The Elephant Man: A doctor becomes overinvolved with one of his patients, who has disabilities.
Alternatively: In one of the least funny films Mel Brooks has produced, a doctor (probably) misdiagnoses a patient.
Elf: Loud man-child does everything to make his father have a merry Christmas.
Elizabethtown: Suicidal shoe designer goes to Kentucky and hooks up with a flight attendant.
The Emperor's New Groove: An utterly selfish boy-king ruminates for a few days and learns to care about others as a result. Features a severely aging Catwoman and half the cast of Just Shoot Me!.
Alternatively, Detective Rosa Diaz's newest case: figuring out why a candle might blow out, and what Luigi has to do with it.
Alternatively: Colombian Meg Griffin faces her grandmother because a candle was dying and her family doesn't want to talk about her uncle Sid the Sloth.
Enchanted: A walking cliché thrown from clichéland falls in love with a lawyer.
The End: A terminally ill man decides to end his life. Hilarity Ensues.
End of Days: Man with peculiar accent tries to prevent a pregnancy.
Equilibrium: A handsome man falls in love with his recently deceased coworker's girlfriend. His interactions with her and a lovable puppy inspire him to confront his boss and quit a job he never truly liked. Can be seen on the Lifetime Channel.
Alternatively, In a futuristic dystopia that has outlawed emotions, a former enforcer of the system must fight for freedom with laughably unrealistic gun-fighting skills.
Eraser: Man with peculiar accent helps people play Hide-and-Seek.
Eraserhead: A man encounters difficulties trying to raise his deformed child.
The Elephant Man: Circus performer quits job, lives in a hospital, befriends Hannibal Lecter and Mrs. Robinson. Based on a true story.
Ernest et Célestine: Two animals rob a dentist and then have an incredibly wholesome time hiding from the cops.
Ernest & Celestine: A Trip to Gibberitia: After the events of the first movie, the two animals are still broke and starving. And it turns out the bigger animal's dad got so mad at his son not wanting the same job as him that he made his son's job illegal, which made his daughter dress like a bird and commit crimes.
Escape from New York: Police arrest badass criminal and order him to break into a very large prison under the threat of exploding his neck.
Escape from L.A.: The exact same thing as above, but from different camera angles. This time, after the criminal is done, he helps everyone save on their electrical bills.
E.T.: Some misfit suburban Emo kid gets high with his alien friend whom his mom doesn't think is real and might be Jesus.
Eternals: A bunch of superheroes attempt to perform an abortion without any experience in the procedures.
Eternal Sunshine of the Spotless Mind: A man dreams about his ex-girlfriend before meeting her on Valentine's Day. They end up going on a date to a lake they used to visit, but they both become upset when she finds a tape of him complaining about her. The moral of the story? Brain damage will bring you closer together.
Or: Boy meets girl. They break up. Girl forgets boy, so boy expresses grudge by forgetting girl. Boy withdraws his consent to the memory wipe right in the middle of the memory wipe. Post-production lazily avoids putting the scenes in order.
Event Horizon: Members of a towing crew get on each others nerves after being sent to tow a missing vehicle. The vehicle's new owner goads them over their past mistakes, encourages them to perform do-it-yourself surgery on their faces, and wants them to relocate to a new home.
In other words, how to use psychological warfare to keep your car from being repo'ed.
Everything Everywhere All at Once: Laundromat owner ascends to godhood, has a philosophical conversation with a sentient rock, and talks her daughter out of committing suicide by bagel.
Everything Is Illuminated: Frodo goes to Ukraine in search of his grandfather's ex-girlfriend, finds an old lady in a house filled with boxes. A blind grandpa does the driving and a rock star (without his famous mustache) translates.
Everything You Ever Wanted To Know About Sex But Were Afraid To Ask: The Film of the Book of a sex guide.
The Evil Dead (1981): Camping trip takes a turn for the worse when the hero's car conks out. The fertility rites of nature are explored in detail. Reading books is bad for your complexion.
Evil Dead 2: Man has another bad camping trip (or perhaps the same one), then beats himself up about an upcoming surgery. Furniture laughs at him.
Alternatively, outside forces drive a man insane. He becomes a badass because of it.
Army of Darkness: Housewares-salesman travels through time, causes and averts Zombie Apocalypse. Then bores his co-workers with tales of derring-do.
Evolution (2001): Two science teachers, a goverment scientist and Stifler saves the world from an alien evasion with gross-out jokes and shampoo.
Exam: 8 people go insane trying to answer a blank exam.
eXistenZ: People don't know whether or not they're playing a video game.
