At the end of episode 7, Jesse hits The Water Part. The Co-Dependent girls (who have played the game and know what's coming) egg him on until he steps into the water, at which point everything dissolves into a confusion of giggling, Angrish and the splashes of oncoming doom. "Keep Out Of The Water..."
In episode 22, Jesse somehow manages to fake out a monster in the funniest way possible.
In one of the missions, they are protecting some people while hanging on a helicopter. They are naturally happy that their driver is Big Purp but when they fail due to their incompetence. They see that Big Purp has been replaced, causing Crendor to rage, put the controller down, and walk away.
Throughout the entire series, both Jesse and Crendor mistake random people for Hitler. Crendor inparticular will go out of his way to kill Hitler, even if it fails the mission.
Jesse plays a round of Magicka for a special Fourth of July livestream. Jesse plays a game with Friendly Fire. With three other people. They let him have a gun. FOR AMERICA!
In episode 24 of the Terraria Let's Play, Jesse throws a bomb in a small space where both he and TotalBiscuit are trapped. TotalBiscuit lives.
Made even funnier due to the fact that they can't kill each other unless they change teams, but they don't even realize it yet.
In one episode, Jesse acquired a top hat that TotalBiscuit wanted. Bad stuff occurred.
This was after TotalBiscuit had killed the high-health top-hat wearing zombie. He and Jesse were killed and when they respawned, TotalBiscuit was complaining and Jesse was agreeing, all the while with Jesse wearing the Top Hat and carrying a torch. TotalBiscuit's response when he noticed was:
Where Jesse tried to trick TotalBiscuit with dynamite by claiming it was what was in a chest. Once again, he lives, and Jesse has killed himself with explosives yet again.
A fan put together a montage of the many, many, many deaths of Jesse and TB during the first Terraria series.
Terraria - The Next World Generation
Episode 10 of Terraria: The Next World Generation has Jesse devolving into Angrish after TB shows that the fruits of their labor in the jungle (where he was constantly dying) happened to be 2 statues that don't do anything.
What makes this even funnier is that TB is laughing so hard that he—in his words here—can't breathe properly.
It was also this episode that the Great Space Butterfly first came into being.
Alternative names were LoLboat One, and Frankenboat Joe.
In Episode 34, TB and Jesse's death counts have been equal, until one point. At one point, while TB is putting items away, Jesse sneaks up to a sky island and aggros a Wyvern so it will kill TB. It worked... to some extent.
For a considerable number of episodes near the end (so far) of the series, TB and Jesse repeatedly tried to reach the Underground Jungle - which was being overrun by the Hardmode Corruption - to harvest Moonglow for potions, and repeatedly died, often when nearly in sight of the jungle (or even in the surface portion of it). Finally Moonglow was acquired, and they returned to home base...only to discover that there had been five Moonglow in one of their chests the entire time.
Jesse: YOU HAVE GOT TO BE KIDDING ME!!
When making the hellivator, Jesse and TB were mining through some obsidian, with lava on three sides and water on top. They mined faster than the obsidian could be created, making them both fall down into the lava and die. Even worse is that one of their tombstones ended up under their shaft, causing more lava-related deaths because obsidian couldn't form over the tombstone.
The same fan that made the video of the Terraria deaths for the first season made another one for this season.
The Elder Scrolls V: Skyrim
Anytime he goes into a vocal rendition, such as saying "Diabeetus" when he sees a Horker.
The entirety of Episode 36, with Jesse's constant confused/scared reaction during the Sheogorath quest, and his frustration with the puzzles.
In Episode 48, while Jesse is 'sneaking' in the Thalmor Embassy, when he is in the courtyard he is ambushed by a dragon! Not only that but soon not one but two more dragons appear as well, distracting the Thalmor
Jesse: (Hears roar) Wait, was that a dragon?! (Gets bathed in flames)
Earlier while he was headed for the Embassy, a dragon attacked him, while he was naked no less. Understandably he died almost instantly. On his second time he equipped as much armor he could (only some gauntlets) and charged the dragon... only for the dragon to One-Hit Kill him. The third time, after deciding to suit up at the nearby town, the dragon doesn't appear at all.
Even funnier, that dragon might have been one of the dragons that attacked the embassy.
In the beginning of Part 15 when Jesse is trying to get past a couple of guards again.
Jesse: "Focus Jesse. Focus with all of your focusing abilities." * immediately gets caught* Jesse: "God damn it..."
The Final Part. Jesse doesn't even make that many jokes in it, instead just reacting the how batshit insane the last part of the game is. And his final reaction to the endings. "WHY IS THERE NO ANSWERS!" indeed.
"Fahrenheit is the fevered dream of a psychopath. It's a nonsensical, insane, ridiculous ride into the maw of madness. One cannot describe it, only experience it. And God help those who tread this path. 10/10, Game of the Year." - Jesse Cox
Just about anytime Jesse's response to a puzzle solution with "Well, that just happened..."
During the second Bonus Level set:
I'm not sure how... womens' undergarments work.
on Part 9 just as he barely survives the vacuum he says:
A similar situation in part 18 where he get's attacked by another of those tentacles, and later fights the boss that the tentacle spawned from. Which, as he points out, can be best described as a 'space anus'.
One of the best parts throughout the entire Let's Play of Dead Space and Dead Space 2 is how Jesse can be perfectly Genre Savvy regarding an upcoming Necromorph attack, yet still freak the hell out at the inevitable Jump Scare.
On a similar note, every time Kendra or Hammond contact Isaac, it comes with a loud blast of static that never fails to surprise Jesse.
Part 46: Jesse escapes the Flooded District and is on his way back to the Hound Pits Pub when he encounters two guards. Paraphrased:
Guard #1: The criminal mind, huh? So what's [Corvo] doing now? Guard #2: Waiting. He's probably watching us right now. Jesse, in hiding only a few feet away: lolol
Far Cry 3
The Craziest F'n Thing I've Ever Seen, a Very Special Episode, focuses around the kind of insanity that results during an open-world game. To wit, Jesse saves a cow's life by running over the tiger that was trying to kill it, drives his jeep off a cliff and into a river (after which the game crashes and he has to restart), wanders into a town under attack from cassowariesthat can apparently blow up cars, is attacked by an alligator right after Tempting Fate (descending into a rareCluster F-Bomb as he tries to fight it off), finds what is apparently a bulletproof goat, and gets murdered by a komodo dragon out of nowhere as he was in the middle of the looting animationin the space of nine minutes.
During the puzzle where Isaac has to move some fuses around to shut down ANTI, he becomes convinced he has the puzzle down. Only to... well:
Jesse: So, red is dead, and blue is in the goo! (Inserts first fuse, which turns blue.) Jesse: Blue! Nice. Okay, stick this down here... (Inserts second fuse. It turns green. Beat) Jesse: Wait, what? What the hell is green?! (bursts out laughing)
Even better, when he connects all the fuses so that they're green, he finds a secret room containing loot and Peng!
Jesse makes fun of Mengsk's special elite squads towards the end of the campaign due to their ineffectiveness relative to their fearsome title, and then creates "Death Squad 7," which is a group comprised solely of Zerg Overlords—units which have absolutely no combat effectiveness or utility to speak of.
About the Lutece twins: "WHY DO I LOVE AND/OR HATE YOOOUUU?!"
After seeing Booker's dream about Columbia attacking New York and arriving in the Garden of New Eden, Jesse then finds the inscription "The Seed of the Prophet shall sit the throne and drown in flame the Mountains of Man."
Jesse's "old-timey" voice. Especially when he decides to sing while using it.
The incident at the raffle: first, Jesse is driven to hysterical giggling by Fink's casually racist comment about "the prettiest white girl in all of Columbia"; then he realizes that he's just won on number 77 after being warned not to... and then it turns out that he's won the first throw in the public stoning of a mixed-race couple. Cue incredulous shouts of "Wait what? What the shit... WHAT?! What is happening here?" Then Booker fights back by ramming a policeman's face into a skyhook, leading to an incredibly bloody fight scene, and all of a sudden, Jesse's laughing again.
Jesse: "Uh, sirs, can we have a conversa—OH GOD, OKAY, NEVERMIND!"
Upon arriving in the Monument Island research center, Jesse finds an overturned chair with a shirt draped over it and a pair of shoes lying nearby; he immediately speculates that the previous owner was just so startled that his shoes and shirt blew off and he ran out of the building completely naked.
Jesse: Future DLC.
In part 9, Jesse comes across a Kinetescope in the arcade after going through and seeing the Colored & Irish bathrooms compared to the White bathrooms.
Jesse: What other horrific racist thing are we gonna fi—"Solving the Irish Problem", of course! Of course...
After pursuing Elizabeth when she panics and flees the ambush, complaining all the time that he's not done scouring the area, Jesse sees that she's not strong enough to activate the gondola lever, and immediately goes back to looting.
Upon encountering the animatronic, poem-reciting George Washington in the Hall of Heroes lobby, Jesse's computer suffered a critical error and crashed. Jesse could only speculate that it simply couldn't handle the awesomeness.
Part 13 has Jesse performing the single most violent mood swing imaginable. After listening to the somber, doomed message on one of Slate's audio-logs he delivers this thoughtful insight:
Jesse: ... Interesting, I'm not sure where to put his character yet... (sees enemy soldier and blasts him in the back) But I know where to put this guy's character! ON THE GROUND!
Jesse's constantly competing with Rex Power Colt's one-liners.
Jesse correctly predicts Rex's dialogue during a scene with Dr. Darling in Part 3, when Dr. Darling is offering an injection to make him as powerful as the Big Bad.
Rex: No, Doc. No way. I swore an oath to a special lady. Jesse: Lady Liberty. Dr. Darling: Your... wife? Jesse: Say it. Rex: No, lady liberty Jesse: yea-ha-hahhh! America! Rex: She taught me that winners... don't use drugs. Jesse: Fuck yeah!
Jesse takes a quick, terror and rant-filled ride down a river in a jet ski in Part 9. It ends when he rides right into the mouth of a mutant crocodile.
Battle Dragon: DO YOU LIKE RIDING ME? Jesse: I do, buddy!
"Can I 'F' this guy?"
Kerbal Space Program w/ Myndflame
The series is full of these. A large amount of the humor though comes from Clint (who is very experienced at the game) being a Deadpan Snarker to Jesse, who is practically new at the game.
In part 3, Jesse wants to send a Space Butterfly themed rocket to the moon. To which Clint has already prepared one but much to his objection, Jesse decides to make his own. The results of their first launch are expected.
Clint: *mocking Jesse* "Or we could just build a Space Butterfly!"
Dead Space 3 w/ Dodger
You know a Let's Play is off to a good start when the first gunfight after the prologue ends with this:
Unitologist: AAAAH! *BOOM* Dodger:What. Jesse:Bane just blew himself up on the top of my damn car!
Part 12: Jesse & Crendor's reactions to watching Hitler Ghost, a.k.a. Walrider, tear up Chris Walker, who they've spend the last couple episodes developing a special hatred for. Crendor starts clapping.
Jesse: You can't applaud Hitler Ghost! Crendor: Why not?!
Jesse and Crendor confused and raging about the ending.
Crendor: Even David Lynch would play this game and be like "What just happened at the end I don't understand."
Jesse: *laughing* Well you see David: this game was like a river. A river of idea fish. And the creators caught those idea fish, but ate them before they had time to lay the, the brain seeds.
Marlow Briggs and the Mask of Death
The Running Gag of Jesse singing "MARLOWBRIIIIIGGS!" whenever he opens a door, and then getting annoyed when there's no one on the other side of it to hear him doing it.
In episode 4, he ends up defeating a boss in 5 seconds when he accidentally knocks the guy off the platform.
In episode 9, he tries out the ice power up and winds up getting a 100 hit combo, this causes the mask to go into a massive rant about how awesome Marlow is, to the point he drowns out the plot.
During Part 3 when he starts playing the lost fawns searching for their mother.
Jesse: I'm saying right now if I get there and the she's dead I'mma be pissed off at that Bambi shit. Oh, by the way, spoiler alert for Bambi...
Jesse compares sneaking past hyenas to Metal Gear then cracks up upon discovering the sequence invlves hiding under a box.
Jesse gets killed but the second deer, still being attacked by the hyena, is immune to harm (due to later needing to die in a cutscene).
Jesse: Brother! If you were impervious to harm you should have led!
Jesse: Oh no, ohh no! They all got boxing gloves. Why do the rabbits have boxing gloves?! Who puts boxing gloves on rabbits?!
From the same episode, Jesse's inability to say Pteranodon. Followed immediately after by a lion club seeing a Pteranodon and running to its mother:
Lion Cub: Mom Mom Mom Mom Mom Mom Mom! Guess what I saw! Guess what I saw! Lioness: Oh my God... Dear diary, please kill me.
Jesse's raging in part 10 as Act 11 of the story mode quickly turns into That One Level for him. At various points he devolves into Angrish and you can hear him throwing the controller down or banging on a desk in frustration, or breaking down as the game starts him far back.
Jesse: Where's Scar? Where the fuck is that piece of shit? I am gonna kill him. I'm gonna personally murder his face right off.
Metal Gear Rising: Revengeance
Part 7 begins with Jesse explaining how some commenters told him that not every secret appears on AR. Meaning from then on, he'd be spending much, much more time scouring the levels for loot. He repeatedly insists that the viewers brought this on themselves.
Jesse's freak-out during part 15 during the boss rush before Sundowner.
Jesse:*Having just destroyed Mistral's body double* Well that shit just occurred and it was kinda freakin' awesome! Also? Her robot body? Still pretty sexy, just sayin'.
*Beat then Monsoon's body double ambushes Jesse and begins ripping him apart.*
The Running Gag of him going in every shower and pooping in every toilet he sees.
His interaction with Ned at the start of part 6.
Ned: You remind me of a guy I served with in 'Nam. Jesse:*Imitating Ned's voice box* Thank you. Ned: Remember you can legally kill anything in self-defense. Jesse: They're coming right for us. Ned: Do you need to borrow my voice box? Jesse:*Speaking normally* Nope! Got it covered!
It takes a while, but in Part 7 Jesse finally finds the fart button.
Jesse's absolute refusal to, when given the option, skip past Jimmy's stuttering attempts to say the words "enchantment" & "destiny"
Oh I'm not skippin' this. Nope. I'm putting the controller down. Let's see how far down the rabbit hole we go.
He enjoys it so much that, in part 12, he doesn't seem to even realize you can't skip an instance that occurs during a side-quest.
Part 10 begins with a disclaimer:
Jesse: Warning: The following episode contains... Butt Stuff. If you don't what that means or you have a problem with... Butt Stuff, then don't watch because you will be offended. But if you made it through, like, episode 2 of South Park back in the 90s, you should be okay. But remember.. Butt Stuff!
Jesse gets an alien helmet, immediately recognizes its resemblance to a Dragon Ball Z scouter, and dyes it accordingly.
Jesse cracks up watching the New Kid staring blankly ahead at the screen:
"I don't know why that's so funny to me! His expression's just like 'Why do you do this to me? Why do you do this to yourself?' *giggles* Shut up, Internet! I thought it was funny."
Jesse sees Jimmy now has the ability "Brown Note:"
Oh my God, I wanna see a Nazi Zombie shit himself!
Diablo III: Reaper of Souls
After speaking to Ivy, an NPC whose husband was killed in the Big Bad's initial attack, Jesse meets another NPC:
Male NPC: At long last, a hero comes to save us. That won't bring my wife back, though, will it? Jesse:(singsong) I know a lady who's single! (normal) If you're lookin'.
Jesse's escalating Big Whats in part two when the early plot twists start kicking in.
During the initial scene between John Yesterday and Henry White:
Jesse: What I thought was a game about a nerdy hero turned out to be a game about a nerdy ginger villain. Ooh, this is even more exciting!
Among the Sleep
Jesse deciding he's going to sneak around in the bushes "like a baby Metal Gear Solid".
Jesse: Baby Snake they'll call me!
Just the way he's so tactical about the whole thing with keeping himself in cover to hide from the monster(s), considering he's playing a two year old. It makes the game slightly less scary - but only slightly.
In the first episode, Cry and Jesse's response to seeing Helena pick up a phone.
Cry: Is it bad that when Helena picked up the phone she looked at it, I just imagined her seeing a dick pic? Jesse: That's why he came back for it Cry: He's like "shit!" Jesse: "Oh, I forgot that!" Cry: "Awkward, fuck..."
At the beginning of the second episode, Leon and Helena realizing that everyone on the campus is infected leads to this amusing conversation between Jesse and Cry:
Jesse: Oh no. OH NO. Zombiecollege students! Cry: Ah shit! Wait! That means we're going to get so much free beers! Jesse:Zombie beers. *Cry and Jesse cracks up* Jesse: I don't know what that means! Cry: It's such a stupid idea! I love it! Jesse: [...] Oh no, lecture halls! Cry: Zombie lecturers! Jesse: This is going to be the worst!
Made even funnier when a zombie lecturer really does show up.
The thumbnail used for Chris and Piers' campaign. Good god.
Jirard: That meat, though, that Youtube meat. Jesse: Ladies! Hashtag YouTubeMeat. Jirard: I don't think there's ever an appropriate time to say "hashtag YouTubeMeat." Jesse: That's why I said it. You know me, I've never been appropriate person.
Throughout episode 2, Jesse's increasing worry and raging about dying as Jirard convinces him to destroy the checkpoints. Coupled by, at one point, Jesse destroying a checkpoint completely without thinking about it.
Jirard: You should see his face right now. So angry.
This exchange as Jirard takes over to replay the level after Jesse dies:
Jesse: You're Spider-Man to my Gwen Stacy. How'd that work out? Jirard: I feel that I have betrayed you. I feel that i am now going to be Spider-Man for forever no matter what anyone says; and Mary Jane Watson and I will never be. Jesse: Nope I'm going to give you a Mephisto bargain and reset the universe so that marriage never happens.
After Jesse gets the "Get to the Point" Achievement for destroying the checkpoints in Pridemoor Keep
Jesse: Oh, and it's only one level? Jirard: There's one all the levels. Jesse: Oh to Hell with that!
PT is known to be terrifying, even for a demo, but how afraid Davis, Jesse, Jirard, and Greg are makes it hilarious to watch. This playthrough probably ranks as one of the funnier ones you will see of P.T.
Jesse's Madness Mantra of "He shot that girl in the bathroom!" is repeated multiple times before Jirard screams that Jesse's freaking him out.
The Fan Fridays are hilarious in and of themselves, as it seems the fans doing the suggesting seem to make it a point to find the craziest games imaginable for him to play. Some particularly good moments, however:
Jesse: "WHY WOULD IT EVEN DO THIS?! I SAID I WOULDN'T RAGE! I PROMISED I WOULDN'T RA-!" * dies* Jesse: *furiously pounds on desk*
Even better is the apparent reason the screen flipped on him at the end. All throughout the video was a notice about a new patch to the game, warning retribution if you didn't download it. When the screen flips, you see at the bottom, upside down, the text "What part of get the patch do you not understand".
Part 2 of that Fan Friday has him playing Slender, and freaking out within seconds before he's even done anything. By the end...
I've never been so afraid of grass rendering in my entire damn life.
That is followed shortly after by momentary distortion and Jesse staring at the screen in silent horror for a good ten seconds.
From The Political Machine Rematch with Crendor: Hipster Lincoln! Jesse laughs for nearly 20 seconds straight before he can come up with a coherent response.
Any of Crendor's characters seems to be able to do the trick. The same thing happens in the final battle.
Before even watching the video: the preview thumbnail for Jesse's 9/27/12 "Revenge of the Q&A" shows Jesse wearing a Bane mask from The Dark Knight Rises. Jesse is inordinately fond of his Bane-slash-Deckard Cain impersonation.
Most of the video is Jesse failing to stop in time to pick up passengers, rambling about nothing in particular, and finally deciding to just screw it and try to derail the train. He manages to do so, AND THE TRAIN GOES THROUGH A BRIDGE.
The Fan Friday featuring Katawa Shoujo. Pretty much all of it, but highlights include his consistent mispronunciation of the Japanese words, the cartoonish voices he gives the characters such as the teacher Mutou, and his reaction to realizing just what kind of game he's playing.
(to the viewers who requested this game) Oh God... you dicks... you dicks... is this a game where a kid with arrhythmia actively tries to bang disabled girls? *sigh* Look, I'm gonna make the best of this but if any of you assholes out there who are gonna start writing me like "Jesse you're making humorous comments about disabled students." This is on you. This is on you, for making me play this!
Also, his comment on the video itself, that suggested that he kept playing and wound up getting the Bad Ending.
So I went ahead and played a bit more today just to see about the possibility of "more". I played for 2 hours and was given 2 additional choices :P Spoiler I failed at each. I'm not sure I have it in me to suck at hitting on girls in anything but real life :P
The Ship Murder PartyFan "Frunday" is pretty much wall-to-wall hilarity. One of the best parts has to be when they start off playing a regular version of the game and Jesse finds himself on the hunt for Dora A. bin-Laden. Then they switch over to "World Leaders" mode server, a mod where the players must hunt down and kill various world leaders. Among them is a certain other bin-Laden. Jesse is in hysterics when he finds this out.
The video was made not long after Margaret Thatcher passed away. She's one of the characters in the game mode. This being The Ship, this creates some awkward moments. Meanwhile, omzit runs through the corridors calling for Thatcher's blood whenever he gets her as a target. So many Too Soon comments are made that one player goes so far as to suggest they ought to just make it the title, and is part of the reason Jesse calls it "The Most Offensive Game Ever".
Later on, as he starts a real playthrough, it becomes clear that he is the worst namer of games on the planet—his process is just vomiting out words that sorta-kinda fit the theme and rolling with it, even the misspellings.
Near the end of Volgarr The Viking, Jesse declares that if he can just finish the level, he'll be happy. He finally reaches the top of the fortress... and meets the first boss. he doesn't finish the level.
Jesse:Son of a bitch!
Five Nights at Freddy's: The Deadpool cupcake, and Jesse absentmindedly playing with the lights during the intro if you know how the game works You're supposed to manage your resources so that the power lasts all night. Jesse just wasted a whole bunch of it..
Minecraft and RPG Makers
Jesse’s blind first foray into Minecraft. Having no idea what he’s supposed to be doing, he ends up confused and terrified.
Slyfox and the Yogscast both have a go at trying to explain Minecraft to Jesse, with variying levels of success.
Meeuwes randomly starts singing a Dutch rap song where the only line in English is “Diamonds on my neck, bitch.” And he keeps going, even while Jesse and the others are making fun of him and trying to figure out what the heck he’s saying.
Jesse:What does that mean? *Meeuwes keeps singing* '’What does that mean?’’
Jesse:*starts singing random nonsense* I can make up gibberish words too, what does that mean? *Meeuwes ignores him and keeps going*
Jesse:People watching right now are probably like “Boy. Thomas is extra annoying today. Well…”
omzit:Oh, annoying, is that what I am now?! Well thank you very f*cking much you…buh, something!
After months of waiting, a new episode finally came out. Hilarity ensued.
Thomas, at Jesse's request, does a rap about pirates. Jesse then asks for a rap about Meeuwes. The result has to be censored multiple times.
The censor beep gets used several more times after that. At one point Lewis repeats something that gets beeped out - all we know is that he didn't know it was offensive and he somehow added a slur and made it worse.
Jesse finds a little grove out in the middle of nowhere that he's told to ignore. Obviously he doesn't, and he decides that it's going to be an Easter Egg with a circle of Omzits/Thomas' that dance once every hour, and a hidden weapon that looks like a cookie and makes more cookies.
Starting off on what would be a trend of focusing on odd things that happen Only in Florida, they discuss the state's notoriety for having the most cases of public masturbation. Jesse comes up with an ad that involved old men masturbating while "Cheeseburger in Paradise" plays, and becomes too amused.
And by "too amused" we mean that Jesse seriously thought that he was in danger of dying from being unable to stop laughing. According to him if he had succeeded: Worth It.
Due to Crendor being a Chicago native, the duo will inadvertently parody Bill Swerski's Superfans when discussing sports, complete with Jesse horrendously attempting a Chicago accent that sounds more Eastern European.
The Valentine's Day episode, in which Jesse gives Crendor a quick on whether or not certain statements are RPG plotlines, or Florida headlines. Some of the answers will surprise you.
Crendor's repeated demands for Squishables, and Jesse's annoyance when fans actually start sending them to him.
TGS Podcast 50, while discussing his past as a teacher, Jesse tells a story in which he went back to his old school to apologize for his past Class Clown behavior, having gained a whole new appreciation for what teachers deal with. Security had been upped since he was there last, resulting in him being accosted by a guard and taken to the office. The office secretary's reaction: "Back in the office again, eh, Cox?"
During Jesse's livestream of Secret of Mana, he constantly makes everyone chant "FLAMEY! FLAMEY!" and banters with Strippin of the Yogscast who ends up being the only mod in the chat at some point.
They name the characters Suplex, L Horse (Lava Horse) and Dooger.
The Blue Whale joke. And even though it crosses the line way too many times, the Cinderblock joke told by Brofu.
Dodger's response to a question from chat. She would kill her old grandmother, marry her twin, and have sex with a guy who later turns out to be her son.
At one Blizzcon, Jesse asked Chris Metzen and Dave Kosak (the head of creative development and lead quest designer, respectively) about a giant snake tail in a World of Warcraft dungeon. They had no idea what he was talking about since it was just something the artists threw in, but Jesse even printed out a poster-sized image of a screenshot he took of the dang thing! Then, nearly two years later, Jesse is interviewing Dave Kosak and Kosak exclaims happily "You were the snake-tail guy!"
TB asks people to watch his Hearthstone vids so he will be more powerful than Miley Cyrus and Vevo, Jesse takes it to mean TB is going to twerk.
And right after they mention Hearthstone, Crendor shows up in the chat.
Jesse putting on a random pointless accent while describing the creature he just played quickly morphs into a Running Gag about a drake flying around Europe picking up accents.
Day9 finally attacks Jesse, and the conversation devolves into Fantastic Racism against merfolk and eventually into Jesse just ranting about how useless all his options are. Day9 declares it the best block phase he's ever experienced.
Jesse consistently draws land cards and basically nothing else useful the entire game. After losing, he takes the top five cards from his remaining deck and slams them on the table, and all five are land. Both crack up, with Jesse lamenting that they weren't playing Monopoly.
There's a Running Gag of Jesse eating foreign "trash snacks" on the Podcasts, stuff that tastes so off to people not-adjusted that it floors him. One particularly memorable time was when the candy came looking like a pill, even TB, who by this point knows how this ends but hasn't stopped it before, told Jesse not to do it. Then Jesse decided to just pour from the box, and his reaction makes you think it sent him into a convulsive fit.