The player character, a bloodthirsty assassin who takes orders from his answering machine. Also known as the Hitman.
Anti-Hero: Yeah, most of the people he kills may indeed be mobsters, but the manner in which he kills them is so brutal that he's a type IV at the very best and a type V at the very worse. The implication that the killings are driving him insane doesn't help.
Decoy Protagonist: Probably. While Jacket gets more focus, it is the Biker that actually gets to the bottom of the mystery while Jacket plays right into the Janitors' plans.
Kill 'em All: He almost never leaves any survivors. Except for his girlfriend.
Mask of Power: The various animal masks he gains gives him different abilities, some of which beneficial, some of which not so beneficial and some of which simply result in cosmetic change.
No Name Given: He's never given a name in-game, not even a nickname. As such, fans simply refer to him as either Jacket, the Hitman or Richard.
No-Holds-Barred Beatdown: For certain characters, he finishes them off by brutally bashing their heads into a bloody pulp, putting out their eyes with his thumbs and in one case, setting the corpse on fire.
One-Man Army: Through the game, he demonstrates a talent for clearing buildings filled with angry thugs. It even culminates in him assaulting the police station by himself, with the police chief and his men actively fearing him.
Pinball Protagonist: Goes through the whole game apparently never questioning what he's doing until the ending, and even then he gets played like a fiddle by the Janitors. Richard even tells him just before his Roaring Rampage of Revenge that nothing he does from that point on will mean anything.
Roaring Rampage of Revenge: After learning that his girlfriend has been murdered, he escapes from the hospital, puts his iconic outfit on, and mows through a fortified police precinct just to find the assassin.
Vomit Indiscretion Shot: Pukes his guts out after he's completed his first assignment (and killed a hobo in cold blood).
Masked Figures and Friendlies
A man wearing a chicken mask. He wears the same clothes as Jacket. Cold and mysterious, but ultimately tells Jacket the truth. Or at least a part of it.
Figure It Out Yourself: He encourages Jacket to do just that. In the end, he tells Jacket that he'll never see the big picture - and sure enough, Jacket gets played like a fiddle while Biker finds the real truth.
The Generic Guy: The mask itself has no special characteristic aside from revealing the Hitman's (possible) name, if the naming conventions for other masks are to be believed.
A woman wearing a horse mask. She wears the same clothes as the Hooker. Friendly, but spacey, and believes that Jacket should stop trying to remember his past.
Ignorance Is Bliss: Thinks it's better that Jacket doesn't remember the things he's done, as he might not be able to handle it.
Nice Girl: Is the first of the Masked Figures to express concern for Jacket.
A man wearing an owl mask. He wears the same clothes as the mobsters that Jacket is tasked with killing. Posh and aggressive, providing Jacket with little more than insults.
Insufferable Genius: He angrily insults Jacket for enjoying the killing sprees, and uses very formal language to do so.
Love Interest: Implied. As she continues living with Jacket, the apartment gets cleaner, Jacket's eating habits improve, and their beds get moved together.
Morality Pet: To Jacket. She is the first (and possibly only) person that he spares, and his apartment becomes cleaner (and their beds closer) over the course of her stay. After she's killed, Jacket goes straight after her assassin, raiding a police precinct to get to him and, if the player so chooses, killing him.
An assassin involved with the phonecalls who decided to take matters in his own hands. He has a vital role in his own chapters, although in his version of events, Jacket dies at Phonehom. Which series of events actually played out is a mystery.
Awful Truth: If you collect all the puzzle pieces, Biker learns the truth of what was going on. It doesn't faze him from either leaving the job or killing the people responsible.
Villain Protagonist: While Jacket's character is rather ambiguous, the Biker is much more openly psychotic, only wishing to get out of the assassination game because he finds it boring. Of course, he's only a villain in the sense that he is bloodthirsty. He opposes the Janitors, can spare the workers at Phonehom, and doesn't kill informants needlessly.
A man who seems to be taking over for Beard at a few stores and bars. He is sent to kill Jacket, but only succeeds in killing Hooker. Jacket later finds him and either kills him or leaves him.
Hero Antagonist: He's just defending himself and doing his job as the police chief, which presumably entails solving the mystery behind the killings. Too bad Jacket had his own method of finding the truth.
Cruel and Unusual Death: After striking her with a heavy trophy, Jacket has to let her crawl around on the floor in pain before finding a position to kill her where he won't be left vulnerable to The Mafiya boss's attacks.
The duo behind the conspiracy to wipe out the Russian mafia to make America strong. They do this by hiring their hitmen and threatening to come after them if they don't do their jobs.
Author Avatar: They physically resemble cactus and Dennis Wedin. Their dialog not only alludes to independent game development, but it is more or less addressed to the player, telling them that the only thing that matters was that they had some fun from the experience.
Awful Truth: They will mock the Biker for not getting the big picture if he doesn't read their files, and tell him that he's better off killing them anyway.
Western Terrorists: They're part of a Neo-Nationalist organization known as 50 Blessings that's attempting to topple the Russo-American Coalition by threatening people into murdering the Mafiya.
Introduced in Wrong Number
Production Crew of "Midnight Animal"
An actor portraying Jacket in the movie Midnight Animal, wearing the Pig mask ("Aubrey"). His character in the film is referred to as the Pig Butcher. He is haunted by nightmares of the original Jacket, who torments him over his role in the film.
Becoming the Mask: The version of Jacket in his nightmares tells him that this is happening.
Fat Bastard: Notably overweight; combine this with his role and growing psychosis...
Members of The Fans. They're (probably) twins, sister and brother, respectively, wearing swan masks and working in tandem on rampages. They are rather hard to differentiate between - they are dressed almost identically, and their physiques and weapons of choice are the only ways to sufficiently tell them apart (though Word of God states that Alex is the sister while Ash is the brother).
Amazonian Beauty: Alex is the sister, and is quite muscular compared to many of the other characters.
The original owner of the cobra mask from the first Hotline Miami. Debuts in the gameplay trailer.
Fat Slob: He's about as fat as both Mark and Martin Brown, and lives in a very poorly-kept apartment.
Flash Back: Jake is found dead in the tenth chapter of Hotline Miami at the day spa, but because Wrong Number is both a sequel and a prequel, his story is explored.
A blonde-haired man in a dark jacket. Debuts in the gameplay trailer.
Badass Normal: Like The Mobster, he doesn't wear a mask - and he's still as deadly as the rest of the protagonists.
Hard Boiled Detective: This character has been referred to in interviews by Nigel Lowrie as a detective. A detective who stops at a shopping center under siege by criminals, takes a shotgun out of the trunk of his car, and brutally slaughters everyone in the building.