%%Zero Context Examples and poorly written examples are been commented out. Examples must explain how these characters fit the tropes before uncomenting.

! The Heroes

* '''[[Characters/ThePowerpuffGirlsTheHeroes The Heroes]]'''- Blossom, Bubbles, Buttercup and the Professor Utonium

! Residents of Townsville

* '''[[Characters/ThePowerpuffGirlsResidentsOfTownsville Residents of Townsville]]'''- The Mayor of Townsvile, Sara Bellum, the Talking Dog, the Narrator, Ms. Keane, Mitch Mitchelson, Elmer Sglue, and Stan and Sandra Practice.

! Main Antagonists

* '''[[Characters/ThePowerpuffGirlsMainAntagonists Main Antagonists]]'''- Mojo Jojo, Him, Fuzzy Lumpkins, the Gangreen Gang, Princess Morbucks, Sedusa, the Amoeba Boys, and the Rowdyruff Boys.

! Minor Antagonists

* '''[[Characters/ThePowerpuffGirlsMinorAntagonists Minor Antagonists]]'''- The Gnome, Dick Hardly, Femme Fatale, Mr. Mime, Boogie Man, The Smiths, Major Man, Abracadaver, Mike Brikowski, Max Von Nitrate, Lenny Baxter, Mask Scara, The Alien, Giant Monsters, Mojo's Monkey Army, Roach Coach, The Broccoloids, The Sandman, The Robbing Leach, The Powerbluffs and the Burglar