During the exam portion, Edel decides to demonstrate the toughness of a particular puni... by kicking it.
Edel: As you can see, this is a very tough puni... enough to make my foot hurt. Firis: (Wow... That sounded really painful...)
In the post-game, Firis decides to go journeying again and visits her parents to tell them, only for her father Lukas to incorrectly conclude that she's about to tell them that she's getting married and try to forbid it because she's too young. After she explains what she's really about, both are fine with it, having honestly expected her to come to them with this a lot sooner. They say that they're fine with her doing whatever she wants...
Lukas: That is, except for getting married... Owwww! Nicola! Don't step on my foot!
In Banjo-Tooie, Biggafoot, who guards a pair of Claw Clamber Boots on the icy side of Hailfire Peaks, limps away clutching his big foot after Chilly Willy sends an ice ball in his direction.
Born Under the Rain: The Foot Bindings for Masika; possibly a reference to the foot bindings of girls of China:
Mummify your feet. Extended use can result in sexy deformity.
The Curse of Monkey Island: One puzzle requires Guybrush to find a way across a scorching-hot beach in order to get the map to Blood Island from Palido Domingo. Guybrush will burn his feet every time you try to cross it unaided, but fortunately, once you get across there's a gate you can open to create a shortcut.
Deep Rock Galactic: Common in some biomes, like the Dense Biozone, which is full of thorned plants prone to stabbing you in the soles if you get too close, and especially the Magma Core, which is full of patches of semi-melted rock that will set fire to any dwarves that step on it.
My boots! My poor boots!
Die Hard for the NES includes a separate health meter for John's feet, representing the injuries he sustained through the course of the film.
In Disney Heroes: Battle Mode, Pete's Green skill, Foot Folly, has him accidentally dropping the bowling ball he uses as a weapon on his foot, hurting him for 10% of his max HP and granting him a shield and increased attack speed.
In Etrian Odyssey, several skills involve striking the target's legs or feet to inflict the Leg Bind status. This prevents the victim from using skills that require foot movement (such as attacks that involve charging at the enemy), dodging attacks, or escaping from battle.
Fallout 4 gives new graphics for Knee Capping a Deathclaw. If you cripple their legs, they're reduced to a pathetic crawl, with their tibias jutting a good foot out of their leg. Yikes.
New to Freedom Planet 2 are grind rails that you can ride on to get to other parts of a given level. Obviously, you grind on such rails with your shoes... until you remember that Milla is always barefoot, and thus has hands, paws and rump on the rail at all times. The wide-eyed expression and yellowish sparks tell you all you need to know.
In Gruntz, this trope is said word for word as a random quote when your gruntz step on Spikez.
In Guilty Gear -STRIVE-, Faust has a super where he accidentally knocks down his opponent, realizes what he has done, grabs a wheelchair, rushes to help said opponent, goes too fast, and ends up smashing their foot/leg with the wheelchair, resulting in exaggerated agonized looks from them.
Kid Icarus: Uprising has a boss, the Great Reaper, that is fought in a two-story battlefield. Each floor has a corresponding weak point, his head and his toes.
In Knights of the Old Republic, the player encounters a computer console that only outputs in an ancient language. The proper way to deal with it is to talk to it until it understands your language, but one option is to simply kick the computer. Doing so only gives you this:
In Mass Effect 2, a Renegade Shepard during the bar scene with Conrad Verner can shoot him in the foot.
Shepard:[levelling his or her gun at Conrad] Let me make this perfectly clear... [brings the gun down and shoots Conrad in the foot] This is not acceptable.
The first boss of Maximo: Ghosts to Glory is fought by first stabbing his foot, then (once he starts jumping) the other foot. Once he falls over, you hit him in the head.
The aptly-named moves Spikes and Toxic Spikes in Pokémon games, which set down traps that cause damage or poison foes, respectively. The only way to avoid taking damage from them if either is in place is to either be Flying-type or have the Levitate ability, so that the incoming Pokémon's feet aren't actually touching the ground (or, for the latter, being Steel-type, which grants immunity to poison).
The "foot stomp" is an actual move that can be pulled off in Sonic the Fighters.
Spot Goes to Hollywood: After Spot is done carving the Sega logo at the start of the game, he twirls his hammer in his hand, only to accidentally drop it right on his foot.
The Scout can scatter caltrops behind him to hinder pursuit. If stepped on, they slightly damage you, to the point where they can kill you. They also give you the "broken feet" debuff, which slows you down until cured by the Medic.
The Sniper can do the same thing by shooting an opponent's legs.
Can happen if they're hit by one of the ground flame attacks in the game, which causes their foot to be set on fire.
Can also happen in the "Sewer Surfin'" stage if you touch the spiked balls.
One boss in the game attempts to do this by throwing honest to goodness lobsters at you. He's comically vulnerable to Hoist by His Own Petard.
One possible news story in Tomodachi Life has a Mii stub their toe on an item while trying to get the phone. Gets ridiculous if the item in question is something unusual, like a travel ticket.
In the Twisted Metal series, the vehicle Axel is usually depicted as two monster truck tires driven by a man suspended between them on a solid platform. The Twisted Metal: Black version of the vehicle removes that platform, as the man intentionally lets his feet drag over the asphalt as torturous repayment for the death of his wife.
In Utawarerumono, Genjimaru and his granddaughter Sakuya defect from the empire of Kunnekamun in order to side with the protagonist Hakuoro. However, circumstances prevent them from fully explaining the reasons for their defection, and given that they were previously some of the Kunnekamun emperor's most loyal retainers, Hakuoro has no reason to take them at their word — a fact they fully realize. Therefore, in order to prove their trustworthiness, not only does Sakuya agree to serve as a hostage, but at her urging, Genjimaru severs her Achilles tendons, leaving her not only unable to escape, but unable to walk, and completely reliant on her captors' mercy to survive. Hakuoro is understandably horrified when he realizes how far they've gone to demonstrate their loyalty.
Yakuza 0 has a non-comedic example: While subjecting Tachibana to Cold-Blooded Torture to get Makoto's location, Yoneda smashes Tachibana's toes with a sledgehammer. Tachibana is obviously in immense pain, but continues telling his torturers jack.
◊. In-game, its effect is to hurt yourself for 1 damage at the beginning of a dash (unless you're at 1 HP) but increase your base damage by 5 every time you do so.
