Film - Live-Action
- The Terminator: Sarah Connor wears a Jetsons T-shirt during the scene where she's answering a phone call from Matt (who is dating Sarah's roommate, Ginger).
- The George Lopez Show: In "Leave It to Lopez", George dreams he's in an episode of The Jetsons with himself as George Jetson, Angie as Jane, Carmen as Judy, Max as Elroy, and Ernie as Mr. Spacely.
- Malcolm in the Middle: In "Malcolm Babysits", Hal mentions a list of evil robots, including "Westworld, Terminator, that creepy maid from The Jetsons...".
- Gilmore Girls: In "Introducing Lorelai Planetarium", Lorelai objects to getting a flat-screen TV:Lorelai: It's so "meet George Jetson, his boy, Elroy" — Leroy?
- In Living Color!: A skit featuring Jim Carrey as Ross Perot (who at the time was running for President against George H. W. Bush and Bill Clinton) has him invading multiple channels demanding equal airtime and at one point he appears in a stand up comedy show:
- The Nostalgia Critic
- In his review of The Star Wars Holiday Special, Critic calls Gormaanda a mix between Lady Tremaine and Rosie the Robot.
- In his Animaniacs tribute, Sherri Stoner, in character as Slappy Squirrel, says that George Jetson is the most shocking cartoon star she's worked with.
- In his review of Doug's 1st Movie, Critic thinks that Roger's robot should be in a deathmatch with Rosie.
- On the SiIvaGunner channel, several of the videos uploaded on September 11, 2016 involved the Jetsons destroying the Twin Towers.
- The final level of The Flintstones: The Rescue Of Dino & Hoppy takes place in the 30th Century, complete with The Jetsons theme song as the background music, and a cameo by George Jetson himself.
- In LEGO Dimensions, it is possible to visit the Jetsons' house by using the TARDIS in the level inspired by "El Viaje Misterioso De Nuestro Jomer (The Mysterious Voyage of Homer)".
- In "Bumbie's Mom", Slappy mentions that her friend Vina Walleen used to date George Jetson.
- In "Space Probed", the Warners leave an alien scientist on a fast treadmill, and he calls for an alien version of Jane to turn it off.
- The Fairly OddParents: In Channel Chasers, one of the TV shows Timmy ends up in is The Futurellis.
- Family Guy
- In "Brian in Love", the family watches an episode of The Jetsons where George finally confronts Jane on not helping him out on the treadmill.
- In "From Method to Madness", an adult Elroy leaves the Drunken Clam to visit Astro's grave, and he gets in a taxi driven by Bamm-Bamm Rubble.
- In "Meet the Quagmires", the opening sequence plays as normal until George stops Jane from swiping his money and sends her down without her pod in revenge. Incidentally, the scene is animated exactly like the show instead of in the normal Family Guy style.
- On Futurama, Rosie is one of the patients at a robot insane asylum.Rosie: Everything must be clean, very clean. That's why the dog had to die, it was a very dirty dog. Also that boy Elroy. Dirty, dirty.
- Harvey Birdman, Attorney at Law
- In "Shaggy Busted", George is seen in jail, talking with his family during visiting hours.
- In "The Devlin Made Me Do It", Potamus is putting suggestive pictures of Jane Jetson into a shredder.
- In "Back to the Present", the Jetsons go back in time to sue the Earth for its pollution forcing them to live in high-rise apartments.
- King of the Hill: in "Glen Peggy Glen Ross", Peggy asks Hank and Bobby who has the world record for being fired the most times, and Bobby replies that it's George Jetson.
- The Muppet Babies (1984) episode, "Muppet Babies: The Next Generation" spoofs several space-themed films and TV shows, including The Jetsons. The equivalent here is The Spacetons, with Baby Kermit spoofing George Jetson, Baby Miss Piggy spoofing Jane, and Baby Rowlf as "Rowlfo the Dog" (the equivalent to Astro).
- The Powerpuff Girls: George Jetson appears as a background character in "Major Competition", "Mime for a Change" and "Get Back, Jojo".
- Robot Chicken
- A sketch from "Kiddie Pool" features Unsolved Case Files investigating the murder of George Jetson.
- A short sketch from "The Ramblings of Maurice" features George opening the wrong briefcase at a meeting.
- A sketch from "Robot Fight Accident" features Elroy bringing home a strange alien egg.
- The Simpsons
- The Couch Gag for "All Singing, All Dancing" features Homer getting swept away by a treadmill. ("Marge, stop this crazy thing!")
- In "Children of a Lesser Clod", Homer, while high on morphine, explains that he got an injured he from playing basketball in space and getting hit in the knee by George's car, making him shout "Jet-SON!".
- In "My Big Fat Geek Wedding", Lenny cosplays as George Jetson while attending Bi-Mon-Sci-Fi-Con.
- The Couch Gag for "My Fare Lady" is a spoof of the opening sequence.