When times are truly desperate and Prayer Is a Last Resort, someone will not only pray, they'll pray to any god or gods out there, in order to cover all their bases.
A particularly Crazy-Prepared person might even carry around holy symbols and relics of multiple faiths, and have memorized prayers to go with each one, just in case he ever needs divine help.
- Willie And Joe has one strip where Joe asks an allied Arab or Indian soldier if he knows any good Muslim prayers; as Joe puts it, "I don't wanna miss any bets."
- The Mummy (1999): When facing Imhotep approaching him, Beni starts praying using Muslim, Christian, Buddhist and Hindu icons and prayers. It's not until he reaches Judaism that Imhotep recognizes the Hebrew language as "the tongue of the slaves" and spares his life in exchange for his services.
- The titular hero of Talladega Nights: The Ballad of Ricky Bobby does this when he thinks he's on fire.
"Help me, Jesus! Help me, Allah! Help me, Jewish God!"
- In the Big Storm Episode of Superstore, Tornado, Glenn, a Christian, prays in the tornado. When that doesn't work, he tries many other gods and is quite surprised and confused when the storm stops after praying to Allah.
- Downplayed in Kaamelott, where King Arthur (who was sent away from Britain and raised by the Romans before becoming king) still prays to Mars, despite being a Christian. The Lady of the Lake calls him out on it, but he turns it right around by pointing out that neither the local gods she represents nor God have been much help either concerning this whole "quest for the Grail" thing. Among others, they've yet to give a clear definition of what it is (it might be a cup that held Jesus' blood or a burning stone) or where they're supposed to look.
- Game of Thrones: Inverted by The Dreaded pirate Euron Greyjoy as a Blasphemous Boast:
"I am the godliest man ever to raise sail! You serve one god, Damphair, but I serve ten thousand. From Ib to Asshai, when men see my sails, they pray."
- Warhammer40000: The Death Guard fell to Nurgle this way: they were trapped in the Warp and were struck with a plague so horrifying that they eventually broke down and begged the aid of any divinity to spare them. Nurgle (who'd sent the plague in the first place) turned them into Plague Marines, inhumanly tough and pain-resistant abominations that are more cancer than flesh.
- In Conquests Of Camelot, Camelot's chapel has separate altars dedicated to Jesus Christ and Mithras. You need to pray to both of them or the one you ignored will smite you.
- In Prison Architect, you can build a Chapel or "Multi-Faith Prayer Room" and hire an NPC to perform Spiritual Guidance services that can calm your inmates. Said NPC is randomly selected from a number of real-life religions and a new one is picked for every service that occurs. A random spiritual leader will also meet with any prisoners you execute.
- In King of Dragon Pass, certain crisis situations allow the clan to propitiate "appropriate" enemy gods not part of the Orlanthi pantheon. Specifically, two members of the Unholy Trio: Malia, goddess of Disease, and Daga, god of Drought. It has a chance of working, but it's generally a bad idea.
- In Civilization: Beyond Earth, a technology research quote from the spiritual Kavitha Thakur is a devotional prayer that beseeches Seraphim, Cherubim, Devas, Yakshas, and Fravashi in service to the Lord Creator, implicitly blending this trope with Interfaith Smoothie.
- In Danganronpa, after Hagakure witnesses Junko being murdered in front of him and thus the reality of the situation sinks in, he claps his hands and shouts "I'm begging you! God, Buddha, Mother Earth, God of Space, King Neptune, come save me!"note
- In an episode of The Simpsons, Lisa prays to Buddha, Jesus, and Spongebob when she's stuck in the trunk of a car. Another episode has Homer praying to Jesus, Allah, and Buddha while being chased by a rhino.
- Futurama: The page quote comes from the start of the episode "The Farnsworth Parabox", when one of Professor Farnsworth's experiments goes horribly wrong and, in agony, he starts begging various deities to help him. Calling upon Satan apparently does the trick since he survives the ordeal.
- Elvis Presley was known to wear a necklace with a cross, star of David, and Hebrew Chai symbol on it; when asked about this, he said he didn't want to miss out of Heaven on a technicality.