- 3...2...1... Internet: Ran entirely in 2009.
- The Animutation genre
- The Adventures Of Jesus And His Brothers
- Ahmed and Salim. Debuted on January 20, 2009.
- The Aquablade Chronicles. Debuted on April 18, 2008.
- Baman Piderman
- Banana-nana-Ninja!
- The Banana Splits 1999
- Big Bunny
- Billy la Bufanda. Debuted in 2007.
- Bonus Stage. Ran from 2003 to 2006.
- Broken Saints
- Captain Distraction
- Cartoon Monsoon
- Charlie the Unicorn
- The Cloak
- Clock Suckers
- Cocomelon
- Cox and Combes' Washington
- DarkMatter2525
- A Day in Dracula's Life
- Dead Fantasy
- Death Comes to Time
- Decline of Video Gaming
- The Demented Cartoon Movie
- Dog Judo
- Doll Face
- Dramatic Hearts
- Draw with Me
- Dr. Tran
- Ducktalez
- Dumbland
- Eddsworld
- The Elvis And Jack Nicklaus Mysteries
- Extra Credits
- The Fairly Oddparents: Crimson Chin Webtoons
- Fairy Foxes
- Flashdeck Animations
- Floating Hands
- Food Chain
- forrestfire Films
- Four Swords Misadventures
- Fred Again
- Garbage Island
- GEOWeasel
- Ghost Motel
- The God And Devil Show
- Gorilla Girl
- Gotham Girls
- Greeny Phatom
- Guest From The Future 2
- Haloid
- Happy Tree Friends. Debuted on December 24, 1999. Most of its run took place in this decade.
- Hard Drinkin' Lincoln
- Heaven 2001
- Hidden Celebrity Webcam Ran from 1998 to 2007.
- The Hiros
- Homestar Runner. Debuted in January 2000.
- Hong Kong Phooey 2001
- Hot Wheels Stunt Strikers
- House of Cosbys
- How It Should Have Ended. Debuted on July 6, 2005.
- The Jackalope Boyz
- James Lee
- Jerry
- Jiz
- Katbot. Debuted in 2001.
- Koishi Komeiji's Heart-Throbbing Adventure. Debuted in 2009.
- Kubo Punko
- Let's Go! Tamagotchi. Originally released in 2007.
- Lobo (Webseries). Debuted on June 15, 2000.
- The Machinima genre
- Madness Combat
- Medical Island
- Meet the Millers
- Mi Perro Chocolo
- The Most Amazing Story Ever Told. First series made circa 2001, second around 2003.
- Mr Wong
- Navy Bear
- NCHProductions: Debuted in 2006.
- One Minute Fly: Debuted in 2008.
- The Paula Principle
- Penelope Pitstop GT
- The Pitch 2001
- Poker Night 2000
- Red vs. Blue: Started 2003.
- Red vs. Blue: The Blood Gulch Chronicles (2003–2007)
- Red vs. Blue: The Recollection (2008–2010)
- Robotbox And Cactus: Ran from 2004 to 2006.
- Rock 'n' Roll Dad
- Ruby Rocket Private Detective. Debuted 2007
- Simon's Cat. Debuted on March 4, 2008.
- Slim Chance: Intergalactic Zoologist
- Sock Series
- Sonic: Night of the Werehog
- Space Tree: Ran from 2004 to 2007.
- Starship Regulars
- The Stump
- Super Mario 64 Bloopers
- Superhero Intern
- Superhero Roommate
- Super Models
- Tankmen
- TektonTV
- T E T R I S ' D
- Thats My Boys
- There she is!! (debuted in 2003 and saw its final installment in 2008.)
- Timber Wolf
- Toon Marooned
- The Trixters
- Trix the Musical
- The Ultimate Showdown of Ultimate Destiny
- Undercover Dog
- Venin Abyss
- Very Bad Children
- Wendell & Wuggums
- Zatanna: Trial of the Crystal Wand
- Zombie College
