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- Inverted in a Dettol (cleaning product) advertisement. It claims to kill "99.9% of all bacteria", including, among others, the flu virus. Viruses are not bacteria.
- If Thrax from Osmosis Jones were actually a virus, he would be about as tall as Jones's ankle.
- Resident Evil: Extinction goes so far as to have most of the world's water supplies go dry due to a virus. It apparently infected and killed the water. For your own sake, don't try thinking too hard about this.
- In Jack Blank, a Rüstov infection is regularly referred to as a "techno-virus", because a way of identifying it is by taking a blood sample and finding nanites in it. However, a Rüstov infection acts nothing like a virus: A Rüstov is a mechanical parasite that attaches itself to a host body (of any multitude of species), and slowly transforms the host's body into a heap of rusted, mechanical scrap, and when the old body is spent they jump ship and find a new one. Nowhere near the behavior of a real virus.
- Spoofed in one Discworld novel: the Discworld's medical technology isn't advanced enough for the concept of viruses to exist, but this doesn't stop a doctor stumped for a diagnosis saying "it's probably a walrus". The Igors, however, have managed to arrive at the concept of 'tiny invithible biting creatureth' and have developed ointments to kill them before they can infect wounds.
- Warhammer 40,000 has the Obliterator virus. Exacctly how it works is anyone's guess (the Warp is involved), but the infectee ends up bonded to his weapon, and ends up able to produce the ammo for it.
- Pretty much all the various viruses in the Resident Evil series.
- For example, the T-Virus is able to infect humans, mammals, reptiles, birds, even invertebrates; real-life viruses are usually limited to a few, closely-related species due to messing with DNA. The third game (and the movie that takes cues from it) even had it affect coffin bound dead bodies in a cemetery, all of which were six feet under and conveniently popped out of the ground. As you might imagine, RE viruses tend to discard the rule of biology whenever it interferes with the Rule of Cool.
- Resident Evil 6 has its zombie-making virus transmissible via gas.
- The videogame Trauma Center seemed determined to use every medical term possible to describe the main evil disease causing thing. The official name is the GUILT Virus, in which the T stands for "Toxin", but when you actually operate on it it tends to look like a tumor or parasite.
- Played straight on Batman Beyond, where one villain's scheme is to pass viruses around via credit cards.
- Subverted in the Justice League episode "Fury", where Superman is felled by a cloud of airborne particles released at him by Aresia. It's assumed to be a fast-acting virus until J'onn's research shows that it is, in fact, an allergen which only affects men.
- The Transformers cartoon had two such cases: the Cosmic Rust and Hate Plague spores were stated to be viral diseases, even though both were clearly specified as spores and could become airborne. Beast Wars and Beast Machines played this straight for the most part, with the former containing actual viruses that needed to be injected to be potent, and the latter's version of the Hate Plague acting more like a traditional virus with a specific carrier. Sadly, the latter's transformation lock "virus" was also airborne, meaning it was more likely a bacterial or spore-like agent. (Or, quite possibly, the other kind of virus).