Sheva versus Wesker. He has Uroboros. She has a knife. Which she uses to stab him with seventeen times in the heart. Sheva Alomar stabs the Big Bad of the series seventeen fucking times in the heart. Also a non-fatal Heroic Sacrifice for Chris when he tells her to [attack] through him. And in that sequence, yes. Chris DOES take damage.
Chris: Suck on this, Wesker!
Sheva: Your time's up, you son of a bitch!