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- Most mutants in X-Men such as Storm have the ability to use physically impossible powers as a result of their mutation. Sometimes, they all come from a mutation of a single gene. Justified in-universe via experimentation on proto-humanity by a race of sufficiently advanced aliens. Comparable to how freak lab accidents can give normal humans superpowers in the Marvel Universe, the infamous "x-factor"/"mutant gene" serves to makes the activation of these powers a natural part of the mutant's biology.
- Certain villains in Spider-Man also have these kinds of abilities. Spider-Man himself sort of doesn't count as he "does what ever a spider can..."
- Attempted to be justified in Ultimate Fantastic Four, at least with Mr. Fantastic and the Human Torch. Johnny's powers come from his nuclear fusion, using his body as an energy source. Reed is able to stretch and not crush his organs because all he has in the way of organs is a colony of symbiotic bacteria who take in food and air and give his body nutrition. Their origin is justified as well now too, as their powers are not from cosmic radiation anymore, but rather from swapping bodies with a double from another universe. He should just pray he'll never catch a disease that requires treatment with antibiotics...
- The Meta-gene of DC Comics. A single gene that provides every possible super-power. Various Human Aliens like Superman, the Legion of Super-Heroes, Martian Manhunter, etc. also attribute their abilities to genetics— Transfer their DNA into a human, and that human becomes super-powered.
- Wildstorm's The Authority has Apollo, genetically engineered to fly and fire solar blasts. The "gen-factor" of Genął and its spinoffs. WildC.A.T.S. get their powers from alien DNA.
- In Strontium Dog, Johnny's mother gets caught in a fallout shower while eight months pregnant with Johnny; as a result, Johnny's eyes mutate to be able to emit alpha particles, which gives him X-Ray Vision and limited telepathy. Not only is this biologically impossible, but alpha particles do not work that way! In fairness, however, Johnny is an exception; 99.9% of the other mutants are just disfigured, with the lucky ones getting extra body parts.
- A comprehensive list of Mutants who develop Psychic Powers in a post-nuclear setting could crash this server.
- The Maximum Ride series have children who are "genetically engineered" to have wings. And occasionally other New Powers as the Plot Demands. Weirdly, it is implied that the early powers that they spontaneously develop were also engineered into them, to help them fulfill their purpose to "save the world" or whatever. In The Final Warning though, Jeb comments that they seemed to be randomly mutating and developing powers on their own, which first manifests with Nudge getting magnetic control.
- Skulduggery Pleasant has magic running in families, to the extent at least one particular type from a particular set of ancestors apparently manifests 'in the blood' so to speak.
- Deryni powers are genetic, though most Deryni must be trained in their use. The trait is described as a dominant one (only one parent needs to be Deryni to produce Deryni offspring, and eggs with the trait are hardier and more fertile). Certain bloodlines, including the Haldanes, also carry the variant trait that permits assumption of the powers and the knowledge to use them without training.
- J. K. Rowling has stated that there was a Magic Gene involved in wizarding capabilities in Harry Potter. This gene could also be present in other magical species. It can remain in a bloodline for generations before manifesting in muggleborns. The inverse is also the reason for squibs. This also doubles as Hollywood Genetics, since the gene is clearly defined as "dominant", but dominant genes cannot skip generations and squibs are much rarer than they should be. However since the gene itself is magic, it can presumably do whatever it likes.
- Wild Cards, full stop. Apparently a virus containing psionic aliens' DNA can do anything. Technically a case of Applied Phlebotinum. The Ilkazam Enhancer (i.e. the Wild Card Virus) was biotechnology designed to bestow superhuman powers. Sometimes it even worked.
- According to Word of God, Magyk in Septimus Heap has a genetic basis, which is why Princess Jenna has no Magykal powers, unlike her adopted siblings. Subverted when Jenna is made into a witch in Darke.
- In the Gentleman Bastard-series, magic is inherited but "does not breed true". Genetics is barely a thing, let alone understood, in the setting, but the implication is that there is a large number of genes with very different and interacting expression mechanisms involved. Mages take genealogy seriously, but bristle at the idea of being bred like cattle, and at the time of the story five of the hundreds of mages that have lived in the past centuries had parents who were both mages.
Live Action TV
- Nowhere on television is this trope in effect more than "Heroes". Apparently everyone's power, from regeneration and invisibility, to clairvoyance and time travel, are just a matter of having the right DNA.
- Stargate SG-1 has a Goa'uld Mad Scientist mutating humans to give them Psychic Powers in order to create a super-host.
- Mr. Spock's ability to mind-meld comes from his Vulcan genes.
- All powers in Mutant X come from genetic experiments conducted by Genomex and the Dominion. These powers include generating electricity, density manipulation, throwing energy balls, time travel, etc.
- Bewitched seems to have this. Witches and warlocks are only born to other witches and warlocks, and Tabitha has strong powers, while Adam has powers, although weak.
- GURPS Bio-tech has a section on magical genetic engineering. Along with replicating scientific possibilities, it allows genengineering ability to cast any spell into a not-yet-born child. It is cheaper than making a ordinary magical item, but risks making a Phlebotinum Rebel.
- Otherwise, it tries hard to avert this trope. For example, angel-like wings can be genengineered, but don't give ability to fly in 1 G. They might be useful at lower gravity or in a space habitat, through.
- BioShock is made of this trope: The game establishes that in-game Plasmids and Gene Tonics work by rewriting their user's genetic code from scratch to allow for fantastic new skills...such as being able to summon fire, lightning, and worst of all, bees from your hands.
- A recurring theme in Star Ocean: Till the End of Time
- Two words: Symbological Genetics. Tinkering with genes can give you magic powers.
- Star Ocean: The Climax Boss and Final Boss were created through genetic engineering to survive a Mordor planet. There is also a species that naturally posesses magical genetics.
- Star Ocean: The Second Story: The main villains were a group of people who were granted god-like powers above the normal magic available to their species in order to take over the universe.
- Star Ocean: The Last Hope: Following World War III, three human babies were modified to survive in harsh and irradiated environments, and gained magical powers in the process. The DNA used to do this was taken from a human subspecies that also had magical genetics naturally.
- Averted in Mass Effect. Gene therapy is standard issue for soldiers and provided free for citizens by most governments, resulting in widespread perfect vision and hearing, robust immune systems, and a near elimination of genetic disorders in industrialized areas. Only modest physical enhancements are available however, with 8%-12% increases in adrenal response, clotting speed, and muscle retention etc. considered state of the art.
- Played with in Mass Effect: Andromeda with the Kett. Their use of genetic engineering is so advanced that they have the technology to make a lifeform transform into a different lifeform in less than a minute. In fact, this is how they reproduce. However, the fact that their genetic technology is commented on in-universe to be shocking implies that their genetic engineering technology is a case of Sufficiently Advanced Technology, thus explaining the lack of realism.
- This was Deconstructed in Tabula Rasa. All player characters are Receptives, or people who have the right sort of genes to allow them to use Logos. However, this is only because those genes are the correct "password" to access Logos Shrines left by the Eloh and receive Logos Element information from them. It's essentially a security system the Eloh set up thousands of years ago by modifying some early humans to express those genes.
- What's more, several quests in the game revealed that the AFS was conducting research into providing non-Receptives the same ability to use Logos. Volunteers met horrific ends, such as fast-growing terminal cancers.
- Reasonably justified in Homestuck. The main characters aren't genetically related to humanity at all, and their DNA presumably could differ drastically from normal DNA in order to allow their powers. Trolls however play a little looser with DNA and there's at least one distinct sub-species of Troll, so there seems to be wider genetic variability to begin with for them.
- Mutants in the Whateley Universe have genetic changes in a host of different genes, labeled the 'meta gene complex', and gain the ability to use some sort of extra-dimensional energy that's supposed to be the power source for the various impossible powers.
- In Danny Phantom, the titular character gained his abilities to become a ghost and use ghost powers after the ghost portal mutated his DNA, combining it with "ectoplasm".
- In Street Sharks, somehow using a formula and the blood of Genghis Khan turns a lobster and a marlin into huge evil mutant soldiers. Injecting the formula and animal DNA into a human turns them into non-evil mutants which are twice the size of their human forms, very top heavy, and able to eat virtually everything (including metal). This one got to fly under Rule of Cool because the Street Sharks were totally jawsome.