The titular character and the overworked, underpaid, and under-appreciated producer of The Dee Show
- Ambidextrous Sprite: She has a strand of of her hair that bends upward and bangs which go diagonally across her face. While they're on and toward the right side of her head (her perspective) when she's shown from in front, they otherwise flip around to what side would be in the background.
- Ambiguously Brown: She looks vaguely Asian with a bit of Native-American. We learn in "Recipe for Dee-saster" that she is at least one quarter Polish.
- Brainy Brunette: She is the brains behind The Dee Show.
- Butt-Monkey: Things rarely go right for her. For example, the end of "A Friend in Dee" was Parker watching Simon's expose of a third-world spa she went to on a serious news channel... only it turned out it was accidentally footage of her being interrupted while getting a bikini wax.
- Byronic Hero: She's the protagonist but she has a slew of personal problems relating to low self esteem and overall bad decisions that wrecks her life and affect her success.
- Dude Magnet: Men, women, infants, robots, computers, and more have all had at least some romantic interest in her.
- Even the Girls Want Her: A few women have found Parker attractive.
- Evil Laugh: Indulged in "Bully for Parker" when her plan to get to revenge on her high school bully is ready, while shining a flashlight upon her face from underneath for added effect.
- Gender-Blender Name: Parker is a name for men and women.
- Married to the Job: Parker's main out-of-work confidant is her talking dog. She loves him but clearly regrets that this is the case.
- Single Woman Seeks Good Man: Parker wants to find "Mr. Right". However, her own neurotic tendencies leads to her forming dysfunctional relationships with men like her fitness trainer and new employees that end in failure and her workaholic nature ruining her chance of finding a better mate.
- Weirdness Magnet: Most, if not all of the craziness in the show is centered around her.
- Workaholic: Despite languishing as the producer of The Dee Show, Parker usually insists she loves her job and keeps doing it. She is certainly aware and regrets the effect this has caused on her personal life, though.
- Why Did It Have to Be Snakes?: It is revealed in one episode that she is afraid of mice.
Parker's dog and best friend.
The alcoholic, self-absorbed and high maintenance host of The Dee Show
The rich, young head of Bellamy Broadcasting.
- Eccentric Millionaire: The first episode has him suggest to his executives that his network try to cash in on fake reality shows by making a weekly show where in one of said executives go in a tank with a live shark. He responds to their terrified fleeing with "Well gentlemen, think it over, get back to me in five.". In "And Dee Winner Is...", he joins the office betting pool of the Blabby Awards for Dee hitting Victoria with a bottle at the awards' presentation.
- Oblivious to Love: Parker has a crush on him.
Voiced by: Aaron Abrams
Parker's co-worker who serves as the writer for The Dee Show
. He aspires to work on hard hitting news instead of writing segments for a talk show.
- Hidden Depths: Simon decries the book 'Feast, Ride, Salsa' when he first hears about it but reads it as necessary to write the author's appearance for The Dee Show. He calls it "populist drivel" and says it didn't do much for him but then it cuts to him sobbing "I'll never meet a woman like that!".
- Nice Hat: Rarely seen without his fedora.
- Only Sane Man: The most level-headed person on staff on The Dee Show.
- Real Men Wear Pink:
- The Slacker: Compared to Parker going about doing what needs doing, Simon's standard pose is leaning back on his chair lazily.
- Stalker with a Crush: For Mimi Chui. The pictures he takes of her in "Recipe For Dee-saster" are so extensive, they count as an alibi proving she couldn't of went and poisoned Dee.
Voiced by: Sarah Cornell
Parker's attractive, yet under-qualified and dimwitted intern and Blake Bellamy's cousin.
- Incest Is Relative: Admits she would be... interested... in Blake were she not a cousin of him.
- Nepotism: Her being related to Blake is the only reason she has her job.
- Too Dumb to Live: In "Dog Dee Afternoon", she reads out a phone message that says there's a bomb in the building. Everyone else runs away panicked to which she responds "Where did everyone go?" until Simon pushes her along with them.
- Too Much Information: Regularly incites such reactions from Parker who usually stops her before she completely finishes saying what's already obvious.
Dee's flamboyantly gay personal stylist and best friend.
Voiced by: Karen LeBlanc
Dee's arch nemesis.