The central protagonist, Lucius is the son of Lucifer.
Lucius's Paternal grandfather. The one who built Dante Manor and gathered the family fortune.
- Asshole Victim: He's a Satanist responsible for creating Lucius in the first place, which doesn't spare him.
- Hoist by His Own Petard: It is his deal with the devil that brought Lucius into being. Lucius still kills him.
- In the Back: Gets stabbed by Lucius while trying to sacrifice a journalist.
- Jerkass: Refuses to go to his own son's funeral because he saw him as a disgrace to the family name.
- The Mafia: Mob connections are said to be part of where the family's money came from.
Lucius's father. A US senator, running for re-election.
- Calling the Old Man Out: To his father Fabius about being a bitter, hateful person.
- Not Quite Dead: The other reason why Lucius lost his powers in the sequel, turns out Charles survived the fire and is in a coma in the hospital, one of your objectives is to finish the job.
- Offing the Offspring: Attempts to do this to Lucius at the end.
- Properly Paranoid: He's right to think there's something wrong with his son.
- Sanity Slippage: Starts to believe there is a curse on the family as the deaths pile up.
- The Scapegoat: By the end of the game the police are convinced he is to blame for everything.
- That Thing Is Not My Child!: Near the end he realizes there is something wrong with Lucius.
Lucius's uncle and Charles brother.
- Boom, Headshot!: Her mind controlled husband shoots her in the head with a nail gun.
- Break the Cutie
- Parental Obliviousness: Refuses to believe there is something wrong with her son.
- Sanity Slippage: The comments she makes as she wanders around the house become more and more unhinged as time passes.
- Taking the Kids: Near the end says she is leaving the house and taking Lucius with her. This does not go well.
Dante Manor Staff
Eldest maid in Dante Manor. A widow. Her room is filled with crucifixes.
Janitor and handyman in Dante Manor.
Family butcher. Comes once a week to chop meat in the cold room.
The lead maid in Dante Manor.
The butler of Dante Manor.
- Driven to Suicide: What her death appears to be, after discovering Tom is cheating on her with Susan.
- Psychic-Assisted Suicide: What her death actually is. Lucius mind controls her to jump off a balcony.
- The Scapegoat: Lucius hid evidence of his other crimes in her room. For a while after her death she is seen as the one responsible for the previous deaths.
Lucius' private tutor.
Detective Jack McGuffin
The detective trying to solve the mystery of Dante Manor. From the second game onward he serves as Lucius' caretaker.
- The Dragon: He serves as Lucius' helper from the second game onward.
- FaceHeel Turn: In the beginning of the sequel, Lucifer himself comes to him and convinces him to serve Lucius.
- Nice Job Breaking It, Hero!: In one of the endings the detective shoots Charles right as he is about to kill his son. Nice job saving the Anti-Christ.
- Noble Bigot: He never suspects of Lucius even after Alastair's death, which takes place while Lucius is the only one who wasn't in the same room as McGuffin during the murder. Despite this, McGuffin jumps very quickly to the conclusion that Will is guilty of Michael's death, without any real proof and even arrests him. Considering the game takes place in late 1972 / early 1973...
- Replacement Goldfish: Part of the reason he works for Lucius is that he reminds him of his dead son.
- Unwitting Pawn: That thing about his son above? Turns out the Devil did that.
Campaign manager to Charles Wagner and friend of the family.
A reporter looking into the mysterious deaths at Dante Manor.
A deputy assigned to Dante Manor
The devil and Lucius real father.