Brian and Stewie make a cameo appearance in a commercial for The Peanuts Movie merchandise from Target. Stewie is dressed in Charlie Brown's shirt, and Brian is dressed in Snoopy's Flying Ace helmet and scarf.
A 2007 Subway commercial had Peter reciting a poem called Ode to the Subway Feast. "Beat that, Jared."
A 2008 Coca-Cola commercial had Macy's Thanksgiving Parade balloons of Stewie and Underdog fighting over a balloon of a Coke bottle. It ends up getting caught by a Charlie Brown balloon.
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A 2012 commercial had Stewie and Brian promoting Wheat Thins, which Stewie pronounces "Hweat Thins."
In Spider-Ham: Aporkalypse Now, Mojo decides Spider-Ham's World of Funny Animals needs to be more "mature", and reinvents Peter Porker as "Hammy Guy", with Mary-Jane Waterbuffalo as Lois, Captain Americat as Stewie, and Thrr, Dog of Thunder, as Brian.
In the trailer for The Incredibles, Dash's teacher is called "Grown-Up Stewie".
In the trailer for Deadpool (2016), Epic Voice Guy says that the movie feels like a really expensive, longer episode of Family Guy. Which causes Deadpool, himself, to ask WHICH season of Family Guy.
In the trailer for A Wrinkle in Time (2018), a clip of Peter saying "Shut up, Meg" plays in response to characters in the movie saying the same thing to Meg.
In the trailer for The Meg, the film is given the alternate title Shut Up, Meg.
In his review of The Thief and the Cobbler, during the scene where the Thief comes across YumYum bathing herself with a jewel-encrusted golden scratcher, the Critic plays the clip from "No Chris Left Behind" where Peter sells butt scratchers at a baseball game.
In his editorial "When Does a Joke Go Too Far?", the Critic addresses the controversy involving the Sarah Palin joke from "Extra Large Medium" and her response to it.
The ending to "Hurricane!", the third part of a crossover of Seth MacFarlane's shows, involves Stan meeting Peter and Cleveland (the latter of whom had his own show at the time).
In "The Unbrave One", Francine takes several pregnancy tests from a shady online gynecologist. In The Stinger, "Dr. Vadgers" is revealed to be Quagmire.
Drawn Together: In "The Lemon-AIDS Walk", Peter and Lois pass by Wooldoor when he is on the street begging for change. Alex Borstein voiced Lois for this joke.
Futurama: In "Bender's Big Score", Fry, after returning to the year 2000, hangs a Family Guy "12 Laughs a Year" calendar in his new apartment.
In the segment Send in the Clones from "Treehouse of Horror XIII", Peter makes a cameo among the many clones of Homer, a reference to criticisms that Family Guy is a clone of The Simpsons.
In "Treehouse of Horror XVI", executive producer Al Jean is credited as "Al 'Family Guy' Jean".
In "The Italian Bob", Italian cops look through a book of wanted felons containing a photo of Peter labeled "Plagarisimo", followed by one of Stan Smith labelled "Plagarisimo di Plagarisimo".
In "'Tis the 30th Season", it's shown that Disney World is constructing a new "Family Guy World" (also referencing Disney's acquisition of 21st Century Fox).
Stewie Mascot: I was the it-boy in 2006!
South Park: The two-part episode "Cartoon Wars" revolves around the news that Family Guy will do a joke about the Prophet Muhammad, and Cartman (who is sick of being compared to it) taking advantage of the ensuing panic to get the show cancelled.
Cartman: I am nothing like Family Guy! When I make jokes, they are inherent to a story! Deep, situational and emotional jokes based on what is relevant and has a point, not just one random, interchangeable joke after another!
◊, Stewie is one of the guests at Curtis' party, along with Dennis the Menace, Bart Simpson, Calvin, Huey Freeman, and Heathcliff.
