Sometimes, family doesn't stay together forever.
This trope is based on when family members, for whatever reason, end up fighting one another for whatever. Generally, this is because of one member making a HeelFace Turn or the inverse. This rarely if ever comes up in works where Status Quo Is God. If a family member changes sides, then they are fighting their former family until the series ends or someone ends up dead. See Big Brother Bully, Cain and Abel, Abusive Parents, Archnemesis Dad, Hates Their Parent, Gruesome Grandparent, and Evil Uncle for examples of characters that tend to end up here.
Note that in order for families to count, both sides have to know that they were family before they started fighting. So Darth Vader and Father (the one from Codename: Kids Next Door) don't count as the family they were fighting didn't know about their relationship until later in the series.
Also see Big, Screwed-Up Family.
- Cross Ange: Ange loved both her siblings until her older brother Julio outed her as a Norma, was responsible for her parents being killed, her sent to Arzenal and attempting to have her killed first by baiting her back, with her sister and then ordering a massacre of all the Norma; her sister Sylvia also turns on her, hating her for being a Norma and holding her responsible for her mother's death.
- Naruto: Sasuke once adored his older brother Itachi until Itachi murdered their entire clan, leaving Sasuke orphaned and traumatized.
- Runaways: After finding out their parents are evil and trying to destroy the world, the titular group gains this dynamic while swearing to stop them whatever it takes.
- The three Kiryuin sisters (Satsuki, Ryuko, and Nui) in Natural Selection used to be a loving trio of siblings that looked after and cared for one another. Ragyo's machinations, abuse, and control over their lives drove them apart, and now they're on opposing sides in the war of the Life Fibers.
- Legend Of The Guardians The Owls Of Ga Hoole: Brothers Soren and Kludd start off close as could be until they are kidnapped by the Pure Ones. At that point, Kludd slowly ends up believing the Pure Ones's mission and attempts to sabotage an escape attempt Soren makes. It ultimately ends with the two brothers fighting in a flaming forest followed by Kludd seemingly falling to his death.
- The Prince of Egypt: Moses and Rameses are very close at the start of the movie, with Moses even trying to defend him from their father. Even after Moses returns many years later, both want to continue their close relationship. However, due to Moses being the one who has the free the slaves, he is forced to do worse and worse things to the people Rameses rules over as Rameses continues to refuse, despite Moses begging him to. Finally, after the final plague which results in the death of every firstborn son in Egypt, Rameses lets the slaves go. However, at the crossing of the sea, Rameses returns to try and kill all the slaves, Moses included, making it clear things are over between the two former brothers.
- Star Wars: Kylo Ren, formerly known as Ben Solo, is the son of Han Solo and Princess Leia. However, after a grave misunderstanding with his uncle Luke and being tempted by the Dark Side turns him evil and he ultimately murders his father. However, he later returns to the light side thanks to both Rey and a final talk with his father.
- In the Warrior Cats arc Dawn of the Clans, the series begins with half of the Tribe of Rushing Water finding a new home; among them are brothers Gray Wing and Clear Sky. Eventually Clear Sky decides that he'd rather live in the forest than on the moor and starts his own group. He then becomes more and more power-hungry and paranoid that the moor group wants to stop him, which leads to battle between the two groups and Clear Sky nearly killing his brother. Clear Sky's son Thunder also decides he can't stand living with his father and starts his own group. Ultimately, what was once one community splits into five. Although the family members reconcile to an extent, their groups, henceforth known as Clans, remain separate forever.
- A Song of Ice and Fire:
- For most of the series, Jaime was the only immediate family member that Tyrion had a good relationship with. Near the end of the third book, Jaime confesses that years ago he lied about Tyrion's first wife, Tysha, being a whore paid to take his virginity when in reality she was genuinely in love with him. Feeling furious and betrayed, Tyrion lashes out by falsely confessing to murdering Jaime's son and exposing the fact that Cersei had been cheating him.
- Catelyn and Lysa Tully were very close as girls, but their father's ward Petyr drove a wedge between them. Lysa was infatuated with Petyr, who only had eyes for Catelyn, who only saw him as a little brother and married someone else. Lysa's jealously festered into full-blown hatred of her sister by the time they were adults. In fact, Lysa gleefully set into motion a series of events that ruined Catelyn's life and ultimately led to her death.
- After Robert Baratheon's death, House Baratheon literally go to war with each other over the Iron Throne. Stannis Baratheon claims he's the rightful heir as Robert's eldest brother, because Robert's children are actually bastards born of incest. Robert's widow Cersei and her family, House Lannister, back Joffrey, who is ostensibly Robert's son. Then Robert and Stannis' younger brother Renly proclaims he should be king because he's more popular and better at winning supporters than Stannis. Renly gets assassinated by Stannis via magic and Joffrey gets poisoned by Littlefinger and Olenna Tyrell for being The Caligula; Stannis has put his war with the Lannisters on hold to deal with the North.
- The Grisha Trilogy: The Darkling was once very close to his mother, Baghra. Though she still loves him, she becomes determined to stop his plans to take control of the Shadow Fold and overthrow the King of Ravka. As punishment for going against him, he rips out her eyes.
- Captive Prince: Prince Damianos had a happy childhood with his older half-brother Kastor and is taken completely off-guard when Kastor usurps the throne. Subverted when Laurent, who's much more adept at deception, realizes that Kastor had always hated Damianos for supplanting him in the line of succession, and might actually have tried to kill him before.
- Harlots: Charlotte has a falling out with her mother Margaret after Margaret's actions almost got Charlotte and her lover Daniel executed for a crime they didn't commit. She leaves home to work for her mother's competitor. Charlotte and Margaret eventually reconcile.
- Paper Mario: The Thousand-Year Door: Downplayed with The Shadow Sirens. Beldam bullies both of her sisters but they work together and all start out as enemies to Mario, but after Beldam mistreats the youngest sister, Vivian, one too many times, she gets fed up and switches over to Mario's side, where she stays for the rest of the game. In the epilogue, they do make up.
- Heihachi Mishima used to be deeply in love with his wife, Kazumi. However, when she reveals that the only reason she married him was to assassinate him before his ambitions for world conquest ruined the world, he is forced to kill her in self-defense. In turn, this made Heihachi bitter towards not only her but their son (because he had the same supernatural curse in his blood that she did). Likewise, when a young Kazuya learned that Heihachi had killed his beloved mother, Kazuya attacked him. Then, both as a test to see if the boy would succumb to his curse and out of spite, he tossed Kazuya off a cliff. Sure enough, the Devil took hold and from that moment on, both father and son were mortal enemies.
- Tekken 7 reveals that while Kazuya loved his mother so much as to try to avenge her after Heihachi killed her, she saw Kazuya as nothing but another aspect of her mission. In fact, she had already arranged for Akuma of Street Fighter fame to kill both her husband and son if anything ever happened to her. Kazuya overhears Akuma telling Heihachi this and is genuinely surprised and hurt to learn that his beloved mother had wanted to kill him. However, being Kazuya, he quickly laughs at the irony, as it no longer mattered.
- Kazuya was also very fond of his paternal grandfather, Jinpachi, who partially trained and doted on him as a youth before Heihachi betrayed him. By the time Kazuya had grown up, Jinpachi had been consumed by a wicked demonic power and Kazuya himself had embraced his devil persona. Thus, in Kazuya's Tekken 5 ending, he briefly holds his injured grandfather in his arms and the two recollect their happier years together...before Kazuya's eyes burn red and he flashes a Slasher Grin before finishing Jinpachi off.
- History repeated with Kazuya's son, Jin Kazama. While not exactly "loving" of his grandfather, Jin was told by his mother Jun to seek Heihachi if something ever happened to her (which it did). Heihachi raised and trained Jin, and even enrolled him in his school, but it was all part of Heihachi's plan to lure out Jun's killer: a creature called Ogre. When Jin gets to Ogre first and slays him, Heihachi decides that he has outlived his usefulness and orders his men to gun him down. Once again, Jin survives because the Devil he inherited from his father takes control, and Jin spends the next several years despising and plotting the downfall of every member of the Mishima family.
- After Jin himself underwent a FaceHeel Turn upon seizing control of the Mishima Zaibatsu, one of his strongest subordinates in the Tekken Force was Lars Alexandersson, who is later revealed to be Kazuya's half-brother (and thus, Jin's half-uncle). While their relationship was mostly that of commander and loyal subordinate (as neither knew they were family at the time), the moment that Jin betrayed him and got the men under his command killed, Lars and Jin became bitter enemies, and in fact, being part of the same family they both despised only made their animosity that much greater. In Tekken 7, the two are forced to bury the hatchet to deal with Kazuya, who had finally killed Heihachi and was now poised to conquer the world unopposed.
- Finally, there's Lee Choulan, who's Heihachi's adopted son and thus the adopted brother of Kazuya and adopted uncle of Jin. Initially he was something of an Opportunistic Bastard who worked with Heihachi or Kazuya against the other, but he was eventually exiled and after seeing how badly things were going for the world due to the Mishima family feud, he ultimately ended up teaming up with Lars to try and put a stop to things, positioning himself as a Big Good who was trying to prevent the others from wrecking the world with their fight.
- Codename: Kids Next Door:
- The sisters Abby a.k.a. Numbuh Five and her older sister Cree, formerly Numbuh 11. Back when Cree was still a KND operative, she and Abby were as tight as could possibly be, with Cree even being the prior owner of Abby's Cool Hat. However, in present day, Cree is now a teen and a traitor to the KND, as well as being a common minion of Father's, with the two now being bitter enemies.
- Numbuh Three and her younger sister, Mushi, start the show very close, with there being hints that Mushi looks up to Kuki. Then Mushi ends up falling for King Sandy and things take a turn for the worse. She ends up stabbing Kuki's Posh Party rainbow monkey, leaving the sisters hating each other.
- Avatar: The Last Airbender gives us Zuko and Iroh. Both were once close with Ozai and Azula, but following Zuko's banishment, Iroh doesn't view them as highly and has joined the White Lotus in hopes of defeating them. It takes Zuko far longer, as he still clings to a belief he can impress his father, but after both he and Azula take a flying leap over the Moral Event Horizon, Zuko realizes he's been on the wrong side of the war and does a HeelFace Turn, leaving them as enemies for the remainder of the series.
- DuckTales (2017): At the beginning, Donald Duck and his uncle, Scrooge McDuck, haven't spoken for over ten years. Donald drops Huey, Dewey, and Louie off at Scrooge's mansion so they stay out of trouble while Donald goes to a job interview, with it being painfully clear this is a last resort. Later, it is revealed that their conflict stems from Donald's twin sister and the triplets' mother, Della, getting lost in space, and Scrooge not doing enough to search for her in Donald's eyes, as well as not stopping her from taking off on the doomed flight. In the penultimate episode of Season 1, Scrooge's family abandons him as the triplets learn the truth about their mother, but their feud is over by the season finale.