"Don't worry. I may not be as big as you, but I can still hold my own!"
Chris' partner during 5, with whom he develops a strong bond. She joined the BSAA to fight against biological weapons since her parents had been victims of experiments carried out in Africa with said weapons.
Good Is Not Soft: Even amongst the other player characters, Sheva stands out. She is one of the nicest characters in the series, especially if you build up her trust, established to be just as good as Chris, Jill, Leon, or Claire, and in the final boss fight, you can have her do one of the most Bad Ass things in the series and turn Wesker's chest into a scratching post.
Heroic Sacrifice: She was about to perform one, but Chris saved her from herself.
Knife Nut: Sheva will straight-up shank a fool if given the opportunity.
Including Wesker. While he's infected with Uroboros.
Aristocrats Are Evil: He's a Lord......his last name is perhaps a Shout-Out to the venerable Spencer family, of which Princess Diana was a member.
Bad Boss: In "Lost in Nightmares" from Resident Evil 5, you can read diary entries of those who worked in Spencer's mansions. It seems he turned a lot of them into test subjects, and ultimately into monsters and zombies.
Chronic Backstabbing Disorder: Kills Marcus through Wesker and Birkin, betrays the latter for attempting to leave Umbrella, betrays George Trevor by locking him inside his mansion, and lastly betrays Wesker by admitting he is his creation.
Cutscene Boss: After waiting numerous games to meet Ozwell E. Spencer in the flesh, Wesker kills him in a cutscene. Although, fighting an 89 year old man on life support probably would not have been an epic boss battle.
Dark Lord on Life Support: The years have clearly taken their toll. He was even the page image for a time. He's reduced to being confined to wheelchair and life support system three years before Resident Evil 5 due to his old age. He expects Alex Wesker to reverse this condition by engineering an Immortality virus, although Albert Wesker kills him to become the Big Bad after Spencer reveals that Wesker was one of many Unwitting Pawns for Umbrella known as "Wesker children" in a project done to create the perfect breed of humans.
Smug Snake: Smart and a capable schemer, he's behind almost every bad thing in-series, but he waited too long to put his plan in motion, allowing Wesker to hijack it for himself.
The Unfought: The heroes never even meet him alive. He's already been killed by the time Chris and Jill bust into his chamber.
Voiced by Nina Fahren
"You're just not ready for me!"
Excella is the CEO of Tricell Africa and one of the people responsible for the creation of the Uroboros Virus. She also shares Wesker's idea of World Domination and intends to be the Queen of the new world with Wesker as her King.
Director of the oil facility headed by Tricell Africa, Irving helped found its B.O.W. research department, and subsequently became known as a "death dealer" on the black market for distributing the products Tricell developed to African bioterrorists. Chris and Sheva going to Africa to capture him is what kickstarts the events of Resident Evil 5.
Irving: "Dying's not so bad. But it doesn't change anything... you're still screwed!" (cue Evil Laugh)
Disc One Final Boss: The first part of the game is all about chasing him, investigating him, and arresting him — it's only upon his defeat that he lets it slip he was merely following orders from Tricell's CEO, Excella.
"You'll be pleased to hear that all experiments are running smoothly."
A trusted servant of Oswell E. Spencer and, after Albert Wesker's death in Resident Evil 5, the sole survivor of the Wesker children project. His existence is revealed by files in Resident Evil 5's 'Lost In Nightmares' DLC (well, actually, if you look hard enough, you can find small references to him in the main game itself, for instance if you read the files on the ship where you fight Excella), where it's revealed he was conducting experiments for Spencer in the South Seas. With Spencer's death, his current whereabouts are unknown.
Chekhov M.I.A.: Seems to be set up as one, since the last we heard of him, he'd disappeared off the face of the Earth with all of the research he'd been doing for Spencer.
Samus Is a Girl: Subverted. Because of botched translations and localizations of Lost of Nightmares, any third person gender identifiers were left out, leading several fans to assume that Alex was female. The Japanese version makes it very clear that Alex was a male.
Stronger Sibling: Is already being set up this way, although who knows if it will last.
Super Soldier: Given the strong implications that he took the same virus as Albert Wesker did in the notes regarding Alex, it is extremely likely that he became this, with all the abilities Albert Wesker had.