The first member and self proclaimed leader of the Powerpuff Girls Z squad. She is very familiar with the mahou shojo genre, along with some typical anime/Super Sentai concepts and is regarded as a "hero maniac" in school.She transforms using the phrase "Hyper Blossom" and uses a yo-yo as a weapon.
The second member of the Powerpuff Girls Z team. Miyako/Bubbles is the ditziest member of the three, often appearing a bit clueless, and doesn't seem to understand her powers completely, along with a few other things. She is, however, more mature than the other girls in the team and will try to calm any situation, although she too can be angered when provoked. She is also very polite and always uses honorifics at the end of names. She is more concerned with shopping, her appearance and her outfits, and perhaps because of this, she seems to be very popular among her male classmates.She transforms using the phrase "Rolling Bubbles" and uses a bubble wand as a weapon.
Mondegreen: Unless it's spelled out for them, a lot of Anglophonic viewers can't figure out the adjective before her name (in part because it makes no sense). A popular guess is "Boiling Bubbles" since that's what bubbles do.
Yamato Nadeshiko: Mature, calm, very polite and always uses honorifics at the end of names. Her Big Fancy Japanese House seals the deal.
Kaoru Matsubara/Powered Buttercup
Voiced by: Machiko Kawana (JP), Kelly Metzger (EN)
The third and final member of the Powerpuff Girls Z team. Like the original Buttercup, she is a tomboy and is the most easily enraged of the three. She is known at school for being the most athletic girl as she plays tennis, practices martial arts, and numerous other activities, and spends a great deal of time watching sports on television.She transforms using the phrase "Powered Buttercup" and uses a giant mallet as a weapon.
The responsible for all those affected by the Chemical Z lights, especially the Powerpuff Girls Z. Professor Utonium was originally experimenting with the substance Chemical X and strove to find a way to change its chemical properties. Professor Utonium has created several inventions throughout the series; the most important one being his Chemical Z Particle Ray, which allows him to transform those affected by the rays back to normal (although it doesn't prevent recurring transformations nor is it able to work on all black ray victims).
A young boy genius, the 8 year-old son of Professor Utonium who is somewhat responsible for turning regular girls into the Powerpuff Girls Z and numerous other characters into villains using Chemical Z. He used it to blast a glacier in order to set the weather back to normal, but the impact resulted in the explosion of several lights, which affected all those who came in contact with it.
Ken's pet robot dog. Poochi was also affected by a white Chemical Z ray, gaining the ability to talk, as well as a considerable boost in intelligence. Poochi's shout prompts the girls to transform either in person or through a long-distance communication device, although a modification to the girls' compacts allows them to transform on their own.
The most frequently recurring villain in the series. He was an ordinary zoo monkey who was made fun of by people and decided to seek revenge on humanity after the ray from Chemical Z made him intelligent.
Arch-Enemy: Or at least the most persistent enemy.
After the explosion of the Chemical Z ray, one of the black lights landed in the forest, creating the monster Fuzzy Lumpkins. This rendition of Fuzzy is as rude and destructive as the original, but is nice enough to help an old man or sign an autograph for a fan who likes his banjo playing, that is before going on a rampage. He has a crush on Ms. Sara Bellum.
A bratty rich kid in the girls' class who is hit by the black Chemical Z rays. Her powers are used based on her wants to be recognized by people. Once she is back to normal however, she does not recall any events that occurred while she was evil.
Himeko/Princess' cat. She was hit by the black light along with her owner. Since then, Sapphire is able to activate her master's transformation by screeching whenever Princess accidentally harms Sapphire's tail (similar to Poochi's activation of the girls' transformation).
A quiet girl who runs a sweets store. She has a crush on a boy named Jason and it is her jealousy over the thought that he likes Miss Bellum what leads her to be hit by the black lights, transforming her into Sedusa whenever she puts on some lipstick.
Brick, Boomer and Butch are created by Mojo based on the DNA found on the girls' personal items. These items form the basis of the Rowdyruff's weapons. Brick's weapon is actually Blossom's heart twisty straw, which he shoots spits balls at the girls, Boomer's weapon is Bubbles' used cotton bud used his own ear wax at opponents and Butch's weapon is Buttercup's smelly gym sock which he would throw to attack opponents with bad smells.
The most powerful enemy of the series, and it is safe to say that he is the main antagonist. Him is a demon, nothing more and nothing less than chaos itself. His biggest weakness is the cold. It is known that he released a strange dust that was responsible for producing some villains.
Sealed Evil in a Can: In ancient times, Him was dedicated to bring about the destruction of a small town, however, was defeated by the Goodenough Girls who took advantage of Him's weakness (cold) to lock him up and take part of their evil and save the mountains. But when Ken ended up destroying that mountain (below) Z-rays were scattered all around New Townsville, and consequently, over producing and giving birth to the many villains in the city. And a black Z lightning struck Him and woke him.
An effeminate hairdresser with strange tastes in hair. As he winds his teddy bear, it got hit by black Z-Rays and uses his power to hypnotize the customers to accept his eccentric hairstyle. He only changes when winds his teddy bear.
A young boy who has spent most of his life in a hospital with an illness and Bubbles' childhood friend and crush. When he is hit by the dark light, he transforms into a werewolf-like monster and escapes, though does not attempt to harm others.
Mayor Mayer's younger brother and the principal of the girls' school. He and his brother don't always get along, and even the most minor of things will set off an argument, which often time leads to name calling. He also deals with his brother when the girls aren't doing well in class due to them skipping class to save the city.
Understanding Boyfriend: Jason eventually finds out in episode 45 that Annie transforms into Sedusa. Jason's reaction is to shout at Sedusa that he doesn't care, he loves Sedusa and Annie because Sedusa is Annie.