Ophelia (duh) from Claymore, who became obsessed with getting revenge on her brother's murderer (Priscilla). Her polite exterior disappears real fast when people interrupt her.. fun. Her death scene after turning into a snake-like awakened being naturally occurred in a lake with her usually-braided hair flowing freely around her.
The Ergo Proxy episode named "Ophelia" (duh) contains liberal amounts of symbolism referencing the titular Shakespearian character. This includes the lead female character's doppelganger floating in a lake and pulling the famous pose.
Sunako in The Wallflower when she's out of her chibi form. She's creepy but still downright gorgeous. Because she is often acting truly dhsieveld and insane, she might be closer to a Deconstruction
Kotori Monou became one in X1999, after seeing her mother Saya die as a little girl. She apparently recovered her mind, but some years later she turned into one full-time when seeing Kamui's aunt Tokiko die in the same way, and spends some time carting around the poor woman's severed head. And then soon after, she dies! And at the hands of her Face Heel Turned older brother! The poor girl can't catch a break...
Subverted in the Tv series. Kotori does shows some signs of this trope when Tokiko dies, but unlike in the manga she falls in a coma. Her subconscious is still active and sorta stable, however, and she begins to use her Dream Weaver powers instead of going crazy.
A darker version is Seishirou's mother Setsuka, the previous Sakurazukamori. In the CD dramas she often spoke about things that looked like nonsense, then counteracted with something quite unsettling and did so with a smile.
SETSUKA (has an ikebana arrangement): Camellias. Red camellias.
SEISHIROU: Your favorite flower.
SETSUKA: I love it. I love camellias best when they fall (gets a dreamy look) It falls on the ground.... plop, like a human head. I love it.
Dilandau from The Vision of Escaflowne eventually dissolves into a male version of this as his mental stability shatters from a variety of influences. Given that he started the series as an Axe CrazyPsycho for Hire, that's saying quite a lot. And then you find out that he actually started out as a girl.
Charlotte from Rose of Versailles, after she cracks from the pressure on her and right before she commits suicide.
Diva from Blood+, who also happens to be the Big Bad. A good example is a scene when we see her giggling, dancing and prancing around in a cute and very princessy gown, with her hair down and lacking footwear... and then she captures her twin sister and rival Saya and almost kills her.
Princess Emeraude in the Magic Knight Rayearth OVA's. How gone is she? So much that she barely realises that Zagato has died, and throws herself at the feet of the throne where his corpse sits
Also, Alcyone in the second part of the TV series zig-zags between Empty Shell and this trope. When she is captured by Cephiro after having become the Brainwashed and Crazy minion of Debonair, the poor woman is seen despondent and quiet, only reacting at the sight of Lantis — and that's because she's so far gone that she thinks Lantis is Zagato.
An Ax-Crazy and openly villainous version is Crimson Miroku from the Sakura Wars TV series. After Sumire kills her and Satan Aoi brings her Back from the Dead, she appears in front of the main cast with her clothes loose, her long hair down, and only being able to speak a Madness Mantra: " Sumire, Sumire... I want your life... I'll take your life..."
Rei Asaka from Oniisama e... has her moments as this, and specially when she's drugged.
Ran Mouri spends a good part of the fourth movie, Captured in her eyes, as one of these due to a bad case of Trauma-Induced Amnesia.
Also, a young woman mentioned in the backstory of the Detectives Koshien arc. More exactly: she was a mentally and emotionally unstable socialite who committed suicide via hanging herself in a room of her Big Fancy House (nicknamed "the Lavender mansion") in an island near Fukuoka. The "young mistress"'s death was wrongfully catalogued as a murder, however, and the main suspect was her young maid, Kana Mizoguchi. Poor Kana also was Driven to Suicide, having jumped off a cliff and into the sea after she couldn't prove her innocence.
In the Kimono Goddess case, we actually get introduced to the episode via a scene in which a beautiful, sad-looking Ophelia throws herself off a building in front of everyone in her women's college. Her name was Sakurako Suzuka, and sheended upthat way after being framed for drug trade by two cruel Alpha Bitches, Ema Anzai and Asuka Shibazaki, who already hated her for being a Wide-Eyed Idealist. Five years later, Ema and Asuka would become the case's Asshole Victims at the hands of Eri, Sakurako's estranged older sister.
Maya Tachibana from the Beautiful Amnesiac Woman case, who has lost her memories due to injuries and acts like a textbook case. Then it's subverted: she's a Dark Action Girl who was hired to kill Kogoro by a dude that got tossed into jail and then escaped, and while her memory loss is genuine at first, she recovers her memories around halfway the episode and then pretends to still be amnesiac so she can corner Kogoro and murder him. Conan barely manages to save Kogoro and then capture her.
The unsettling fate of Mie Iwamoto from Shigurui after a particularly traumatizing incident. Eventually she recovers, but is still deeply disturbed.
Death Note: Misa Amane. Beautiful? check. Insane? check. Puts on pretty dresses and murders people? Definitely.
Sakura Gari features the young and pretty maid from the Saiki household who becomes this after surviving Sakurako's torture/murder of Souma's lovers, but losing the baby of Souma's that she was pregnant with. We meet the girl shortly after Souma attempts to kill himself; she looks pretty but frail and pale in her dark kimono, and attempts to speak to the Saikis and then to Masataka to learn what's going on — but then she catches a glimpse of Sakurako herself and has a massivemeltdown, screaming for a " white-haired demon" that is around the gardens, so the policemen have to calm her down. Considering that she was tied up in Unwilling Suspension manner, gagged, savagely beaten and then photographed while half-naked and still Bound and Gagged, she can't be blamed.
From the manga-only Onisarashi-Hen (Demon Exposing Arc) in Higurashi no Naku Koro ni, Natsumi Kimiyoshi becomes this in the story's epilogue. After failed attempts at living with relatives, later living with Akira Toudou, who married her so she would be able to drop her maiden name and move past her murdering her grandmother and parents, she's consigned to a psychiatric hospital. Though she seems to be doing better, she's actually aware of her crimes, even though Akira is shouldering her guilt for her. By contrast, she was more of a tragic Ophelia with her relatives than after she was moved to the hospital, where she was more of a Madwoman in the Attic.
Several of Junji Ito's characters, particularly the one who killed people and sewed their corpses together. And she was the protagonist's girlfriend too!
Manji's older sister in Blade of the Immortal. When Manji kills her husband without knowing who he is, she crosses the Despair Event Horizon and reverts to a child-like stage. She remains like that until she's murdered in front of her younger brother.
At his most vulnerable, Clair Leonelli from Heat Guy J can seem like a male version of this trope.
The manga by Michiyo AkaishiPrivate Actress gives us the legal wife of Shiho'sDisappeared Dad, Masakazu Ogata, shown as a sickly and sad lady who is often alone at her Big Fancy House. Her son Kyousuke tells Shiho that she is "a little mentally unstable", implied to be a consequence of Ogata's constant womanizing on top of being an Ill Girl. This is confirmed when, after seeing Shiho, Mrs. Ogata tries to kill herself; for worse, when Shiho and Kyosuke try to aid her, she mistakes her for Shiho's mother Sayuri (the better known of Ogata's flings) again and begins to insult and threaten her. (Though she later comes to her senses, realises the mistake and asks Shiho who she actually is.)
Later, in the Boarding School two-parter, Ophelia the character becomes vital to the confrontation between Shiho and the murderous Alpha Bitch Kana Juumonji, who recite Hamlet lines to each other with Kana playing Ophelia so perfectly that she's still reciting her lines as she's taken away by the police, her deceit uncovered. Kana/Satoka actually becomes this towards the end, after Shiho succesfully scares her into Trauma-Induced Amnesiaas specific punishment for having caused the deaths of Misaki and later Yuuichiro's, aside of the people whose deaths she provoked before.
"Crazy Jane" by Richard Dadd fits this trope to the T. So much so that she was inspiration for the character's name in Grant Morrison's Doom Patrol (While that other Crazy Jane does NOT fit this trope).
The Symbolist movement of the 1890s was fond of Ophelia as a subject.
In the Pony POV Series, Diamond Tiara's mother Golden Tiara - a.k.a. "Screwball" - is like this, a former Blithe Spirit whose mind broke years ago under the pressure of cutthroat high society. However, we later learn that there's a lotmoretoher...
Syaoran in "Shattered Secrets" is a male example of this trope - and lacks most characteristics of a Bishounen, to boot.
Feferi from Hemostuck. A very beautiful seadweller who spends her days singing to herself, swimming, and having a somewhat tenuous grasp on reality.
Delirium from The Sandman is sometimes portrayed this way.
[Some] say that Delirium has no tragedy, but here they speak without reflection. For Delirium was once Delight. And although that was long ago now, even today her eyes are badly matched: one eye is a vivid emerald green, spattered with silver flecks that move. The other eye is vein blue. Who knows what Delirium sees, through her mismatched eyes?
Ginny, the post-traumatic fairy in Aria. Her cousin Kildare, the protagonist, refers to her as "beautiful and damaged" (or some permutation).
Subverted in the Yoko Tsuno story "The Prey and the Shadow". Everyone thinks that Cecilia, the local Non Royal Princess, is one of these after the death of her mother Mary... but she's actually sane, just extremely sheltered, and it's her Evil Uncle who makes everyone think otherwise so he can set her up for an "accidental" death.
Subverted again in The Devil's Organ, where Ingrid is introduced as one but it's just temporary since she was not only depressed by her father's death, but she was drugged by someone else. After an incident where she was thrown into the Rhin but Yoko saved her, she mostly recovers.
Alice, the first major villain in Batwoman, has many hallmarks of an Ophelia, dressing in bizarre Victorian-esque clothes, speaking almost entirely in quotes from Alice in Wonderland, carrying a poisoned razor blade in her mouth and frequently having her makeup run down her face. She also turns out to be Beth, Kate's long-lost twin sister, and there's a heavy implication that she underwent serious Mind Rape after she was captured in the shootout that killed their mother when they were 12. And the icing on the cake is that she drowns in the river and essentially commits suicide.
Andy of The Goonies flips her shit and begins babbling nonsense about "having a beautiful body" shortly before the group encounters the corpse of Chester Copperpot... which doesn't help the situation.
Rachel Weisz plays twin sisters in Constantine, one of whom is a sort of peripheral Ophelia - confined to a mental hospital, she commits suicide by leaping from a building, plunging through a roof and into a swimming pool (a cross-shaped one to boot) where, naturally, she can float all flowing-haired and dead. The other twin begins to manifest aspects of the trope - visions and immersion in water - without actually losing her mind.
Crazy Cora in Quigley Down Under goes between this and being more or less sane. She has very long hair which is sometimes down and tangled, though no flowers or water motif as it takes place in the Australian Outback.
Kirsten Dunst's character Justine in Melancholia could be a variation of this trope. She has few of the above mentioned traits, but a certain aesthetic scene in the movie is a clear reference to her. Justine is also mentally ill, but this is portrayed in a much more realistic and thus even more heartbreaking way.
The Italian film The Best of Youth centers around the lives of two brothers. A pivotal moment at the beginning of the film that ultimately influences their life choices is when the brothers meet Giorgia, a mental patient who has been subjected to electrotherapy. One of the brothers, Nikola, comments that they were both kind of in love with Giorgia at the time.
Gina, Tony Montana's sister, in her last scene in Scarface (1983). Tony has been playing Knight Templar Big Brother to her throughout the movie, having a violently territorial reaction every time her virginity is the least bit endangered, to the point of being a Yandere. This culminates with him discovering her post-sex with Manny Ribera (his best friend) and shooting him dead right in front of her, only for her to tearfully reveal that they'd gotten married the previous day. At his mansion that night, amidst the attack by Alejandro Sosa's men, she appears semi-nude and drugged out, telling him he can have her now since he clearly wants her for himself, all the while shooting at him with a revolver. One of the attackers kills her; Tony kills him in turn and then basically loses his mind over her body. Of course, he's the one who has the swimming pool death. (Incidentally, Incest Subtext is a somewhat popular reading of Laertes's overprotective attitude toward the original Ophelia.)
The titular character of Agnes Of God fits this trope to a tee. Agnes is rather childlike and naďve, and she also constantly speaks of random things that make sense only after being pieced together. It is unclear whether she was born mentally challenged; she says she was "dropped on her head" as a baby. The local doctor, Martha, is never sure whether Agnes is really mentally challenged or it's a result of her mother's virtually imprisoning her for years.
Mal from Inception. She was driven mad after being unable to tell between dreaming and reality, causing her to kill herself.
The Woman in White by Wilkie Collins has not one but two Ophelias, Anne Catherick, the titular woman in white, and her near-doppelganger, (and secret half-sister) Laura Fairlie. Both are sane (although seemingly at least a bit odd in Anne's case) when confined, in turn, to an insane asylum by the villain in a Batman Gambit involving substituting one for the other, but both are driven mad by their incarceration there.
Jeanne from Charles Baxter's Shadow Play could have had a touch of this in her young years: she was apparently rather pretty, but lived in her own universe. When she got older, she turned into a Cloudcuckoolander.
In The Lady of the Lake by Sir Walter Scott, a bride carried off and raped on her wedding day wanders the highlands decked with flowers and singing.
While still a child, Jane Austen parodied the hell out of this in her spoof romance Love and Freindship (sic). When the husbands of the two heroines suddenly die in front of them, they each exhibit the standard Gothic romance reactions — one swoons, while the other has a fit of madness. This proves the healthier choice, as lying unconscious for two hours on the wet grass gives the other girl a cold that ultimately kills her, and she dies exhorting her friend "Beware of swoons, dear Laura. . . . A frenzy fit is not one quarter so pernicious; it is an exercise to the Body and if not too violent, is I dare say conducive to Health in its consequences—Run mad as often as you chuse; but do not faint."
Fuchsia Groan in Gormenghast. Unusually, she's rather more like this earlier on, with the dark events of the plot giving her a more conventionally depressed outlook. She does ultimately drown herself, although it's unclear how deliberate it was.
Subverted with Elfine in Cold Comfort Farm by Stella Gibbons — Elfine runs around in a green cloak "like a Pharisee of the woods" (i.e., a faerie), making cryptic remarks, until the main character, Flora, gives her a makeover and sets her up with a cute guy. Then she's normal.
In the YA novel Black Jack by Leon Garfield, the hero finds himself falling in love with Belle, a fragile young girl who's first encountered in a wood, having a vision of "A white tower with a shining top." She's been swinging between gentle strangeness and violent hysteria since an illness in childhood. Much of the drama turns on whether her madness is the result of an illness exacerbated by neglect and isolation (in which case it's assumed to be curable) or hereditary (in which case it's not).
Margaret Atwood has an interest in the trope and deconstructs it in The Blind Assassin. The narrator's sister, Laura, is a beautiful, intensely spiritual young woman given to loopy statements, odd activities like painting "the colour of people's souls" onto old photographs and falling/jumping into rivers. She seems incapable of fending for herself and is revealed on the first page to have driven a car off a bridge, killing herself, at the age of twenty-five. However it later appears that it's only in the arid context of pre-war upper class society that she can't function, and there are people who have a vested interest in discrediting her insights as mere insane babble.
Charis in The Robber Bride has also exhibited symptoms of this, the more so during her university days. Arguments can be constructed on both sides of the crazy/not crazy spectrum.
The Warlord Chronicles takes a moment out of deconstructing the King Arthur mythos and pulling it into The Dung Ages to deconstruct this trope in the person of Olwen the Silver, an insane Cloudcuckoolander first used by Merlin, (her etheral beauty, a little paint and special effects convinced people that she was a spirit and Merlin was summoning the old gods back to Britain) and later by Merlin's Knight Templar former pupil Nimue.
In Mary Jo Putney's ''The Wild Child', the titular heroine appears to be mutely insane or at least mentally handicapped, but in the pretty, well-groomed way. However it turns out she's just really stubborn and unsocial.
From The Hunger Games: Katniss near the end of the third book, after killing Coin. Annie fulfills this trope much more consistently, being unstable at the best of times. She even has the water motif (she's from the seaside District 4 and won the Hunger Games when she was young by swimming through her flooded arena while the other tributes drowned).
In Patrick Rothfuss's The Kingkiller Chronicle, the supporting character Auri is a shy young woman who lives underneath The University, hiding from almost everyone. She makes grave but completely nonsensical statements and presumably was driven mad by the University's demand on her mental faculties.
In Dragonlance Raistlin and Caramon's mother is written as never having been quite sane and likely driven mad by her latent magic. She's described as being ethereal, beautiful and will often talk to people who aren't there or randomly start dancing. Eventually she slipped into an episode that killed her when she couldn't be woken up.
Isabelle Angelfield in The Thirteenth Tale. Highlighted and foreshadowed by an incident where she falls into a lake at a picnic.
Lee Smith's epistolary novel Fair and Tender Ladies features the narrator's sister Silvaney, who is depicted as ''odd' (possibly retarded or mentally ill) and is eventually institutionalized and lobotomized. Prior to that, however, she runs around singing and laughing, and is mostly let alone by her family. This trope was especially prominent in the musical version produced by the Alabama Shakespeare Festival.
In Alethea Kontis's Enchanted, "full of woe" Wednesday is dreamy and poetical and ends up leaving human lands for the fairy at the end.
Susie becomes this in the second half of Repeat It Today With Tears by Anne Peile; although she chops off her Rapunzel Hair after being committed to a psychiatric hospital.
Two gender inversions of this occur in Doctrine of Labyrinths by Sarah Monette. In Melusine, wizard and former prostitute Felix Harrowgate goes mad from Mind Rape and wanders around saying things that people either don't understand or don't believe, sometimes to their peril. Vincent Demabrien, a boyhood acquaintance whom Felix meets again in The Mirador, is both a gender inversion and a subversion, as his affinity for ghosts makes him seem insane, but he really isn't. Interestingly, both characters are pretty boys described as delicate and beautiful.
Vibeke in Scott G. F. Bailey's The Astrologer is a full-blown Expy for Ophelia, as the novel is a Shout-Out to Hamlet. Unlike the original, though, she's having a secret relationship with the King, who has impregnated her, and she commits suicide by burning herself alive atop her father's corpse.
Felix's Missing Mom in the Chilean novel Golondrina de Invierno (Winter Sparrow). He son describes her as gentle, sweet and a bit sad, and after her death he learns that she spent months in an institution when Felix himself was very young; the discovery causes him to fall in a brief Drowning My Sorrows state, as he believes he has inherited her mental unstability. And he's right: later in the book he mentally collapses and becomes a Rare Male Example, but he ultimately manages to get better.
There's River Tam from Firefly, who is also a Cassandra of course, but her lyrical madness fits the trope to the letter, and Ophelia's River is even there in her name. She has a faithful Laertes in Simon.
Drusilla from Buffy the Vampire Slayer. "Do you like daisies? Hmm? I plant them, but they always die. Everything I put in the ground withers and dies." She was driven mad by being terrorized by Angelus.
In Angel, Fred recovers relatively quickly, but gets in a fair amount of babbling and scribbling on the walls first. "You're not real! Or I'm not real. Somebody here isn't real and I suspect it's you..." She was stuck in a demon dimension where humans were treated like cattle for five years and, after escaping her captors, stayed in a cave by herself for months until the team ended up in the dimension and saved her.
Glory's sanity stealing powers provided an entire season of these at the ready.
Most notably, Tara.
The ensouled Spike has his own moments of Male Ophelia Syndrome. This is my place! You need permission to be here! You need a special slip with a stamp!
And frankly, "Restless" turned the entire cast of Buffy into this.
In the episode "The Doctor's Wife", Idris/ the TARDIS is this when she's put into human form. Of course, experiencing your own past, present and future at the same time would make anyone a bit mad.
When Susan Foreman is in her more alien moods, she becomes like this, particularly in "The Edge of Destruction", which she spends drifting around waifishly in a long kimono-like dress babbling about visions in her mind, staring blankly into space with her big sad eyes, and shredding furniture with scissors while screaming and crying hysterically. (When she's in a more human mood, she's The Ingenue.)
There's also the Big Bad's daughter in "The Crimson Horror."
"All the Sinners, Saints", a thoroughly depressing, Shoot the Shaggy Dog episode of Without a Trace, features Katie, a beautiful young woman who's suffered from a severe and apparently untreatable mental illness for years and believes she's possessed and vanishes after suffering visions of a murder. after discovering that she committed the murder in question, she slits her wrists in a bath, fulfilling the trope's association with water.
Anorexic Cassie is an Ophelia who just about manages to function socially, except for when she... doesn't. When thoroughly out of it as she attempts suicide, she is seen dancing ethereally in floaty clothes on a hilltop bench against the setting sun.
Subverted in the second series. The Ophelian tendencies go out of the window and it's just plain disturbing when she's out of it.
Effy straddles the line between "pretty" and "disturbing" during the fourth series.
There was an age where every Hispanic Soap Opera heroine snapped in an Ophelia Phase if broken enough. Given its roots in Victorian romantic literature, it's not a surprise. They tended to get back into sanity in time for their Roaring Rampage of Revenge, although by the time they snapped back they had already do something unforgivable, like giving their newborn to beggars.
In The Addams Family, Morticia's older sister (also played by Caroline Jones in the series; seen for about two seconds in the movies) fits much of this trope. She wears flowers in her hair (if you try to pluck one, her leg lifts up); she's vague at least, though not babbly; and she's very good at karate, not noticing that it hurts when she flips men to the ground. Oh, did I mention her name is Ophelia?
In an episode of Xena: Warrior Princess, Xena is driven mad by the Furies. Oh, she can still kick butt(in a Three Stooges style) but she suddenly wants to weave daisies in her hair.
CSI: New York has a suspected murderer, who seems dazed and begins babbling about law procedings. As it turns out, she's just a sleepwalker that only just woke up. Bonus points for her name actually being Ophelia.
Annie from Community, especially back in her Adderall days.
This is more or less Katie-Jane Garside's (Of Daisy Chainsaw and Queenadreena fame) stage persona. Actually, imagine the girl in the picture at the top of this page stumbling around in a terrified daze and you're practically there.
The basis for the Emilie Autumn album Opheliac, which was described by Autumn as "being another drowning story". And as the album is somewhat autobiographical, the attractiveness part is arguably passed too.
Yoshiki Hayashi in both stage persona and Real Life is a male example of the trope, though somewhat less, both as he's gotten older and as therapy for the conditions from which he has suffered has improved from what it was. Arguably, from Yoshiki's autobiography, Yoshiki's father was also a Real Life male Ophelia, one whose life sadly ended from suicide at 33.
Florence + The Machine used this idea in at least The Drumming Song off of the Between Two Lungs album. Other songs also feature this idea, and any Drinking Game involving how often she mentions drowning will quickly result in liver failure.
Linda in Linda di Chamounix has the unusual good fortune of getting over it and having a happily-ever-after.
Margeurite in Gounod's Faust goes mad after falling pregnant and committing infanticide, and sings, of course, about flowers.
Gilbert and Sullivan parody the type with Mad Margaret in Ruddigore. Her supposed madness does no more than make her a Cloudcuckoolander (and a sympathetic one, to boot). In the second act, she's mostly reformed but sometimes bursts into hysterical fits, which can be quieted by reminding her of the word "Basingstoke" (an English town which is noted for not being Birmingham; both towns start with the same letter as Bedlam, though this is not mentioned in the play).
Male example: In the Stravinsky opera The Rake's Progress, Tom imagines himself as Adonis after he goes insane.
Daffney Unger patterned herself after Harley Quinn from Batman and WCW, envisioned her as an expy to Mallory Knox. You know, criminally insane people? WCW also put her in a wedding gown match with Miss Hancock so apparently no one thought it took away from the appeal.
Victoria was WWE's version. Despite being mad to the point of seeing and interacting with things that simply were not present, an affinity swinging heavy metal objects and questionable relationship with Stevie Richards, she still got put in the bikini and other photo shoots on the website.
Then, there's Dolores Whateley in Deadlands. Ethereally beautiful? Check. Long, raven-black hair? Check. Access to mind-breaking knowledge? Check. Dancing through the graveyard at night singing nursery rhymes to her "friends" in the graves? Ooh. That's a big check. In the short-lived DeadlandsCCG, she provided some of the best Flavor Text, such as the quote on the "Event Card" where every aced character became playable again for exactly one round.
"Everyone's coming out to play!"
In Vampire: The Masquerade we're provided with an entire vampire clan of these, courtesy of the Malkavians. Subverted, in that while some of them are genuine Ophelias, just as many are Ax-Crazy or Psychopathic Manchildren, or have less obvious kinds of crazy like personality disorders or compulsions, and a fair number are just pretending to be The Ophelia to put the rest of the world off their guard.
Mary Tyrone in the final scene of Long Days Journey Into Night, when she wanders into the room so intoxicated by morphine that she thinks she's a young convent girl again and rambles accordingly. Her acerbic son James even lampshades this: "The mad scene. Enter Ophelia!"
Tennessee William's use of this trope is believed to be inspired by his own life. Williams was very close to his sister Rose, who was described as a "slim beauty"; she was diagnosed with schizophrenia and spent much time in mental hospitals before having a lobotomy that incapacitated her. Williams never got over it and it is believed to have played a part in his drug addiction and alcoholism.
Lucy Westenra becomes this trope as a vampire in Dracula: a Love Stronger Than Death, down to the loose hair, white gown, and flower crown. This is a big change from the book, where she's an utter monster after her transformation.
Ophelia from Blood: Caleb's backstory mentions her home was burned down by the Cabal after her husband tried to leave them. She is left there for some time, mindlessly babbling on and blaming her husband's cowardice for the death of her son. She, well, gets better, then worse, then better again.
Yeesha from Uru has a touch of this- her speeches have her dancing about the room, using odd phrases, and describing the flow of water.
F.E.A.R.'s Alma appears to have many Ophelia-esque aspects, particularly in Project Origin. She is shown singing in several hallucinations, and in the prequel videos she dances around a doctor who she's been gleefully mindraping. Water shows up often in her hallucinations, which makes sense, as, like Ophelia, she drowned to death (in her case, in amniotic fluid). And her hair in her "child" form tends to be wild and frazzled.
Penny from Advance Wars: Days of Ruin vacillates between being an Ophelia and being Ax-Crazy, mainly depending on the wishes of her stuffed Mr. Bear.
Penny: Hee hee! Penny likes you...but Mr. Bear HATES YOU!
This is the backstory of Nadia Grell in The Old Republic, bar that rather than being mentally ill, her talent with the Force was awakening and her species had no history or awareness of the Force. She snaps out of it when the Jedi teach her how to control her powers.
Ninian from Fire Emblem Elibe spends a brief time like this. When you find her in either Eliwood's or Hector's path, she's adrift in a small rowboat and totally amnesiac, so the cast takes her in since she can't be left alone. Soon we learn why she's like that: she and Nils tried to escape from the Dread Isle to not be forced to open the Dragon Gate and call other dragons through it, with the help of Eliwood's captured father Elbert; however, Nils fell into the sea and the already unstable Ninian snapped, blocking everything from her mind. She does't recover until Nils reappears and snaps her out — and just in time, as she's Brainwashed and Crazy and just about to open the Dragon Gate under Nergal's orders. From then on she's mostly sane, if extremely shy and reserved.
Sara from Fire Embem: Thracia 776 is regarded as such by her grandfather Manfroy and the Lopto cult. She's more of a slightly-off but otherwise functional Oracular Urchin, however, and she eagerly joins Leif's group as soon as she has the chance.
Depending on how well you do on a certain event, Garry from Ib can lapse into this temporarily or permanently. After being terrorized literally out of his wits, he begins babbling to himself and ignoring the world around him. He follows the tradition of male Ophelias, in that he is feminine, pretty, and gentle.
Young Reisen of A Broken Winter is a rare male example. We're introduced to him sitting on the desk with his headphones in and the fire extinguishers merrily destroying his room, while he muses as to the music of the gods. It's portrayed as a very classic Ophelia moment.
Quinn from Daria babbles nonsense and rubs mud on her face after she eats the "glitterberries" along with the rest of her family, save the title character.
Lucia Joyce, daughter of James Joyce. Schizophrenic. Institutionalised. Pretty (rather Flapper-like), with an artistic temperament: she was a skilled dancer in her youth, good enough to train with Isadora Duncan.
America's Next Top Model's seasons 12 and 17 contestant Allison Harvard (also known on the Internet as "Creepy-chan"). Long, messy hair, weird, crazy vibe and everything.
In 1720 Susan Mountfort, an institutionalized actress who had been known for playing Ophelia, escaped her keepers, went to her former theater, hid in the wings, and took the current actress's place in Ophelia's "mad" scene, dying shortly afterwards.
The aforementioned sister of Tennesee Williams, Rose.