As depicted in the opening sequence of each episode, the Powerpuff Girls were created by Professor Utonium in an attempt to create the "perfect little girl" using a mixture of sugar, spice, and everything nice. However, he accidentally spilled Chemical X into the mixture, granting the girls their superpowers.
Artificial Humans: Also leads to an in-universe case of the Uncanny Valley, since the girls' eyes, hands (or lack thereof), and proportions are often mentioned as being creepy and strange to the people they meet. The reporter in The Movie actually calls them "little bug-eyed freaks".
Blossom is the redhead in the pink outfit and signature red bow. She's the "smart one" and the self-proclaimed leader of the group, although at times she can be bossy or over-analytical. Her unique ability, introduced in the episode "Ice Sore", is ice breath.
Arch-Enemy: Mojo Jojo, Brick of the Rowdyruff Boys and Princess Morebucks.
Bubbles is the one in the blue outfit with the blonde hair and pigtails. She's the most childish, naive, and timid of the three, but also the most gentle, caring, and playful. She's a Friend to All Living Things, and she has the unique ability to talk to animals and speak any language.
Arch-Enemy: Mojo Jojo, Boomer of the Rowdyruff Boys and HIM.
Dumb Blonde: Not stupid per se - in Him Diddle Riddle, she scored a 1075 on the SAT whereas Blossom and Buttercup scored a 10 and a 25 respectively - but a bit ditzy. Observe!
Genius Ditz: She can be very ditzy at times. However, as mentioned below, she is an Omniglot and Suddenly Fluent in Gibberish, and scored a 1075 on the SAT, which (despite being impossible) is pretty good for a kindergartener.
Talking the Monster to Death: Okay, not really. After Blossom and Buttercup fail to land a single hit, Bubbles kindly asks the monster to leave Townsville. It works.
Buttercup has the green outfit and black hair. She's a tomboy, and the "toughest fighter". She's the most aggressive and confrontational sister, and has gained a reputation among the bad guys of Townsville as the most vicious of the trio. Unlike her sisters, she doesn't have a unique ability (to her chagrin); however, it's eventually revealed in the Season 6 episode "Nuthin' Special" that she's the only member of the team who can curl her tongue. Well, at least it's something.
Added Alliterative Appeal: "So we have Blossom, Bubbles, and, hmmm, Buttercup because... it also begins with a B."
Compressed Vice: In the episode where the girls must face their greatest fears Bubbles's is the dark, Blossom's is underachiving and Buttercup's is... spiders. Despite the fact that she's been handling bug-themed villains as far back as episode 1!
She does react especially violently to insects, though, which is perhaps her way of dealing with it.
Forgot I Could Fly: In "Down D Dirty", she is being chased by a mob of townsfolks for refusing to take a bath, when she abruptly stops and asks, "Wait, what am I doing?" before taking off into the air.
Girliness Upgrade: In the infamous teen flashback from "City of Clipsville".
Sort-of gets one at the end of "The Rowdyruff Boys" where she kisses Butch.
Hidden Depths: Although she rushes headfirst into situations and prefers to solve things with violence, she is smarter then she is given credit for and often gives others an Eureka Moment, like in the movie.
I Just Want to Be Special: An episode was dedicated to Buttercup being unhappy that she didn't have a unique power like her sisters.
Although her special power is to curl her tongue, she was established in "Speed Demon" to be slightly faster then her sisters, and she's generally considered the physically strongest of the three.
Professor Utonium is the brilliant scientist who created the girls in his lab. He acts as a father figure, caring for them as a single parent would. He's enthusiastic about his work, and cooks up all sorts of inventions and experiments in his lab.
Overprotective Dad: Every once in a while, it really hits the Professor that his three daughters are out laying their lives on the line to fight crime. His attempts to assist them, like in "Powerprof" and "Uh Oh Dynamo", usually end up not so good.
Crouching Moron, Hidden Badass: Despite being portrayed as incompetent and immature, the Mayor has shown to have the potential of being one of the most badass mayors in existence:
In the episode "Him Diddle Riddle", the Mayor successfully decodes Him's riddle "Where is boiling and freezing at the same time?" as coordinates in a matter of seconds through rapid explaination to the trio of dumbstruck girls, along with a more simple alternative.
Mayor: "... Or it could be there's an ice cream truck on fire somewhere. Have a nice day, girls!"
Also in the episode "Impeach Fuzz", Villain of the Week Fuzzy Lumpkins becomes the new mayor. The Mayor doesn't really care about this until he learns Fuzzy is wearing his hat and accepts a challenge to wrestle him for the hat and his title as mayor again. He's easily tossed around by Fuzzy and his kin until during a pin, Fuzzy mockingly puts the Mayor's hat on in front of him. Suddenly, the tables were turned in a matter of a second.
Mayor: "FUZZY! No one wears my hat!" [Suddenly rips his vest off, becoming RIPPED]
You Don't Look Like You: The Mayor was drastically different in "Meat Fuzzy Lumpkins". But that could be a different mayor.
Sara Bellum
Voiced by Jennifer Martin
Ms. Bellum is the mayor's much-more-competent personal assistant, helping him out with whatever he can't handle on his own (i.e. just about everything). She's tall and has long, bushy red hair, but her face has never been shown—it's always blocked by the top of the frame, a conveniently-placed obstacle, or something like that.
Action Girl: She is one of the most accomplished martial artist in the series, capable of go toe to toe with Sedusa.
Badass Normal: She managed to defeat Sedusa in a fight.
MeaningfulPunny Name: Cerebellum, a region of the brain that plays an important part in motor control. In comparison to the Mayor, she seems more like the person who would be more fit to run Townsville.
Undying Loyalty: If all her interactions with the Mayor were not enough clues, during the Bad Future episode, an old Ms. Bellum is shown holding the Mayor hat years after he passed away, and when the girls try to come close, she snarls like a cornered animal and screams that the mayor is "hers and hers alone".
The series' enthusiastic narrator is never seen at any point in the series, though he is a person and not just a disembodied voice—for example, in "Monkey See, Doggie Do", he's turned into a dog along with the rest of Townsville, and in "Simian Says", Mojo Jojo kidnaps him and takes his place as the narrator. As the narrator, he, of course, has the ability to break the fourth wall.
The kindergarten teacher of Pokey Oaks Kindergarten. She is patient, understanding and very protective of her students, making her a well-liked, motherly figure.
A Mad Scientist chimp with great intelligence, notable for his pseudo-Japanese accent and his convoluted, repetitive manner of speaking (inspired by the speech patterns of characters in the English dub of Speed Racer). As revealed in the episode "Mr. Mojo's Rising", and expanded upon in The Powerpuff Girls Movie, Mojo Jojo was Professor Utonium's reckless lab assistant, Jojo, before Professor Utonium created the Powerpuff Girls, and it was he who caused the Professor to accidentally add Chemical X to the mixture, thus making him responsible for their creation. The reason he hates the girls so much is out of jealousy of the affection they received from the Professor that he did not, though he never deserved it due to his destructive nature. According to a countdown of the 10 worst villains in the series held by Cartoon Network, he's the number 1 worst villain in the series.
Department of Redundancy Department: He speaks this way all the time, which is to say that the manner in which he vocally expresses himself is extremely roundabout and repetitive, containing long and elaborate sentences which tend to reiterate their own subjects constantly. This is taken to extreme levels in "Mo' Linguish", where he's forced to teach a beginner's English class at Townsville Community College and ends up re-teaching the entire city to speak this way.
From Nobody to Nightmare: He was originally just Professor Utonium's lab assistant, constantly wrecking and destroying the lab, but after starting the accident which made the Powerpuff Girls, he got an incredibly high IQ, had the girls create his lab through trickery, and has since established himself as the Arch-Enemy of the girls.
Genius Bruiser: Mojo is capable of building complex machinery in mere days. He also once defeated an alien invasion singlehandedly using only his gloved hands and a stale loaf of bread.
Luke, You Are My Father: Professor Utonium pointed out to Mojo, had he not pushed him as he was mixing the batch to create the perfect little girl, the Powerpuff Girls would never have been created. Meaning that Mojo Jojo is, on a strange technicality, the father of the girls.
Still shows it at times in the series. For example, tricking a group of kids who idolized the Powerpuff Girls into allowing him to grant them powers. Turned out the Chemical X was spiked with something that made them go Drunk with Power and do anything to get more, including destroying the Powerpuff Girls.
One-Winged Angel: At the climax of the movie, he infuses himself with a massive amount of Chemical X, mutating himself into a gigantic monster with enough power to nearly defeat the girls. Undone when he's exposed to the antidote.
Shout Out: His character is a reference to Dr. Gouri, the main villain of Spectreman.
Superpower Lottery: In the finale of the film, he grows to become at least Kaiju size with most of the advantages, but also has generally impressive speed, the ability to use a thunder-clap, shooting his hair out like thorns, and fire breath.
Villainous Crossdresser: In "Slumbering With the Enemy", he attends the girls' slumber party as a girl. The Powerpuff Girls, naturally, treated the situation with hostility towards him, but once they see that he isn't doing bad things to anyone, it becomes Go Karting with Bowser. Once eveyone goes to sleep, however, Mojo sets on his real mission: to get the Antidote X.
A mysterious, supernatural, red-skinned, effeminate (apparently androgynous) and immortal caricature of Satan. He is the ultimate embodiment of pure evil, and talks in a chilling voice that echoes at all times as if in a cave; the voice itself can vary from a high pitched falsetto voice, to a deep, booming, demonic voice. He is also the Girl's most dangerous foe as well as the hardest villain to defeat. He's one of the girl's main enemies, but in particular an enemy for Bubbles.
Beware the Silly Ones: Despite all his comical attributes, he's the girls most dangerous and vile enemy who consistantly comes close to victory with his plans. And then there's the Bad Future we see were he won...
He Who Must Not Be Named: In His introductory episode, the Narrator states that "Him" is the only designation that is safe to describe Him with. According to Tom Kane, saying his real name causes you to explode.
One-Winged Angel: In a Bad Future were he conquered Townsville (at least we hope it was just Townsville), he eventually turns into a giant demonic monster. He also performs this in "Power Noia" were he turns into an insect-like monster embodying the Girl's fears.
Thigh-High Boots: High-heeled version, which makes him even freakier.
Ultimate Evil: Actually called this by name by Princess Morebucks in one episode, though he concedes to her claim that her "cold hard cash" trumps that.
What an Idiot: In-Universe. In a demonstration of how evil he is, Him knocked the Earth out of its orbit, heading straight for the sun. Mojo Jojo went on a rant about how stupid that was, since Him will be destroyed along with everyone else. This gets subverted during the actual rant, as Him, not taking his eyes off Mojo, raises his hand in a stopping motion towards the sun, and it moves away. Or, the Earth moved back, it's all a matter of perspective.
A large, husky, furry pink bear-like hillbilly monster with a wide jaw, a green nose, two antennae on his head, bib blue overalls and brown countryman shoes. He talks with a Southern accent, and will shoot anything he finds trespassing on his property and is otherwise harmless. He lives in the woods next to the city of Townsville. He is also prone to destructive fits of rage during in which these times, gaining enough physical strength to overpower (and sometimes intimidate) the girls, to which they must outsmart him to beat him.
Affably Evil: He almost never gets involved in the plot unless somebody annoys him. Otherwise, he's happy to just sit on his porch strumming his banjo.
Took a Level in Dumbass: In the pilot, Fuzzy was smart enough to make a gun that turned things into meat, plus he had an overall calm demenor. In the rest of the show he's an anti-social hick who goes ballistic when you touch his stuff and can't invent a glass of water to save his life.
A gang of teenaged hoodlums that are green-skinned and unhealthy looking (as if suffering from gangrene). They do not have powers, nor are they truly a threat in many ways.
Mistreatment-Induced Betrayal: In "Aspirations", when they team up with Sedusa, who makes them much more formidable in exchange for some artifacts that'll help regain her lost hair after it was cut off in her last encounter with the PPGs. However, once they bring her the artifacts and she becomes all powerfull, she kicks them to the curb. They tell the struggling Powerpuffs how to de-power her and even get the last insult in by knocking Sedusa into a mud puddle when she comes begging for their help.
The Unintelligible: Grubber...ppphhhttthhh! In "School House Rocked", however, he did show the ability to physically re-form himself and said "Hello, I'm Grubber, very nice to meet you all" before turning back into his normal self, if only for a few seconds.
"If I can't be a Powerpuff Girl, than there won't be any Powerpuff Girls!"
A spoiled rich girl, whose partially unseen and mostly mute "Daddy" allows her to finance various evil plots to destroy the Powerpuff Girls. Her hatred of the girls stems from her deluded rebuffed attempt to become one of them. She is also the only female villain in the series who is not an adolescent or young adult woman; she is approximately the same age as the Powerpuff girls.
The Sociopath: Cares only for herself, with a disturbing Lack of Empathy for anyone else. For that matter, her father likely qualifies too, as he shows no care whatsoever for his daughter outside of just casually giving her whatever she wants.
A master (or rather, mistress) of disguise who uses her cunning and her sex appeal to trick powerful men into doing her bidding. True to her Punny Name, she has Prehensile Hair, which is her greatest asset in combat.
Attack of the 50-Foot Whatever: When the Gangrene Gang bring her three anciet artifacts, she grows into a huge giant that regains her lost hair (which are literally snakes, properly fitting her name) and more then a match for the girls.
Bald of Evil: Her third appearance is this as she still hadn't recovered her hair after Ms. Bellum and the PPG cut it off.
Batter Up: Says this when she hits the Powerpuff Girls with her scepter when she grows into a giant.
The Amoeba Boys are a trio of human-sized anthropomorphic protozoan gangsters. They'd like to be the greatest criminals Townsville has ever seen, but their brains aren't developed enough to come up with any schemes more evil than petty shoplifting or littering. The Powerpuff Girls consider them harmless, to their dismay—they'd consider it a badge of honor if they were evil enough to get beaten up by the Girls. Ironically, they've come closer to destroying Townsville and defeating the Powerpuff Girls than most of the other villains combined—all by accident, of course.
Voiced by Rob Paulsen (Brick/Boomer), Roger L. Jackson (Butch)
A team of male counterparts of the Powerpuff Girls, created by Mojo Jojo out of snips, snails, and puppydog tails. They love causing mayhem, mischief, and chaos. They were originally one-off villains, killed off in the same episode they were introduced, but they were a fan favorite and were later resurrected by Him to become recurring members of the Rogues Gallery.
Anti-Hero: In the anime version, and implied when they're adult.
Something Else Also Rises: After they're brought back, the girl's kisses no longer defeat them, they make them grow larger. And when their masculinity is threatened they shrink.
A one-shot villain in the show, appearing only in the Season 4 episode "Knock it Off", he used to be Professor Utonium's college roommate. He discovers the formula for creating the Powerpuff Girls and abuses it to mass-produce Shoddy Knockoff Product versions of them on an assembly line. Despite being only a one shot villain, he manages to be one of the most evil and memorable characters on the show.
Establishing Character Moment: In flashbacks, his lecherous and greedy tendencies were made all too apparent. Made even more apparent when he looks through the professor's mail and calls him a geek (albeit not in front of his face), almost as if they just wanted to make sure you know he's still not a nice guy.
Evil Counterpart: To Professor Utonium, in that he's a man of science (though with slightly less "science"), but has none of the compassion and legitimate love the Professor has for the girls.
From Nobody to Nightmare: He was originally just a sleazy jerk who took advantage of Professor Utonium, but by the end of "Knock It Off", he's more or less a literal monster.
Hoist by His Own Petard: When the replicas saw the Professor's love for the real girls, they questioned why they weren't loved to Dick. He told them to back off. Simply put, it didn't end well for Dick.
Killed Off for Real: His creations realize that he doesn't love them and turn on him, ultimately killing him by bringing his own factory down on his head. Notable as he's the only villain in the entire series to actually die.
The third notable female villain in the series, next to Princess Morebucks and Sedusa, despite being a minor villain. She only appears in the episode "Equal Fights" as a man-bashing Straw Feminist who only stole coins with Susan B. Anthony's portrait on them.
Not Himself: Yet when he's turned back to normal, the girls still beat him up and send him to jail. He apparently made parole since he was seen at the Powerpuff Girls' birthday party.
The Power of Rock: The only way to defeat him and change him back to normal, apparently.
Appears only in the episode "Boogie Frights." He hatches a plan to blanket the world in perpetual night by blocking out the sun with a giant disco ball, so that he and his fellow night-terrors can wreak havoc forever.
Ace Pilot: He pilots a space-ship to confront the girls when they attempt to shoot down his disco ball.
Narrator: Uh-oh, looks like evil runs in the family.
Appear only in the episodes "Supper Villain" and "Just Desserts". The Smiths were an average family living next door to the Powerpuff Girls. Harold Smith had become sickened by his routine life and menial job at a mustard factory. Inspired by Mojo Jojo, he began to embrace the life of a supervillain. Unfortunately, he chose to do this on the night his wife Mary Anne invited Professor Utonium and the PPGs to dinner. Everything eventually devolved into a food fight, and the police arrest Harold. Mary Anne, however, put a lot of effort into the dinner, and upon seeing it get ruined, she vowed to destroy the Powerpuff Girls.
Red Eyes, Take Warning: Mary Anne when Harold reunites with her at the beginning of "Just Deserts".
Rummage Sale Reject: Harold, who wears a Blankman-like uniform. This makes him stand out when the rest of the family reveal their own supervillain uniforms.
Harold: Oh, criminy. How come you guys get cool supervillain stuff? Mary Anne: We've had more time to prepare, dear.
