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- Shishio, the season 1 big bad of Rurouni Kenshin. He was shot in the head and lit on fire before being left for dead. The fire left him disfigured, and all of his sweat glands were destroyed. As such, he has incredibly high body temperature, which (apparently) grants him almost superhuman speed and strength. The downside is that he can only fight for about fifteen minutes before the heat buildup kills him.
- JoJo's Bizarre Adventure:
- The Pillar Men have each mastered a type of fighting style called "Mode", where they freely transfigure their own bodies to emulate Elemental Powers. Esidisi's Mode is Heat Control, which entails heating his blood to 500 degrees Celsius then extending his blood vessels from his body and injecting his blood into an opponent. The results are just as horrifying as they should be.
- A lesser example would be Robert E.O. Speedwagon during Phantom Blood. It's never really explained how or why, but Speedwagon is so hot-blooded that he could melt Zeppeli's frozen arm just by holding it to his chest for a minute. Unfortunately, his hot blood makes him unable to use Hamon Techniques.
- In Kill la Kill, Ryuko is normally simply Hot-Blooded, but when she finally confronts her father's murderer her rage reaches a boiling point. That is to say, her blood is literally seen to boil, driving Senketsu into a frenzy.
- The Titans of Attack on Titan have extremely high body temperatures, which appears to increase along with their size. The Colossal Titan radiates superheated steam thanks to its lack of skin, and another Titan, twice the size of the Colossal, is so hot that it causes nearby vegetation to combust.
- In PS238, Suzi has an internal body temperature which can melt lead, which appears to stem from her radioactive nature. Incidents where she loses her temper are explained as "gas leaks".
- Supergirl's blood was burning-hot during her Red Lantern tenure in Red Daughter of Krypton. This is true of Red Lanterns in general, as the Red Rings' energy replaces their blood. As such, the removal of a Red Ring from their host would, under the majority of circumstances, result in their death.
- Runaways has a variation; while it is unknown if Karolina's Majesdanian blood is especially hot, it is supercharged with solar energy, a fact that the vampire Topher learns the hard way when he tries to feed on her.
- In Pokémon Reset Bloodlines James notes that Red has an unusually high body temperature when they shake hands.
- What happens when you piss off someone upgraded with Extremis in Iron Man 3. (Volcanic Ghost Chili level)
- The Assblasters from Tremors. As their name indicate, they fart fire to fly in a rocket-like manner.
- Inversion: it's implied in Frozen that Elsa's body temperature is colder than the average person's.
- Werewolves in Twilight. (Perhaps that's why they so rarely wear shirts.)
- The Marat in Codex Alera are slightly warmer than humans. This is important in the first book, when one is trying to sneak into a forest guarded by creatures who see in infrared.
- Sauron himself in The Lord of the Rings. The reason why his ring was glowing on his hand was because he was inhumanly hot.
- Invoked in The Sookie Stackhouse Mysteries (books that were the basis for True Blood); werewolves and other shifters are mentioned several times time as "running hotter" than their human counterparts.
- The "vampires" of I Am Legend are humans with a disease that (among other things) sends the body into overdrive. They run a fever of about 103 Fahrenheit as a baseline.
- Dragons of A Song of Ice and Fire do this. In fact, wound them and leave the weapon behind, and it may start to glow with the heat depending on how high quality the iron or steel is. Bronze and copper are likely to fare worse and could well start to turn molten if left too long (and goodness knows if they can give the poor dragon blood poisoning or not). Good luck trying to play vet, though.
- Simes in Sime Gen have a body temperature noticeably higher then that of Gens and children. This incidentally means they don't get sick as often as many germs can't tolerate the higher temperature.
- In a novel based on Magic: The Gathering, a Black-aligned vampire is set to fight a Red-aligned Geomancer in arena-style combat. The vampire manages to evade the torrents of stone and dirt, sink his fangs into the mage's neck and begins draining him dry... At which point the Geomancer turns his own blood into lava. Cue burning vampire.
- Anyone in Eden Green whose needle symbiote takes over their body completely begins to exhibit elevated body temperature, immediately noticeable to non-infected people.
- True Blood has its Werewolves.
Alcide: We run hot.
- In Farscape, Scarrans are extremely hot, and can project this heat as a weapon. Compare with Sebacceans, who are colder than humans and vulnerable to hot temperatures. Scorpius, being a hybrid of both races, needs cooling rods implanted in his head to survive.
- In the Supernatural Season 4 finale, Sam Winchester was said to have reached body temperature of 150F (65C) when he was killing Lilith, courtesy of the demon blood he was using.
- Foreigner's "Hot-Blooded", with the singer saying he's got "a fever of 103."
- Dungeons & Dragons: Remorhaz - hot enough that nonmagical metal weapons melt on contact and if it swallows you it's game over, instant death, no save, do not pass go, do not collect £200.
- Pathfinder has Xotani, a gigantic worm whose title is The Firebleeder. Dealing too much damage to it in one attack (read: an amount large enough to actually harm it) triggers the equivalent of a flamethrower as burning blood sprays from the wound.
- Warhammer 40,000 has the Avatar of Khaine, which has molten iron running through it's veins. It's also Wreathed in Flames.
- Psionics: The Next Stage in Human Evolution features a somewhat realistic example of how this would play out in real life. The pyrokinetic ability Temper, Temper, Temperature can be used to raise the body temperature of living things. Raise it enough and they'll die from boiling in their own skin.
- Many Fire-typed Pokémon are described as having a flame-producing sac or other such organs in their bodies. Some Pokémon like Magcargo and Heatran literally have magma for blood.
- The Ax-Crazy bioweapon Alexia Ashford from Resident Evil – Code: Veronica's main method of attack is slinging her blood at her foes, which combusts on contact with the air. Another host of T-Veronica, Manuela Hidalgo shows these same powers, though she's not nearly as evil as Alexia. It can be assumed that the fire-based attacks of her father Javier's V-Complex form run on the same principal as well, as they spring from Veronica too.
- The various Mutons in Xcom Enemy Unknown and Xcom 2 are noted to have bodies that remain warm hours after their deaths. Dr.Tygan mentions this makes them quite disconcerting to dissect.
- The whiptail lizard has an average body temperature at 106 Fahrenheit (Roughly 41.11 Celsius).
- The hotheaded naked ice borer, a cryptozoological animal invented for an April Fool's hoax.
- Canines in real life have normal body temperatures that are slightly higher than a human's, which may or may not have anything to do with werewolves usually having high body temperatures too. This is mostly true for most small warm-blooded animals. Mostly due to the Square/Cube Law.