail. The Type 1 A is a shapeless mass of tentacles, with one huge tentacle tipped with a serrated bone blade, which it whips around to hack Leon with. The Cephalo is a tentacle/centipede hybrid that ends in jagged spurs of bone; it spins itself around and around in constant arcs as the host strides forward, slashing at anyone in its way.
- Dead Weight: The aptly named "Big Man Majini", a hulking and stout-bodied Type 2 Plaga host with Super Toughness and Super Strength, sits somewhere between this and Fat Bastard.
- Elite Mooks: Both outbreaks have specialised Plaga hosts who aren't "true" bosses, but are much, much more dangerous than the normal Plaga hosts. The chainsaw-wielding Dr. Salvador, Bella Sisters, and Chainsaw Men are Mighty Glaciers who can dish out a One-Hit Kill. The Garradors are armored Lightning Bruisers who can only be hurt if you Attack Its Weak Spot. The Regeneradors and Iron Maidens have a Healing Factor that makes them almost impossible to kill without specialised equipment and precise aim. The Executioner Majini is a massively powerful Mighty Glacier. The Big Men and Giant Tribal Majini are both Made of Iron even by Majini standards and deal far more damage than their basic comrades.
- Expy: The Verdugos look a lot like the titular xenomorph from Alien.
- From Bad to Worse: The Type 2 Plaga was literally designed to be this compared to its ancestor. It spreads much more quickly, can take control of a host in seconds, and is resistant to sunlight.
- Also, the switch over from Tribal/Marshland Majini in acts 3 and 4 to Base Majini in acts 5 and 6; now they have guns too.
- Healing Factor: The Plaga-based B.O.Ws called Regeneradors and Iron Maidens have this ability, but have lost their human form as a result.
- Hive Queen: The Dominant Strain Plagas, which command the obedience and loyalty of all subordinate strain Plagas — and thusly their hosts.
- Lovecraftian Super Power: Hosts of a Dominant Strain Plaga can command the obedience of lesser Plagas and often have far greater strength and durability, as well as a One-Winged Angel form of truly horrific appearance.
- Made of Iron: Thanks to the Plagas' coopting of their hosts' nervous systems, those under a Plaga's control are far more resistant to pain and injury than is normally the case.
- Meaningful Name: The various Type 2 Plagas receive these kinds of names from Swahili; the spider-like unhosted adults are referred to as "Bui Kichwa" ("Big Spider Head"), the head-replacing tentacle-like "Cephalo" ("Head", and short for the Kenyan root vegetable "Cephalopentandra"), the flying bat-leech "Kipepeo" ("Butterfly") and "Duvalia" (after a kind of African carrion-flower).
- Mercy Kill: Plagas latch onto the spinal column and are virtually impossible to extract, so once they have control, killing the host is really this.
- More Dakka: The Base Majini all wield AK-74s, having enough of their old minds to shoot guns, but not really enough to aim very well. Taken Up to Eleven with the Gatling Gun Majini (and their spiritual predecessor, J.J the unique Gando), who all wield massive gatling guns.
- More Than Mind Control: As Plagas take over the brain and nervous system as part of their parasitism, they alter the host's behavior, causing them to descend into savage barbarism.
- No Woman's Land: Zigzagged; there are female hosts, but these generally only appear in the first region and are far rarer than males, being replaced entirely by male hosts in later areas. Somewhat justified; there were plans for female Zealot Ganados, but these were scrapped, and the "Mercenary Ganados" are, well, based on mercenaries, so they wouldn't be likely to have any female members. Meanwhile, the Type 3 Plagas from the Kijuju incident are genetically incompatible with female and child hosts, killing them if they try to infect them.
- One-Hit Kill: Chainsaw-wielding hosts, the centipede-like "Type 1 B" Plaga in 4, and the Duvalia in 5 can all kill you with a single strike.
- Our Giants Are Bigger: The ogre/giant-like El Gigante and Ndesu are massive, hugely strong and dangerously violent Plaga hosts.
- Raising the Steaks: Plaga-infested canines appear in both outbreaks. Spain's Colmillios lash out with Combat Tentacles, whilst Kijuju's Adjules can split their heads in half to bite your player character in half.
- Red Eyes, Take Warning: The eyes of a Plaga's host turn bright red once it has control. When a Type 2 Plaga infects a new host, they actually bleed from their eyes, nose and mouth as a side effect of the physical control.
- Super Soldier: Technically, any Plaga host will do, since it turns them into unnaturally tough vicious killers who feel no fear for their own lives and will hunt down anyone and kill them without a qualm. However, further experiments with Plagas have produced unique and horrifying monsters in their own right, such as the Regeneradors and their Iron Maiden cousins, the bug-like Novistadors, the salamander-based Del Lago, the insectile Verdugos, the brutal Garradors, and the hideous failed experiment "U3".
- Technically Living Zombie: A Plaga's host displays some zombie like traits, such as a resistance to pain, mindless violence towards those not infected, bloodlust, savage and impulsive behaviors, and a hunger for flesh, but are still living creatures, just subsumed by the bestial urges of the parasite within them. This is slightly more pronounced in Type 2 Plaga hosts, who have an instinctive directive to "spread the infection" as far and as fast as possible.
- Weakened by the Light: Ultraviolet light is anathema to Plagas. Consequently, Type 1s won't expose themselves until night falls. Type 2s have had this trait weakened and so will operate in the day without harm. Both types, however, cannot withstand the concentrated light released from a Flash Grenade, making these Trick Bombs a One-Hit Kill weapon against them.