Drugs & Wires has a relatively small but well rounded cast.
Dan - Screen-name: The Escapist
Misanthropic to a shocking degree, Dan nonetheless has a strange pull on other people, and makes friends easily much to his dismay.
- Addiction Displacement: He was always addicted to drugs, but his primary addiction was to Dream Space. Now that he can't use Dream Space, the drug abuse has gotten worse.
- The Aloner: Prefers to mope alone. Lin has to practically drag him to social events.
- Cybernetics Eat Your Soul: An interesting variety. He channeled so much of his emotional creativity into his VR trips that when he became barred from Dreamspace, he became an emotional wreck who turned to drugs to replicate the trips.
- Deadpan Snarker: Appears to be his defense mechanism.
- Dull Eyes of Unhappiness: Constantly.
- Expy: Of Case from Neuromancer. He is much more of a mess though, which is impressive considering that Case was already a huge mess. Lampshaded by Lin here.
- Functional Addict: Inverted. Dan is only a functioning member of society when he's high. When sober, he just kind of mopes about.
- Misanthrope Supreme: Not that it's hard to blame the guy, considering half his country wants him dead.
- Mushroom Samba: Suffers from repeated bouts of extremely disturbing flashbacks and hallucinations even when he's sober.
- Riches to Rags: Implied to be his backstory.
- The Stoic: Not the "unflappable" variety, but the "emotional burnout" variety.
Responsible for saving Dan's life from the skullfuck.exe virus that nearly fried his brain, Lin is one of the few people Dan can truly rely on as he tries to figure out who wanted him dead.
- Ax-Crazy: In a barely-contained cheery sort of way.
- Back-Alley Doctor: A mildly psychotic dropout from med school who runs an unlicensed cyborg clinic. The hygiene and ethics of the "Kutting Edge Klinik" are exactly as dreary as you'd expect.
- Covert Pervert: She doesn't talk about it much, or at least with Dan, but her character bio reveals pornography is one of her top five favorite things.
- Expy: Definitely takes inspiration from Molly from Neuromancer, though she's much less blatant than Dan. For one, she's a surgeon instead of a Street Samurai, and her personality is somewhat different.
- Hollywood Cyborg: Has scalpels built into her fingertips and what appears to be a microscope for a left eye.
- Labcoat of Science and Medicine: Or in her case, a Labcoat of Mad Science and Unethical Medicine. Complete with High Collar of Doom.
- Mad Scientist: Treats her patients (except Dan) as test beds for dangerous and dirt cheap cyber implants and surgery techniques. If she accidentally cures them in the process then its just icing on the cake.
- Meatgrinder Surgery: Uses tools such as fish hooks, cattle prods and her bare hands in her surgeries, and she's never even heard of anesthetics. At one point she eats Chinese takeout over a patient's open chest cavity, and accidentally drops in a forkful of noodles.
- Occidental Otaku: Her favorite type of pornography is hentai.
- Odd Couple: Dan and Lin's only real common ground seems to be general misanthropy and a love of tech. They've made the friendship work somehow.
- Platonic Life-Partners: With Dan. They have no romantic chemistry, and while they may fight a lot, they clearly care a lot about each other.
- Playing with Syringes: Surgery is mostly just an excuse for Lin to try out various implants on her patients that they don't even need.
- Wolverine Claws: Keeps a lot of sharp surgical instruments in her hands.
Vlad Adsky - Screen-name: 666_Satan_666
- Badass Longcoat: Say what you will about him, he really does rock that leather trenchcoat.
- The Friend Nobody Likes: His public renown (and infamy) allows him to host rather large parties, during which most of the guests try to stay as far away from him as possible.
- Hollywood Satanism: Deliberately cultivates this image. Dan describes his style as "discount LaVey".
- It's All About Me: According to Eve, he's the most obvious case of NPD she's ever seen.
- Large Ham: Obnoxiously melodramatic and tends to veer poetic, in a pretentious way.
- Mad Artist: Considers himself a renaissance man and artistic genius. In reality, most of his VR "artworks" are barely-playable, edgy pieces of soft porn with an obvious Self-Insert of himself as the player character.
- Small Name, Big Ego: His only claim to fame is authoring several VR trips which are widely ridiculed across the mindtripper scene. That does not stop him from having an ego the size of Australia.
Eve - Screen-name: Eve
- Amicable Exes: Downplayed. While she's still not comfortable with the idea of getting back together with Dan, she's quite friendly to him and willing to talk out his issues.
- Everyone Has Standards: She's very patient in general, but eventually even she couldn't deal with Dan's repeated drug abuse anymore.
- Morality Chain: Used to be this for Dan until their falling-out.
- Shaped Like Itself: Her screen name is just her own real name.
- Token Good Teammate: Seems to be one of the few genuinely good, altruistic people in the comic.
Nate - Screen-name: Cybernator
- Child Prodigy: He's been hacking since he was a kid. At the start of the story, he's still not even 18 yet is one of the most accomplished operators in the scene.
- Insufferable Genius: He is genuinely gifted with technology, and he won't forget to remind you of that.
- Teeth-Clenched Teamwork: With Dan in the backstory, back when Dan could still use Dream Space and they went on operations together. Nate hated Dan's downer-misanthrope attitude, Dan hated Nate's cockiness. They still managed to work together to become two of the most respected operators in the scene.
Mira - Screen-name: Terminatrixx
- Everyone Has Standards: Not even she will give Vlad the time of day.
- High-Class Call Girl: Works as a dominatrix-for-hire for rich tourists looking for the forbidden trips they can't get at home.
- Good Bad Girl: Seems to be concerned for Dan's wellbeing as she objects to continuing Fixer's attempts to restart his implants when it's obvious it's hurting him.
- Skunk Stripe: Rocks the look.
Fixer - Screen-name: Fixer242
- The Big Guy: Towers over most everyone in the cast.
- Everyone Calls Him "Barkeep": Never called anything else than Fixer.
- Gadgeteer Genius: Fixing and tweaking VR equipment is his business, and he's damn good at it.
- Mr. Fixit: If you need something repaired, he's the man to visit.
- New-Age Retro Hippie: Inexplicably fascinated with the 60s beat scene, and even makes trips themed around it. Nate thinks they suck.
- Cloud Cuckoo Lander: Hooo boy. She barely seems to register her environment.
- Crazy Homeless People: She dresses like a bum and lives in a half-ruined building scheduled for demolition. She's also quite crazy.
- Creepy Shadowed Undereyes
- I See Dead People: At least she thinks she does. She's convinced that Dan is actually a ghost who hasn't found peace.
- New-Age Retro Hippie: Aside from VR and heroin, she also seems to be into New Age faiths and various paraphernalia of unrelated pagan and folk religions are strewn across her apartment.
- The Nicknamer: Consistently refers to Dan as "Pale Rider".
- The Ophelia: Deconstructed. Her "pretty insanity" is actually the result of a debilitating addiction to heroin and VR, and it's not pretty at all.
- Beware the Silly Ones: "Do not scorn your dealer" still stands even if your dealer is a jive-talking clown, as Dan painfully learns.
- Foreign Culture Fetish: Obsessed with Western pop culture.
- Jive Turkey: Talks in a mishmash of painfully forced street slang.
- The Nicknamer: Makes a sport of coming up with new punny nicknames for Dan related to the letter D.
- Pretty Fly for a White Guy: He's the whitest kid to ever live, but he tries so hard to appear "gangsta".
- Spoiled Brat: Apparently his parents pay for all his bling.
- Good Ol' Boy: Basically the Eastern European equivalent of a redneck.
- The Pigpen: He is unbelievably filthy.
- The Slacker: Leaves the actual work to Dan whenever he can while he goes to kidnap dogs or get drunk.
- Bad Boss: Working under her is extremely unpleasant.
- Corrupt Corporate Executive: Ruthlessly utilitarian, exploitative and treats her employees like factory equipment.
- Deadpan Snarker: For all her reprehensible qualities, she has some excellent snark.
- Today isn't your daddy's cushy little factory floor in Cowpat, Nebraska. Today is cyber-factories in Indochina pushing out goods in 18-hour shifts. "Made in America"? Cute. There's AI-driven lines in the heart of Seoul that'll crank out 50 tractors in the time it takes for you to finish a long shit.
- Electronic Eyes: She has cybernetic eye implants which give her black sclera and glowing irises which change color based on her mood. Usually, they're red.
- Meaningful Name: Hope-Fokker.