- Odysseus' dog Argus dying of old age right after getting to see his master one last time. Red certainly thinks so, given that there's a cutaway to her openly crying and letting out a Big "WHY?!"
- Sun Wukong being nearly burned to death by the True Fire of Samādhi wielded by Red Boy, the son of the Bull Demon King, in Journey to the West Part 6. Seeing the invincible Monkey King being consumed by ethereal blue fire and faced with one of the few things in existence that could actually kill him is simultaneously disheartening and terrifying. Even the celestial army sent to aid them - the same heaven that Wukong wrecked, mind - is thrown into disarray by his fall. Sandy's horrified face as he holds Wukong's unconscious body is sad as well.
- Showing that he has undergone character growth is Wukong's reaction to his failure. The warrior who at the beginning of the journey impulsively abandoned Tripitaka without a second thought, and had to be forced to stay, is more distraught over not being able to rescue his mortal friend than over the fact that he almost died. Even when so injured he can barely move, let alone fight, he does his best to push past the pain and exhaustion to aid his allies with what strength he has left.
- If you take into account that Sun Wukong is representative of the human mind, it's basically a graphic depiction of extreme depression.
- In the All Quiet on the Western Front video, Red describes the beginning, interlude, and end of Paul's journey through the First World War in a much more solemn tone than usual— which really drives home how serious the issue of war really is in both the book and in real life.Red (after a deep breath): Don't do war, kids.
- After this, the ending song is the appropriately fitting "Last Night I Had the Strangest Dream", a solemn and sweet anti-war song about how great it would be if everyone agreed to end war forever. I'm not crying, you're crying...
- In the Trope Talks video about plot twists, we have the whole What If? scenario of What Could Have Been with Quicksilver joining the Avengers during the period between Captain America: Civil War and Avengers: Endgame: which primarily focuses on him and Wanda conflicting over the Sokovia Accords, their separation via Thanos' Badass Fingersnap, and the ensuing emotional turmoil from Quicksilver's end in the five-year timeskip.
- Cardenio's reaction to Luscinda apparently going back on her word to kill herself rather than marry Fernando (who had tricked her parents into accepting marriage between himself and Luscinda). After the whole fiasco, Luscinda is pretty clearly distraught at how much her plan had hurt Cardenio.
Tearjerker / Overly Sarcastic Productions