There was a commercial that had a woman do "EEK a Mouse!" bit and her husband hunts the mouse down but before he can dispatch it the wife see the mouse cornered and now it's a cute little mousey and she stops him. End of commercial has couple cuddling on the couch and mouse in a cage running on a wheel.
This Samsung Infuse commercial, only with the image of a large spider.
A cheese advert in New Zealand in the early 1990s featured local celebrity Lana Coc-Kroft in this situation. She finds a wedge of Gouda cheese to ward off the mouse, only to frown and pause for a moment before eating it herself. Oops.
Used for a second in the last episode of Gakuen Alice, where Hotaru uses a gang of robot mice to keep two Girly Girl classmates at bay.
In Hayate the Combat Butler, Maria is scared of cockroaches (they even have a nickname within the story so they can be talked about around her). Shiranui brings one into the house and she shrieks standing on Hayate until he apparently shoos the kitten away. Still trying to figure out how he did anything with her standing on him like that.
In Saber Marionette J, in order to make the marionette robots as much like (stereotypical) women as possible, every one of them is programmed to be afraid of mice — except the tomboyish Lime, who merely finds them cute.
Kekkaishi had Tokine perform this trope, right after fighting a much bigger rodent that could breathe fire. She and her grandmother also have a similarly disproportionate fear of cockroaches.
In the Gundam SEEDVisual NovelTomo to Kimi to Senjou de, Athrun decides to make a robot pet for his crush Cagalli. He ends up giving it a hamster design, but when she first sees it she has this reaction and smashes it. Kira steps in and explains, and Cagalli is both very touched by the gesture and very apologetic for destroying it.
InuYasha: Kagome can handle youkai, blood, guts, wounds, two-timing boyfriends, time-travel, saving the world while trying to pass exams, lifting the spirits of the depressed, downtrodden and bullied and can even befriend the reclusive, the painfully shy, and aggressively hostile, but ask her to help a giant beast-faced hanyou in his herb garden when there's an earthworm in plain sight and she'll fall to pieces.
In Dragon Ball, Goku is fighting General Blue of the Red Ribbon Army. Blue has Goku paralyzed with telekinesis, and is about to finish him off...when a small mouse appears. Blue flips his lid, freaks out, and loses focus. Goku is grateful enough for the unwitting save that he rescues the mouse when the cave they're fighting in collapses.
This once happened in Archie when Ms. Grundy jumped on her desk and Jughead took a picture of it for the school newspaper. She actually was worried that the picture would be about how scared she was of a little mouse but instead it turned out to be proof the school needed an exterminator.
The protagonist of Jennifer Blood takes advantage of this stereotype in issue 3, when a neighbor who's convinced she's attracted to him has cornered her in a bathroom and exposed himself to her. She doesn't want to ruin her "perfectly ordinary suburban housewife" facade by maiming or killing him, but as someone who moonlights as a brutal Vigilante, that's all she's trained to do. So she starts shrieking about a pretend mouse.
The main plot of the Calvin At Camp episode "Bringing Down the Mouse."
There is a scene in Conan the Destroyer where Grace Jones' character, who up until now has been afraid of nothing, taking on whole villages and men much larger than her in combat fearlessly, jumps and screams at the sight of a mouse. When all of her party look back she looks sheepish.
The 1959 movie The Mouse That Roared opens with the Columbia Studios girl-with-torch logo suddenly hiking up her gown and fleeing from a mouse at her feet. (The title is a metaphor for a tiny, innocuous nation that ends up holding the fate of the world in its hands.)
The 1934 film Hollywood Party has a whole roomful of women doing this when one of them sees a mouse. It turns out to be Mickey Mouse.
In She's The Man, Duke and Viola scream and leap on the bed, hugging each other, when a big spider enters their dorm room.
The two female leads in 8 Heads In A Duffel Bag take this kind of behavior Up to Eleven when they find a disembodied head in their luggage during a family vacation. ("Eek, A Head!"?) One shuts herself up in a closet and refuses to come out (until the protagonist jokingly suggests that the dead guy's body might be in there), while the other attacks the protagonist with a fork. The latter is especially hilarious because what causes her to snap is the protagonist innocently asking, "Would you like an enchilada?"
Disney's Bedknobs and Broomsticks has the "mouse frightening an elephant" version. During the animal soccer game on the Island of Naboombu, an alligator uses a mouse to scare the elephant goalkeeper of the opposing team.
Timothy Q. Mouse uses this to his advantage against the cruel female elephants in Dumbo. Sure, those "over-stuffed hay-bags" can be mean to a little elephant with super-huge ears, but facing Timothy? They're scared to near-stampeding!
During the Wizard's Duel in The Sword in the Stone, Madame Mim turns into an elephant, and Merlin counters by turning into a mouse, scaring her.
Journey Back To Oz has the returned Dorothy scaring off Witch Mombi's elephant army with a herd of magical white mice.
Moscow — Cassiopeia has a rare male example. Lob tears through the entire ship and ends up accidentally causing it to travel faster than light all because of a mouse. May be justified, as the window was blown up and made tiny Pacnuty seem like a giant monster.
In one scene in Willow, a woman shrieks at the sight of mouse-sized humanoid creatures called brownies.
Invoked by Becky in the Alfonso Cuaron version of A Little Princess. As the students are stealing Sarah's locket from Miss Minchin's office, Becky screams to distract Minchin and eventually stammers that she thought she saw a mouse.
In The Marvelous Land of Oz, Scarecrow and his friends enter his palace (taken by rebels), and are captured immediately, to be brought before their leader. However: 1) the rebels are all women and 2) Scarecrow has recently met the Queen of the Field Mice and asked for permission to take a few of her subjects along.
In The Witches Bruno's mother flips into hysterics when the witches start turning into mice thanks to drinking their own potion. She literally climbs over her husband screaming about them climbing up her skirt. Although in this case it's completely understandable since there are over a hundred of them running around.
In one of the Clue mystery books, Mr. Boddy reveals that several white mice have escaped. The first one to actually do this trope is the duel-crazy Colonel Mustard, but the other guests don't laugh because they're doing the same thing.
The non-fiction book that inspired Homicide: Life on the Street mentions that one of the detectives had been called home by his wife to deal with a rampaging mouse. "I disposed of the body, but considered leaving it as an example to others."
Happens in a Doctor Dolittle story: A smaller African kingdom is warred upon by a bigger, expansionist one, whose crack troops are Amazons. The White Mouse who lives in Dolittle's pocket points out that while they are fearsome warriors, the Amazons are still women, and gather a force of local mice who scares them away.
Played with and justified in the last Hawk & Fisher story, where a crime lord keeps a bunch of naked Amazons as bodyguards. Rather than fight them, Hawk and Fisher turn a sackful of ravenous sewer rats loose in the crime lord's lair, and the bodyguards start climbing the furniture in a panic when the starving rodents swarm them to bite their bare toes.
In Mousenet, this is part of the "EEEK Test," a test used by mice to gauge a humans' feelings towards mice. Jumping on a chair results in a "Loud EEEK" and a grade of C, with fainting being the worst possible response and earning an F. Talking to or touching the mouse is "No EEEK" and an A+.
Miss Murchison: No. In your days I suppose all women were afraid of mice.
Mr Pond: Yes, they were, but then, of course, their garments were longer.
Miss Murchison: Rotten for them.
The Bronze Horseman by Paullina Simons. Alexander is rather bemused when his young wife Tatiana has this reaction, as he's seen her brave 500-kg bombs, cannibals and starvation in the Siege of Leningrad.
Live Action TV
The Three's Company episode "The Best Laid Plans" revolved a mouse being loose in the trio's apartment, with Janet being the mouseophobic one.
Spinoff the The Ropers featured a gender-flipped version of this trope: it was Mr. Brooks, not his wife, who leaped up onto the couch screaming at the sight of a white mouse—safely in a cage, no less.
Justified in the episode when it was a venomous snake that was loose in the room.
Played with on Hope And Faith: when the two title characters get office jobs together, the ever-immature Faith dangles her computer mouse into Hope's cubicle and yells this trope name.
Used in an episode of the Adam West version of Batman; villainess Nora Clavicle manipulates Gotham City into hiring only women police officers, then unleashes an army of tiny mechanical mice. At least Batgirl remains "immune".
Referenced in The Goodies episode "Kitten Kong", where a housekeeper (suspiciously similar to the one in Tom and Jerry, we even hear her shouting for "Thomas") jumps on the table and shrieks at the sight of the team dressed as mice.
Also referenced (and inverted) in Punky Business when a mouse trying to assure Tim that he is ugly tells him that when he walks into a room all the mice jump onto a chair.
On Imagination Movers, Knit Knots wasn't scared by Warehouse Mouse to the point of panic, but did urge the Movers to keep the "woodland creature" away from him. An episode of the show also focused on the Movers helping a TV repairman to get over his fear of mice, so that he could stick around to fix their TV and not be afraid of Warehouse Mouse.
An amusing variant happened on Xena: Warrior Princess. Gabrielle (not quite an Action Girl yet) was hiding from some bad guys when she noticed a rat crawling about. She had to remain perfectly still and silent lest she blew her cover, and Hilarity Ensues as she stares at it with wide eyes and covers her mouth before a whimper comes out.
Double-subverted on an episode of Unhappily Ever After. Ryan, who believes the old legend that the Earth would spin out of its orbit if all the Chinese people in the world jumped off their chairs at the same time, panics when he spies a group of Chinese exchange students standing on their chairs in the school cafeteria. One of the students explains that they had just seen a mouse, causing Ryan to calm down. Once Ryan is gone, though, the student gets angry and mutters: "Curses! They're onto us!"
The late 80s sitcom Kate And Allie spent an entire episode dealing with a mouse, complete with jumping on chairs and tables in fright(Allie's son Chip was taking care of his classroom's pet mouse and it got out of its cage). Subverted in that 1) they realized that they were behaving like 60s sitcom housewives, 2) Kate and Allie were running a catering business at the time and were justifiably concerned about mice on the premises, and 3) Allie's sportscaster boyfriend also turned out to be deathly afraid of mice.
As mentioned in Real Life below, the "Elephants are afraid of mice" variant was tested by the MythBusters, who were stunned when the elephant actually stopped dead in its tracks at the sight of the mouse, and gave it a wide berth when walking around it, rendering the myth plausible.
When testing the effects of mood on gas consumption, Grant was forced to drive a course while a pair of mice were allowed to run loose inside the car; his reaction screamed this trope.
A late episode of El Chavo del ocho has Doña Florinda's restaurant plagued by mice. She and Chilindrina exhibit the expected reaction throughout, especially in a hilarious scene where Chavo unknowinlgy brushes the latter's leg with the broom he is using to hunt the mouse; she has an absolute panic attack, thinking it's the mouse climbing up her leg.
In the Mexican Soap OperaCarrusel, Pablo releases a mouse in the middle of class. All but one of the girls start screaming and crying. The one girl who isn't scared, Valeria, "punishes" Pablo by pretending to pass out and tricking him into believing she had a heart attack.
Pan Am has Laura reacting this way to the appearance of a lizard in her hotel room in Rangoon, as she jumps on her bed to get away. Maggie calmly appears to pick it up and put it outside then joins Laura on the bed shrieking upon discovering a snake in the bathroom.
Averted in the premiere episode of Buffy the Vampire Slayer. The heroine doesn't even twitch when a sewer rat runs over her foot.
And subverted in its spin-off Angel when Gunn and Wesley freak out over a rat and Cordelia is the one to get up and deal with it.
On a late 1960s episode of The Tonight Show, Johnny Carson freaks and jumps into Ed McMahon's arms after a cheetah cub hisses at him.
Jane on The Mentalist once escaped from jail by scaring a rodent-phobic guard with a live mouse he'd caught.
Exploited in The Worst Witch when Helibore and Rowan-Webb have a wizard duel (no not like that one). Helibore turns Ethel into a goose girl and Rowan-Webb counters by turning himself into a mouse to scare her.
In the 1990's Australian mini-series Phoenix, the only female member of the Major Crimes Division is mocked by her sergeant when she has a fender-bender accident after a spider drops out of the sun visor in front of her. At the end of the episode, he hands her a can of bug spray and declares he's not going near that car until "that horrible monster" has been killed.
Happens with Alice on The Brady Bunch when a pet mouse gets loose. Although, it's averted another time-she hands it to the boys and isn't scared.
Dollhouse. At the start of Season 2, a pissed-off Dr Saunders puts lab rats in Topher's cupboard, in a not-too-subtle message of what she thinks of him. His female assistant Ivy has to retrieve them while Topher climbs the nearest railing to get away.
Danger: UXB. A sapper screams when he encounters a rat, just when Lieutenant Ash is about to defuse a bomb designed to blow up at the slightest touch. He's not impressed.
Played with in one Garfield strip, where Garfield screams and scurries up onto Jon's head upon seeing a mouse - and Jon is disgusted, because Garfield is a cat.
Calvin and Hobbes: Calvin once tried to gross out Hobbes by telling him he had a loathsome bug hidden in his hands. When Hobbes asked if it was a centipede with poison pincers, Calvin did an Oh Crap, dropped the bug, and jumped into Hobbes's arms, declaring: "It's a lucky thing you guessed so fast!"
Religion and Mythology
According to one of the stories about the Chinese calendar, the reason why the rat is the first in the list instead of the ox is this trope. The people were shown the ox and the rat, and only the rat was called "huge". Well, if it's bigger, then it should be first.
A Challenge of Arms had a mastodon that was afraid of mice.
Ellie in Donkey Kong Country 3 is an elephant who rapidly runs away from any Sneeks (basically rats) that she sees. One level requires the player to either dispatch the Sneeks from a distance or in the dark (apparently, she doesn't mind if she can only barely see them), and another features her running madly away from a trio of Sneeks, with the player only able to control her jumping until she settles down.
Also quite funnily used in the 101% ending of Donkey Kong 64, where Dogadon (aka the huge dragon who's fought twice in the game) is scared of a tiny mouse squeaking. Well, among various other jokey scenes, as seen here
Mongoria from Comix Zone, an otherwise extremely formidable enemy, had this as her weakness.
Elh from Solatorobo absolutely hates bugs and insists that Red kill them as quickly as possible when you come upon them (which is a good idea, since the bugs attack you like most everything else in video games). There are also twoProtection Missions in which the goal is just "don't let the bugs get near Elh" (this includes if you accidentally throw a bug across the line, because apparently even a dead bug is creepy).
Played with for a laugh in Final Fantasy IX. Incognito princess Garnet picks up an oglop (a beetle-like insect), having no problem with the little critter whatsoever. However, since she's supposed to be undercover as a normal country girl, when an old woman comments that most girls hate them, she squeals theatrically and flings it into the air.
Can be invoked for rewards in the PS2 release of The Bard's Tale, by summoning and dismissing the rat in bars. In fact, this is how the eponymous Bard starts the game.
Frog in Chrono Trigger manages to frighten Lucca when they first meet. Later, if Marle is in the party when Crono and Lucca see him off from Guardia Castle, he'll approach Marle to comment on her resemblence to Leene, prompting her to shriek.
In Brain Lord, Ferris screams her head off when she encounters a room full of mice in the Tower of Light.
Often Florida wildlife will invade the live webcast of The Funday Pawpet Show, leading Ezra to envoke this trope, while Mutt commands the show's border collie to "Eat it, Bandit! Eat it eat it eat it!"
Referenced in South Park episode "Eek, A Penis!" where a mouse frightened women with a genetically engineered human penis growing on its back. Actually they were frightened by the penis. But the trope still stands.
Monterey Jack actually uses this trope in the Chip 'n Dale Rescue Rangers episode "The Carpetsnaggers" to chase humans from one side of a flying house to the other to prevent it from hitting any buildings.
Including a short where the "Eeker" was Tom's cowardly identical cousin.
The Elephant variation is averted in one episode where Jerry befriends a baby elephant, then disguises it as a giant mouse.
Averted in one episode when the lady who owns Tom buys a pet white mouse.
Played straight and then subverted in an episode of Tom and Jerry where during the usual chase, Jerry stumbles on a circus elephant weeping from a tack stuck under its foot. Jerry removes the tack and the elephant panics, afraid of Jerry (as he is a mouse), desperately trying to hit him with Tom (who happened to be there at that moment) like a drum on a stool. Jerry shows the female elephant the tack and, in Androcles Lion fashion, hugs Jerry in appreciation. From then on, she treats Jerry like her own child, protecting him from a persistent Tom in addition to giving the cat a good beating.
In one short, a mouse mocks the way the housewife panics.
Also played with in the Ren and Stimpy short "The Boy Who Cried Rat", in which Ren impersonates a rodent so Stimpy can earn his keep by catching him.
The Dog's reaction to rats in Foot Rot Flats. The cat, Horse, has the opposite reaction.
In the premier episode of Courage the Cowardly Dog, Courage was afraid of a mouse in the beginning. Muriel plucks the little rodent and sets it loose outdoors. But after the battle with The Chicken From Outer Space, we see Courage looking at it again as it fed on the ashes of the fallen fowl. The mouse's eyes turn bright red as a result. It was a Justified Trope as Courage screams in terror.
Courage: This shouldn't happen to a dog!
Bella from Fireman Sam often freaks on seeing mice, regardless as to whether they're real or clockwork ones.
In the special Toot and Puddle: I'll Be Home for Christmas, the boarding of Toot's train home is delayed by an elephant who doesn't want to be left alone in jumbo class. He's afraid that a mouse might sneak in. When Toot expresses disbelief that a big guy like him would be terrified by a small mouse, the elephant responds "What can I say? It's genetic." Toot agrees to ride with him to watch for mice.
Subverted in The Simpsons at Apu's wedding. When a mouse runs out in the the elephant's path, the elephant recoils for a moment... and then proceeds to deliberately step on it.
Taken to ridiculous lengths in an episode of The Powerpuff Girls where a rivaling villain reanimates a mammoth (which appears as comically large as any city destroying monster) to cause destruction in Townsville. To stop it, Mojo-jojo instructs the girls to leave a large hunk of cheese to attract the town's mice and scare the mammoth off. And you know what? It works!
The main villain of the second half of Disney's Goliath II is a mouse in which only the titular elephant can get rid of.
Tex Avery, naturally, built an entire cartoon out of this trope. "Slap Happy Lion" has a mouse scaring a much-feared lion simply by saying "Boo!" at him. The cartoon ends with the mouse being scared by a much smaller mouse.
The narrator of that cartoon- a mouse- even wonders why anyone would fear a mouse.
Stu from Rugrats has a moment like this when he discovers the thing wrecking his garage wasn't a rowdy Spike, but a mouse. He even apologizes to his dog when he "saves" the day by chasing it away with a bark.
When Captain Fanzone winds up on Cybertron in Transformers Animated, this is basically the Transformers' response.
In the silent Krazy Kat cartoon "Krazy Kat and Ignatz Mouse at the Circus", Ignatz knowingly employs this trope this to scare a woman in the circus dressing room. When Krazy tries it himself, he gets hit with a broom.
In Cinderella III: A Twist In Time, Jaq and Gus help Cinderella get into the palace by scaring the kitchen servants while Cinderella poses as the "royal mousecatcher".
Who Killed Who? has a ghost who scares the protagonist, laughs, then promptly gets scared of a tiny mouse, in the classic housewife way.
Wild West COW Boys Of Moo Mesa: When a circus arrived in town, Mayor Bulloney tried to use a mouse to scare an elephant so the resulting distraction would allow Saddlesore and Boothill to steal a diamond.
While elephants don't typically leap onto small objects at the sight of a mouse, research has provided a possible reason for the elephant's fear of mice: an elephant's eyes are located on its head in approximately the same position as a human's ears — add this to the elephant's large body, (relatively) poor eyesight, and sensitive hearing, and what the elephant sees turns from a small, furry rodent into a small, barely-visible, blurry and mostly-unidentifiable squeaking blob somewhere near its feet. It was tested by the Mythbusters. Myth Plausible.
If a mouse is brought close and shown to an elephant, however, it's generally not alarmed in the slightest, and may even lift the rodent in its trunk for a better view. The reality may be that elephants are wary of any small moving critter on the ground, just in case it turns out to be something a lot nastier than a mouse (e.g. a scorpion or coiled-up cobra).
Semi real-life, with another type of vermin rather than a mouse: The late X Japan guitarist Hide and the drummer/bandleader Yoshiki were/are both terrified of cockroaches. One story has it that when the band members were in Los Angeles for the first time, a roach had gotten into the room hide and Yoshiki shared. This trope ensued with both, according to the story, jumping up onto the bed and shrieking until it was finally agreed that someone had to kill the roach, and depending on who's telling the story, either Hide or Yoshiki finally did.
Psychologists who studied the Eek, a Mouse!! phenomenon concluded that it's not the mouse itself which the typical distressed housewife is afraid of, but her awareness that she'll probably have to kill the animal to remove it from her residence. The mouse is harmless, killing is Squicky.
Besides, as humans have co-evolved with mice ever since the dawn of agriculture, screaming, shouting and stamping if a mouse enters your kitchen is a moderately sound response- perfectly sensible for a woman to aggressively protect her food-store by trying to frighten away small invaders.
In the nonfiction book Retail Hell: How I sold my soul to the store, this happened in the "Big Fancy" store when someone returned a product to the handbag department that had a huge Cockroach in it. Naturally; this trope ensues and Freeman is told to kill it as the sole male working the department.
In Real Life, there's very good reason to be afraid of mice. House mice in particular can carry deadly diseases and there have been reports of ones growing so large they attack albatross chicks nearly one meter tall. In addition, in 1993, Australia was beset by one of the most devastating mouse plagues in the world; mice began eating the livestock alive.
Inverted with mice and rats as pets, which are far more popular with women than men. This was even so in Victorian times, where some upper-class young ladies would keep them almost like toy dogs.
Actress Jaimie Alexander has admitted that, while she has no problem with things like snakes or spiders, she is terrified of mice. You read that right - The warrior goddess Sif is afraid of mice.
In the pregame of the Florida Panthers's home opener in 1995, a mouse entered the Panthers locker room and startled the players. One of them hit the animal with his stick. Given in that same game he scored two of the goals in the 4-3 victory, Panthers fans embraced the rat theme with pleasure, including throwing plastic mice into the ice every time a goal was scored (nowadays doing that after every goal becomes a two-minute delay-of-game penalty on the Panthers, something which is of major concern for the Panthers if unscrupulous fans of the opposing team toss a rat onto the ice to try to snag a cheap power play).
While "camel spiders" (which aren't spiders) are not actually very dangerous, there's a lot of misinformation out there about them, most of which makes them sound scarier than they are. Freaking out is predictable if you think something can literally gouge out chunks of your flesh.
Special effects legend turned actor Tom Savini is terrified of cockroaches. When he was working on Creepshow, specifically the segment "They're Creeping Up on You", one of the cockroaches touched his ankle. Savini has no memory of actually crossing the room, but he ended up on the other side of it.
Akira Toriyama, creator of Dr Slump and Dragon Ball, has an intense fear of mice, such that when his work suffered when his workplace had an infestation, since he was too scared to step inside.