Deus Ex: Human Revolution has Utility Remotely-Detonated Explosive Device. Also, augmentation clinics belong to an organisation called Liberty In Mind and Body.
Disney Infinity had the heroes (Elsa, Captain Barbossa, Captain Jack Sparrow, Mr. Incredible, The Lone Ranger, Sulley, Merida, Tonto, Maleficent, Donald Duck, Phineas, Agent P, Princess Jasmine, Tinkerbell, Stitch, Groot, Rocket Raccoon, Thor, Captain America, Iron Man, Hawkeye, Black Widow, The Amazing Spider-Man, Han Solo, Luke Skywalker, The Incredible Hulk, Vanellope Von Schweetz, Wreck-It Ralph, Jack Skellington and Rapunzel) fighting against the villains (Loki, Venom, Green Goblin, Darth Maul, Darth Vader, Davy Jones and Syndrome) in a battle known as Heroes Unite Against Bad Guys (or HUABG).
EVE Online players will notice the ingame target painter is very useful. Meta versions of it are sometimes more expensive but give a little more boost and are easier to fit onto a ship. The meta versions are named: 1) Partial Weapon Navigation, 2) Peripheral Weapon Navigation Diameter, 3) Parallel Weapon Navigation Transmitter, and 4) Phased Weapon Navigation Array Generation Extron.
Alliance and Corporation names tend to exhibit this as well, despite ticker names being limited to five characters. The Goonswarm alliance and corp used to be set up that viewing the full, long name of a ship would include "OH GOD BEES".
As part of the celebrations of the widely-popular April Fool's Day mode (Ultra Rapid Fire, in which all cooldowns are 20% of their normal values), a professional game was set up with several well-known faces for the League tournament scene. These were divided into two teams, Ye Olde League Organisation and the Society of Worth-Assessing Gentleman.
Ultra Rapid Fire mode itself is a case of this, as a play on the name of the character announced for the game's first April Fool's Day - Urf, the Manatee.
Banjo-Tooie has the Big-O-Blaster, better known as B.O.B.
San Andreas example: Ban Immigration Greencards Outright Today!
San Andreas also has Community Resources Against Street Hoodlums, which was an actual unit of the LAPD. note Funnily enough, the San Andreas version is actually less corrupt than the real organization had ended up.
In Vice City Stories, there's an anti-drug program called Consider Our Kids Everyday.
In Grand Theft Auto IV, the army no longer shows up at higher wanted levels. Instead, Niko is pursued by heavily armed agents of the National Office Of Security Enforcement, the Grand Theft Autoverse's version of Homeland Security.
The Federal Investigation Bureau.
Liberty Sanitation Department.
One Weazel News report mentions people rallying against murders related to the movie Dragon Brain. They call themselves Cizitens Understand Medieval Games Undermine Loving Parents.
The revolutionary group AVALANCHE from Final Fantasy VII doesn't stand for anything. Nor does the elite private army unit, SOLDIER. This is due to the fact that those terms, in the original Japanese version, were written and pronounced in English, and in Japanese, English words are written in all caps. So, they were never meant to be acronyms at all. Why yes, Sony does have a reputation for putting out Blind Idiot Translations around this time, why do you ask?
Many fans have tried to figure out what the 'SeeD' elite mercenaries stands for in Final Fantasy VIII. It sets up the entire theme of them being trained at 'Gardens', and it's ALWAYS spelled with a capital S and D - but we never find out what, if any, significance there is in this.
The ending implies that "SeeD" and "Garden" have no meaning, and the terms came about as the result of a Stable Time Loop. This doesn't account for why the Kramers capitalize just the S and the D, though, as they only heard it spoken.
While still on the topic of Final Fantasy games, the iPhone/iPad game Final Fantasy: All The Bravest features heavy use of the series' famous "Active Battle System".
The Wings of The Goddess Expansion pack has a kids group from the past called the Windurstian Teen Force.
Drug Runners And Takers in the old NES game Wrath of the Black Manta
Special Tactics And Rescue Service in the original Resident Evil, a surprisingly sensible name.
There's also the Umbrella black-ops operative HUNK from the second game, whose nickname stands for Human Unit Never Killed, stemming both from his ability to successfully carry out the most difficult of missions and survive, and his tendency to be the Sole Survivor on those mission (Primarily because all he cares about is completing the mission, and he views the operatives working for him as resources to be expended)
Umbrella Chronicles has the Tyrant Armored Lethal Organic System, named after a giant from Greek mythology.
Portal has GLaDOS, a Genetic Lifeform and Disk Operating System.
The Aperture Science Computer Aided Enrichment Center, or CAEC. Cake, anyone?
Before Issue 21 revamped the starting levels, new heroes used to report to one of five divisions of the Federal Bureau for Super-powered Affairs, depending on their origin:
Tech: Department of Advanced Technology Application
Mutation: Genetic Investigation and Facilitation Team
Science: Scientific Experimentation Research and Application to Paranormal Humans
Natural: Enhanced Logistics for Insight and Tactical Excellence
Magic: Modern Arcane Guild of Investigation
The police force of the Rogue Isles in City of Villains is, sensibly enough, the Rogue Island Police.
The trial where you finally defeat Praetor Tilman, who calls herself "Mother" (enemies call her "Mother Mayhem"), is the Minds of Mayhem trial. (This also means the Master of... badge for that trial is comically abbreviated "MoMoM.")
The plot of Trauma Center revolved around a group of man-made parasites known collectively as GUILT, which stands for Gangliated Utrophin Immuno Latency Toxin. Particularly hilarious, because every form of GUILT is a giant parasite of one form or another.
In Snatcher, the task force assigned to hunt down and destroy the titular robots is known as JUNKER: Judgement Uninfected Naked Kind & Execute Ranger - in the Japanese version. If you prefer something with less Engrish, there's Japanese Undercover Neuro Kinetic Elimination Ranger.
Archaic Sealed Heat is a story about an army that dies in a fire and comes back from their ashes...
Night Trap casts the weary player as a hacker assistant to Dana Plato in employ of the special forces unit, the Sega Control Attack Team. Sega was never above these puns, or using their names in their games.
In versions made for non-Sega systems however, it was changed to Special Control Attack Team.
The Sonic the Hedgehog games had the military organization Guardian Units of Nations. The actual meaning of the acronym was never stated in-game until Shadow the Hedgehog, but could be gleaned from some obscure sources around the time of Sonic Adventure 2's release.
G.U.N., and S.H.I.E.L.D. from X-Men, are possible U.N.I.T. shout-outs.
In the comic series of Sonic X there's an anti-Sonic group hanging about by the name of the Society for Observing and Neutralizing Interdimensional Creatures and Xenomorphs. S.O.N.I.C.X. The blue blur himself finds this rather hilarious.
It might be a Punny Name considering GUN is the spelling of the Japanese word for military.
In Team Fortress 2, the competing intelligence agencies are known by the names of their front companies - Reliable Excavation Demolition and Builders' League United.
There's also the Heavy's two unlockable melee weapons: from the Heavy update came the Killing Gloves of Boxing. The beta also had the Gloves of Running Urgently, which were recently re-added to the game.
In the Wild ARMs series, the acronym ARM or ARMS stands for something different in each game. In Wild Arms, it's Ancient Relic Machine, in 2nd Ignition, it's Agile Remote Mission Squad, in Advance 3rd, it's Artifacts of Ruins' Memories, and in The 4th Detonator, it's Ambient Reorganization Material.
In the fan-made RPG Barkley, Shut Up and Jam: Gaiden, the main antagonist of the game is the leader of the terrorist organization BLOODMOSES. What does BLOODMOSES stand for? Nobody knows, nor does anybody seem to care, as it's never revealed in the game. However, since this game was only the first chapter in the Hoopz Barkley SaGa, it may be revealed in a future chapter.
The robot that came with NES systems was called the Robotic Operating Buddy in the US.
And the Family Computer Robot in Japan. Make of that what you will.
The antagonists in Evil Genius are 5 international alliances; named P.A.T.R.I.O.T. (consisting of "Allied" nations such as North America and Japan), S.A.B.R.E. (Europe and British Colonies, like India), H.A.M.M.E.R. (Russia and Cuba), A.N.V.I.L. (China and... more China), and S.M.A.S.H. (Africa and South America). The player is never told what those stand for.
According to an advertisement, ANVIL stands for Asiatic Notorious Villain Incapacitation League.
The Legend of Zelda: Twilight Princess has a really hackneyed example with a bizarre minigame known as "The S.T.A.R. Game", whose acronym is basically the game's rules and goal: So all you must endeavor is to Track down all the glowing orbs And collect them all before time Runs out!
Command & Conquer gives acronyms to the Mission Control systems, including the Electronic Video Agent and the Computer Assisted, Biologically Augmented Lifeform.
You forgot the very hero faction of the entire series, the Global Defense Initiative (or, if you want to get technical, the United Nations Global Defense Initiative, but "UNGDI" is a bit more tedious than just "GDI").
Battlezone many of the weapons have acronyms that state their function such as the Magnetic Inversion Tethering Snare mine (pulls objects and vehicles towards it), the AntiTank-Stabber, the Targeting Atuomation Gun. It also goes for the factions of the series such as the National Space Defense Force, the Cosmo Communist Army (or Cosmo Colonist Army). By the second game, we get the International Space Defense Force and the Alliance of Awakened Nations. The fanmade Forgotten Enemies expansion introduces the Earth Defense Force.
Mass Effect, in a rather bizarre example, has the Spectres. Despite the fact that Spectre is never capitalized, the fact that the official name for the branch they belong to is the Office of Special Tactics and Reconaissance suggests that it was, in fact, intended to be an acronym. If we assume both are actually translated from alienese, then the english acronym would have been made up by the translators to match the full name. Now, the silly part (in-universe) would be why the acronym isn't simply Special Tactics And Reconnaissance, but in real life we can all guess why the writers passed on STARs.
Also, General Area Defense Integration Anti-spacecraft Network is the name given to the point-defence laser arrays on starships.
In No One Lives Forever, the villanous organization is known as HARM. A running gag of the series is that files and characters often refer to what it stands for without ever revealing it to the player.
Intelligence items that can be collected by the player humorously detail the exchange between the crime organization and the Hair Alternative Replacement Membership club in a dispute over the H.A.R.M. "trademark".
HARM ends many of its communiques to its agents with the phrase "Remember what HARM stands for!"
The good guys' organization is called UNITY. No full name given.
Following on from the example above, Phantom Brave uses Human Activists for Rare Monsters. Guess what the leader's misguided policies actually do...
In Sam & Max: Reality 2.0, the Freelance Police meet the C.O.P.S., or Computer Obsolescence Prevention Society, a support group for outdated computers.
Metal Gear Solid 4 has Snake and Drebin being pursued by a variant of the Stryker called the Mobile Gun System. Also, there's the Sons Of the Patriots system.
SOP is also a subversion; the military and private contractors who use the system would think it means "Standard Operating Procedure," which is what the acronym means in actual military parlance. The system is designed to provide a whole new level of assurance that soldiers will never deviate from standard procedure, after all.
In Metal Gear Rising: Revengeance, Raiden is confused for a moment when the Doktor tells him he needs to take a DOOMP, which turns out to mean a Digital-Oriented Output Mounted Proxy.
Many Guild Wars fans have noted that the title of the Expansion Pack, Guild Wars: Eye of the North could be reasonably abbreviated as "GW:EN;" perhaps not coincidentally, the question of what happened to Gwen after the Searing is resolved in the expansion.
In said expansion, the Asura use constructs called Genius Operated Living Enchanted Manifestations.
Mega Man ZX and its sequel, Mega Man ZX Advent had the ROCK (Rebirth Of Crystalized Knowledge) and MEGA (Meta Encapsulated Granulated Awareness) systems for its transforming system in the Japanese and English releases respectively.
In Japan, the Mega Man Legends series is called Rockman DASH: Digouter's Adventure Story in Halcyon Days.
Unreal Tournament III attempts to justify the presence of Capture the Flag in its single-player campaign by changing them into Field Lattice Generators. Lampshaded by the player character, upon hearing this:
It looks like a flag, it waves like a flag, it's a flag.
Also the GES Bio Rifle Green Exploding Shit and the ASMD Shock Rifle And Suck My Dick.
In beatmaniaIIDX 11 RED, RED stands for "Revolutionary Energetic Diversification version". Conveniently enough, the color scheme for IIDX 11 was predominantly—you guessed it—red.
S.T.A.L.K.E.R: Shadow of Chernobyl stands for Scavenger, Trespasser, Adventurer, Loner, Killer, Explorer, Robber.
Warhammer Online: Age of Reckoning is one in itself.
Two scrolls in MySims Kingdom, one of which is called "S.C.R.O.L.L.", give you the power to create items such as a D.O.O.R., a C.L.O.C.K., and S.I.D.I.N.G.. There are even three lengths of (decorative, as far as we can tell) piping, which are called, from smallest to largest, p.i.p.e., P.i.p.e., and P.I.P.E.. These scrolls are associated with a robot named T.O.B.O.R., who mixes this with Sdrawkcab Name. None of the acronyms are expanded.
In MySims Agents, it is revealed in the course of a dispatch mission that T.O.B.O.R. was originally built to be a fruit juicing supervisor, and the acronym of his name stands for Tangerine Orange Banana Orange Revisor. ("Tobor" may also be a Shout-Out to a villain from the old TV show Captain Video by the same name.) Still no idea about those others, though.
In EarthBound, there is a billboard in Threed warning children not to spend all their time playing video games. It was erected by the supporters of the Parents Opposing Obsession Plan.
In Siren: Blood Curse, there is the JOYLiNK Network King portable LCD game system and its updated successor, the JOYLiNK Ultra Network King, or JUNK.
In Star Control, the cowardly Spathi ships fired B.U.T.T. (Backward Utilised Tracking Torpedo) missiles out of their rear. There's also the Kohr-Ah's special weapon, the Fiery Ring of Inevitable and Eternal Destruction (F.R.I.E.D.) and the Chenjesu's special battery-siphoning drones, De-energizing Offensive Guided Interceptors (D.O.G.I.) which make dog-like sounds. "VUX" is a subversion, being the proper name of the alien species (all caps included), but humanity made it into a Backronym for "Very Ugly Xenomorph".
Outpost 2 has the Disater Instant Responce Team and Garbge and Ore Recycling Facility. The DIRT was present in the first game as well, along with another version of the GORF called a SPEW and an atmosphere regulator called a CHAP.
Sewage Processing and Environmental Waste and Closed Habitat Atmospheric Production. Outpost 2 hid several of these in the fluff as well, including the controller for the guard posts, the Targeting And Fire Tasking computer (TAFT) or the Robot Assist Mechanic of the Garage (RAM). Also present was a Shout-Out to another Dynamix game hidden in the flavour for Eden's Meteor Defence system - it fires a High Energy Ray - Composite.
In the Starsiege series, you play with one or severalgiant mecha, called Humaniform-Emulation Roboticized Combat Units with Leg-Articulated Navigation, aka HERCs.
''Senko no Ronde's Booster of Over-Armed Shell System is the term used to describe what happens when a player's Rounder attaches to larger and bulkier weapons, thus emulating the appearance, mobility, and firepower of a danmaku shmup boss. The subtitle for the game's sequel, Dis-United Order, continues this tradtion.
The title of S.C.A.T., a Forgotten Worlds-style shoot-'em-up by Natsume for the NES, stands for Special Cybernetic Attack Team. (The European and Japanese versions used different titles.)
The "Acid" portion of Metal Gear Ac!d apparently stands for "Active Command Intelligence Duel.
The bad guys in the NES version of SNK beat-'em-up P.O.W. are named "GOON" (Government Of Offensive Network). In the Japanese version, they were called "GOD" (Government Of Darkness).
In Left 4 Dead 2 in the Dead Center campaign in The Streets, the CEDA, based off of FEMA, sent trucks with the words Disease Emergency Assessment Dispatch to the scene. Note that CEDA is trying to save everyone from a zombie apocalypse.
There's also CEDA itself, which stands for Civil Emergancy and Defense Agency. The misspelling was apparently intentional.
In Afterlife, you manage an Heaven and Hell for mortal Ethically Mature Biological Organisms, who upon death appear in your Afterlife as Stuff Of Unending Lifes for the powers that be. One of the types of SOULs in your afterlife may be a AAAAOPRASUMARALFist, who believes that there's always an Afterlife, one only goes to hell, is punished for every one of its major sins, and then gets reincarnated. It's basic AAAAOPRASUMARAL Fism: Absolutely Always An Afterlife, Only Pit Realms Await, Souls Undergo Multiple Afterlives Reincarnationm Always Loop Fate. And that is just a few in the game.
Descent II: The first level is named Ahayweh Gate. Which stands for "Abandon hope, all ye who enter here". There's also the Portable Equalizing Standard Transbot, and the Preliminary Integration Groundbot.
A quest in the browser game Billy Vs SNAKEMAN rewards you with the H.A.R.O.: the High-Explosive Anti-RNG Ordnance.
Fallout loves these. Of particular note is the acronym for the attribute system, S.P.E.C.I.A.L. (Strength, Perception, Endurance, Charisma, Intelligence, Agility, Luck), developed after negotiations broke down with Steve Jackson Games to use their GURPS system.
Street Fighter IV has a weapon called Boiling Liquid Expanding Cell, which shorten is name called BLECE. Assuming the OVA is canon, it is what is sounds, a weapon that releases some kind of energy that causes parts of living cells to boil and explode.
Classic LucasArts adventure games run on the Script Creation Utility for Maniac Mansion or SCUMM for short. This actually got them into a bit of trouble when the system was adapted to the NES (for the port of Maniac Mansion) and dubbed the NES SCUMM; apparently Nintendo misinterpreted it as a Take That! and requested its removal from the credits.
SCUMM is also a host for embedded game engines such as iMUSE (standing for Interactive MUsic Streaming Engine), INSANE (standing for INteractive Streaming ANimation Engine) and others.
SCUMM was (briefly) succeeded by the Grim Fandango Engine, or GrimE.
The Executable and Linkable Format, was originally designed along with Debugging With Attributed Record Formats.
In Activision's Atari 2600 game H.E.R.O., the player is part of the Helicopter Emergency Rescue Operations team and must rescue trapped underground miners with a one-man helipack.
In Dragon Quest IX, there's an "Herbalist" accolade presented by the Herbalist Institute for Potions, Poultrices, and Investments in Extracts.
In the Facebook game Mousehunt, one of the traps is called the Arcane Capturing Rod of Never Yielding Mystery.
KOS-MOS from Xenosaga: Kosmos Obey Strategic Multiple Operation Systems.
Raskulls gives us the Super Nuclear Ultra Gem Grabbing Laser Extraction System.
One joke related to inferior ports is that "port" is an acronym for Piece Of Reprogrammed Trash.
In Hidden Agenda (1988), an '80s-era computer game set in a Banana Republic, the Former Regime Personnel can either be prosecuted for their crimes or given a blanket amnesty. If given an amnesty, they will form a paramilitary group called LIMPIA, which launches death squad attacks on peasants, human rights activists, and labor leaders. "Limpia," as a conjugated verb, is Spanish for "cleanse" or "purge."
In Nine Hours, Nine Persons, Nine Doors there are two devices that function along with the numbered doors. The first one is a red device called the Recognition Device, or RED for short. It activates a bomb located inside the characters that will explode should you not deactivate it. Oh, and how can you deactivate it? Just find the Deactivation Device, or DEAD for short.
FreeSpace 2 has the Target Acquisition and Guidance Missile.
Super Mario Sunshine has Mario's water-spraying backpack FLUDD, or the Flash Liquid Ultra Dousing Device.
Solatorobo has CODA, which stands for Continent Orientation Defloat Alignment.
Some of the Nancy Drew video games are known by three-letter nicknames, among them Shadow at the Water's Edge (SAW) and Trail of the Twister (TOT).
In Keith Courage In Alpha Zones, Keith fights for the Nations of International Citizens for Earth (N.I.C.E.) against the Beastly Alien Dudes (B.A.D.).
In a case of fun with what an acronym stands for instead of what it spells, checkpoints in Mighty Switch Force! are indicated by the U.T.D. — which is a sensible-sounding initialism that you'd expect to stand for something like "Universal Tracking Device." Nope. It stands for "Ugly Twitching Dog."
No matter which of the two main title translations you choose for Sora no Kiseki, be it Tracks in the Sky or Trails in the Sky, you're gonna end up with TITS. When Xseed localized the game (under the latter name), they played along and lampshaded this on the description for the game's forum.
The name of the continent on which the Dragon Age games are set, Thedas, is actually derived from "THE Dragon Age Setting." One imagines the designers were stuck trying to think of one and finally said "Eh, what the hell."
Borderlands: The 'Claptrap's Revolution' DLC gave us the "WIRED" device. The Wireless Information Router Encoding Device is a wireless controller for rebooting the Claptraps.
The Kirby series has several cases where the world names are used to make a word:
This practice goes all the way back to Kirby's Adventure, though this one's a bit of a stealth example as it involves Sdrawkcab Name: Vegetable Valley, Ice Cream Island, Butter Building, Grape Garden, Yogurt Yard, Orange Ocean, and Rainbow Resort in reverse order makes ROY G BIV, a mnemonic for the colors of the rainbow.
Kirby: Canvas Curse had Reddy Land, Arange Gorge, Iello Adventure, Neo Greo, Bloo Hills, Omarine Zone, and Wonder Lilane, with RAINBOW tying into the game's theme of paint and color.
Compilation Re-releaseKirby's Dream Collection includes extra challenge levels Happiness Hall, Apricot Atrium, and Last Land; for developers HAL Labs.
In Kirby: Triple Deluxe, the levels are titled Fine Fields, Lollipop Land, Old Odyssey, Wild World, Endless Explosions, Royal Road, and Eternal Dreamland. Like in Return to Dream Land, FLOWERED drops a hint towards the final boss.
It happens again in Kirby: Planet Robobot, the levels this time are titled Patched Plains, Resolution Road, Overload Ocean, Gigabyte Grounds, Rhythm Route, Access Ark, and Mind in the Program. This is another subtle hint towards the final boss.
It happens yet again in Kirby Star Allies, each of the levels in Planet Popstar, Friendly Field, Reef Resort, Inside Islands (Extra Stage), Echo's Edge, Nature's Navel, Duplex Dream, and Sacred Square, make up the word FRIENDS, which is fitting with the theme of befriending characters to solve puzzles and play through the levels.
Pokémon strategy is partially about making your Pokemon's moves stronger by using the same type of move that your Pokemon is (for example, a Water-type Pokemon using a Water-type move). This is known as Same Type Attack Bonus. Rather fitting, since some moves can be truly devastating.
In the metagame, two gimmicky strategies are the "Focus-sash Endeavor quick-Attack Rattata"note the Focus Sash is a held item that ensures that Rattata will survive an attack with one hit point, Endeavor reduces the enemy's HP to equal Rattata's, and Quick Attack guarantees Rattata will hit first for Scratch Damage, which is enough to KO the enemy and "Sturdy Aron shell-Bell Endeavor Recovery"note starting in 5th gen, the Sturdy ability works like a built-in Focus Sash, so Aron holds a Shell Bell, which lets it recover all hit points when it hits with Endeavor.
The arcade/SNES Shoot 'em UpS.T.G. expands its Initialism Title as STrike Gunner (the three capitalized letters are in red on the title screen), but "STG" is also a common Japanese abbreviation for the Shoot 'em Up genre.
For Tekken Tag Tournament 2, Bandai Namco set up a stat-tracking website called the World Tekken Federation.
M.U.G.E.N. It stands for something, but not even Elecbyte themselves know what it stands for.
The title of the Shoot 'em UpS.W.I.V. officially stands for Secret Weapons Installation Verification, Special Weapons Interdiction Vehicles, and SilkWorm IV, though many fans believe it really stands for "Silk Worm In Vertical."
Many guns with acronym names get deadlier-sounding, completely redundant overhauls after being Pack-a-Punched. Prime examples include the Dead Specimen Reactor 5000 (DSR-50) and the Malevolent Taxonomic Anodized Redeemer (MTAR).
Overwatch: D.va (Hana Song) is a pro gamer turned mech pilot when she became a member of a military unit called the Mobile Exo-Force of the Korean Army.
Star Fox contained the original version of the Super FX co-processor, labeled "MARIO CHIP 1." "MARIO" was a backronym for "Mathematical, Argonaut, Rotation & I/O."
Subverted in Saints Row: The Third when the DJ from radio station WDDT CPDG gets asked what the letters mean. He looks it up, only to discover that real life call numbers don't stand for anything.
Kyo Kusanagi from The King of Fighters has a special move called the R.E.D Kick or "Rainbow Energy Dynamite" Kick.
Moebius has the secret government agency "Future Intelligence Science & Technology".
WildStar has the Dominion Research and Experimentation Division (DRED), run by the brilliant, psychopathic Chua, feared and despised by everyone.
The antagonists of The Wonderful 101 are an alien race called the GEATHJERK, or the "Guild of Evil Aliens Terrorising Humans with Jiggawatt bombs, Energy beams, Ray guns, and Killer lasers".
The flash game/indie game Concerned Joe has "IHTMOID", which doesn't really mean anything, but sounds ridiculous, and the programmer even admits this to Joe. However, Joe doesn't find it so funny when he finds out what it stands for: IHave To Move Or I'll Die
Phantasy Star Online 2 has a meta example among English speaking players: one type of quest is referred to as Time-Attack Client Order, or simply "TACO".
In Gradius III, the player's ship is the M.A.X., or Modulated Artillery Exalter.
Halo has the Office of Naval Intelligence, more commonly referred to as "ONI".
The Secret World: Orochi's Anansi Alpha is working on the AEGIS system project and is filled with living scientists thanking you for the data they've gained. They're also brainstorming what the hell "AEGIS" means:
Anima Enhancement Global Integration System
Actualized Extreme Guided Immunity Support. Somebody adds that it's horrible and includes a frowny face.
Armor Enhancement Guidance Intelligence System
Agency X Enhancing Guarded Impenetrable Shield
Finally, somebody got fed up and created an acronym for "acronym"—Assholes Creating Ridiculous Obtuse Nonsense Yowling Meaninglessly—with an underlined notice to quit fucking around.
The Assault character Markov from Evolve Wears the SALGE, a Space and Low Gravity Environment suit. When Caira asked what kind of suit it was and got SALGE as an answer, she asked if he was telling her to fuck off in Martian.
Altairlion from Alpha 3 has GRaMXs (Gravity-control Rapid acceleration Mobility break Cross(X) shoot).
Finally, new line of mech in OVA is GESTALT for Global Expanded Stamp out Tactics works ALTogether.
Etrian Odyssey has the infamous FOE's, randomly encountered enemies that are MUCH stronger than normal. The acronym is officially "Field-On Enemies" (changed to a Latin phrase in the English translation), but most players have declared it to stand for "Fucking Overpowered Enemies".
ARCANE, a government organization in the Nightmare AdventuresHidden Object Game series, stands for Advanced Research Commission on the Anagogic, Numinous & Esoteric.
In The Legend Lives! Akmi Yooniversity student housing on the more...remote planets is called Yooniversity Economical Graduate Off-site Dwelling Stations.
Dota 2 (Defense Of The Ancients) has Invoker's EMP spell. In this case, EMP stands for Endoleon's Malevolent Perturbation (or Extractive Mana Pulse given what it does).
In Sub-Terrania by Zyrinx, the number of miners rescued is tallied under the label P.O.W., which according to the manual stands for Processed Ore Workers.
Undertale plays with acronyms a bit. A couple of Enemy Scans jokingly expand "HP" as "Horsepower" (for a seahorse) or "Hit Poodles" (for a dog). More seriously, near the end of the game, when receiving your final judgment from Sans, he tells you that EXP (usually short for "Experience Points" in RPGs) stands for "Execution Points" (a measure of how much you've abused Video Game Cruelty Potential), and LV ("Level") is short for LOVE, or "Level of Violence" (a measure of your Killing Intent). However, some other common terms in the game do not appear to be acronyms despite being usually (though not invariably) capitalized.
The Big Bad of SPY Fox 2: Some Assembly Required led the Society of Meaningless Evil, Larceny, Lying and Yelling, better known as SMELLY.
The evil organization in Secret Agent goes by the acronym of "DVS".
The Institute for Applied Noematics. One text that can be read at a terminal explains the origin of this name.
Elohim is actually EL-0 HIM, the Holistic Integration Manager of the EL-0 partition of the supercomputer that the whole project is being run on. EL stands for Extended Life, the name of the digital archive hosting the Talos project.
MechWarrior Living Legends features the 'Puma' light mech, whose brawling variant is called the Close Range Assault Puma, or CRAP. In the Solaris Arena, the announcer calls BattleArmor ('BA') users "Badass"
Evolve has robots called Emergency Medical Evacuation Technicians whose acronym helpfully creates the word, later name, Emet.
The Shantae series has recurring villainess Risky Boots use long-winded names for some of her machines, some of which can invoke this trope. Taken to its logical conclusion in Half-Genie Hero with the first boss, the...
Risky: ...the Part Omni-Organic, Partially Titanic, Ocean-Optional Tinkerslug! Shantae: P.O.O.P.T.O.O.T.? Risky: Don't call it that!
Graceful Explosion Machine is all about gems. Your ship's hull is decorated with gemstones, most of the planets are named after gemstones, and the enemies leave behind diamond-shaped explosions when they're destroyed.