Good Luck Charlie, It's Christmas! has many notable similarities to the film's plot. These include the mother doing whatever they can to reunite with her child for Christmas, one of the children missing the plane flight, and even "Run Run Rudolph" playing while the family runs through the airport to catch its flight.
The Fresh Prince of Bel-Air: "Hex and the Single Guy" has Carlton dressing up as Macaulay Culkin for Halloween and even doing his trademark hands on face while screaming pose after the family members gradually get hexed.
In the Dinosaurs episode, "Out of the Frying Pan", Baby becomes a celebrity thanks to his appearance in the Myman frying pan commercials. One of the movie scripts he is offered, which Robbie reads over, involves him being left home alone while his family goes on vacation.
Hitman (2016) got a Christmas Episode where Agent 47 is sent to eliminate two burglars named Harry and Marv in a christmas-reskin of the first non-tutorial level. Marv floods sinks around the palace and a challenge requires you to knock him out thrice with bricks.
In the Central Park episode, "Live It Up Tonight", after Molly and Cole get lost in the park and can't recognize where they are due to the darkness, Cole asks Molly if they should call their parents for help. Molly then gives Cole a Rousing Speech using Home Alone 2: Lost in New York and said Kevin McCallister didn't call his family when he got lost in New York ("Never mind they didn't have cell phones and his family was in Florida."), she continues on how Kevin was lost longer than them and he was able to get through it. This motivates Cole to get back home.
In "Chitty Chitty Death Bang", Peter blows away two of the Three Little Pigs' houses and pretends to be UPS to get into their brick house. As he gloats, they hit him in the head with a paint can tied to a rope, referencing Kevin's traps.
The plot of "Baby Not on Board" parodies the movie. A few moments, including the ending, also parody the film.
The episode "Christmas Guy" features a Deconstructive Parody of the movie "with competent robbers"; here, they are smart enough to avoid Kevin's traps, and they shoothimon sight instead of chasing him.
There is also a crossover sketch with the 2018 sequel to Halloween in which the McAllisters' next-door neighbor happens to be Laurie Strode. The Wet Bandits and MichaelMyers end up targeting the wrong houses, leading both Harry and Marv on the one hand, and Kevin on the other, to realize just how out of their respective depths they are.