Bonus points: It's a video game sprite comic with tons of filler, formulaic patterns, and the author screws with the audience for his own amusement.
Abe Kroenen: An undead clockwork Nazi assassin has a secret romance with a psychic fishman who works for a government agency—and in the movie the comic is based on, the two characters were never even in the same scene together. Also it's a Toy Comic.
Absent Minded Theater: The heroine has one arm and no legs and no badass replacement prosthetics. Not even normal prosthetics, she gets from place to place by the power of moxy.
Achewood: A group of stuffed animals, cats, robots and a cokehead squirrel drink hard and wheel and deal in the author's house, Hell and outer space... among other things.
The Adventures of Dr. McNinja: A ninja family, a 12-year-old mustachoed gunslinger, a gorilla secretary and a velociraptor named after a certain videogame character fight Ronald McDonald, a giant lumberjack, giant lumberjack poachers, pirates, dinosaurs, banditos, Fox News, The Grim Reaper, an 80's action movie star, zombies and vampires.
Alternatively: The eldest son of an Irish-American warrior clan attempts to redeem himself in the eyes of his parents while attempting to cure other people's strange medical problems.
Alternatively Alternatively: A comic including Chain-Saw Chucks.
Or: A masked eccentric, his sole employee, and his young ward struggle to find stability in the aftermath of the increasingly surreal events threatening their small East Coast hometown.
And in the alt text to a recent comic: Very stupid ideas taken very seriously.
Orrrrrr: Every conceivable variant of cliched badassery crammed into a single comic.
Or: The child of two of the most messed up characters in all of anime does cute things.
Alien Dice: A deconstruction of Pokémon, in which an alien slave is turned into a Mon and keeps his own Talking Animals turned into Mons. Victory could mean freedom for him and other slaves. Failure will mean his death.
Ansem Retort: Kingdom Hearts sprites (as well as Darth Maul, Red XIII, and Jesus...who is himself an edited Vexen) adopt much more cursing and violent tendencies. They all have severe mental problems, and fight for the fate of the universe. They're in a reality show. Run by the Antichrist. That is, to say, the Fox TV network. How they haven't gotten the Hell sued out of them is beyond me.
Or: One man attempts to find out how many times you can cross the line before it ceases to be funny. So far, the answer is never.
This also also describes The Wotch, to some extent.
Awkward Zombie: 50% more self-esteem issues than found in most gaming comics!
Axe Cop: A comic written with all the writing ability of a 5-year-old boy.
Or, a psychopathic police officer forms his own police agency with his long-lost brother, amputee best friend, and pet dog in order to stop crime by killing all the criminals in the world. Most of them wear sunglasses.
Bad Gods: A bald man with a goatee provides everyone with a series of D&D jokes, wry commentary on life, and cocktail recipes.
Better Days: Twin cats have typical childhood adventures, go to school, make friends, have incestuous sex. Later, one joins the army, the other becomes a radio host who has sex with a rabbit. Filled with lots of Objectivist overtones.
Charby the Vampirate: He's a Vampire, but he was raised as a pirate! He's also a Chosen One among Chosen vampires who have none of the weaknesses vampires have! He lives in a house with a dozen supernatural children, one of which turns into a sexy winged bunnygirl!
Ciem: A girl who just graduated from high school finds out she has a Big Screwed-Up Family in which one of her grandmothers is a centipede and one of her half-brothers is a space alien. She ends up with something of a Cartwright Curse while dressing up in an orange costume and beating up pedophiles and cyborgs.
Circle Versus Square: Two geometric shapes spend their time coming up with new and creative ways to insult each other.
Collar 6: REALLY! IT'S NOT PORN! It's in the style of a shonen anime!note About BDSM.
College Roomies from Hell!!!: A coming-of-age story about an angsty teen surrounded by people with wacky quirks that come to look more like serious mental problems as it becomes increasingly clear that The End of the World as We Know It is nigh and his destiny is to try and inevitably fail to avert it. Also, he got laser vision trying to drink his sorrows away and shares his name with at least two English singers from The Sixties. Oh yeah, and they all are battling the devil but won't know it until half-way through the series.
Commander Kitty: A spaceship full of animals seek fame, glory, and the aid of a red panda outlaw.
Comedity: A man deals with life by consulting the many, many facets of his personality in his head; they regularly argue with each other, and include a penguin, a Ninja, and the Red Right Hand. His computer's a Robot Girl.
Concerned: A moron bumbles through a dystopia, somehow making everything worse. Then he dies.
Concession: A bunch of anthropomorphic animals work in a movie theater. Some characters eventually get psychic powers. Oh yeah, and there's a lot of sex too. And even more gay sex.
Count Your Sheep: A little girl and her mother live with a talking sheep in a world where everything is blue. (Except when it's purple.)
Cuanta Vida: Two teams whose only difference is the color of their outfits attempt to leave.
Alternatively: A man is bad at his job, and ends up attempting to quit with several others. Mildly gay adventures ensue.
Or: Two lovers plan to quit together. Everyone gets involved as it snowballs downhill.
Cucumber Quest: In a land where most people are named after food and look vaguely rabbit-ish, a young boy is sent on a quest by his jerk father. The boy's little sister is much more enthusiastic about said quest.
Curvy: A normal teenage girl has a run-in with a girl from a world made entirely of candy. After a quick round of lesbian sex, they decide to stop the candy girl's moronic fiance from attempting to conquer the normal world, which is apparently called Boring World. Contains copious amounts of lesbian sex.
DM of the Rings: A famous literary classic is wiped from history, which results in a group of Role-Players trudging through copious amounts of boring backstory at the whim of a Railroading dungeon master in order to get to a meaningless ending.
Dreamwalk Journal: An erotic poser comic about two horny, naked women who visit a world inhabited by horny, naked, half-human insects and spiders.
Dresden Codak: A young half-Asian robotics enthusiast has philosophical arguments with two twins who wield the power of physics and a miniaturized version of a famous psychologist (but not the one you're thinking of). Later, she gets hired by the government explicitly to undermine the government.
Alternatively: Science-themed future superheroes and supervillain go to college together, become friends. Told from the POV of the future supervillain.
Fans!!: Sci-fi geeks fight bad guys straight out of sci-fi stories.
Final Blasphemy: A Sprite Comic that has Loads and Loads of Characters amongst Loads and Loads of subplots with connections between them only gradually becoming apparent. The main plot thus far involves a young man (and tremendously thin Author Avatar) being drafted into saving all reality from several mysterious forces. Things go downhill from there.
Femmegasm: Various vaguely connected jokes usually involving a video game or other pop culture reference. Main characters are a Tamarin monkey, a Axolotl salamander, a dragon, and a dog.
FreakAngels: A club of purple eyed weirdos set up in the White Chapel district of London while a guy they kicked out of their club tries to get revenge.
Freefall: A humanoid wolf works as a spaceship engineer for a squid with no sense of right and wrong and his childish Robot Buddy. She's popular among robots. And fans.
Friendly Hostility: The asexual (Or is he?) host of a children's program and his pansexual boyfriend get themselves a slave, make friends with demons and try to take over Venezuela.
Actually, Scottish-Irish ... or rather, "Scirish".
Girly: Lesbians fight crime and have adventures in a town that is periodically invaded by squirrels.
Goats: Two guys search for a programmer who can fix a bug in a laptop programme created by a Mayan god of the underworld which will make the whole multiverse crash. Meanwhile, a badass cybernetic goldfish, a chariot-pulling goat and the son of a Satan-worshipping chicken have a feud.
Grumble: Creatures that look like soup cans speak an incomprehensible language.
Gunnerkrigg Court: A girl who can talk to dead people almost accidentally causes a war. Her best friend builds an anti-gravity generator out of a thermos and coathangers, then falls in love with a bird. Her other friends are a demon-possessed doll (who tried to kill her), a sentient shadow (whose cousin tried to kill her), a robot she built (who got possessed and tried to kill her), and various gods of death (who taught her a bunch of languages).
Hanna Is Not a Boy's Name: A boy with a misleading name tries to solve peoples' problems using a Sharpie and a hammer. Cast includes a green amnesiac, a neurotic vampire, a masochistic med-school dropout, a pervy sharkboy, and a walking grandfather clock.
Hark! A Vagrant: About 70% comics about historical figures/events/occurrences, many of them Canadian. The rest are mostly about the author as a child.
Irregular Webcomic!: Groups of pirates, fantasy characters, an incompetent spy, two zoologists, and a fan-fic writer called William Shakespeare among others engage in a variety of pun-laden misadventures that frequently results in one of them dying. They, however, are brought back via the incompetency of a collection of Grim Reapers who have very specific specialisations. Mostly, though, it's about LEGO bricks and college-level physics.
Alternatively, a guy plays with his LEGO minifigs, GURPS figurines, and dinosaur and frog figures. Then he kills himself.
Knowledge Is Power: A group of grad students gain unwanted superpowers after being in the wrong place at the wrong time.
Kyle And Atticus: A young girl pretends to be a boy, but no one notices because they're too busy ogling her sweet pet robot.
Lackadaisy: Set in the 1920s, a psychotic guy who likes to spout improvisational poetry and his no less psychotic cousin play troubleshooter and rumrunner for a woman who may or may not have killed the guy's last boss. Oh, and they're all cats.
Listening To 11975 M Hz: A girl with strange hair decs has adventures... well, allegedly has adventures with her friends, none of which are coherent. Both her friends and their alleged adventures. It might be a comedy? Your guess is as good as ours.
Looking for Group: An elf who doesn't know he's supposed to be evil, an undead necromancer, a green-skinned person and a sentient bull travel together and eventually a dwarf joins them. It has nothing to do with the Warcraft game series.
Man-Man: A non-powered superhero with a drunken psychotic Belgian for a butler and his nemesis as his lodger fights crime and meets other often unimpressive heroes and villains. Only his reluctant sidekick thinks any of this odd.
Manly Guys Doing Manly Things: The daily trials of an employment center run by an ex-soldier whose unit was powered by brand awareness. His assistant is a rather bad pokemon trainer.
The Meek: A naked girl looking for her grandfather, a ruler copes with some serious problems with his cat, while a butch lady and a brat partake in shady business.
Ménage ŕ 3: A man who is a virgin shares an apartment with a nymphomaniac and a buxom, naive waitress.
Megatokyo: A manic-depressive artist, an insane computers teacher, their girlfriends, ex-girlfriend, students, and adoptive sister subvert, parody, and deconstruct miscellaneous anime tropes. Also, magic, zombies, Humongous Mecha and Kaiju are real, and video game companies secretly employ death-squads and make pacts with Satan.
BardQuest: A choose-your-own-adventure story supposedly about slaying a dragon, but ends up mostly being about codpieces. Then the author gives up.
Problem Sleuth: A group of detectives spend over a thousand pages attempting to break out of an office building.
Homestuck: A group of kids play a convoluted video game with God, who is in fact another group of kids.
Alternatively: Four kids get together to play a video game that they accidentally Sequence Break. Con Air is a fundamental chunk of the plot.
Four kids play an incredibly hard RPG together while more experienced players troll them. Elsewhere, an argument over a dress code occurs, which results in the deaths of billions.
Grey aliens with orange horns killing each other. There's also some complex world changing plot involving four heroes with complicated origins, but who's following that?
Some kid plays a game with his friends before everything goes wrong when his sister accidentally creates one of the toughest villains, who is an anthropomorphic flying one-armed dog wearing sunglasses.
Four kids play a game that promises to destroy the Earth and make them gods. Unfortunately, it doesn't go so well thanks to a bunch of cross-time trolls and an omnipotent puppet with a cue ball for a head.
It gets really good after the first few acts (which tend to take at least a month to read if you don't flat-out Archive Binge), but if you skip ahead you'll get more confused than you've ever been by anything else on the internet you have ever seen. Also, the first few acts are pretty confusing themselves even if you start from the beginning.note Which is how people genuinely tend to attempt to recommend it anyway.
A group of kids try to stop a naked black man from killing frogs. Meanwhile, a green kid with a skull for a head becomes an immortal God-like being after playing an extremely difficult game of pool.
Act 5; Hivebent: The ultimately tragic tale of how a group of quirky, hilariously flawed minor characters became more popular among fans than the actual main characters.
Alternately to the above: Twelve bloodthirsty, Zodiac-marked hermaphrodites with various neuroses play a game together.
A comic that consists entirely of the writer indirectly insulting the people who would like it. This is one of the most popular webcomics on the entire Internet.
A bunch of kids play a game together and cause the apocalypse, leading them to get involved in a chess game about frogs. They are then forced to abandon the planned course of events to collaborate with dysfunctional aliens to kill a homicidal dog-man, and end up being manipulated by a sapient puppet in order to summon a skeletal green monster named after a nationality. Then the universe explodes.
Oceans In The Sky: A young boy inherits his uncle's old sailing ship, so he drags along his best friend for a summer vacation adventure. It turns out the ship is really an interplanetary spaceship, and its former captain is still around, albeit trapped in the body of a ragged stuffed doll. Hilarity Ensues.
Off-White: After potentially dooming all of reality to go bugger-up, a demigod spends his final days goofing off with his adopted family, then is confused as to why other think this is irresponsible.
Alternatively: An alcoholic evangelical, a gender-confused magician, a growth hormone deficient homocidal maniac, a penitent criminal, a complete idiot and a black guy with daddy issues battle a literally by-the-book villain and his sidekick che guevara while crayons threaten to destroy the world. The black guy dies first, but not before the villain.
Out at Home: A cartoon family with a dumb father have wacky adventures or just sit around the house. Also, one girl knows it's a comic strip, but nobody else does.
Parallel Dementia: A female government employee who has trouble sleeping lives with three guys, two of whom do almost anything she tells them to and the third of whom was a friend of hers as a kid and now frequently kills things.
The Parking Lot Is Full: A series of surreal, oftentimes unsettling comics that make even the lamest of jokes seem scary.
Shortpacked!!: A couple of former special forces agents (one has a sugar addiction, the other is the biggest jerk in the entire universe), a gay Transformers fanboy with a heart of gold, a man who is convinced he is a ninja, a talking car with a cream-pie fetish, Ronald Reagan, the embodiment of pure brown-nosing evil, and... somebody without any terribly ridiculous-sounding attributes work at a toy store (owned by a fascist dictator) and have Seinfeldian Conversations about the 1980's and action figures.
Or: A government trained super soldier, a sugar addicted congress-woman/super soldier, a ninja, Ronald Reagan, and a talking car work in a toy store run by a facist dictator along side people who aren't completely out of place in such a setting, including a gay nerd who has an intense rivalry with the comic's author, a Yaoi Fangirl, a brown-noser, a lesbian, and a former sex addict.
Sinfest: A short skirt-chasing man hangs out with his sexy love interest, a talking stoner pig, Jesus, Buddha, the Devil, God, and the latter two's respective groupies.
Sister Claire: An innocent, cat-loving nun gets inexplicably pregnant and is later visited by a blue-skinned angel who saves her from her friend who is possessed by a cat demon.
Skin Deep: A young girl learns that in addition to normal social problems, she is also a monster. Thankfully, her friends are too.
Exchanges: A young boy learns that his effeminate friend is not gay, he's just a monster. Also, the first boy is a monster too, though he's less than cool with the idea. Meanwhile, all the other monsters go about their day to day lives, because people screaming in broad daylight about growing wings isn't all that unusual for them.
Skin Horse: A transvestite psychologist, a zombie psychopath, and a talking dog rescue the creations of mad science for a paranormal Witness Relocation Program.
Slightly Damned: The main character is dead to begin with, makes friends with the worst example of a demon ever, comes back to life, helps an angel who's cursed to turn into a rabbit, and goes on a quest to find the angel's brother. Also, there's plenty of Interspecies Romance.
A Softer World: A girl photographs things and a boy makes short, introspective "artsy" comics with them. They're often surprisingly funny.
Something Positive: A Deadpan Snarker plays tabletop games with his extraordinarily violent friends, one of whom owns a tech support/phone sex hotline. He gets given a cat who is over twenty years old, has no bones, and is recovering from chemotherapy. Loads and Loads of Characters come and go. He works on a catgirl comic (which is directly responsible for as many as five or six deaths) in his spare time.
Spinnerette: Young woman develops serious medical condition, talks her roommate into sewing three Venom costumes together, then goes out to fight crime alongside a Mahoromatic cosplayer and an ex-cop who's very tired of people getting his name wrong. Their boss is Ben Franklin and they regularly butt heads with a guy who went all super-villain from reading Ayn Rand.
Star Guys: Multicoloured roomates go about their daily lives. Several of them also have their own multicoloured stalkers.
Starslip: A man has a crush on a woman he won't see for a very long time, and has to cope with the loss of authority to someone of lower class. Someone who works for him constantly vents his bodily emissions.
Subnormality: A cast of characters including a perpetually down-on-her-luck girl with pink hair and a giant talking sphinx wax philosophical about life and its irritants. Has lots of words. No, seriously, dude, lots of them.
The Suburban Jungle: A carnivore tries to be a supermodel. Her roommate is kidnapped by aliens.
Superego: Ten multi-colored dysfunctional people with wake up in a floating building and try to survive their encounters with squiggly lines.
Supermegatopia: Furry superhero comic where the heroines often win battles by losing their tops.
Surviving The World: A man in a baseball cap and lab coat stands by a chalkboard to deliver daily advice on life, love, social situations, metaphors, and baseball.
Templar Arizona: In a slightly bizarre alternate-history world, a depressed Washingtonian moves to a town in Arizona where he's quickly befriended by a clinically retarded but friendly rock star, his overweight and flamboyant neighbor, a kind black man who habitually wears a kilt, and two guys whose family worship the ancient Egyptian gods.
The 10 Doctors: A Fan Fic in which a guy meets himself nine times. Old friends, acquaintances, and foes turn up everywhere you look.
Terror Island: Two roommates engage in elaborate plots to attempt to force the other to buy groceries.
VG Cats: Two cats play computer games, swear at each other, and occasionally die violently. The cast is rounded out by a man who wears pants on his head and an oblivious demon-thing.
...and a idiotic hobo, who might just be, just maybe, not a licensed doctor...or not.
Wapsi Square: An ordinary big-breasted Latina girl from Minneapolis has regular conversations with gods, monsters and demons but is convinced there's a rational explanation for it all. Oh yeah, and she can teleport.
What Birds Know: Three young women climb an old tower that leads to another dimension where everything looks the same, but where they find themselves laying eggs. Golden eggs. For at least one of them this ends very badly.
YU+ME: dream : Lesbians go through high school. The love interest's past comes back to haunt the main couple. The relationship was just a dream, though.
Zebra Girl: A woman takes a radical change badly. A magician, his sister, a werewolf, and a giant anthropomorphic rabbit are involved.
Cast includes a perverted magician, his talking book, his sister that doesn't do anything except for dating a werewolf, his sister's best friend who he turns into a demon (and is actually the main character) and recently went bat-shit insane, the alternate universe verson of the girl who gets turned into a demon who's not even the same gender or species as her (he's a rabbit). And a guy with a yucky face on his forehead.
Zoophobia: A young woman finds herself employed into a world that she's deathly afraid of. She must overcome her fears to give guidance to animals, magic animals, giant animals, shapeshifting animals, humanoid animals, and demonic animals. And humans. Oh, and animaloid humans too.