This page is for characters introduced in Resident Evil 5 only. For characters in other games or films in the game continuity, go to their respective debut media.
Kevin Ryman, Alyssa Ashcroft, Cindy Lennox, Mark Wilkins, David King, Jim Chapman, George Hamilton, Yoko Suzuki, Linda, Carter, Monica, Rita, Regan Mallet
"Don't worry. I may not be as big as you, but I can still hold my own!"
Chris' partner during 5, with whom he develops a strong bond. She joined the BSAA to fight against biological weapons since her parents had been victims of experiments carried out in Africa with said weapons.
True Companions: She's pretty much about this, either for Chris or for her team.
Josh Stone
Voiced by: TJ Storm
The captain of BSAA West Africa Branch and Sheva's mentor. He becomes Jill's partner in DLC, Desperate Escape.
Badass: Firmly establishes himself as one, both as Jill's parter in Desperate Escape and in the Mercenaries game, where he's lugging the shotgun and an RPG.
Lower Deck Episode: A DLC campaign ("Desperate Escape") in Resident Evil 5 allows you to play as him and Jill Valentine trying to escape from the Tricell headquarters.
Wrestler in All of Us: His melee takedowns include elbow drops, German suplexes and chokeslams.
Ozwell E. Spencer
Voiced by Adam D. Clarke
A British lord and founder and President of the Umbrella Corporation, who set in motion the events of the entire series in an attempt to make a new, superior race with himself ruling over it.
Aristocrats Are Evil: He's a Lord......his last name is perhaps a Shout Out to the venerable Spencer family, of which Princess Diana was a member.
Bad Boss: In "Lost in Nightmares" from Resident Evil 5, you can read diary entries of those who worked in Spencer's mansions. It seems he turned a lot of them into test subjects, and ultimately into monsters and zombies.
Celebrity Resemblance: His voice actor, who is a self-admitted Star Wars fan, based his voice on that of Ian McDiarmid's role of Emperor Palpatine.
Chronic Backstabbing Disorder: Kills Marcus through Wesker and Birkin, betrays the latter for attempting to leave Umbrella, betrays George Trevor by locking him inside his mansion, and lastly betrays Wesker by admitting he is his creation.
Cutscene Boss:After waiting numerous games to meet Ozwell E. Spencer in the flesh, Wesker kills him in a cutscene. Although, fighting an 89 year old man on life support probably would not have been an epic boss battle.
Dark Lord On Life Support: The years have clearly taken their toll. He was even the page image for a time.
Evil Cripple: He's in a wheelchair when Wesker finds him.
The Man Behind the Curtain: He's behind all the bad stuff in series, whether directly or indirectly, but he's little more than a pitiful old man, whining about how he was unable to achieve godhood.
Nice Job Fixing It, Villain: If Spencer didn't order Wesker and Birkin to assassinate Dr. Marcus, none of the events relating to Umbrella's downfall and afterwards would have happened.
Smug Snake: Smart and a capable schemer, he's behind almost every bad thing in-series, but he waited too long to put his plan in motion, allowing Wesker to highjack it for himself.
The Unfought: The heroes never even meet him alive. He's already been killed by the time Chris and Jill bust into his chamber.
Excella Gionne
Voiced by Nina Fahren
"You're just not ready for me!"
Excella is the CEO of Tricell Africa and one of the people responsible for the creation of the Uroboros Virus. She also shares Wesker's idea of World Domination and intends to be the Queen of the new world with Wesker as her King.
Femme Fatale: Subverted. She has all it takes to be one, beauty, intelligence and cunning, but in the end she is the one who falls for Wesker's masculine wiles and pays for it.
Stripperific: A backless mini-dress and pumps is not the appropriate attire for running around the African jungle or an oil rig.
Too Dumb to Live: It's hard to believe she really thought Wesker wasn't going to stab her in the ribs.
Unholy Matrimony: With Wesker, though they weren't indeed married to each other but in her head...
What Could Have Been: She would have simply been a secretary to Tricell, and her death was portrayed very differently (she would have died in the hands of a Tyrant-like creature, literally), and the Tricell CEO would have been a different, male character. The two characters were ultimately combined in order to create a powerful female villain.
Wicked Cultured: Her dress and shoes are both based on pieces by real life designers.
Woman in White: Though it's not played for mystery or necessarily to show that she is evil.
Ricardo Irving
Voiced By: Allan Groves
Director of the oil facility headed by Tricell Africa, Irving helped found its B.O.W. research department, and subsequently became known as a "death dealer" on the black market for distributing the products Tricell developed to African bioterrorists. Chris and Sheva going to Africa to capture him is what kickstarts the events of Resident Evil 5.
Disc One Final Boss: The first part of the game is all about chasing him, investigating him and arresting him — it's only upon his defeat that he lets it slip he was merely following orders from Tricell's CEO, Excella.
"You'll be pleased to hear that all experiments are running smoothly."
A trusted servant of Oswell E. Spencer and, after Albert Wesker's death in Resident Evil 5, the sole survivor of the Wesker children project. His existence is revealed by files in Resident Evil 5's 'Lost In Nightmares' DLC (well, actually, if you look hard enough you can find small references to him in the main game itself, for instance if you read the files on the ship where you fight Excella), where it's revealed he was conducting experiments for Spencer in the South Seas. With Spencer's death, his current whereabouts are unknown.
Dragon with an Agenda: It's implied in one file that he betrayed Spencer shortly before his death, having ceased all contact with him.
Evilutionary Biologist: Spencer notes that Alex's experiments to find the secret of immortality required "thousands upon thousands" of test subjects. It's unknown if he succeded or not.
Genius Bruiser: Said to be the brightest of all the Wesker children, and has comparable powers to Albert having been administered the same experimental virus.
Samus Is a Girl: Subverted. Because of botched translations and localizations of Lost of Nightmares, any third person gender identifiers were left out, leading several fans to assume that Alex was female. The Japanese version makes it very clear that Alex was a male.
Stronger Sibling: Is already being set up this way, although who knows if it will last.
Super Soldier: Given the strong implications that he took the same virus as Albert Wesker did in the notes regarding Alex, it is extremely likely that he became this, with all the abilities Albert Wesker had.