Threaten Phoenix Wright's loved ones and you are in for a world of hurt. Nearly invincible scary German prosecutors and actors with possible split personalities beware- you are doomed.
Dual Destinies has the law teacher Aristotle Means. Fairly pleasant guy, even if he has kind of a Knight Templar philosophy he just can't wait to share. He won't even be annoyed if you accuse him of murder. Tell him his aforementioned philosophy is bullshit, however, and he'll unleash his inner Sadist Teacher, hit you with several pieces of chalk, and lecture you into depression.
Even AdventureQuest Worlds isn't safe from the wrath of anyone under this trope. For example, Vath, the third lord of Chaos, has his Berserk Button pressed (add in a Red Eyes, Take Warning as well) once he realizes from the hero that he/she freed the dwarves and the dwarves are winning against his army.
Vath: No matter! You are their beacon of hope, hero. Once I finish with you, I will throw your body down to them and they will SEE what happens to those who oppose my might! (leaps at the hero with his sword above his head)
When fighting against the fifth lord of Chaos, Wolfwing, when his HP starts to bottom out and therefore a message appears saying "Wolfwing goes berserk! End this before he ends you!" it means you've pressed his Berserk Button, and his attacks will be dished out twice as fast as usual.
The same goes for the eighth lord of Chaos, Tibicenas, when his HP drops low enough and a message appears saying "Tibicenas goes berserk! Kill him quickly!"
Maximilian Lionfang doesn't approve of the Great Truce between Good and Evil because - yep, you guessed it - he doesn't take too well to Evil.
Lionfang: You DARE come into MY tower and corrupt MY soldiers with your lies?! I will SHOW YOU the fate that awaits all EVIL!
Lionfang ends up on the wrong end of this trope when, in his second appearance, he burns down the Frostval gifts meant for the people of Lore in a major Kick the Dog moment, putting the hero into This Is Unforgivable! mode.
Mess with Andre Jr., Andre the giant's giant son, especially by putting him to sleep with a knock-out potion, and you've hit Andre's Berserk Button and he'll therefore stop at nothing to crush you into dust. That is, until you can beat up all of his body parts and grab the key from his giant necklace.
Andre: What have you done to my son, you filthy vermin?! I'LL CRUSH YOU INTO DUST!!!
And for god's sake don't make him think you took his keys. Even if you didn't do it, he'll tie you up, beat the crap out of you, possibly make you drink laundry detergent, and then when that's not enough, he might decide to implicate you in the assassination of a world leader to take heat off another he may like more. Poor Wen.
Conrad Marburg despises unprofessionalism. By taking advantage of this (and doing some research) Mike can actually goad Marburg into fighting to the death rather than simply retreating.
Albatross is quite sensitive about anything to do with his bodyguard Sis. Asking questions will tick him off and killing her will put Mike on his shitlist.
As a well known berserk button instory, everyone in A Profile does their best to avoid saying anything to Kaine about his physical sex though occasionally he interprets things that are unrelated to be about the issue as well.
The first one was being betrayed, his wife killed and his daughter Mithra kidnapped by his former brethren to be used to power a superweapon fueled by human souls, which kickstarted his Roaring Rampage of Revenge.
He also does not take kindly to being called a god or worshipped like one, mainly because of the behavior of the "gods" mentioned below.
Part of why Asura is so pissed at the Seven Deities is their "purification" (read: callous slaughter) of innocent humans for the sake of collecting their Mantra.
During the close of the second act of Asura's Wrath, Asura's companion for much of the act, a girl who reminds him very much of his daughter Mithra, is killed along with everyone else when Olga unleashes the full force of her fleet of warships upon the village they're in to try to kill him. Shit really hits the fan when this particular button is hit, resulting in one of the biggest episodes of Unstoppable Rage in the entire saga.
And probably the biggest one of all: don't you dare make his daughter Mithra cry. Even if you are a frigging God and the most powerful being of the known universe, Asura willEND YOU.
Insulting Dynaheir or Khalid (especially after either's storyline death) is a good way to forfeit your life.
Minsc has an actual berserk button - as in, there's a button you can click to send him into a berserk rage. He also goes postal if whoever he's adopted as his "witch" in the second game gets killed. (In both these cases, it's a good idea to hide most of your party on the other side of a locked door, since Minsc in berserk mode has a somewhat overactive target acquisition sensor.)
The Big Daddies of Bioshock: Hulking great fellows grafted into old-fashioned diving suits who have found themselves on permanent escort duty. They take this duty very seriously. For the most part they are calm and placid, patiently lumbering along in the wake of their creepy little charges and frequently displaying a touching degree of tenderness. But... should anyone pose the least threat to his Little Sister, Big Daddy will... get angry. And, good Lord, when this happens, you will know about it.
One of the audio diaries tells the story of the Big Daddies bonding for the first time with the little sisters through the accidental discovery of this beserk button. Lets just say that helping create them does not give you the right to slap a little sister when right in front of a Big Daddy.
Sander Cohen has a few of these buttons. Harm his art, interrupt his music, even doubt him (or, as the player found, be suspected of doubting him) and you better be ready for a face full of fire.
Dr. Steinman will horrifically mutilate you if you don't fit his standard of beauty. Though considering he views himself as "the Picasso of Surgery", everyone probably qualifies.
Dr. Neurosis from Brain Dead 13. Don't call him "average." Just don't.
While he doesn't completely flip a shit, he still overreacts.
If you hurt Dimitri of Call of Duty: Black Ops, Reznov will make you pay. Even if it takes 23 years and a proxy, he will kill your ass.
On that note, don't mention Dragovich, Steiner, or Krevchenko anywhere within fifty feet of Alex Mason. Especially if you ARE Dragovich, Steiner, or Kervchenko. He WILL kill you.
In the Command & Conquer games, if you so much as lay a finger on the AI's resource harvesters, you'll find yourself at the receiving end of a massive all-out attack by the computer's forces. The AI doesn't mind if you kill its harvesters with air or naval units, or landmines though.
Jin Saotome from Cyberbots (& Marvel vs. Capcom) goes into a rage if his opponents mention his dead father.
Darksiders: Upset the balance. War will find you. He WILL make you suffer. He never eats. He never sleeps. He will hunt you like a dog.
Darksiders2: Go ahead and tell Death that War caused the apocalypse. Realize that he is stated as the strongest horseman. Let the fact that he once proclaimed that he'd storm HEAVEN itself to save War sink in.
In Dark Souls, mortals trespassing on the symbolic tomb of Gwyn is one for Gwyndolin. Clerics in general are this for Patches.
Dead Or Alive 4 Do not gleefully reveal that you killed Helena Douglas' mother with Helena as the target to Helena's face.
Dead Rising 2 has a host of psychopaths, same as the original game. One of them is the tamer of the casino's tiger, a mentally handicapped man named Ted. When captured by Ted, Chuck tries to talk his way out of it, but makes the mistake of saying they should take things "nice and slow." An unfortunate choice of words that ruins any chance of peaceful solutions.
Deus Ex: Human Revolution: Don't bring up the Mexicantown Massacre in front of Adam Jensen, if you know what's good for you. You may also want to keep your metal hands away from his girlfriend, unless you want his armblade to end up in your ass.
Then there's the part where Faridah's dropship gets shot down with you in it. You get the chance to either defend it, and her by extension, or not. For many players who'd come to know the character over the course of the story and were attempting to finish the game non-violently, this moment broke their run.
If you think calling Etna flat is a bad idea, then steal one of her desserts or her panties. I dare you. I DOUBLE dare you, muthafucka! While panty theft is a berserk button for women in general, if Etna finds out you were responsible and her prinnies don't get you first, you will wish you called her flat instead.
DON'T call Laharl "kind" or anything similar, and don't mess his hair; it took him all morning to get it just the way he wanted it. But most of all, doing anything to harm Flonne will make him want to kill you.
Harming or threatening to harm Adell's family or friends is a good way to get yourself a few broken bones. If you're lucky.
Fuka and Desco enjoy their love talk, especially when dredging Valvatorez' past with Artina out of him. Interrupt it, however, and heads will roll. Namely, yours. Do not take a perverse interest in Desco, or Fuka will go nuts. That means you, MAO.
Dishonored: Revenge solves everything. In this specific case, it solves the problem of the conspirators behind the murder of the Empress, the woman Corvo Attano was hand-chosen and sworn to defend, living long and happy lives.
In Divinity II: The Dragon Knight Saga, the dragon knight Amdusias absolutely loathes his former master, Maxos, and will freak out at the mere mention of his name. You can not only mention it multiple times before fighting him, but also confront his soul in the Hall of Echoes and say it again, and much later you can instruct a man on the verge of dying to carry a message for you, saying it again.
Donkey Kong will show no mercy to those who are stupid enough to steal his Banana Hoard, just ask K. Rool and more recently the Tikis.
In Tropical Freeze, the second boss puts a banana on an altar and smashes it with a hammer. Donkey Kong smashes the altar with his bare hands (to be fair, he was aiming for the boss).
Duke Nukem Forever: May God have mercy on the souls of any ETs whom Duke catches mass abducting his babes. Normally, he'd have to tell you he was pissed; take this button Up to Eleven, and you will know you fucked up something fierce.
Not my babes! Not in MY town!!You alien motherfuckers are gonna pay for this!
If Sima Shi is eating meat buns, don't try to take them away from him. He doesn't like that.
The Edutainment GameEagle Eye Mysteries in London gives us Nigel Eagle, who'll chow down on fish and chips at every opportunity, plays cricket like any English chap, and is usually very cheery and chummy. He will not, however, take it very well if you cheat at chess, which he considers a royal game.
Never hurt or scare Peter Puppy. Otherwise, he will get revenge on you!
Calling a Nord a "milk-drinker" is something not recommended unless you want a fight.
The outlawing of the worship of Talos has a lot of Skyrim's people up in arms, especially given the Thalmor's penchant for dragging people off in the middle of the night just for doing this.
Messing with the Arcaneum is not recommended unless you want to answer to its big and very rough-mannered keeper, Urag gro-Shub, who is fully capable of making his wrath felt in the form of angry Atronachs.
Getting too close to a giant or messing with one of the mammoths that graze near its camp is a very good way to get sent into low orbit.
Ulfric Stormcloak utterly loses it when Elenwen, ambassador of the Thalmor, crashes the peace talks during the Season Unending quest. Said Thalmor was in personal charge of his torture back in the Great War, during which he was made to believe that the info he gave up was instrumental to the fall of the Imperial City, so he has plenty of reason to hate her guts.
Ulfric hates Elenwen so much that, if you agree to have her kicked out of the negotiations, then it is considered a major concession to the Stormcloak side. In other words, Ulfric is totally willing to cede a small hold (say, Dawnstar) to the Empire just to avoid sitting in the same room as that "elf bitch".
Ulysses of the Lonesome Road DLC despises those who use symbols without any understanding as to their meanings. Notably, he was offended by the White Legs braiding their hair in dreadlocks in honor of him since they actually served a symbolic purpose in his former tribe while the White Legs simply did it because they thought it looked cool.
Fujimura Taiga in Fate/stay night is typically playful and cheerful...unless you call her Tiger, in which case you'd better have a will ready. Getting called Tiger actually pisses her off so much that saying it is enough to lift her out of unconsciousness.
Even worse is when she gets no food at all. The mere suggestion of skipping a meal caused her to nearly beat Shirou to death.
Shirou himself has one in regards to his family and loved ones, Taiga especially. When Shinji doesn't just harm her but then proceeds to mock her attempts at resistance, it causes Shirou to flip out in a manner that heavily resembles Shiki Tohno.
Machina and Al Bhed are initially Berserk Buttons for Wakka - using machina or being of Al Bhed heritage was a good way to get yourself on his bad side. He does mellow out about it later on in the game though. Also, DON'T talk about Chappu in front of Lulu.
Rikku apparently can't stand people who just blindly follow Yevon's teachings without thinking for themselves, as shown when she chews Wakka out for it shortly after her (proper) introduction. Also, hurting Yuna is a good way to get her mad.
Even Yuna has one, though it depends somewhat on interpretation - don't say the summoner's pilgrimage is useless or that there's no point to it. Even though she didn't get that angry when it was mentioned, that could just be because it was Tidus who said it - the implication is that if it had been anyone else, Yuna's reaction would have been a bit more severe. Also, NEVER insult her guardians.
Princess Ashe was given an audience with their gods the Occuria. The leader of the Occuria was delighted enough that their chosen had come for her tasks: to become their new Dynast-King and to destroy, Venat, an Occuria who did not agree to their plans for Ivalice. The leader maintained an eloquent and neutral tone when speaking to her, but when Ashe questions the task to destroy Venat, the leader's tone of voice changed so much viewers can feel the spite and anger the Occuria have towards Venat. To add to the effect, the calming background music changed into something tense and dark.
In Genealogy, hurting or threatening Sigurd's friends will instantly get him to invade your country regardless of odds. Verdane finds this out when one of their princes abducts Aideen, as does Chagall of Agustria when he imprisons Eldigan and attacks Raquesis.
Harming and generally mistreating children is one for Eyvel in Thracia 776. She slaughtered an entire troupe of slavers when she found them holding Mareeta, and when they later find Mareeta's father, is pretty pissed for letting his daughter get captured in the first place.
The Force Unleashed: Never, ever attempt to harm Juno Eclipse. Ever. Starkiller will find you and do his level best to reduce you to your constituent subatomic particles. Some examples of his speech after Vader Force-Pushes Juno out of a window and she appears dead:
I WILL KILL YOU!!!!!
YOU WILL DIE WHERE YOU STAND!!!!
God of War: Notwithstanding Kratos being Unstoppable Rage incarnate, he does have two buttons that will ensure your death with be especially brutal. The first is bringing up the failures of his past. The second is insulting Pandora.
Ghost of Sparta gave us a third: killing his long lost brother in front of him. You almost feel bad for Thanatos....
Kornell goes nuts and breaks out of a trap in Grandia III when Miranda calls him a "muscle-bound peabrain."
CJ from Grand Theft Auto: San Andreas reacts very badly to being called a 'bustah'. Badly enough that the game goes to pot whenever someone does...
Also, do not talk smack about his sister Kendl or threaten her in any way. In the "Deconstruction" mission, when he heard about how a bunch of construction workers were calling Kendl a hooker, C.J. paid a visit to the construction site, thoroughly trashed the place, and, just to top things off, trapped the boss of the place in an outhouse, dumped him in a hole, and buried him alive in cement. Damn. Just damn.
And again for May? Don't be bald. She hates baldies so much that she'd attack any bald person in sight.
Similarly, Dizzy has her own Berserk Button as well, as shown in her win quote against Venom. Threatening her friends at the May Ship is not good for your health unless you want some butt-whoopin' from her and her guardian wings Undine and Necro.
If you are in Half-Life 2, threaten any member of the Vance family and you'll have to answer to Dog. Dog is a giant robot built like a gorilla. He throws cars at people he doesn't like. He rides Striders like bulls and tears off their heads. He certainly won't be intimidated by you.
San Oko, the track team captain from Hatoful Boyfriend, goes berserk upon encountering any inferior pudding. In Holiday Star it's shown that serious threats to Sakuya are this to his usually casual, carefree brother Yuuya.
Carpenter is a powerful and vengeful spirit from Hunter: The Reckoning who was a convict in the Ashcroft Penitentiary decades ago, where, like all the other convicts, he was used as cattle by the vampires in charge and tortured endlessly in the twisted experiments of Dr. Hadrian. When the spirits break through and tear Ashcroft apart in their anger, Carpenter is the only one who retains his sentience, and has one all-consuming obsession: capture Hadrian and subject him to "three days of neverending pain." But when he finds out that the Hunters encountered Hadrian and killed him, he has an emotional breakdown, followed by Unstoppable Rage and a very difficult boss battle.
In Jericho, don't call Billie "Wilhelmina." Only her father calls her "Wilhelmina."!!
Also, don't damage Cole's computer. Cole does have a subversion of this as well, though. Ask her about maths, and she calms right down.
Pit is usually the Nice Guy of the game, quick to wisecrack and joke. But if you hurt Palutena in any way, then the only thing you can do at that point is buy yourself a coffin because he will END YOU! It doesn't matter if he's trapped in a ring for three years. He will hunt you down, he will find you, and he will thoroughly kick your ass with every goddamn weapon in his arsenal. Ask the Chaos Kin. Oh wait, we can't. He's trapped in the Chaos Vortex for all eternity.
Palutena will go off on anyone who calls her ma'am.
Dark Pit does not take kindly to anyone calling him "Pittoo"
Hades will not stand for anyone questioning his rule. Medusa learned this the hard way.
Kingdom Hearts 2 gives us Saix and the moon. When he's exposed to it for long enough, he'll flip out and become nearly impervious to damage, all the while dishing out wickedly-fast attacks and howling like a banshee.
Terra and Aqua have the same button - namely, trying to hurt their friends. It's not just villains who can trigger it in Terra's case, as Master Eraqus could attest.
King Mickey. A mouse that is almost the ultimate good figure in the series… until you kill Goofy. Then he'll hunt you down and kill every heartless in his way on a murderous rampage. Even though Goofy ends up okay it's still something that no one saw coming.
He actually has several moments. Do not insult his missing friends that could be dead for the last ten years. Even though Mickey hasn't lost his cool yet, the very fact that he shows anger can lead to this.
The King of Fighters: Never remind Kyo Kusanagi that he's a higschool drop-out. Obviously, neither be Ash Crimson nor Iori Yagami, nor harm his girlfriend, friends and partners. Having Yashiro tell him that the Orochi wanted to have Yuki as a Human Sacrifice and later being only able to witness how Ash stole Chizuru's powers were two times when he totally lost it.
One, if she asks you where her beloved Andy Bogard is, do NOT give her an answer that doesn't sound like his whereabouts, for she is most devoted to Andy ever since she was a child. (Not even his older brother Terry can get away with that one. And he weaponizes it to get under Andy's skin once)
Do not, I repeat do not steal Kirby's food. He will go on a Roaring Rampage of Revenge throughout the whole dream land and devour/beat up everything in his way.
In one cutscene in Kirby's Epic Yarn, when Fluff knocked Kirby off the tree, after a Big Lipped Aligator Moment, Kirby got angry and ran after Fluff. note And anger yarn butts come out of Kirby's head as he ran. Kirby chased Fluff for so darned long that he forgot all about being hungry.
Don't bring up Taris in front of Juhani. If you have to, be prepared to remember the Jedi Code in order to cool her off. Likewise, you're better off not talking about the Genocide of Cathar...
And Mission does not want to be treated like some helpless kid. Seeing as she's a nubile, pretty Twi'lek female that fended for herself in one of the worst Wretched Hives in the galaxy for most of her life, it's kinda justified.
When it comes to Zaalbar, you can kill his father, and abet Czerka's slaving operations on his homeworld... if you're evil, but don't threaten Mission unless you want a large, pissed-off Wookiee charging you, and to hell with the life debt. If you are a bastard and force him to kill her, he will make an attempt to kill you on the Star Forge.
If you suggest that Canderous is a coward, make peace with The Force beforehand.
You also probably want to avoid mentioning Carth's wife in front of him. Or Admiral Karath.
L.A. Noire: Do not call the recently deceased Courtney Sheldon, a former soldier in Cole's platoon on Okinawa back in WWII a druggie. Cole will pull out his gun, aim it at you and threaten to blow your fucking head off if you say one more word about him. Oh, and for that matter, don't withhold information that could help him arrest a culprit, especially when women and children are involved and are the victims.
The Witch in Left 4 Dead is the most passive enemy in the game, not attacking until you shine a flashlight on her, bump into her or do anything to disturb the woman. She then promptly stands up, annihilates the person responsible, before bursting into tears and shrieking as she runs away from the survivors.
As long as you and it draw breath, you are this to the Tank.
The Legend of Zelda: Aww, isn't Link a cute/handsome and nice young man? And what an innocent farmer/island-boy/Kokiri. Surely, he would never do something devastating on purpose, huh? So come on and try to hurt someone who's close to him. Come on. I dare you.
Do not open a mass relay without knowing where it leads first. The Council... frowns upon such shenanigans.
Kaidan Alenko may be one of the most mild-mannered Marines in the Alliance, but don't threaten his girlfriend. Bad idea.
Did you break the law in front of Samara? You're in for a world of pain.
Endangering the Migrant Fleet while Tali's around is a good way to get a shotgun to the face.
Feel like getting a bullet (or several) to the chest? How about you try to threaten Miranda's sister?
If Mordin finds out that you're using live test subjects, you're probably about to be subject to at least one of the many, many different ways he knows how to kill people.
Don't imply to Zaeed Massani that his vengeance-turned-obsession against Vido Santiago is a mere grudge. He will flip his shit. Also, if you deny that vengeance...he doesn't take it well, to say the least. Vido, in general, is one big red button to him.
A text file from the previous Broker reveals that this is a weakness shared by the rest of its species: when calm they are terrifying and calculating. When angry they become mindless berserkers that, while still formidable are easier to bring down.
You may also wish to avoid even suggesting that Grunt is not a true krogan, unless you like walking around without a head.
Also, holding Jack captive... not a good idea, if you don't want her to tear your prison to pieces with her mind. And Cerberus in general is one giant Berserk Button for Jack. In Mass Effect 3, harming her students is equally suicidal.
Krogan in general - if hurt badly enough, their secondary nervous system kicks in. According to Grunt, higher mental functions like "restraint" and "taking cover" don't always translate well.
Betraying Urdnot Wrex is an excellent way to get him to end you in spectacular fashion. If you sabotage the genophage cure for the salarians in 3, you will have to kill him, as he's intent on doing just that to you.
Go on... separate rachni offspring from their mother...I dare ya.
Max Payne 3: Max takes it mutely when a bunch of Joisey punks badmouth him and wave guns in his face. But when they threatened a woman standing up for him, it became time to dish out 9mm headaches.
Shit really hits the fan later on in the game when Max discovers the organ-harvesting ring that the bad guys are running.
InMega Man X: Command Mission, Resistance member Steelheart Massimo has a bit of an idol issue. Never speak poorly of his predecessor sharing the same name. Especially do not call him "weak", "feeble", or mock tearing him apart while saying "rrrriiiiiiipppppp". You will be thrown through a wall... if you're lucky.
To put it into perspective, the Reploid that decided to do this was the massive Triceratops-based Silver Horn, who's twice as tall as Massimo and built like a tank. He got sent flying across the room and onto his ass with one blow.
"Feeble Massimo? FEEBLE Massimo?! *growl* You sonuva-"
The memory of your insulting him will not wash away, either. A copy Reploid impersonating Silver Horn appears in the obligatory Mega Man Boss Rush. Massimo treats him as if he was the real deal, stating his intent to take the guy out.
Rockman 4 Minus Infinity: Pharaoh Man gets pretty upset when you destroy the statues in his pyramid, and later blasts Mega Man through the roof of the pyramid when he destroys a coffin.
Mega Man Zero: Copy-X seems to have a Hair-Trigger Temper already (at least when he's about to do battle). He's a mix of Knight Templar and immature, spoiled brat who knows nothing of true adversities or sacrifices, any of those things that made the original X a true hero. Tell that truth to him at your own risk... like Zero did.
Zero: He was not as naive as you are. That's what made him a hero.
Needless to say, Copy-X took this as a major insult on his "heroic" character (since he believed himself superior in every way to the original X) and, hating Zero already, became exponentially more desperate to crush Zero dead as a doornail.note Pummeled into such critical condition, it is remarkable that this Big Bad was able to react so destructively! Turns out, he manages to only crush himself while Zero (narrowly) escapes unharmed.
Metal Gear Solid 3: Whatever you do, do not let yourself get caught posing as Raikov by Volgin, or else he will give you hell to pay before torturing you, or attack you even faster than before.
In the first chapter of the Neverwinter Nights mod The Bastard Of Kosigan, the player character gets really, really pissed off when any Germans mix up France and Burgundy. Bigger and more justifiable examples occur in the third and fourth chapters, when someone digs up your mother's grave looking for a sword and when Alex dies, respectively.
Travis from No More Heroes is shown to have one when Jasper Batt Jr. has Travis' best friend killed. Pretending to have killed his brother, girlfriend and apprentice has similar results.
OFF: If you piss off/upset an Elsen normally, they'll become a regular Burnt and attack you, which pose little threat. If you threaten to take away their sugar, however, they'll become a Calvary-Burnt, and try to shred you with their huge new-found claws. It's worth noting Elsens are normally so easily frightened that a rollercoaster that was actually a bunch of immobile chairs was still too much for them, and yet they'll easily slaughter spectres when their sugar's threatened. Of course, it makes sense when you find out they're addicted to it.
In Ōkami, Susano spends most of the game being (if often hilariously) useless. But when Orochi tries to eat his girlfriend...
An individual's Shadow will go berserk if the person in question says anything to the effect of "You're not me!" When this happens, it usually ends badly for anyone who doesn't have a Persona. For those who do have Personas, however, it's Boss Battle time.
It's not a good idea to use the word "strange" around Kanji Tatsumi, or imply that he's gay ("You sayin' I like dudes?!"). It's also not a good idea to disrespect Naoto when he's around.
Yosuke does not take kindly at all to people who disrespect Saki Konishi or the protagonist.
Teddie goes bear-serk when Mitsuo calls him a freak.
Naoto will not stand for weird nicknames or being called "useless."
And the one thing that will bring down the wrath of the entireInvestigation Team is anything bad happening to Nanako. In fact, when Nanako appears to have died toward the end, everyone is more than ready to make her kidnapper Namatame pay, and if you don't snap them out of it, he'll get thrown into the TV and you will get the worst ending of the game.
Plants vs. Zombies: The newspaper reading zombie really gets pissed when you ruin his paper.
In Pokemon Diamond And Pearl, a new ability was added called Anger Point. Only three mons can have it (Mankey, Primeape, and Tauros), and they all have alternate abilities that are generally considered much more useful (Vital Spirit for the former two, Intimidate for the latter). However, if one of those Pokémon does have Anger Point and an opposing attack used on it is a Critical Hit, that Pokémon's Attack stat is automaticallymaximized, even if it was already lowered by something like Charm or Intimidate. In other words, the Attack boost is equal to a Belly Drum minus the HP sacrifice, or three simultaneous Swords Dances at neutral stat change. The ability has no importance to the story and is generally not worth basing one's strategy around, but it is likely one of the best examples of a Berserk Button within the gameplay.
Try to harm a Pokemon Trainer with a Gardevoir. I dare you. Just warning you, don't get fooled with the "cute girl" looks.
In Portal 2, Wheatley's reaction to calling him a moron is a clear indication that you should Beware the Nice Ones. Even GLaDOS, who prides herself on insulting anyone and everyone in every way possible, recognises that it's a bad idea.
The whole point of Postal 2 is that the protagonist, an average, down-on-his-luck citizen of a simple little town can go on a mass-murdering rampage while performing boring, menial tasks that try their hardest to frustrate him. The catch is that the player can choose to do so or not.
Don't endanger the city of London, don't threaten to harm innocent people, don't mess with Luke Triton and do not abduct Flora Reinhold. Professor Layton may seem harmless, but he's also a Memetic Badass for a reason, and he becomes quite the relentless Determinator if anyone poses a threat to his city, his neighbors, his apprentice or his daughter.
Also, though it's a bit milder than the above, don't call Professor Layton a detective. He is a professor of archaeology.
Luke, Layton's apprentice (number one!) will absolutely flip his shit if you insult the professor in any manner. This can be anything from doubting his puzzle-solving prowess to simply being "rude" to him (like, by asking him to leave the scene of a crime). He's quite the fanboy.
Prototype: Alex Mercer, full stop. If you so much as look at his sister, Dana Mercer, in the wrong way, much less harm her or, God forbid, try to kill her, then you are in for a world of hurt. If he lets you live long enough to feel pain. Which, to be honest, he probably will.
To put it into perspective, Alex is a nigh-indestructible murderer/terrorist/monster with Lovecraftian powers, who spends his time fighting Eldritch horrors. He can kill everyone within certain radius, take down tanks with his bare hands, throw cars off the Empire State Building, kick helicopters out of the sky, and survive a nuclear explosion to the face. So... yeah. Don't touch his sister.
Survival tip in Ratchet & Clank: Don't threaten Ratchet's home planet of Veldin. Just trust me on this one. Other dictators didn't and got metric tons of RYNO missiles thrown at them. This is not something you want to happen to you. Just... leave the place alone. Seriously. Insulting Veldin is also unwise, especially when Drek referred to it as a "pathetic lump" that "no one will miss."
See that tiny robot? That's Clank. He's very important to Ratchet. For your own safety, do not attempt to harm the tiny robot.
Red Dead Redemption: You can push around John Marston all you want, push around men while John Marston is present, but do NOT and I mean do NOT threaten John Marston's family or a defenseless woman. He will not hesitate to put a bullet in your skull for that woman's sake.
Ada Wong or in actuality, Carla Radames is Chris Redfield's button in Resident Evil 6.
RosenkreuzStilette has Zorne Sepperin, who is willing to mop the floor with anyone who hits her Berserk Button by either calling her a Baka or messing with Father.
Zorne: Tia! Don't think I'll go easy on you if you get in Father's way! Zorne: What!? Who are you calling an idiot!? Damn it! I won't let you get away with that!
Zorne will even go berserk on anyone who has defeated Trau, accusing them of brainwashing her.
Whatever you do, don't humiliate Zorne, unless you want her close friend Trauare Wrede to come at you with her Chaos Spear Leviathan and "seal that impudent mouth of yours once and for all."
Trauare: Grolla... it looks like Zorne was no match for you. I'll have to take this seriously, then.
Also, there's Grolla Seyfarth, who will stop at nothing to bathe Grollschwert's blade in the blood of anyone who presses her Berserk Button in any way. For example, if her friend Sichte has already been defeated, Grolla threatens to cut Tia down as punishment for Sichte's defeat.
Grolla: Still your tongue! I shall cut you down, here and now! My time will not be wasted on the words of the Empire's lapdog! Lilli: Hey! Tia's doing what she thinks is right! The Empire's got nothing to do with it! Spiritia: Grolla, I'm not siding with the Empire. Even so, there's got to be a better way to make everyone happy... Grolla: Silence, traitor! Grollschwert's blade shall be bathed in your blood!
Also, Grolla's Berserk Button gets pressed when Iris reveals that she arranged for her father to disrupt her grandfather's peaceful slumber by resurrecting him as The Grim Reaper.
Grolla: ...That does it. You have just signed your own death warrant.
In Rosenkreuzstilette Grollschwert, Tia's Berserk Button gets pressed when Grolla speaks of killing Iris.
Spiritia: ...I can't let you do that! Grolla: Hmph. I knew it would come to this. I have always desired a serious match with you. This may just be the perfect opportunity. Spiritia: I won't let anyone hurt Iris... and I don't want you carrying that sin! I'll stop you if it takes everything I've got! Grolla: So be it. Come at me with all you have, Spiritia!
Telling from her quote in her profile, Dolis Warmind doesn't take too well to being called small.
Dolis: Hey! Don't call me small!
Iris reacts rather badly when Grolla says, "I don't care if you're a God, a human, or even an insect — I will rip you apart just the same."
Iris: You pompous maggot...! I shall show you the limits of a commoner!
Iris also doesn't take too well to any interference with her plans.
Rink Refraktia also has a Berserk Button that will be pressed if anyone threatens her twin sister Lecht in any way, leading her to stop at nothing to remove the threat.
Rule of Rose: Hurt Jennifer's loyal Canine Companion Brown and you'll regret it. And this from a girl who, until this point, used to faint over the smallest things.
Saints Row: Never betray the Boss. You can be an undercover cop or a snitch. But try to betray the Boss and you will not live to regret it.
While Mitsunari of Sengoku Basara is always some form of pissed off, insulting his precious Lord Hideyoshi, allying with Ieyasu or worse, the act of betraying him redirects all of his rage towards you for the moment before going back to Ieyasu.
Don't ever think that you can bring harm to Masamune while Kojuro is around if you don't want to take a Narukami to the face. Just a warning - Kojuro can be a lot more brutal.
Don't betray Mitsunari while his Co-Dragons Yoshitsugu or Sakon are around. Yoshitsugu will shift all his hatred for humanity on you for the time being while Sakon pounds you into stew with his boots.
Judge Motonari on how he conducts himself plans or otherwise, or even imply that he will amount to nothing in the eyes of everyone and he really WILL lose it. Motochika is already a hothead to begin with, but his crew are like brothers to him and be assured that you will die if you dare kill them. Motonari and Yoshitsugu just happened to hit that button VERY hard by planning the massacre of Shikoku, and when Motochika finds out that it was their doing in his green path not even Motonari having his button stepped on by Motochika in a "The Reason You Suck" Speech could save him from Motochika's rage.
Keiji is a nice guy until you threaten Toshiie or Matsu, in which case he drops the smile and batters to paste. A button that only Hideyoshi has the means to press is handwaving Nene's death as a trivial matter. Hideyoshi found out the result of pressing that button the hard way
This is a key element of demon conversations in Shin Megami Tensei games. Making wrongful conversation choices can cause the demon to do anything from ending the conversation, to leaving in disgust, to outright getting a free attack.
As revealed in Dummied Outcontent in Silent Hill: Homecoming (around 7:08), don't ever tell Walter that his mother is not Apartment 302. For those of you who aren't willing to watch the video, the psychiatrist has to call for help because Walter, as a child, is attacking him.
If you don't want "The Murray" to floss his teeth with your spine, never hurt his friends.
Do not tell Dimitri his suit sucks. Ever.
Never tell Bentley that you think turtles are "stew-pid".
Sonic the Hedgehog: Sonic and gang do have things that tick them off. We haven't seen exactly what will send Sonic over the edge, but harming any of his friends is close enough. Erazor Djinn got three screamin' strikes; [A] he killed Shahra when she sacrificed herself for Sonic's sake, [B] he continually disrespected Sonic (calling him a rat was the tip of the iceberg), and [C] his goal would encompass the real world if left alone. Suffice it to say he didn't end well.
A smaller one, but Rouge found out the hard way that Tails does not like it when people flirt with him.
Whatever you do, never harm Shadow's friends. Doing so causes his wrath to become genocidal, which humanity learned in Sonic Adventure 2 and what the Black Arms learned the hard way in Shadow the Hedgehog (Black Doom's actions set off the chain of events that resulted in Maria's death) in one of his Crowning Moments Of Awesome. The thought of Omega being damaged/destroyed in Sonic Chronicles made him a bit unhinged, so you can imagine what would have happened to the Marauders if Omega was actually destroyed.
Likewise Mega Man Geo-Omega from Mega Man Star Force is the same way as Hollow found out the hard way when he tricked Harp Note to turn against Geo-Omega and then again in when Joker decided to datafy Luna in the third game. Needless to say the result wasn't pretty.
It is a bad idea to try to hurt Lan in the presence of Mega Man.EXE as the darkloids found out the hard way as he rips Shademan.EXE to shreds and then then he tries to strangle his dark counterpart.
The Orz in Star Control will get angry and attack you for asking too much about the Androsynth.
Orz captain: Nnnggggaaaahhhhh!!!!!! It is *dancing*!!!!
Pointing out to the proudly evil Ilwrath that since their culture accepts evil, they are in fact good drives them berserk on the grounds that you're being annoying.
While Ryu from Street Fighter isn't exactly a social person and primarily fights to test himself against the strongest opponents he can, he does have close friends and allies, who are not to be harmed in front of him. Seeing Bison injure Sakura in Alpha 3 was a trigger strong enough to snap Ryu out of a Brainwashed and Crazy state, and Crimson Viper found this out the hard way as well in The Ties That Bind when she not only kidnapped the wife of ryu's best friend Ken, but also tortured Cammy to almost death in front of him, Ken and Sakura —— the already stressed Ryu almost gave into the Satsui no Hado out of anger. It took Sakura a Cooldown Hug to bring him back to sanity.
Similarly, you do not harm children in front of one Chun-Li. Specially pre-teen or teenage girls. Witnessing the horrible effect that Bison's brainwashing brought to Cammy and the Dolls in Street Fighter Alpha and having one of her adopted daughters kidnapped in Third Strike sent this Action Girl into an utter rage.
Also, if you harm any of the Dolls — Hell hath no fury like a Cammy scorned. She ain't pleased if you harm her other friends or threaten her, either.
Please don't be a threat to the security of either Hong Kong or Shanghai. Neither Yun nor Yang will have mercy on you.
And if you are Yun and/or Yang, don't leave home without telling Houmei. She won't be pleased.
Vega will go absolutely BATSHIT if his beautiful face is ever touched, double if you damage it, and tripleif the one who damaged it was a young woman. In the Animated Movie, Vega threatened to kill Chun-Li after she repelled his attacks and rearranged his face with her foot. In the comics, he went straight into kill mode when Eliza (then Ken's fiancée) so much as slapped him in the face (she's not a fighter like Chun-Li). If it wasn't for Ken arriving just in time, she'd have been torn to shreds.
El Fuerte: "Lay off the mask, amigo! I'll show you!"
And in the case of Adon... don't be Sagat.
The Suffering: Do not threaten Torque's children. Do not claim to have sold drugs to them - not even as a joke. And never, ever, suggest that Torque wasn't their father. Yeah, the blood still hasn't washed off the barroom floor, either.* Do not refer to Suikoden I's Ronnie Bell as "Giant Woman." She will beat your ass to a bloody pulp.
Luigi from Super Mario Bros. has one: Don't make fun of his mustache, don't call him a pushover, and, if you value your life, do not call him a pushover and make fun of his mustache. The only person who dared to do both was a psychotic jester who could warp time and space. His game is over.
Luigi was the one person in the party who didn't help end his game, for obvious reasons.
And don't harm or kidnap his brother. Sure, he didn't show any anger, but he hunted down and captured a small army of Boos including their King, dooming them to be trapped in a small space for all eternity, when they kidnapped Mario.
Paper Mario: The Thousand-Year Door has a very interesting one: Do not mess with the Gamecube/Wii clock. Lucky, a Bob-Omb who runs the Happy Lucky Lottery, will almost give you a Game Over if you do it once because the Lottery runs on the console's clock, but if you want to continue playing, you need to pay 500 Coins. Do it again... well, Lucky warned you.
Also, don't read the Toad Ghost's diary in that game. If you do, it pisses him off so much it's a Non Standard Game Over!
A slightly less berserk example, but Wigglers tend to get really pissed when you jump on their heads. They get a entire level in Something Else called Wigglers' Dwelling.
Narcis Prince in Super Punch Out!! admires his face a ton. If you even punch his beautiful face once, he'll get pissed off and will become more aggressive with his attacks. His berserk button is turned off if you manage to knock him down.
Aran Ryan will go berserk on you if you hit him with a super punch...however, this also presents an opportunity to trap him in a loop that leads to a guaranteed TKO.
In the Wii Punch-Out!!, punching Soda Popinski's bottle out of his hand or nailing him with a Star Punch makes him go into an uppercut frenzy. Don Flamenco, meanwhile, flips out (read: stops taunting you and goes into an endless attack string) should you knock off his toupee.
3 obvious berserk buttons were pressed by beating Don Flamingo, Super Macho Man & Mr. Sandman. Don tore up a poster of Little Mac before lifting weights. Super Macho Man put a Little Mac poster on the punching bag he was using after seeing his babes, paparazzi & other media start surrounding Little Mac. Mr. Sandman.....well just ask the rubble of the building that he destroyed with his bare damn hands after he saw Little Mac's facial poster on it!
In Super Smash Bros. Brawl's Subspace Emissary Adventure Mode, the plot diverges slightly based on player action in the first stage, which determines which of the game's two resident princesses is initially captured by the baddies. The one who escapes is later believed by her corresponding hero to have been assaulted by allies. The batshit rage which results from this erroneous belief indicates that for Mario, endangering Princess Peach presses his Berserk Button; to press Link's, endanger Princess Zelda.
The latter is confirmed in The Legend of Zelda: Skyward Sword. Due to Link using the power of the Triforce to flatten the Imprisoned, Ghirahim winds up kidnapping Zelda, making it crystal clear that he is going to sacrifice her to his master, and jumping into the Gate of Time. You will never see Link in an angrier state as he jumps through the Gate after him, steamrolls over countless Bokoblins, and tears Ghirahim a new asshole.
If Little Mac's trailer is any indication, one shouldn't draw too much attention to his height, lest you're looking to get your liver liquified by a single punch.
Barbatos Goetia from Tales of Destiny 2 is already batshit insane from the start, but there are some ways to make him even crazier... Cast a spell in front of him? No, not that, he may counter immediately with a spell, but he still keeps his tone to usual... but use an item in front of him, and he'll charge over (Or even teleport in some games), grab you, slam you, stomp you and slash you while emitting a spectacularly Badass scream of "NO. ITEMS. EVEEEERRRRR!!!!!". Even more in the Japanese version, since he got Norio Wakamoto as his seiyuu.
Raine, despite her normally rather cynical and sensible behaviour, has archaeological mania. Woe betide anyone who disparages or harms any ruins in her presence.
It is usually a very, very, very bad idea to intentionally harm Colette or Sheena if Lloyd is present.
Or to speak ill of Lloyd's mother Anna.
Don't insult Alicia in front of Presea, unless you want her axe embedded in you.
In the same game, if you call Cruxis's leader, Lord YggdrasilMithos,yes, the one from the Kharlan war and you were not one of his old, OLD companions, prepare to get brutally killed by a ball of mana. Just look at what happened to Pronyma.
And, as Kvar found out the hard way, do not refer to humans as "inferior beings" when Kratos is around. Kratos' rage was fueled even further when Kvar insulted his dead wife, Anna.
Rita from Tales of Vesperia isn't exactly the nicest person to begin with, but she has an especially strong hatred of people who destroy blastia (At least until she finds out they're slowly killing the world). She also hates perverts, if her frequent abuse of Raven is anything to go by. He'd probably be dead if she had found out he peeped on her and the other girls while they were at a hot spring...
Team Fortress 2: Never, under any circumstances, are you to touch The Heavy's gun. Ever.
Also, never tell the Soldier that he isn't technically a real soldier. He would even kill his best friend over it. Check here
Time Crisis 4 has Captain William Rush, who is so full of Patriotic Fervor that he gets extremely angry at those who try to betray and commit acts of terrorism against the United States, especially if it's an entire company of the U.S. military doing it. You get to see Rush really at it when he wrestles Jack Mathers, the Stage 2 boss:
Captain Rush: "You...YOU'RE A DISGRACE TO YOUR COUNTRY! YOU TOOK AN OATH OF LOYALTY TO YOUR COUNTRY!"
In the Tokimeki Memorial series, if you don't wanna by hated and / or severly maimed, avoid at all costs pressing the following Berserk Buttons with the following people:
Shiori Fujisaki: Telling her she's sexy (she doesn't want to be seen as a sex object).
Yumi Saotome: Telling her she's cute (she wants people to see her as an adult).
KotokoMinaduki: Talking or showing her anything related foreign culture, especially curry (she's passionate about traditional Japanese culture). Also, doing anything that could hurt her best friend Hikari.
Tenshi has a habit of pressing most people's berserk buttons, usually intentionally. As one notable example, Komachi finally loses her cool when she finds out that Tenshi had been the person murdering the ghosts. While she doesn't lash out angrily, Komachi's behavior at the time is completely different from her normal calm, carefree, and somewhat lazy attitude. She even considers switching jobs so that the collection of souls (specifically, Tenshi's) falls within her jurisdiction.
Yuuka Kazami is incredibly old and powerful even by Gensoukyou standards, but is more concerned with her flowers than fighting, and takes pride in being civil and courteous. Those who mess with her flowers, however, have a tendency to never be seen again.
The fandom in general has one in the form of the question "What anime is this?" It's because they hear it all the damned time, and most are rather sick of having to explain things over and over again.
The Player Character detests any mistreatment of women. It goes double when said mistreatment includes outright violence, whether psychological/physical/sexual: he can be seen either angrily calling out Ryouko's brother when he finds out how controlling he is to his sister, screaming and swearing at Mikazaki-sensei when he abducts Mayumi to sexually abuse her, straightforwardly attacking Remi's kidnapper despite said kidnapper being armed with a prop gun or kicking out Toshio from his doorstep when he intends to see if he's got a girl in there (he does, but said girl's in the shower after she got caught in a huge downpour and Toshio's known for being The Casanova).
Mikae, the local Tsundere, has some of her own too. First, don't blow her off if she comes talk to you. Two, don't miss your date in August. Third, and the most important one... NEVER go out in a second date with Remi (whether it ends in Glad-to-Be-Alive Sex or not) and then go out with her in her birthday.
While all the girls get upset if you miss your dates with them, the usually sweet and kind Miyuki will be specially angry. i.e., Mikae may give you a second chance in regards to you forgetting her August outing — this girl won't.
Yumi does NOT like it when her students are slackers, and double if it's the MC. And even worse: NO ONE should ever harm said students, whether it's Mayumi or the MC or anyone else.
In Wet, the main trigger for Rubi's Rage Mode is getting blood on her face. When that happens, it's not going to be pretty for anyone in her general vicinity.
Wildstar: the Aurin like nature, and would very much appreciate that you don't mess with it (especially their trees). Otherwise, they will gut you.
Wolfenstein: The New Order: J explains that he had very little sympathy for the fall of America because of the racism in society at the time. As far as he's concerned, the white American government was little different from the Nazis themselves. Blazkowicz does not appreciate the comparison. Not at all.
The World Ends with You: Say 'Daisukenojo Bito' in front of Beat. I dare you. Getting whacked to death with a skateboard is the very least of your worries!
And destroying XT-002's Heart is generally foolish as well.
Do not threaten Genn Greymane's family. Ever. He will EAT YOU.
The normally calm and mellow Big Good Tirion Fordring will flip out if you so much as mention anything negative about his dead son. He violently one-shot the (powerful) man who killed his son. Just leave Tirion's family alone if you value your life.
Garrosh Hellscream lives up to the 'Hell' in his name if you mock his father, as Taran Zhu found out the hard way. In World of Warcraft, insulting or threatening anyone's family is a surefire ticket to a maiming or an early death.
Kazuma Kiryu, of Yakuza fame, is a scary and imposing man, but won't go out of his way to hurt anyone. That is, unless they harm a child, particularly one under his care, in which case, he will beat the living snot out of you. Worse still: if you harm his foster niece Haruka, he will straight-up murder you.
In Zanac, DO NOT pick up Weapon 2, the shield subweapon, otherwise the System (aka the game's Dynamic Difficulty) will go berserk and immediately send out reinforcements.