In the Aqua Teen Hunger Force episode "100", the theme from the in-story "reimagining" ends with the words 'in space'.
Silverhawks is ThundercatsIN SPACE! (Compare Mumm-ra's and Mon-starr's Transformation Sequences.) It even used most of the same voice actors. Rather odd in that Thundercats is in space in the first place...
Inspector Gadget is Get SmartAS A CARTOON CYBORG! (Maxwell Smart and Inspector Gadget were both played by Don Adams.)
It was followed by Gadget Boy & Heather, which was Inspector Gadget AS A SIX-YEAR-OLD! With Penny AS AN ADULT! And Brain AS A ROBOT! And Chief Quimby AS AN ITALIAN!
You can also make the case of Inspector Gadget being RoboCop rebuilt out of Maxwell Smart instead of Alex Murphy.
The original animated version of The Addams Family was ON THE ROAD IN A HOUSE-SHAPED CAR! The 90's version was essentially just an Animated Adaptation of the movies, though.
More like Loonatics Unleashed is Teen TitansWITH LOONEY TUNE CHARACTERS!, since that's how it was pretty much described in the original PR announcement.
Duck Dodgers is DAFFY DUCK IN THE 24TH-AND-A-HALF CENTURY!
"Yosemite Sam of Outer Space!"
The Flintstones, Looney Tunes, and Scooby-Doo all have AS KIDS! spinoffs. Even if in the original, there's a scene where they met for the first time, they knew each other as kids and have forgotten. Yo, Yogi! which features Yogi Bear, Huckleberry Hound, etc. AS KIDS!
Gravedale High is Scooby-Doo and The Ghoul SchoolEXCEPT FOR THE FACT THAT RICK MORANIS REPLACES SCOOBY, SHAGGY, AND SCRAPPY IN THAT STORY AS A TEACHER RATHER THAN AN ATHLETIC DIRECTOR! AND THE STUDENTS AT THE SCHOOL ARE BOTH MALE AND FEMALE!
Aversion. The Futurama writing staff have claimed that a large part of the reason behind the Executive Meddling that the show suffered was that, much to the network's annoyance, the show was notThe SimpsonsIN SPACE!
Directly referenced in "Into the Wild Green Yonder":
Bender: It's gonna be fun on a bun! IN SPACE!
A canon example, however, is that apparently the only reason Fry accepted another delivery boy job (after having basically losing the one from his own time and running away from the one being assigned to him forcibly) was that it was IN SPACE!
Some fans have affectionately described Futurama as Friends... ANIMATED AND IN SPACE!
Bobobobs is The Smurfs and The World of David the GnomeIN SPACE!
Recess is essentially Hogan's Heroes on a 90s elementary school playground. One such episode of Recess does a very good adaptation of the Hogan's Heroes pilot and another features a scene where expys of the characters are in a Hogan's Heroes-style WWII POW camp; complete with the Colonel Klink expy wearing a monocle.
Pound Puppies (especially the 2010 revival, which is made by the creators of Recess) is Hogan's HeroesIN A DOG POUND!
The Super Mario Bros. Super Show is practically nothing but this. Just about every episode is a different-themed world; these include IN SPACE, IN AUTHURIAN TIMES, IN JACK AND THE BEANSTALK, IN GODZILLA-TERRORIZED TOKYO, AMONG PIRATES, IN SOME MEXICAN DESERT PROTECTED BY A MASKED HERO NAMED "ZERO", IN A RACE, etc.
Showdown, an episode of Batman The Animated Series featuring a Jonah Hex storyline, was made because the writers recognized Hex as Batman OF THE OLD WEST!
Tom And Jerry relies on this trope a lot. Granted, it's because there's only so much you can do when the premise of the entire series is "cat chases mouse."
Popeye received similar recyclings, especially once Famous Studios took over in the 1950's and the writers ran out of ideas.
TROLLZ is WITCHWITH... are you sure they're supposed to be trolls? Yeah, I know what the title says, but come on, they're obviously elves or dwar...okay, you have a point there... -WITH TROLLS!
Pretty much every classic Hanna-Barbera cartoon is a classic TV show (or at least a character) done with animals. Top Cat is Sgt. Bilko with alley cats.
Angel's Friends is WITCH, or Winx Club, depending on what fandom you prefer, WITH ANGELS AND DEMONS!
The spin-off Pop Pixie looks like TrollzWITH PIXIES!
Jimmy Neutron parodies the trope with an in-universe example when their school principal puts on a production of Macbeth IN SPACE! He later mentions that next year, he'll be doing Hamlet ON ICE!
Seeing as how Green Lantern: First Flight is largely based on Green Lantern stories that were first published in the 60's, Training Day is actually Green Lantern.... ON EARTH!!!!!
Hanna-Barbera made a whole bunch of iterations on Tom And Jerry, many of which were back-up segments on other shows:
Pixie and Dixie and Mr. Jinks is Tom And JerryWITH TWO MICE! AND THEY TALK!
Punkin Puss and Mushmouse is Tom And JerryBUT THEY'RE HILLBILLIES! AND THEY TALK!
While it didn't get made, one of Greg Weisman's spin-off ideas for Gargoyles was Gargoyles 2198, which was basically Gargoyles IN THE FUTURE AND LARGELY IN SPACE TOO!
When the final season of Hanna-Barbera's All-New Popeye Hour during the late 1970's was reformatted into The Popeye and Olive Comedy Show for its final season, one of the segments was called "Prehistoric Popeye." Basically a combination of Popeye and The Flintstones with Popeye eating his spinach out of cans made from rocks!!
Several Veggie Tales videos often do this to several stories from The Bible, such as the story of Joseph and the Exodus IN THE OLD WEST, and the story of Shadrach, Meshach, and Adbenago AS FACTORY WORKERS!
