Sniffles and Mime as Vulcans.
- "Double Whammy" is probably a huge reference to Fight Club.
- Blatant one to The Shining in the episode "Aw Shucks!" Lumpy is trying to get a crow out of his house, and the crow seeks refuge in his bathroom. Cue Lumpy (with ax in hand) breaking through the door, complete with a Simlish "Heeerrrreee's Lumpy!"
- Splendid, an unashamed pastiche resp. parody of Superman as a character, once traveled back in time by flying around the Earth faster than light just like Superman did in the 1978 film to Set Right What Once Went Wrong, but not to prevent the several catastrophes he participated in in the original timeline, but to prevent the cake in his oven from scorching.
- Episode #55, where in which Pop buys Cub a cursed book, reads from it, and Cub becomes possessed by something, is a blatant parody of The Exorcist.
- One early episode is called "Whose Line Is It Anyway?".
- "Wrath of Con", being named after Star Trek II: The Wrath of Khan and taking place at a con, would of course be packed with visual nods to other series:
- Several people are dressed up; Giggles and Petunia as Leia and an Ewok respectively, Nutty as Batman, a background character as Rorschach...
- The building which the episode takes place in was based on the Hall of Justice.
- The dentist mechanism that Nutty has to wear after breaking his teeth in "Chew Said a Mouthful" is a reference to the Reverse Bear Trap from Saw.
- Another Halloween episode, "A Vicious Cycle", is an obvious parody of Christine. The title even has the same font as the movie's.
- Lifty and Shifty's van in "Concrete Solution" is the The A-Team van.
- One of the December 2016 episodes is titled "An Inconvenient Tooth". The episode itself has something to do with plants, which may add more similarities with the film it references.
- In "Blast from the Past", Sniffles is watching a DeLorean-lookalike boosting away and disappearing.
- Lumpy running into a shed after having his arm torn off in "Remains to be Seen" is almost similar to what happened to Ash in Evil Dead 2, albeit (stupidly) attaching a leaf blower instead of a chainsaw.
- From the same episode as the above, Zombie Cuddles and Zombie Giggles can be seen reenacting the "spaghetti kiss" scene from Lady and the Tramp. They use a brain in this case instead of actual spaghetti.
- In "Wingin' It", Toothy is seen watching a cartoony-looking version of Godzilla.
- The presence of Pod Lumpys in "Peas in a Pod" is a reference to the 1978 film Invasion of the Body Snatchers.
- The Cursed Idol looks almost similar to the fertility idol from Raiders of the Lost Ark. The episode "Idol Curiosity", one of the episodes featuring the idol, is also basically a loosely-based parody of said film.
- "Without a Hitch", color-wise, appears to be animated in the style of Sin City, being an almost entirely grayscale movie with only occasional splashes of color, mostly from blood.
- The entire Sniffles vs. The Ants rivalry is possibly a reference to a 1969 cartoon called The Ant and the Aardvark.
- At one point in "As You Wish", Genie Lumpy wiggles his nose to grant a Happy Tree Friend's wish.
- At one point in "Dream Job", Sniffles can be seen swinging on a vine until he crashes into a tree, familiar-sounding background music included.
- From the same episode as the above, Sniffles can also be seen playing what appears to be The Price Is Right, specifically the show's wheel part.
- In "Party Animal", Nutty spins like a tornado after consuming a bit of sugar.
- Petunia and Giggles's waiting pose in "Eyes Cold Lemonade" is similar to how Charlie Brown and Linus are seen leaning against a brick wall. It also helps that, according to Kenn Navarro, Peanuts served as some inspiration for the show.
- Splendid and Lumpy are inspired from Rocky and Bullwinkle.
- Sniffles is dressed as a red shirt with Vulcan ears in "Remains to be Seen" and "Something Fishy" (Mime also joins in in the latter). They even performed the Vulcan salute in the latter episode.
- The credits sequence used in episodes starting from "Wrath of Con" reference the back designs of the Little Golden Books series.
- "Breaking Wind" is filled with two Twilight references. The first is the title itself ("Breaking Dawn"), and the second is the book that Splendid is reading (which is heavily involved in the episode's plot).
- The irregular episode "Cubtron Z" is a homage to Astro Boy.
- In "Brake the Cycle", Lumpy's fate ends with him being set on fire while riding his motorcycle. Even the episode's BlurB! version points out this moment.
- The "False Alarm" episode is packed with video game references, being an HTF episode made as a tie-in with a video game of the same name.
- At a construction site, Nutty jumps over a rolling barrel and then smacks it with a hammer.
- Before that, Nutty stops Cuddles driving and shoves him off his car, then drives away with the rabbit's car.
- After Lifty and Shifty crashed their van, their decapitated heads resemble Pac-Man and a ghost.
- In this episode, Petunia rides a bicycle around the suburbs to deliver newspapers as her job. When she's killed by Nutty, her intestines form Tetris pieces.
- Note that the latter has happened earlier to Cub in the HTF Break short "Chore Loser".
- The pilot episode has prototype Lumpy playing "Dueling Banjos" on his banjo. The same music can also be heard in the credits.
- One Season 3 episode is named "Swelter Skelter", a pun of The Beatles' song "Helter Skelter".
- There's an early episode named "Stayin' Alive", named after the Bee Gees' song of the same name. Fittingly, the episode marks the debut of Disco Bear.
- There’s a lesser known video titled “Hot Tub Shake”, which is a reference to the Harlem Shake meme.
- In "Disco Bear's Halloween Smoochie", Disco Bear dresses up in Michael Jackson's "Thriller" outfit at the beginning of the fittingly named "Thrillah" option.
- The TV season's fifth episode set, "Marooned Five", takes its title from Maroon 5.
