He is best known for his dual role as George Bluth Sr. and his twin brother Oscar on the Cult Classic sitcom Arrested Development. He is also well-known for portraying Hank Kingsley on The Larry Sanders Show and for his Emmy-winning performance as the transgender Maura Pfefferman on Amazon's original series Transparent. He was a regular during the Tom Bergeron hosted run of The Hollywood Squares and served as The Announcer for its first season as H2.
In November of 2017, Tambor left Transparent after several women came forward accusing him of sexual harassment. Since then, his acting career has slowed down significantly.
Selected filmography:
- ...And Justice for All (1979): Jay Porter
- The Ropers (1979-80): Jeffrey P. Brookes III
- Saturday the 14th (1981): Waldemar
- Hill Street Blues (1981-87): Judge Alan Wachtel
- Mr. Mom (1983): Jinx Latham
- The Man Who Wasn't There (1983): Boris Potemkin
- The Twilight Zone (1985) (1985-87): Kyle Montgomery/Milton Baumsey
- Three O'Clock High (1987): Mr. Rice
- Max Headroom (1987-88): Murray Mckenzie
- Brenda Starr (1989): Vladimir
- Lisa (1990): Mr. Marks
- City Slickers (1991): Lou
- Life Stinks (1991): Vance Crasswell
- Article 99 (1992): Dr. Leo Krutz
- The Larry Sanders Show (1992-98): Hank Kingsley
- The Radioland Murders (1994): Walt Whalen, Jr.
- Heavyweights (1995): Maury Garner
- My Teacher's Wife (1995): Jack Boomer
- Big Bully (1996): Art Lundstrum
- The Twisted Tales of Felix the Cat (1996): Oscar in Phoney Phelix.
- Dr. Dolittle (1998): Dr. Fish
- There's Something About Mary (1998): Sully
- Meet Joe Black (1998): Quince
- Muppets from Space (1999): K. Edgar Singer
- Teaching Mrs. Tingle (1999): Spanky Winchell
- Girl, Interrupted (1999): Dr. Melvin Potts
- Pollock (2000): Clement Greenberg
- How the Grinch Stole Christmas (2000): Mayor Augustus Maywho
- Eloise at the Plaza and Eloise At Christmastime (2003): Mr. Salomone
- Arrested Development (2003-06; 2013; 2018-19): George Bluth, Sr; Oscar Bluth
- Hellboy (2004) and Hellboy II: The Golden Army (2008): Tom Manning
- The SpongeBob SquarePants Movie (2004): King Neptune
- The Muppets' Wizard of Oz (2005): Wizard of Oz
- WordGirl (2007-15): Mr. Big
- Super Sleuth Christmas Movie (2007): Santa Claus
- Welcome To The Captain (2008): Saul Fish
- Leisure Suit Larry: Box Office Bust (2009): Larry Laffer
- Monsters vs. Aliens (2009): Carl Murphy
- The Hangover trilogy (2009-13): Sid Garner
- Paul (2011): Adam Shadowchild
- Mr. Popper's Penguins (2011): Mr. Gremmins
- Archer (2010-11): Torvald Utne; Len Trexler
- Transparent (2014-17): Maura Pfefferman
- Star vs. the Forces of Evil (2015-18): Glossaryck (replaced by Keith David)
- The Accountant (2016): Francis Silverberg
- Trolls (2016): King Peppy (replaced by Walt Dorhn)
- Tangled: The Series (2017): Big Nose
- The Death of Stalin (2017): Georgy Malenkov
- Magic Camp (2020): Roy Preston
