Droopy
A tiny, very modest Basset Hound that was apparently a master of Offscreen Teleportation and The Cat Came Back, capable of great strength when roused to anger. Is quite a good samaritan, constantly doing good deeds, especially when it comes to catching criminal wolves. His voice sounds similar to that of H.G. Wells of all people. Possibly his best short is Northwest Hounded Police. Droopy cartoons continued to be made after Tex's departure from MGM, with Michael Lah as director, And Droopy himself became a Canon Immigrant, having made numurous appearances -sometimes along with his co-stars- in Tom and Jerry works ever since.
Screwy Squirrel 
Voiced by: Wally Maher (classic shorts), Charlie Adler (Droopy Master Detective), Paul Reubens (Tom and Jerry's Giant Adventure), Sean Kenin (Tom and Jerry Show 2014), Jeff Bergman (commercials)
An insane squirrel that often picked on his antagonists for no reason other than because it was funny. His series was short lived because Avery never cared for the character much. There are stories of Tex's automatically throwing fan letters depicting Screwy Squirrel into the trash.
- Adaptational Name Change: He's called Screwball Squirrel in Droopy, Master Detective.
- Goofy Buckteeth: He is a wacky trickster squirrel who naturally has buckteeth.
- Killed Off for Real: He met his match with Lonesome Lenny in his final short of the same name, though, in which he was presumably crushed to death by the Of Mice and Men-inspired dog.
- The Mad Hatter: He's not afraid of admitting he's crazy.
- The Prankster: A merciless variety who starts playing pranks on others for no good reason.
Wolfie 
Voiced by: Bill Thompson (Blitz Wolf), Kent Rogers (Red Hot Riding Hood, One Ham's Family), Frank Graham (40s shorts), Patrick McGeehan (The Screwy Truant), Daws Butler (50s shorts), Frank Welker (Tom and Jerry Comedy Show, Tom and Jerry Kids, Droopy Master Detective), John DiMaggio and Richard McGonagle (Tom and Jerry: Robin Hood and His Merry Mouse), Stephen Stanton (Tom and Jerry Show 2014)
Wolfie made his debut in "Blitz Wolf" as an Adolf Hitler caricature, but it was in "Red Hot Riding Hood" that he became the womanizer with off-the-wall wild takes he was famous for being. Red herself was based on pin-up girls of the 1940's, and often would sing and perform in her appearances. Both characters frequently co-starred in cartoons with Droopy, with Wolfie usually being the antagonist. In cartoons of The '50s, he was replaced by a country bumpkin wolf who speaks with a Southern accent. In those cartoons with Droopy, he was still usually the antagonist, but without Droopy, he was a protagonist instead.
- Anti-Villain: When he simply represents lustful men. When against Droopy or the three pigs, he's quite villanous.
- Beard of Evil: As Paisley-Beard McWolf the Pirate in "Yo Ho Ho... Bub".
- Big Bad: To Droopy in both The Tom and Jerry Comedy Show and Tom & Jerry Kids.
- Cartoonish Supervillainy: Most of his plots come out as this.
- Eye Pop: If he was ever in a room with Red, you can expect this kind of reaction from him.
- Fangs Are Evil: Mostly averted, but there are instances of this trope in some episodes.
- Zig-zagged in "Dakota Droopy and the Lost Dutch Boy Mine". In some scenes, he is shown to have fangs, but in other scenes he doesn't seem to have fangs at all. Sometimes, within one scene, he will alternate between fangs and normal teeth. Whether this is Off-Model or not is highly unknown.
- Subverted in "Foreign Legion Frenzy". While he is shown to have fangs in the "Wanted!" Poster, he does not wear any throughout the rest of the episode.
- Fully-Dressed Cartoon Animal: Was always fully dressed.
- Hawaiian-Shirted Tourist: Wears one in the beginning of "Fear of Flying".
- Iconic Outfit: Despite wearing a wide variety of outfits in different episodes, his most recurring outfit is a blue shirt, black vest, and brown/red pants in Tom and Jerry Kids.
- No Name Given: But in the 80s shorts he's called Slick and in the 90s he's called McWolf.
- The One Who Wears Shoes: Most of the time, whenever Miss Red or another main human character is not present.
- They Killed Kenny Again: At the end of "Red Hot Riding Hood", he commits suicide, and yet came back alive in his next cartoon.
- Throw the Dog a Bone: After 70 years, he once actually wins Red's hand in marriage.
- Villain Protagonist: Had the starring role in most of his shorts.
- Wild Take: The Trope Codifier.
- Wolf Whistle: The Trope Codifier. He would let out two-note glissando out of lust upon seeing beautiful women like Red.
Red 
Voiced by: Sara Berner, Imogene Lynn (singing voice), Teresa Ganzel (Tom and Jerry Kids, Droopy Master Detective), Grey DeLisle (Tom and Jerry moviesnote )
- Adaptational Curves: Who would've thought the Little Red Riding Hood would look this good?
- Adaptational Personality Change: Later appearances in Tom & Jerry's Direct-to-Video films give her a more innocent and lady-like personality, while still keeping her as Ms. Fanservice.
- Alien Princess: She assumes the role of a space princess in the episode Deep Space Droopy. Likewise, in the episode Conquest of the Planet Irwin, she is the queen of the titular planet.
- Bedlah Babe: As Princess Scheherazade in "Trés Sheik Poodles".
- The Cameo: In Quest for Camelot.
- The Chanteuse: Plays this type of role in all of her original shorts.
- Damsel in Distress: Every so often.
- Glamorous Wartime Singer: Red was based on these. In "The Shooting of DanMcGoo", she does sing a song with a wartime theme.
- Head-and-Hip Pose: Red makes this pose often, like in her page image.
- Head-Turning Beauty: Whenever she was in a room, all men would immediately notice her (especially Wolfie).
- Hotter and Sexier: Very much so when compared to the usual little girl type character that plays Little Red Riding Hood.
- Interspecies Romance: Sometimes with Droopy Dog.
- Impossible Hourglass Figure: Very much so.
- Lady in Red: Her outfit may vary depending on the short, but she'll most likely be seen wearing red, such as her red Burlesque she debuted in.
- Ms. Fanservice: The trope codifier.
- No Name Given: The eponymous Red Hot Riding Hood wasn't given a real name in any of her theatrical appearances, but most fans generally refer to her as "Red." Her later appearances in the Tom and Jerry DTV-features ultimately made "Red" her official name.
- Parent Service: Clearly meant to entertain adults as much as kids.
- Red Riding Hood Replica: Based off the original tale, but much Hotter and Sexier.
- Sexy Backless Outfit: This is her normal attire in most of her original MGM shorts.
- Shout-Out: In her original short, she speaks in a Katharine Hepburn-like voice. Another short has her speak like Mae West, and another like Bette Davis.
- The Tease: All of her musical numbers have her dancing as provocatively as possible while wearing sexy clothes and singing songs about wanting arms wrapped around her.
Spike/Butch 
Voiced by: Tex Avery (40s shorts), Bill Thompson (50s shorts), Paul Frees (Cellbound), Jim Cummings (Tom and Jerry: The Magic Ring), Jeff Bergman (Tom and Jerry Meet Sherlock Holmes), Joe Alaskey (Tom and Jerry: Wizard of Oz movies), Joey D'Auria (Tom and Jerry Show 2014)
Originally named Spike, he had his name changed in order to avoid confusion with a bulldog from another MGM cartoon series with the same name. He would often be the antagonist to Droopy, though he also starred in his own shorts as well. He was often tormented by a Small, Annoying Creature with a prankster attitude in his solo shorts. Appearances of note include "Rock-A-Bye Bear," "Magical Maestro," "Millionaire Droopy," and "Cock-a-Doodle Dog."
- Cheaters Never Prosper: Pretty much any attempt to play dirty against Droopy only led to slapstick.
- Iron Butt Monkey: One of Tex Avery's most recurrent subjects for surreal Amusing Injuries.
- Laser-Guided Karma: All his attempts to cheat Droopy failed miserably. He did sometimes win against other more malicious opponents however. "Rock-a-Bye-Bear" and "Cock-A-Doodle-Dog" have Butch get the last laugh when his foes torment him first.
- Oireland: When he speaks, it's usually with an Irish brogue.
- The Rival: To Droopy in many of his shorts.
George and Junior 
Voiced by: Dick Nelson and Tex Avery (classic shorts), John Rubinov and Tony Pope (What a Cartoon), ??? (Tom and Jerry Show 2014)
George and Junior: The pair from Of Mice & Men reincarnated as bears. George has a plan, Junior is an idiot, and usually gets a kick in the pants he wasn't wearing for his bungling.
- Ass in a Lion Skin: George as a worm and Junior as a chick in "Henpecked Hoboes"; George as a dog in "Hound Hunters".
- Catchphrase:
- George: "Bend over, Junior."
- Junior: "I done a bad thing."; "I'm bend over, George."
- The Ditz: Very much so with Junior.
- Killed Off for Real: At the end of their final cartoon, "Half-Pint Pygmy", both commit suicide.
- Literal Ass-Kicking: George's preferred method of punishing Junior.
- Shout-Out: Based off of George and Lennie from Of Mice and Men.
- Team Rocket Wins: "Red Hot Rangers" ends with the duo being victorious.
Blackie the Cat 
Voiced by: Patrick Mc Geehan, Paul Frees, Daws Butler
- Ass in a Lion Skin: Disguises himself as a dog in "Counterfeit Cat".
- The Jinx: In "Bad Luck Blackie".
Southern Wolf 
Voiced by: Daws Butler (classic shorts), ??? (Tom and Jerry Show 2014), ??? (commercials)
- Captain Obvious: Has a habit of pointing out what is obvious to the audience.[After failing to demolish Droopy's doghouse] Now there's a well-built doghouse, man.
- Catchphrase: Uses “man alive” to mean surprise.
- Mellow Fellow: Following his very hammy introduction in "Three Little Pups", he drops the stage-villain theatrics and makes a hard shift into the laid-back Good Ol' Boy personality that he'd retain for the rest of his appearances.
- Southern Gentleman: Daws Butler uses the voice he would later give Huckleberry Hound.
- The Stoic: Barely reacts to all the injuries he suffers, even a guided missile to the butt.
- Verbal Tic:
- Has a habit of ending sentences with "man".
- In "Billy Boy" his lines repeat at the end Like A Broken Record.
Droopy Junior 
Voiced by: Bill Thompson (Homesteader Droopy), Charlie Adler (Tom & Jerry Kids, Droopy, Master Detective)
Droopy's young son.
- Badass Adorable: Despite being quite small and adorable, he can surely kick some butt.
- Beware the Nice Ones: He's generally a good-natured little guy, but he does NOT take kindly to those who mess with his father. He's given Wolfie and other villains quite a beatdown if they give Droopy a hard time.
- Half-Dressed Cartoon Animal: Averted in some episodes.
- Kidanova: If the pretty girls can't have his dad, they don't mind him instead.
- Kid Detective: Several episodes and the whole spin-off Droopy, Master Detective depict him as one.
- Missing Mom: In the 90s his mother's identity has never been revealed.
- No Name Given: But in the 90s shorts he's called Dripple.
- Perpetual Frowner: Like his dad, Dripple hardly ever smiles.
- Pint-Sized Powerhouse: He's a tiny pup, but like his father, Dripple has displayed some amazing feats of strength.
Meathead 
Voiced by: Dick Nelson (40s shorts), Pinto Colvig (The Screwy Truant), John DiMaggio (Tom and Jerry's Giant Adventure)
Country Wolf
Voiced by: Pinto Colvig (Little Rural Riding Hood), ??? (Tom and Jerry Show 2014)
