Though not a very plot-intensive game, there are still some twists that occur throughout the series. Thus, be warned that there be Spoilers Ahead!
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Thomas RoganAn AMS agent who was called to the Curien Mansion in 1998 by a distress call from his fiance, Sophie. Although it looks bad when Chariot appears to kill her prior to his battle with Rogan, she survives and together the two manage to have a daughter, Lisa. Twenty-one years after the Curien case, the world has collapsed due to the zombie outbreak detailed in the fourth game. Rogan leads an assault team on the EFI Research complex in order to track down the source of the disaster, but gets in over his head.
GAn AMS agent and Rogan's partner during the 1998 Curien case. Together, he and Thomas managed to put an end (or so they thought) to Curien's most diabolical invention, the Magician. In the year 2000, he heads to Venice to quell a new outbreak happening in the streets, but is overwhelmed and injured. Despite this, he survives and later assists Kate Green after James Taylor sacrifices himself to stop "The World". Sixteen years later, he assists Lisa Rogan when she attempts to find the whereabouts of her father after his doomed mission to the EFI Research building.He and Issac Washington were also the duo who put an end to Papa Ceasar's activities in 1991.
Sophie RichardsThomas Rogan's finace at the time of the Curien Mansion incident and a researcher working for Dr. Curien. Later becomes Lisa Rogan's mother.
James TaylorAn AMS agent who was working on the Venice, Italy case. He was scheduled to meet G in Venice on February 26, 2000, until he ran afoul of Zeal. Together, he and his partner Gary discover the plot of Caleb Goldman and pursue a mission to track him down to the DBR Corporation headquarters. They put a stop to Goldman's plan to unleash the "Emperor", but fail to arrest Goldman.Three years later, he and AMS agent Kate Green visit the European archives of the AMS, with James believing that the crisis from 2000 has not completely subsided. However, as they are researching the files within, an earthquake traps them underground. While waiting for a rescue squadron, they are suddenly overrun by new leagues of the undead. The pair fight their way back to the surface to discover that Goldman has enacted a plot from beyond the grave to launch a nuclear strike on the world. James returns to the DBR Corporation headquarters in order to reach Goldman's office on the fiftieth floor and stop the launch. However, Goldman has yet another failsafe, called "The World", which will be unveiled by the opening of "Pandora's Box". James and Kate battle The World in the courtyard of the DBR building, but are unsuccessful in destroying it. James is left with no other option but to destroy the beast by blowing himself and the monster up together.
Lisa RoganThomas and Sophie's daughter, who goes to the EFI Research building, along with Rogan's former partner G, to find her father after he disappeared two weeks prior on a mission to put an end to the disaster that ruined the world.
Kate GreenAn AMS agent who assisted James Taylor in 2003. After she and James uncover Caleb Goldman's final plan, together they stop "The World" from coming to fruition. She later teams up with G in order to fight a newly-resurrected Magician.
Daniel CurienThe son of Roy Curien whose childhood illnesses inspired his father to research the essence of life and death. He believes he bears the responsibility to put an end to the evils unleashed on the world by Curien in his name.
Dr. Roy CurienA genetic researcher who was pursuing a way to command the forces of life and death in order to save his dying son. Although he started with good intentions, he eventually succumbed to madness as he delved further into his research. He invented two means by which to control these forces: the Magician, a sentient and bio-mechanical android, and the Wheel of Fate. The Magician proved too unruly and independent to control and ultimately killed its creator. Curien's remains were brought to the EFI Research complex, where his Wheel of Fate device was housed. Over the span of twenty years, it would revive him and allow him to bring about the ultimate judgement upon mankind. He was eventually destroyed for good by the efforts of Lisa Rogan and his own son Daniel.
Caleb GoldmanThe CEO of the DBR Corporation and the real driving force behind Dr. Curien's research. He funded Curien's research in order to gain access to the wealth of genetic information Curien had so he would be able to employ them to his own end: to end the sin of mankind's mistreatment and destruction of the planet. When Curien was killed by the Magician, he retrieved the Magician (following its defeat by the AMS) and rebuilt it to serve him. He used it as a guard to protect the DBR headquarters, which is also where he housed his own monstrous creation: the Emperor. However, the Emperor was unsuccessful in turning away the AMS, and after its defeat, Goldman chose to end his life rather than be taken in by the AMS.Three years later, he is revealed to have planted the seeds of destruction regardless of his death through a planned nuclear launch in 2003. James Taylor (one of the agents who stopped his original plan) and Kate Green deter this, but also uncover a second plot that would enact in case his nuclear missile did not launch, called "Pandora's Box".
Warden Clement Darling
The ChariotA large zombie wearing a full suit of armor, who is the first boss fought in the first game.
The HangedmanA flying stone gargoyle who kidnaps Rogan's girlfriend and later attacks him and G on the roof. He's the second boss of the first game.
The MagicianCurien's most powerful creation, which is a mutant with fire control and psychic powers. The fourth (and final) boss of the first game. It later serves as the fifth boss of the second game, and the second (and once again final) boss of The House of the Dead 4 Special.
JudgmentA small imp (Zeal) and a living suit of Armor (Kuarl), who are met in Venice by James and Gary. It's the first boss in The House of the Dead 2.
The HierophantA triton-like zombie armed with a trident. The second boss of the second game.
The TowerA Hydra-like mutant who dwells in the sewers of Venice. The third boss of the second game.
StrengthA huge, chainsaw-wielding brute fought in a Coliseum. The fourth boss of the second game.
The EmperorA humanoid being made of shape shifting molten metal, and Goldman's last creature. The sixth (and final) boss of the second game.
DeathA huge skull-faced mutant dressed as a Security Guard and armed with a club. He'll chase G and Lisa for two levels. One of the bosses in the third game.
The FoolA mutated giant sloth who resides in a well-like cage inside the building. One of the bosses in the third game.
The SunA mutant giant plant with many tentacle-like roots and human faces on its stalk. One of the bosses in the third game.
The Wheel of FateCurien's ultimate creation/transformation, it is a cybernetic monster surrounded by a metal ring. It manipulates electricity to fight. It's the final boss of The House of the Dead 3, and is actually Dr. Roy Curien himself.
JusticeA huge, four-armed mutant that chases Kate and James in the sewers. The first boss of The House of the Dead 4 and The House of the Dead 4 Special Edition.
The LoversA pair of mutated Tarantulas which attack Kate and James as they try to leave the underground via Elevator. The second boss of The House of the Dead 4.
The EmpressA powerful purple zombie armed with a ludicrously big double-chainsaw. He/she chases Kate and James on the train. The third boss of the fourth game.
TemperanceA morbidly obese, giant zombie that chases our heroes down the streets. He's so fat that bullets won't damage him. The fourth boss of the fourth game.
The StarA humanoid mutant armed with swords and a purple aura, which acts as a "test" of strength for Kate and James. When he dies, he wounds James with a shard of his body. He's a perfected model of The Magician, and the fifth boss of The House of the Dead 4.
The WorldGoldman's last trick, which is a powerful, constantly-evolving monster made of ice. He's destroyed by James's sacrifice.
Jasper GunnsThe first boss in OVERKILL, he's Varla's quadriplegic younger brother, who has injected himself with a Psycho Serum in order to kill Papa Caesar, but got distracted by G and Issac, allowing Caesar to escape. Unfortunately, Jasper ends up so far gone that he can't tell ally from enemy, and ends up attacking G and Issac instead.
Coco and SindyExclusive for the Playstation 3 version, they're Varla Guns' fellow coworkers who borrowed Varla's bike before getting infected. Appears as a fat woman and a skinny woman. Chronologically the second boss fought in the PS3 version.
The ScreamerAnother creation of Caesar, who's released in a hospital in order to kill G and Isaac. Appears as a zombie girl with a mutilated face and powerful screams. The second boss in OVERKILL (third if you count the PS3 version).
Nigel and SebastianA pair of circus freaks mutated by the virus, who are now feeding on corpses in the circus. Nigel is the large guy, while Sebastian is the tumor-like thing embedded in his belly. The third boss of OVERKILL (fourth in the PS3 version).
Meat KatieExclusive in the PS3 version, it is a gigantic cow-like mutant who wields a butcher's knife in the butcher shop. Chronologically the fifth boss of the game.
The CrawlerA huge mutant similar to a bug, it attacks Isaac and G on the train. The fourth boss of OVERKILL (sixth in the PS3 version).
The LobberA massive frog-like mutant who's infesting the swamps. The fifth boss of OVERKILL (seventh in the PS3 version).
BrutusA huge, mutated criminal who was executed for his many awful crimes. He's seen together with another similar mutant, who he kills. The sixth boss of OVERKILL (eighth in the PS3 version).
MotherClement Darling's mother, who was exposed to the compound and had her brain put in Varla's body. She mutates to a giant, grotesque monster which births smaller mutants from her oversized vagina. The seventh and final boss of OVERKILL (ninth and tenth if you count the playable "Missing Reel" in the PS3 version).