The 2000s gave us all friending networks, Wikipedia, dozens of wikis (including this one), the site YouTube, and just about anything web based.
- =3
- The Abridged Series
- Rob Ager
- The Amazing Atheist
- The Angry Video Game Nerd
- Arfenhouse
- The Art of Manliness
- Asrika Films
- Awesome Series
- The British Railway Stories
- Channel Awesome
- The Cinema Snob
- ContraPoints
- The Day the Music Died
- DesuDesBrigade
- DeviantArt
- Doctor Steel
- dril
- The Editing Room
- Evangelion: ReDeath
- The Family Gaming Team
- The Federal Vampire & Zombie Agency
- Feeding the Trolls
- Fin, Fur, and Feather Bureau of Investigation
- Furry Fury
- Gary: Landlord of the Flies (started in 2009, ran until 2010)
- Goodbye Strangers
- Hadriex
- The Hardcore Kid
- Heaven Sent Gaming
- The Horribly Slow Murderer with the Extremely Inefficient Weapon
- I'm a Marvel... And I'm a DC
- Idols of Anime
- Improv Everywhere
- The Indiana Jones Interrogations
- IndoHogwarts
- Jandrew Edits
- The Joker Blogs
- Laci Green
- Lasagna Cat
- Let's Play (and conversely Retsupurae)
- Line Rider
- Living in Oblivion
- Lonelygirl15
- The Muppets
- The Music Video Show
- Nitro Game Injection
- Pixiv
- Allison Pregler
- Planetcopia
- Protectors of the Plot Continuum
- Psychopathic Radio
- The Rageaholic
- The RPG Fanatic
- RedLetterMedia
- SF Debris
- Short Fat Otaku
- SMOSH
- Sonic the Hedgehog 2: Special Edition
- Sonic the Hedgehog Twitter
- Space Monkey Mafia Studios
- SpongeBob Edited
- The Spoony Experiment
- StacheBros
- Stop Skeletons From Fighting
- Survival of the Fittest
- Survival Of The Fittest Mini
- Talking Classics
- That Long-Haired Creepy Guy
- True Capitalist
- TV Tropes
- The Vampire Diaries: A Darker Truth
- Le Visiteur du Futur
- Whateley Universe
- We're Alive
- Yotobi
- Zero Punctuation
- Foil, Arms and Hog
- Tumblr
- Wisecrack
- YouTube Poop