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Anime & Manga
- In Mushishi, most mushi are giant magical microbes.
- Phyrexian Living Weapons in Magic: The Gathering come into play automatically attached to a 0/0 Germ token. The germ can't survive on its own outside of the weapon, but with a few buffs to its toughness and power it's possible to beat things up with a giant Germ.
- In the Don Rosa Scrooge McDuck story "The Incredible Shrinking Tightwad", Scrooge and Donald are eventually shrunk down to microscopic size due to the effects of a malfunctioning shrinking ray, and are menaced by a horde of microbes.
- In a Super Goof story, a villain used a ray gun to enlarge animals. In the final battle, Super Goof was pitted against a van-sized amoeba.
- One old horror comic dealt with an alien seeking the most ferocious creature on Earth but as he probes the human protagonist's mind he finds everything offered up (like bears and tigers) to be quite boring, until he picks up on a subconscious thought from the protagonist and teleports them where a truly horrific tentacled beast awaits that the alien quickly photographs then kills. The monster? It was the CANCER infecting his terminally ill wife, only now she's cured.
- An old Silver Age Superman story dealt with a sheltered bubble boy who believed a futuristic version of the Fugitive on TV was real after seeing that Superman was real and deciding that his parents had lied and that everything on TV was real so escapes to warn the TV character being hunted that the future cop's about to capture him. He tries to trick the kid into killing the other actor to save his career only to end up consumed by one of the kid's white blood cells, as his parents never informed him that exposing his blood to air caused them to grow to blob monster size and he'd scratched himself on a bush earlier.
Films — Live-Action
- Evolution used a giant microbe. Technically, it's an amoeba...
- The B-Movie The Flesh Eaters features the titular micro-organisms joining together to become one large creature.
- Star Trek III: The Search for Spock has a set of microbes that get supersized thanks to the Genesis Effect. Later, they get so big that Captain Kruge gets to have a fight with one of them!
- In Fantastic Voyage, the heros had to survive being caught in the crossfire of antibodies versus bacteria, "recticular fibers" that clog the intake ports, an direct attack on Grant and Cora by antibodies, and white corpuscles.
- In some Choose Your Own Adventure books that involve some shrink-ray device, a few bad endings have microbes (e.g. paramecium, or white blood cells) attach themselves to an object which returns to normal size. In the case of an amoeba, it took Kentucky for breakfast, then Louisiana for lunch. Even at their normal microscopic size, they look very large.
- The oldest known example of this trope dates back to a French pulp adventure Une Invasion de Macrobes / The Invasion of the Macrobes published in 1909.
- The Belgian sci-fi/horror book La sortie est au fond de l'espace by Sternberg starts like this. All the microbes start growing, making the Earth uninhabitable in a series of scenes between horror and Black Comedy. For the survivors who fled in a spaceship, it goes From Bad to Worse.
- In Danny Dunn and the Smallifying Machine, the shrunken characters observe microorganisms swimming in the tiny puddle where they stop to take a drink. One of the kids mistakes them for fish at first glance, then realizes they're far too small for that.
- Galaxy of Fear: The Planet Plague gives Tash an electroscope-thing which she uses to see the virus behind The Virus. It's stated a few times to be magnifying the microbes, but is used more like magic glasses that reveal invisible things — she sees them overlaid over her normal vision and can tell at a glance if someone's covered with them. The viruses themselves seem to swim through the air after people.
- In Illuminatus!, the massive sentient one-celled creature Leviathan is beleived to have been inspired by the xenophyophores discussed in Real Life, below. Robert Anton Wilson and Robert Shea realised an amoeba is practically immortal - if it evades diseases and predators it has no reason or need to die - and wondered what would happen if one grew rather than divided. Over millenia.
- William Tenn's story "Winthrop Was Stubborn", one of the luxurious pastimes available in the far-future world is getting shrunk to microscopic size to hunt microbes.
- Star Trek:
- In an episode of Star Trek: The Original Series, the Enterprise crew fight a giant space amoeba at least as big as a planet.
- There is another episode that involves Puppeteer Parasites that are described as single cells that act as a Hive Mind.
- An episode of Star Trek: Voyager has the crew dealing with Giant Basketball-sized flying viruses.
- Used in Fringe, with a single-celled cold virus grown to the size of a cucumber. Yes, they did call it a "single-celled virus".
- The Baomea Mooks of Bakuryuu Sentai Abaranger are humanoid amoeba.
- Doctor Who:
- The episode "The Invisible Enemy" uses this trope both ways. First, the Doctor sends miniaturized clones of himself and Leela into his own body to root out the sentient space virus that's infected his brain. Second, the virus (which resembles the front half a lobster) is extracted from the Doctor's body and enlarged to human size.
- In "Kill the Moon", the Moon is revealed to be a giant egg for some sort of space dragon...thing, with spider-shaped "microbes" on its surface the size of a large dog. They can still be killed with Lysol, though.
- The Giant Microbes toys are this trope (in plush form). However not all are infectious microbes. One is yeast, a few are cells.
- The Trash Pack has the team of the Bin-Fections, who are the same size as the other Trashies. This is later expanded into a whole wave, with Series 7 being themed around "Junk Germs".
- Pokémon has Solosis and its evolutions, all of which are giant cells. There's also Deoxys, a giant, humanoid space-virus.
- The third boss of El Viento is a huge single-celled organism.
- Morpha from The Legend of Zelda: Ocarina of Time, whose Boss Subtitles identify it as a Giant Aquatic Amoeba.
- City of Heroes has Hamidon, giant single-celled organism and endgame raid boss.
- In Xenoblade, these show up as enemies in the Bionis' Interior, and all possess the trait of being highly resistant to physical attacks.
- Giant vaguely-microbial... things were present in earlier Final Fantasy games as generic Mooks, and seem to have been abandoned as the series became more "realistic".
- In Pikmin, one of the creatures Captain Olimar can encounter is a giant unicellular organism at least a foot across (gigantic compared to the tiny Olimar) with a watery interior and two nuclei.
- Viruses in the Mario & Luigi series. Back in Dr. Mario, these were a reasonable size (bigger than they should be, but still small enough to fit rows of them inside a medicine bottle). In Mario & Luigi: Superstar Saga and Mario & Luigi: Dream Team? They're about as big as a person is and come in armies about 16 strong at a time. They also tend to show up in rather unusual places like deserts, caves, mountains, parks and towns.
- Illusions involves guiding "amoeba-like creatures" called Gleebs to safety.
- The Giant Amoebas from Epyx's Temple of Apshai series.
- In E.V.O.: Search for Eden, the final boss, Bolbox, appears as a giant algae cell who thinks he's human. In contrast to the natural evolutions of the protagonist, Bolbox took advantage of Martian crystals in order to rapidly mutate.
- The comic Irritability played with this once, with Chappy bragging about his victory over a giant plankton.
Chappy: It was huge!
Tatanya: Like this? (pictures a building-sized plankton screeching "RAR!")
Chappy: ...for a plankton. (pictures himself grasping that same plankton, now about the size of an apple, and saying "I have u now!")
- Awful Hospital has the toddler-sized virus Dr. Phage and Zoe the protozoan receptionist on staff; there is also a thriving community of "bacterians" on a corpse-themed world, most notably the grandmotherly Dr. Staph.
- Johnny Bravo episode "The Incredible Shrinking Johnny" ends with an amoeba accidentally enlarged to giant size, which proceeds to chase Johnny and Carl down the street.
- In one episode of Captain N: The Game Master Kevin gets sick and the source of the disease is microbe called Viroid. In response to this the N Team shrinks down to confront him inside Kevin's body
- Superman: The Animated Series featured a brief appearance by ameoba enlarged to human size in the episode ("Monkey Fun") that introduced the giant ape "Titano".
- The Amoeba Boys are a gang of three dimwitted crooks in The Powerpuff Girls. They're about the size of humans, and sort of float along the ground.
- SWAT Kats had a legion of gigantic purple bacteria monsters in its second episode, "The Giant Bacteria". The trouble is, they didn't much look like germs, possessing eyes, mouths and a definite torso shape with arms and legs, due to the first one having originally been an ordinary guy (more or less) who gets mutated by Mad Scientist Dr. Viper.
- Godzilla: The Series had a gigantic bacterium the Big G had to fight. It could infect other organisms with smaller versions of itself, depending on how large the organism was.
- In Futurama, a giant paramecium is the winner of the Miss. Universe pageant.
- In the Darkwing Duck episode "Getting Antsy", the antagonist Lilliput shrinks Darkwing down to the size of a germ with his Shrink Ray - and Darkwing convinces a handful of friendly germs to make Lilliput sick. When Darkwing is turned back to his regular size, two of the germs, whom Darkwing introduces as "Blob and Ray", are turned human-sized too. They look like green Blob Monsters, but with recognizable facial features.
- The largest known single-celled lifeforms on the planet are amoeba-like protista called xenophyophores. They run about ten centimeters across. Small by monster standards, but positively kaiju-sized by cell standards. They are found exclusively in the deepest parts of the ocean.
- A fertilized human egg cell (and for that matter an unfertilized one) is 0.12 mm in diameter — visible to the naked eye.
- Eggs, in general, are these. The yellow part is the cell itself. An ostrich's egg is the largest single cell known to man.