Buford (Frank Welker) is a smart but sleepy bloodhound, living deep in the murky swamp country of Fenokee, who teams up with two teenage humans, Cindy Mae and her older brother, Woody. The trio solves mysteries that baffle Sheriff Muletrain Pettigree and his overeager yet dimwitted deputy, Goofer McGee. Buford's abilities are expanded with ears that revolve like radar dishes, and his nose responds to clues like a Geiger counter. he also howls his heart out when the moon comes out and has a running feud with a brown raccoon.
Nugget Nose (Frank Welker) is a short and feisty ghost prospector who finds adventure riding his invisible horse. He is also a guardian to Wendy and Rita, two cowgirls working at the Fuddy Dude Ranch, whose owner is grouchy old Fenwick Fuddy. Nugget is always battling Fuddy and takes delight in harassing him in odd and humorous ways. Whenever the girls are in trouble, Wendy summons Nugget Nose by rubbing her special nugget necklace.
This cartoon provides examples of:
- Bears Are Bad News: Actually averted in "Bad News Bear"; despite the title, the bear is actually quite friendly. The "bad news" is that he won't leave the girls alone when the dude ranch is scheduled for an inspection.
- Depending on the Writer: Sometimes Fuddy will interact with Nugget Nose and be aware of him, other times he'll deny any ghosts exist.
- Drill Sergeant Nasty: The episode "Sagebrush Sergeant" reveals that Fuddy's sister is one of these.
- Mad Libs Catch Phrase: The chant that Wendy recites before summoning Nugget Nose is different in every episode.
- Our Ghosts Are Different: Ghost Prospector.
- Running Gag: Wendy kissing Nugget Nose to get him to do something he doesn't want to, followed by him having a Wild Take reaction.
- When Wendy scolds or talks to Nugget Nose around someone, they'll question what she was saying followed by Rita giving a Verbal Backspace.
- "Scooby-Doo" Hoax: Both examples of the same formula
- Two Girls and a Guy: Wendy, Rita and Nugget Nose
- What Happened to the Mouse?: In the Space Race segment (later spinoff) while Wendy, Rita and Nugget Nose are all together, Buford's kids, Cindy Mae and Woody, aren't included and instead Buford is paired with Jabberjaw.
- Wingding Eyes: When a famous director is scheduled to visit in "Phantom of the Horse Opera," Wendy gets stars in her eyes thinking about possibly auditioning for him and becoming famous.
