The Entire Cast
- Hot Scientist: Calleigh is a blonde, leggy Southern girl who likes guns, Natalia is a tall, curvy Latina, Eric is half-Cuban/half-Russian, Ryan has perfectly tousled hair, and Maxine Valera is fairly cute. Also, yes, some people do find David Caruso sexy.
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- Played By: David Caruso
- Cartwright Curse / Fatal Attractor: He has notoriously bad luck with girlfriends. They always seem to die.
- Flanderization: He used to have moments when he would actually emote.
- Friend to All Children: Caine is quite the example of Hard Boiled Detective... but not to kids. Kids always bring out his soft side. And woe betide anyone who hurts a child near him.
- Glasses Pull: Caine's main gimmick, always followed by a Quip to Black and the 'YEAAAAAAAHHHH—' sample.
- Good Is Not Soft: His response to being told an adult film director suspected of murdering one of his stars has two daughters is a great example."Would they be appearing in your movies when they are older? Just out of interest."
- Hard Boiled Detective: Though he's technically on the force, fits this trope to a T.
- Jumping Off the Slippery Slope: Seems to be going this way after his near-death experience. He is noticeably more vicious and ruthless, savagely beating a suspect and even letting a man fall to his death as he begged for Horatio to help him. Granted, one man had killed a police officer and was involved in a kidnapping, and the other man was a pedophile with a long history of abducting and molesting young female beauty pageant contestants, but still.Pedophile: *While hanging onto a ledge* I can change - I know it!
Horatio: I doubt that.
Pedophile: *His fingers starting to slip* You have to help me!
Horatio: *Coldly and dispassionately, while stepping away from the man* Do I?
Pedophile: *Falls to his death*
- Luke, You Are My Father: He has a son he didn't know about.
- One-Liner, Name... One-Liner: Making a drinking game out of the amount of times Caine did this in the show was just asking for alcohol poisoning.
- Papa Wolf: Hurting kids is a gigantic no-no around Caine. To provide three examples: an Arc Villain that was a murderous pedophile ended up getting a Murder by Inaction by Caine, a man who kidnapped a little girl got thrown through a window when Caine interrogated him on her whereabouts and a man who brutalized his family ended up with the absolute shit pummeled out of him by Caine inside of an interrogation room after the episode cut to credits.
- Played By: Emily Procter
- Southern-Fried Genius: Blonde, gorgeous Southern belle - who knows more about ballistics than the rest of the team combined.
- Played By: Rory Cochrane
- Everyone Calls Him "Barkeep": Speed, never Tim or Mr Speedle.
- Jerkass: Definitely had his moments, usually when speaking to women. He told one victim of harassment that it was her fault and she'd lead the guy on (she hadn't), and was rude to other female characters (excepting Alexx, Megan, Calleigh and Yelena).
- Killed Off for Real: Speed is shot and killed halfway through the Season 3 premiere by security guards at a jewelry store when his gun jams thanks to negligent keeping.
- Tempting Fate: When walking into a jewelry store with Horatio, Speed discusses expensive cars, disdaining them in favor of his bike. Caine mentions that he might need "something with doors" some day. Speed says he has plenty of time. He is fatally shot not five minutes later.
- Played By: Adam Rodriguez
- Played By: Johnathan Togo
Natalia Boa Vista
Natalia Boa Vista
- Played By: Eve LaRue
- Played By: Boti Ann Bliss
- Played By: Khandi Alexander
- Played By: Megalyn Echikunwoke
- Put on a Bus: Arrested for stealing drugs from the morgue.
- Played By: Eddie Cibrian
- Played By: Kim Delaney
- Played By: Omar Benson Miller
- Played By: Sofia Milos
- What Happened to the Mouse?: Her final appearance was in the Season 7 finale, when she assists Horatio with an escaped and dying fugitive; although she was advertised as being billed for more guest appearances, her character and her son's character were dropped with no announcement instead, invoking Chuck Cunningham Syndrome.
Detective John Hagen
- Played By: Holt McCallany
Detective Frank Tripp
- Played By: Rex Linn
Sergeant Rick Stetler
- Played By: David Lee Smith
- Inspector Javert: Most if not all of his appearances involved him barging into whatever plot was happening in the episode in a constant search for Caine's team (and especially Caine) being either criminally incompetent or just plain criminal, up to and including forcing members of Caine's team to try to play mole. It was unsubtly implied that he kept doing this because of his beef with Horatio.
- Internal Affairs: He's one of the MDPD's Internal Affairs officers, something he uses to constantly barge into the crime lab looking for corruption.
- Put on a Bus to Hell: In his final appearance it is discovered that for all of him trying to sniff out Caine as a Dirty Cop, he was one himself, stealing vehicles impounded by the MDPD to sell off and having a District Attorney assassinated to keep it under wraps. He is arrested and never seen again.
- The Resenter: Horatio made Lieutenant faster than Stetler. Stetler decided to believe that Caine accomplished this via corruption.
- Played By: Kim Coates
- Played By: Andrew Divoff
- Played By: Roger Bart
- Played By: Damian Young
- Played By: Gonzalo Menendez
- Played By: William O'Leary
FBI Agent Glen Cole
- Played By: Mark Rolston
Special Agent Dennis Sackheim
- Played By: Tom Hillman
Agent David Park
- Played By: Lance Reddick
- Played By: Malcolm McDowell
- Played By: Max Martini