Character Development: Becomes more proactive throughout The Darkside Chronicles. By the end, she comes to understand herself and her powers better, learning how to hold on to her soul and maintain control of herself by embracing both humanity and the pain that comes with it.
Earn Your Happy Ending: Throughout The Darkside Chronicles, we are shown numerous examples where virus infectees meet very messy ends. The end of The Darkside Chronicles says that Manuela coexists stably with the Veronica virus and is no longer terminally ill, very likely as a result of her personal growth.
Eleventh Hour Ranger: She's been with you for a while, but she'll join the fight against the final boss with her powers. She'll do most of the damage too, if you let her.
Eleventh Hour Superpower: Unleashes the powers granted to her by the Veronica virus right before the final boss fight. She's able to toss her blood out as large explosive fireballs, vastly speeding up the process of whittling down the final boss.
Foil: To Alexia Ashford, especially as she is presented in The Darkside Chronicles. Both are Veronica virus infectees with similar powers, coexisting with the virus, but are at polar opposites on the morality globe.
The Ingenue: She is soft-spoken as all get-out, but also intelligent and highly courageous. The naivety fades out as she comes to develop her own philosophy regarding the Veronica virus and its gifts, which certainly serves her better than everyone else who tried to use it for power.
Red Right Hand: The bandages on her arm are covering scarring that is from her infection with the T-Veronica Virus.
Scars Are Forever: Averted in the bad ending. Just before she dies, her arm heals up.
Sweet and Sour Grapes: The essence of her relationship with the T-Virus within her. If the pain of living sickly gets too much, she can just let go and become a monster—that's the very basis of the T-virus, as Darkside Chronicles shows again and again. It is withstanding pain and holding on to both the good and bad in life that allows her to live with the virus, and Krauser and Leon's faith in her gives her a reason to do so.
What Measure Is a Non-Human?: Somewhat discussed in Darkside Chronicles. Leon's only heard of psychos wanting the Veronica Virus or people horribly mutating if they were forced to contract it. He expresses shock that it was used as a treatment. Once he adjusts, though, he shoots down Krauser's idea that they should kill her before she becomes a threat.
Woman in White: Runs around the entire game in a tattered white bloodstained mini dress.