Set in the near future, it features the exploits of gun sharks (hitmen) Finnigan "Finny" Sinister and Ramone "Ray" Dexter in the city of Downlode, sprawled across Central Europe. Occasional stories have taken place in other cities, or off planet.
This comic provides examples of:
- Abnormal Ammo: Sinister's Minigun is capable of firing normal and Hi-Ex rounds.
- Awesome Mc Coolname: The main characters full names are Finnigan Rapunzel Sinister and Ramone Algonquin Winnibago Dexter respectively. Other awesome names include "Holy" Moses Tennenbaum, Kal Cutter (though it isn't his real name), Miss Deeds, Satan Brink and others. Seems Abnett loves this trope.
- Badass Normal: Sinister. Many characters are cyborgs or genetically enhanced. Even Dexter has a Headcase installed, allowing him to have Improbable Aiming Skills and watch tv at the same time. Finny simply relies on his trusty Hand Cannon.
- Captain Ersatz: Abnett has stated he based the duo on John Travolta and Samuel L. Jackson's characters in Pulp Fiction.
- Cool Car: Dexter's Edsel is admired by many characters and serves the duo well for its speed and durability. It's stated to be a modern replica.
- Cool Shades: Finny's, is rarely seen without a pair of sunglasses. Which type is, of course, Depending on the Artist, though he is often depicted with Lennon Specs.
- Cultural Cross-Reference: In "The Why-Shaped Cut," Polly Alloy dresses as Sailor Moon.
- Executive Meddling: Parodied in universe in one strip that is essentially a parody trailer for a Sinister Dexter movie. The movie appears to cast vactors (virtual actors) as the main characters. Finny and Ray are disgusted to find that Bruce Willis has been cast as Sinister and Eddie Murphy has been cast as Dexter (Each even using lines from Die Hard and Beverly Hills Cop as Pre Ass Kicking One Liners). While Finny expresses some joy at Scarlett Johansson being cast as Demi Octavo, they both walk out of the theatre once the trailer is over, expressing disgust at having sold the movie rights to their own life stories.
- Fighting Irish: Sinister is an Irish, redheaded Professional Killer with a penchant for a drink order known as a Piston Broke and a Hand Cannon as a Weapon of Choice.
- Guns Akimbo: Dexter's pair of Rugers. After the events of "Malone", when Finny returns to Downlode and thinks that Dexter is dead, he briefly takes up the same type of pistols in tribute.
- Hand Cannon: Finny's minigun, which is a misnomer. It resembles a shotgun (Depending on the Artist) but is just a really huge handgun.
- Hitman with a Heart: Finny and Ray may be the best Professional Killers in the 'Lode, but they're always willing to do favours for friends. If It's Personal with them, be prepared to be whacked badly. This happens quite often.
- Meaningful Name: In Latin the words sinister and dexter mean "on the left side" and "on the right side", respectively.
- Mega City: Downlode. It's not quite clear how big the city is, but it certainly seems to sprawl from parts of Spain all the way into Eastern Europe. For a while the series' blurb at the front of the comic described Downlode as "sprawling across Central Europe like a hit and run victim"
- Pretty in Mink: Carmen Hosanna wears a long, white fur coat.
- Punny Name: Almost everybody. Not just people, the entire world seems to run off of this. An example in one episode was an Italian restaurant with an American Civil War theme called Spaggestisburg. This gets lampshaded, as one character doesn't get the connection between Italian food and The American Civil War.
- Too Dumb to Live: In Dunce Macabre, Kal reckons a man that they have just chased out into oncoming traffic is the dumbest mark that has ever had a price on his head. Finny and Ray proceed to tell him about some of the stupidest hits they ever performed, including a man who hid in a wardrobe (He was told he needed armour and thought they said "armoire"), a man who jumped out the window onto some live power cables and a man who filled in the form incorrectly and got himself killed and paid for it.