- The Adventures of Jimmy Neutron: Boy Genius: Tails is a child prodigy. He often fights Squidward and his friends are Hoity Toity and Miyamoto Usagi. Iris and Tak are Tails' rivals. Bugs Bunny is the cool kid at school. Franky and Nico Robin are Tails' parents
- Adventures of Sonic the Hedgehog: The fast hedgehog Doraemon and his friend Meg defend Mobius from evil Megatron.
- Adventure Time: Fernando the human and Samurai Jack the dog have adventures with Princess Kim Possible and Oprah Winfrey the vampire queen. They often fight the evil king Lenny Leonard. Snow White is an electronic device.
- The Amazing World of Gumball: Manny Delgado (who sings like Charlie) gets into various highjinks with his family and friends, usually with his goldfish-turned-brother Hugo. Their father is Kermit the frog, their sister is Ponyo, and their mother is Bulma.
- American Dad!: Borat is a government agent working for Kaa (later Robbie Rotten). Borat lives with his wife the Queen of Hearts, their kids Dink, the Little Dinosaur and Fang, an alien named Experiment 625, and a fish who sounds like Dave. Dink's girlfriend is Spinelli.
- Angelina Ballerina: Blackarachnia, daughter of Ling Ling, trains to be a dancing star.
- The Angry Beavers: Salem and Agumon are brothers sharing a home.
- Animaniacs: The Warner Brothers Lelouch, Viral and their sister Hikari get free and do crazy stuff around. Meanwhile, Rico, Peter Griffin, and Freakazoid! are gangster pigeons.
- Arthur: SŰsuke Sagara lives in Elwood City.
- Avatar: The Last Airbender: 100 years into the future, Tommy Solomon is unfrozen by a water bender Roberta and her brother Pippin (later Astro Boy). Sadie from the earth tribe later joins them. Meanwhile, Prince Edward Cullen of the Fire Kingdom travels the world with his uncle Nicolai in pursuit of Tommy. After fighting Arc Villains such as Edward's rival Max Goof and Evil Chancellor Mike Brady, everyone must all defeat Edward's sister Mary Jane Watson and their father, Fire Lord Tigger.
- The Legend of Korra: 70 years after Tommy and friends defeated Tigger, he's been reborn as Luanne Platter, who is taught by Roberta and Tommy's son Starscream. Brothers Irwin and Scott Pilgrim, as well as Asami, join her on her quest to fight Rico and Van Kleiss. Hermione's daughter Anna Williams is a police officer.
- The Avengers: Earth's Mightiest Heroes: Tai Lung, Ernie Potts (later Mike Cosgrove), Foreman (later Steve Williams), Buzz Lightyear, Fry (later Prince Zuko), Cheetara (later Lucy), someone who became Barricade, and Leeron (later Deadpool) are a team of superheroes.
- Baby Looney Tunes: Eric Forman (sometimes Pinocchio), Robin (sometimes Sportacus), Frodo Baggins (sometimes Sonic), Naruto, Lisa Simpson (later Lee Kanker), Katara (later Hyatt), Aichan and Wasp are babies in Jo's kindergarten. In Season 3, they travel with Jo's nephew Wheeljack.
- The Backyardigans: Dil Pickles, Aang, Amy Rose, the first Ma-Ti, and Dot Warner have adventures in their backyard... using their imagination!
- The Batman: Daisuke Jigen fights crime with his sidekicks C-18 and Static. The bad guys include Gecko Moria, Lugia, Skulker, Kratos, and Blackarachnia. Seiryu is Jigen's butler, and C-18's father Moichi Taoka is police commissioner. Other police officers are Cranky Doodle Donkey, Kaito Kid, and Jean Grey.
- Batman: The Animated Series: Asuma and his sidekick Russell fight villains like Clank, Rei, Cheetor, Alex Louis Armstrong and Snips.
- Batman Beyond: 40+ years after the animated series, Max learns that Asuma (now Discord) was once Batman. So Max becomes a crime-fighter to avenge the death of his father Squidward Tentacles.
- Justice League: Asuma, JACK ATLAS, Haku, Itachi, Doraemon, and Dexter's mom form a team of superheroes so they can fight Megatron and Snips.
- Beast Wars: The heroic Maximals Nappa, Squidward, Pegasus and Martian Manhunter (later adding Goldar, Baroness, Chief Quimby and Tuxedo Mask) fight Predacons Robotnik, Professor Layton, Link, King Koopa and Gecko Moria (later Bane arrives).
- Beast Machines: Nappa, Squidward and Pegasus (who have become Lexington, Spike Spiegel and Tyler), altogether with Littlefoot, came back on Cybertron, only to discover that Robotnik (now Koji Kabuto) conquered the planet, turning Martian Manhunter and Goldar into his allies, Zoidberg and Simba. Later Simba becomes Van Kleiss and comes back in the Maximal lines. Meanwhile, G3!Rainbow Dash is a super computer, and Link has become Mr. Crocker.
- Beetlejuice: Huckleberry Finn (Elijah Wood's character) summons Roscoe from the dead.
- Ben 10: Bobby Hill finds a watch that can turn him into several aliens (such as Tech E. Coyote, Slade, Jon Arbuckle, Wayne Cramp, and Ziggy). He then travels the world with his cousin Ami and their grandfather Kup. Bobby fights people such as Doc Saturday and Kevin. Eventually Kevin becomes a good guy.
- Bob's Burgers: Klaus, Viral, Milo, Fionna, and Harry Potter work at a hamburger restaurant.
- Bob the Builder: Ned Flanders (later Mifune) and Teela work with their talking vehicles Von Kleiss (sometimes Dr. Hamsterviel), Richard Watterson (later Crimson Chin), Ironhide, Bob and Haruko Haruhara (later Daisy Duck).
- Bonkers: Peter Pan loses his job as Wackytoon Studios' biggest cartoon star and becomes a cop alongside Flotsam and Jetsam.
- The Boondocks: Brenda Meeks and Susie Carmichael are two sisters raised in the suburbs by their grandfather MacGyver. Jack Bauer is a lawyer who married Marceline, and Lucius Heinous VII is a white supremacist.
- Breadwinners: Russell and Yuma are two ducks who deliver bread around the world.
- Brickleberry: Ken Cosgrove, Juliet, the second Papa Smurf, Chris McLean, and the narrator of Aladdin work at a ranger station. David Frost is the talking bear.
- Bubble Guppies: Eliza Thornberry, Suzy Johnson, Derpy Hooves, Franklin, Ayame, and Tim are the students of Zak.
- Bucky O'Hare and the Toad Wars: Orochimaru is a space adventurer who meets the human boy Lyserg. In another universe, Orochimaru is fighting the Toad Empire.
- Camp Lakebottom: Clemont, Zoey and Kristoff attend a freaky summer camp. Mr. Gus is the drama teacher.
- Camp Lazlo: Tucker Foley is a cheerful monkey who is at a summer camp run by Starscream.
- Captain N: The Game Master: Sesshomaru gets warped in Videoland by Princess Amy Rose in order to save the land from evil Marge Simpson. Urkel and Racer X are helping him.
- Captain Planet and the Planeteers: Our world is in peril. Miss Spink, the spirit of Earth, can no longer stand the terrible destruction plaguing our planet. She gives five special rings to five special young people. Samwise, with the power of earth. From North America, Napoleon Dynamite, with the power of fire. From the Soviet Union, Ariel, with the power of wind. From Asia, Widget, with the power of water. From South America, Adam Lyon, with the power of heart. Together, they summon Earth's greatest hero... Tai Lung!
- CatDog: Dizzy Devil and DJ Lance Rock share a body.
- Catscratch: Buster Bunny, ZIM, and Dog are cats who live in a mansion with their butler Wally Walrus. Buster has a crush on his human neighbor Jazz Fenton.
- Clarence: Dave has adventures with his friends Hayley Smith and Jean. Dave's mother is Meredith Blake. Jamie James is the school bully.
- Class of 3000: Wilt is Flapjack, Joan of Arc, Abraham Lincoln, Panini, Phil, Rarity, and Robotboy's music teacher.
- Clifford the Big Red Dog: Ingrid Third adopts Oz, who grows to gigantic proportions due to Ingrid's love. Ingrid's parents (Timmy's mom and Professor Frink) decide to move the family to Birdwell Island, where Oz becomes friends with Piglet.
- Clone High: Clones of several historical figures attend high school, such as Gaara, Ricochet, Tallulah, Kamina and Izumi. The school principal is King Einon.
- Codename: Kids Next Door: Spider-Man, Jimmy Olsen (later Milhouse), Emily Elizabeth, Tyrone, and Liz Sherman are crime-fighting children. Milhouse's little brother is Chuck the Evil Sandwich Making Guy!
- Courage the Cowardly Dog: Shinigami-Sama is an easily scared dog who lives with the elderly couple Jessica Rabbit and Poe the Raven (later Vector the Crocodile).
- Cow and Chicken: Miss Fowl and Roger Rabbit are the inhuman children of Connor MacLeod and Liane Cartman. Hagrid is bad at disguising himself.
- Danny Phantom: Stitch! is a high school student with ghostly powers, thanks to his parents (Batman and Kate McAllister) having built a machine. Stitch hangs out at high school with Ash and Max. Stitch's sister Sari Sumdac just wants to lead a normal life; they are all taught by Professor Birch.
- Daria: Elmyra Duff (later Robin Scherbatsky) is an intelligent, snarky girl who observes the world around her. She lives with her parents and her sister Alex.
- Darkwing Duck: Mr. Bean is a crime-fighter who lives with his adopted daughter Beth and a pilot named Gaston. Bean fights bad guys such as an electrician named Philip J. Fry, a toymaker named King Julian, an evil look-alike of Bean (who also controls water) named Waylon Smithers, and a plant-based scientist named Principal Prickly. Patches O'Houlihan is a criminal implied to have killed Beth's grandpa.
- Dave the Barbarian: While king Harold and queen Lois Griffin are away, Udrogoth is being ruled and protected by their son Donnie Darko, his sword Annie, his sisters Backpack and Olivia, his uncle Grizzlykoff, and his pet dragon Abu. Their most fearsome enemy is the Dark Lord Sonic the silly piggy. Their adventures are narrated by Anton Ego.
- Dexter's Laboratory: Max has a hidden lab in his bedroom. His sister Sailor Venus ruins everything every time. Their parents are the Joker and Dorothy. Max later forms a rivalry with Gilda.
- Sometimes, Max's pet monkey fights crime, under the orders of Princess Clara.
- Dinosaur Train: A young T-rex named Timmy Turner (with his adopted pteranodon siblings Arnold, Vince la Salle, and Becca Moody) takes a train operated by Billy through the time of the dinosaurs.
- Dofus: The Treasures of Kerubim: Lugnut (who was Ghetsis when younger) tells of his adventures at his step-nephew Rumble and his housekeeper Sonia.
- Donkey Kong Country: Ratchet and Daxter protect Terrorsaur's Coconut Crystal from Bulkhead, Hardshell and Principal McVicker's attacks. Leonardo is Ratchet's boss at the barrel factory and they fight eachother for Dee Dee's love.
- Dora the Explorer: Jessica and Angelica Pickles teach children how to speak English (and/or Spanish). Their backpack talks like Gosalyn, while Paul McCartney tries to steal stuff. Later, Jessica's cousin Phineas gets his own spin-off show.
- Dragon Tales: Agent Honeydew and her brother Chopper explore a world of dragons.
- Drawn Together: Roy Mustang, Van Hohenheim, Princess Jessie, Babs, Mikey Simon, Foxxy Lovenote , Gandhi, and Jewel (later Rupert) share a house.
- Dungeons & Dragons: Wolverine the ranger, Honker Muddlefoot the barbarian, Lisa Simpson the thief, Wesley Crusher the magician, John Winchester the cavalier, and Blaineley the acrobat are youths who find themselves trapped in a magical world and now they must fight James West to get home.
- Ed, Edd n Eddy: Will Smith, Hamsterviel (later Abraham Lincoln), and Cyborg have tons of misadventures in their cul-de-sac. Will's sister is Sabrina Spellman.
- El Tigre: Bugs Bunny is a child who can turn into the cat-themed superhero El Tigre. His father Gary Oak is a world-famous hero, but his grandfather Sonic is a world-famous supervillain. Bugs works with his friend the human Kimberly to defeat villains.
- Extreme Ghostbusters: Wonder Woman, Maddie Fenton, Captain K'nuckles, Batman, and Bob Oblong are five youths trained by Chief Quimby to catch ghosts.
- The Fairly Oddparents: Jeff has to put up with his parents (Huckleberry Hound and Vanquish), a Babysitter from Hell named Francine Smith (sometimes Yuki Nagato), and an Evil Teacher named Howard the Duck. Jeff gets by with two special fairies named Calcifer and Mary. Jeff's best friends are Cody (temporarily Metabee) and Finch (later Dan Kuso). Jeff, Mary, and Calcifer are often visited by a strong fairy named Lennie Briscoe (sometimes Alex Haley).
- Family Guy: Pleakley, Chip, Juandissimo Magnifico, Tim Possible, Tinky Winky, and Lumiere share a Rhode Island home. Carl, Mousse, and Superman are Pleakley's drinking buddies. Timon's mom became Pleakley's boss after Howard de Ville choked on a dinner roll, and Rhonda is Lumiere's ex.
- Fanboy and Chum Chum: Shinji Kazama and Fez dress up like superheroes.
- Fangface: Chucky is a teenage werewolf who travels with his best friends Ferris Bueller, the Penguin, and Mindy. Chucky's baby cousin later arrives.
- Fish Hooks: Scott Pilgrim, Harold, and Dana are three high-school aged fish. Bladebeak is a Jerk Jock.
- Foster's Home for Imaginary Friends: Franklin brings his imaginary friend Sparky to a special home run by Patsy Smiles and Littlefoot. Other imaginary friends at the home include Ernie and Edward.
- Freakazoid!: Derek Zoolander is a crazy superhero.
- Futurama: Rattrap is unfrozen into the year 3000, where he befriends the robot Emmett Brown (later Nick Fury), the one-eyed mutant Stifler's mom, Rattrap's relative Professor Lawrence of Arabia (later Peter Griffin), and Doctor Worf (later Galvatron).
- Gargoyles: RoboCop leads a team of stone monsters. These monsters fight a Corrupt Corporate Executive named Jet Black.
- Gary the Rat: Jean-Bob is a defense attorney who wakes up one day, transformed.
- Geronimo Stilton: Zoro is a mouse reporter going on adventures with his nephew Kid Trunks, his sister Batgirl and his cousin Tarantulas.
- Gormiti: The Lords of Nature Return: Rock Lee, Yusei Fudo, Blue Beetle and Taruto (sometimes Doremi) became the Lords of Nature with the help of Blunk and fight Volcano Gormiti like Patrick Star and Captain K'nuckles.
- Gravity Falls: McGee and his twin sister Snowflake spend their summer vacation in the countryside with their great-uncle Shnitzel. Prince Brad is a child psychic. Raymundo and Yancy work for Shnitzel.
- In one episode, Snowflake meets the merman Michelangelo.
- Green Lantern: The Animated Series: Sasuke Uchiha and Wolverine find their way onto a spaceship voiced by Debbie. Jak helps Sasuke and Wolverine to form a team.
- The Grim Adventures of Billy & Mandy: Mr. Conductor and Chuckie Finster befriend Death himself, Skips.
- Grojband: Wybie, Coraline, Leonard Hofstadter, and Kon start a rock band. Wybie's sister is Margaret.
- Hero Factory: A rookie team formed by Death The Kid, Leonard and Kid Icarus and the Alpha Team formed by Bunnymund, Soundwave and King Julien fight against Maxum Man's bad guys like Dr. Drakken, Gabumon, Beaker and Gizmoduck. Later they fight other villain teams, like Davy Jones's one formed by Scrooge McDuck, Young McGuffin, Cyborg, Dr. Doofenshmirtz and Monterey Jack.
- Huntik: Secrets & Seekers: Orion Pax joins the organization led by Zoro along with Fionna, Kururu and Ino Yamanaka to search for the Titans hidden around the world.
- Invader ZIM: Seto Kaiba arrives on Earth with his robot Sam Manson for one reason: to Take Over the World. Brock and his sister Barbie try to prove that Kaiba is an alien. Their teacher is Thelma, and Nami is Kaiba's rival.
- Iron Man: Armored Adventures: Sasuke (later Robin) builds a suit of armor. He and his friends Twilight Sparkle and Danny Phantom fight against James and Megatron.
- Jakers! The Adventures of Piggley Winks: Plucky Duck (who grows up to become Professor Oak), Toodee, Cheese Sandwich (son of Batman), and Spanky Ham have adventures on their farm.
- Jem and the Holograms: Sailor Jupiter, with her sister Mystique, and friends Maddie Harrington, Pollyanna, and later on Sailor Pluto, form a rock band. Big Bad Iron Will starts a rival band, which consists of PeeBee Kappa, Rupert Bear, the Queen of Midland, and later on Jenny Willis Jefferson. Season three brings in a new band, which has Troy McClure, Dimitria, and Sabrina. With Troy in the season, Jupiter finds herself in a love triangle with him and Jadeite.
- Jimmy Two-Shoes: Ash Ketchum lives in Miseryville, which is ruled by Principal Skinner and his servant Pinky. Ash's friends include Skinner's lazy son Leeron and the evil scientist girl Numbuh Five.
- Johnny Bravo: Gregory House is an Elvis Impersonator who tries (and fails) to get women.
- Johnny Test: Edward Elric is an 11 year old boy whose pet dog is Portgas D. Ace. Tux's sisters Kurama and Jessica are inventors who have a crush on Usopp,but Yugi has a crush on Jessica. Tux's parents are Fancypants and Catwoman.
- Kappa Mikey: Hal Jordan is an American actor on a Japanese superhero show.
- Kick Buttowski: Power Man is a daredevil, and his best friend is Simon. Power Man lives at home with his parents Lois Griffin and Don Karnage (?), brother Gale Hawthorne, and sister Yin.
- Kim Possible: Under the orders of Kick Buttowski (later Kid Flash), Elle Woods and Numbuh One (alongside Numbuh One's pet Mandy) split time between high school and crime fighting; they often fight Drew Pickles, Sidney Prescott, Darkwing Duck, Merlock and his son Jocktopus (later Dawson Leery). At school, which is run by Bumblebee, Elle cheerleads with Tucker and Alpha Bitch Johanna Mason, has a crush on George Michael, and is best friends with Ed. Elle lives at home with her parents Lois Foutley and John Munch and younger twin brothers Tommy and Chuckie.
- King of the Hill: Alan Garner and Louise Fitzer live together in Arlen, Texas with their son Shinji Ikari and niece Sam Sparks Their neighbors include the Laotians Bob, Rita Skeeter, and Roo; the ctazy Hiro Nohara, his wife Lois Lane and their son Milo (whose father is actually Major Monogram); the fast-talking Elchavo Del Ocho; and the pathetic Darnell. Alan's father Sir Hiss is a war veteran.
- Legion of Super Heroes: Ben Tennyson, Harold, Bella Swan, and Randy Taylor go back in time to get help from the man of steel himself, Marty.
- Littlest Pet Shop (2012): Scootaloo moves in a new town with her father Jazz. After discovering she can talk to animals, she decides to work in Airazor's pet shop where the pets are Sumo, Misty, Jessie, Kakashi, Kiba, Tenten and Kyubey. Scootaloo's rivals are the twin sisters Hana-chan and Sam.
- Loonatics Unleashed: Shinji Ikari, Keitaro, Kagome, Tripp Campbell, XLR8, and Red Forman must now save the world.
- The Looney Tunes Show: Riiya and Chicken (who have both been Petrie at some point) share a home. Marie Kanker is a Stalker with a Crush on Riiya.
- The Magic School Bus: Babs Bunny, a Crazy Awesome teacher, teaches her students (Dee-Dee, D.W., Batgirl, Gaz, Donnie Thornberry, Ben, Susan Test, and Jenny "XJ-9") about science with her Magic Bus.
- The Marvelous Misadventures of Flapjack: Spongebob Squarepants, against the will of Clay, raises Lil' D to be a sailor. The duo do crazy things like begging Mr. Turtle for candy or getting surgery/haircuts from Jabberjaw.
- Martin Mystery: Sokka (later Wolfgang), his stepsister Nathalie Breeze and caveman Garfield fight monsters together with the little alien Heloise.
- Megas XLR: After finding a robot in a junkyard, Leonard flies it into outer space while Lydia Deetz and Kumamon watch him fight aliens.
- Mike, Lu & Og: The Gossip Girl, Padme, and Cosmo have adventures on their island.
- °Mucha Lucha!: Jay, Betty and Ulrich attend a school for wrestlers.
- My Gym Partner's A Monkey: Gwen, Fievel, WALLēE, Olive Oyl, Mrs. Potato Head, the Crimson Chin, and Colin Hart attend a school for animals run by Hannibal Lecter. Gwen is the Token Human.
- My Life as a Teenage Robot: Misty is a teenage robot built by Ling-Ling. Her best friends are the human brothers Bling-Bling Boy and Twister.
- My Little Pony: Friendship Is Magic: Sakura and Riza Hawkeye, the students of Fifi, move to Ponyville, where they befriend Chopper, Wendy, Jimmy Neutron, Jem and Tenma.
- Cheetor is Tenma's brother, her cousin is Kristoff, her grandma is Luna and her sister is Mikami. Later Mikami, Wendy's sister Pop and Dia form a secret club to find their talents. At school, the "Cutie Mark Crusaders" are bullied by Kitty Pryde and Keroppi. Chopper, Dia and Tenma become Lucy when they sing. Jem works in Dib and Hilary Higgenbottom's bakery; they later have two babies that Jem has to take care of. Sailor Venus is the local teacher.
- Season 1: Aquaman and the Joker brought news of the Great and Powerful Aki Izayoi, who claims to have fought the Ursa Major. Eli (later Raymundo) and Chibiusa (later Hikari Hanazono, and later more Droite) are stunt flyers, Airachnid lives in the forest brewing magic potions, Link is a famous stylist, Spanky Ham, Meowth and Antoine kidnap Wendy for gem colecting, the Tasmanian Devil is chief of the buffalo tribe, Mandark is Chopper's childhood friend who's also a jerk, and Wendy falls for Bummer at a dance.
- Season 2: Wolverine brings chaos, Jem offers her friendship to grumpy Roshi, Wendy enters in the Canterlot …lite meeting Professor Layton and Blitzwing, Otto Rocket and Joey Wheeler challenge Tenma's family to make apple cider, Dr. Robotnik teaches assertiveness to Jimmy, Catwoman replaces Jean Grey at her wedding with Sakura's brother Geronimo Stilton, Tiff is Fifi's sister, Chopper reads a book about Miko Nakadai fighting Megatron and Sayaka Miki is the fan-favorite cross-eyed klutz. On the night of tornado, Tintin can't stop coughing. Tarantulas and Terrorsaur are two great chefs.
- Season 3: Aki returns for a magic duel with Sakura, Mikami's cousin Mandy becomes the fourth crusader, and King Sombra once ruled the Crystal Empire. Sam becomes Chopper's rival.
- My Little Pony Equestria Girls: Sakura follows Harley Quinn, who stole her crown, into the human world. Here she falls in love with Chiaki and meets the parallel counterparts of her friends.
- Season 4: Chopper discovers that Miko really exists and helps her in defeating King Bradley and Megatron (now Eek), the Mane 6 get vacuumed in a comic book and fight against Motoko Kusanagi, Howie challenges Jem to a Goof-Off, Astral is a popular trendsetter, Manic is the leader of the Breezies, Jem reunites with her sister Batgirl and Edward Newgate is an evil demon lord who drains powers out of ponies. Wolverine pretends to be sick; as Plankton, he tells Jean Grey and Sakura what he needs in song. Mikami disobeys her sister and meets a chimera formed by Strudel, Rebound and Simone, Otto and Joey sell a "miracle tonic" with the help of Bloo.
- My Little Pony Equestria Girls: Rainbow Rocks: Sakura returns to the human world, where she joins a batle of the bands against Gretchen, Keesha, and Dorothy.
- Over the Garden Wall: The theme song singer for countless 90s TV shows accompanies a comic book artist back home.
- The Penguins of Madagascar: Santa Claus, Luigi, Pepe le Pew, and Dave Seville are penguins living in the New York Zoo. Amu is their best friend, while Courage the Cowardly Dog (along with Captain Typho and Aladdin) is their rival.
- Chris Griffin is an evil dolphin!
- Peppa Pig:(seasons 1 and 3) Reese and Urara are Morticia and Troy McClure's children. Fox Mulder narrates.
- Pepper Ann: Gi is a middle-school student who lives with her tomboy sister Lois Lane. Her beat friends are Cinderella and Danger Duck, and the school principal is Doggie Kruger.
- Pet Alien: Michelangelo meets some aliens and lets them into his house.
- Phineas and Ferb: Cody and young Samson (later Cameron) are inventors, while their sister Ed tries to expose their plans to their parents Lois Griffin and Ren McCormack. Meanwhile, the boys' pet platypus is told by Principal Skinner to fight the evil inventor Mr. Pink and his daughter WordGirl (sometimes Live-Action!Sabrina Spellman). Harry Potter is Ed's boyfriend, and Carl Foutley is the local bully.
- Pinky and the Brain: Mr. Garrison (later Mace Windu) is a lab mouse who wants to Take Over the World, with his assistant Krusty the clown. In the last season, they get adopted by Giselle.
- The Powerpuff Girls: Kate Beringer, Raven, and Ruby Gloom are three sisters created by Shenron (later Mr. Barkin) who set out to save the day before bedtime and defeat enemies like Otaki (later Eeyore).
- The Proud Family: A look inside Pocahontas' crazy family, including her mother Sgt. Calhoun, father Tenma, and grandmother Jessica Rabbit. Pocahontas' friends include Brittany Miller, Brittany's real life sister Millie and Alex Mack.
- Randy Cunningham: 9th Grade Ninja: Fox McCloud becomes a ninja and protects his school.
- The Real Ghostbusters: He-Man (later Luke Skywalker), Machete, Robert Barone, and Colonel Stuart are ghost hunters.
- ReBoot: Secret Squirrel, Faye Valentine, Pocahontas, and the Penguin are computer programs.
- Recess: Optimistic, energetic Mepple is a nine-year-old boy who leads his friends in adventures at their school. His team consists of athletic Boots, tough-as-nails Haruhi Suzumiya (who has a crush on Mepple), girl genius Liz Wilson, over-dramatic Lindsay, and shy new kid Danielle. 9 and Buford are identical best friends who spend their time during recess digging holes. Their bubbly and sweet fourth grade teacher is Zira, while Bushroot is the school principal.
- Regular Show: Marker Clan and Iron Man work for Hatchi, along with Grim, either Father Time or Cupid, and Slam Tasmanian.
- Rekkit Rabbit: Finn's life is normal, until he buys a magical hat and wand online and the giant rabbit Viral appears.
- The Replacements: Whenever they have a problem in life, Pretty Sammy and her brother Shin-chan call their uncle to replace the troubling adults. Sammy and Shin live with their adopted parents: a secret agent named Norma Jean and a daredevil named Wolverine.
- Rocket Power: Caleb, Dexter, Nico Robin, and (female) Commander Shepard do extreme sports. Caleb and Dexter's father is Animal.
- Rocko's Modern Life: Dr. Drakken and his wife hate their next door neighbor, the title character, whose best friends are a cow Raised by Wolves and a turtle.
- Rugrats: The adventures of Meg Griffin and her friends. T.J. and Katara are twins who enjoy the dirt.
- The 7D: Dopey, Uncle Grandpa, Shoutmon, Oogway, Bail Organa, Billy Nolan, and Steve Williams are seven dwarves who fight Haruhi Suzumiya and her lover Quackerjack.
- Sabrina: The Animated Series: Misty is a teenage witch. She lives with Tarantulas, the ex-wizard turned into a cat Dib and her two aunts Arcee and Sakura. At school, Nami, Bugs Bunny and Krillin are her best friends and Barbie is her rival.
- Samurai Jack: Mace Windu is a warrior sent into the future by Inferno.
- Sanjay And Craig: Sparrowmon does crazy hijinks with his pet snake Teru Mikami.
- Scaredy Squirrel: Jacob Black works as a stacker at a grocery store run by Bartok. Jacob's best friend is Uncle Grandpa.
- The Secret Saturdays: John Lennon is the son of Agent Six and Betty Ross. They fight Mumm-Ra.
- Sidekick: Kyon (later Scott Pilgrim), Simon, Beth and Dizzy (later Dot Warner) attend a school for superhero sidekicks. Kyon is Cyborg's sidekick.
- The Simpsons: Axel Foley (later Ramon) married Charlie Brown (later Magica De Spell). They have a son named Enzo (later Takato), daughter Juniper Lee, and a baby.
- 6teen: Steve Urkel, Sharkboy, Raven, young Tarzan, Brenda Blue, and Wilbur Robinson are 6 teens who hang out at the shopping mall.
- Slugterra: After the disappearance of his father, Bren goes in the underworld to protect it along with Professor Layton, Kilowog and Diamond Tiara.
- Sofia the First: Anais is a princess.
- Sonic Underground: Triplets Patrick Star, Sideswipe and Tea Gardner search for their mother Athena as they fight against Optimus Primal, Splinter and Shredder. Jimmy Two-Shoes lives alone on Angel Island; he hates thieves.
- South Park: (seasons 1-4) Stewie Griffin, B.O.B. (later Megavolt), Dwight Conrad, and one of the show's creators are 4 boys from Colorado.
- Space Goofs: Tarantulas (later Kaito Kid, Marshall, Raphael, Newton and the two-headed Superman and Duo Maxwell are five aliens living in a human house.
- Spider-Man: The Animated Series: After the death of his uncle, Lupin III uses his spider powers to fight crime. He works as a photographer at Vishinsky's newspaper. Lupin's love interests are Princess Sissi and Prue Halliwell. He fights the 8th Doctor, Hobgoblin, Optimus Prime, and the narrator of Nausicaš of the Valley of the Wind. Banzai, Captain America, and Professor Frink sometimes help Lupin.
- Spongebob Squarepants: Pegasus lives in a pineapple. His neighbors are Captain Barbossa and the third Hokage. The third Hokage and Pegasus work for Mewtwo, whose main rival is Franky. Also, Clover is from Texas.
- Squirrel Boy: Manny Rivera is the pet squirrel of Joan of Arc.
- Static Shock: Lazlo gains superpowers after a freak accident and must keep them secret from his father, Venom. Later, Lazlo's friend Xandir gets his own powers.
- Star Wars: The Clone Wars: Ron Stoppable and Chihiro are the Jedi apprentices of Jason Bourne.
- Steven Universe: Ravi Ross, Sky, Ricky Sprocket, and Kitty Wilde are a group of magical heroes. Ravi's father is Roger Smith. Naruto and Wimzie work at the donut shop.
- The Superhero Squad Show: Darkwing Duck is mayor of Superhero City, where various heroes and villains live, such as Harold, Trent, Beth, and Leeron.
- Superman: The Animated Series: Iron Man is the Man of Steel (not literally)! He is adopted by Darkwing Duck, and works at the local newspaper with Katherine Mayfair (Meg Griffin in season 3) and InuYasha. As Superman, Iron Man fights villains such as Clayton and Yao.
- The Super Mario Bros. Super Show: Giovanni and his brother Aphrodite protect princess Rei from evil King Scorponok.
- Super Robot Monkey Team Hyperforce Go!: Spyro and his monkey friends Otto, Louie, Darkwing Duck, Tim the bear and Caitlin fight against the monkeys' creator Gendo Ikari.
- Sym-Bionic Titan: On a dying planet, Eggman sends his daughter Nunnally, Shu, and a robotic Alejandro (who sometimes disguises himself as Ed Bighead) to Earth where they disguise themselves as humans. With their Humongous Mecha powers they become the "Sym-Bionic Titan" to stop Lordgenome's army of monsters. Military leader Kowalski and Robbie Rotten's alien army are also following them. Shu falls for Precious.
- TaleSpin: Mayor Adam West loses his cargo delivery business to Doraemon (whose daughter is Sierra) and has to work as her pilot, accompanied by his new navigator, Max Goof. Surely Darkwing Duck is a pilot pirate.
- Teacher's Pet: Launchpad McQuack is a dog who dresses up as a human boy and goes to the same school as his master, Light Yagami, whose mom, Agent K, is also their teacher. The other pets in the family are a cat named Peter Griffin and a grouchy green canary named Mr. Miyagi.
- Teamo Supremo: Toph, along with two boys, are child crime-fighters. Puffin provides the kids' gadgets.
- Teen Titans: Aang recruits Naruto, Jonah Hex, Buttercup, and Cindy Campbell to form a team of superheroes. (Shampoo later joins them, but she later drops out.)
- Teenage Mutant Ninja Turtles 1987: Pilaf teaches 4 turtles named Mixmaster, Harvey Kinkle, Hoity Toity and Bakura in martial arts; they fight against the evil Metalhawk.
- Teenage Mutant Ninja Turtles 2003: The turtles (who keep their '87 voices) are now taught by Krush and often fight Mr. Krabs.
- Teenage Mutant Ninja Turtles (2012): The turtles (now Harold, Aang, Mamoru Endo and Gandhi) are trained by Optimus Prime and fight against Il Palazzo. Madoka Kaname helps them.
- ThunderCats (2011): After their planet is destroyed by Ice King; Joseph Gribble, Serena van der Woodsen, Togepi, and Lex Luthor go on a journey.
- The Tick: Chief Thunderhooves and Shining Armor fight crime.
- Time Squad: Kowalski, Dale Gribble, and Juni Cortez go to the past, helping historical figures live correctly.
- Tiny Toon Adventures: Barney Rubble, Mrs. Puff, Pinkie Pie, Elmo, Princess Sally, Starscream, Dee Dee and Meowth attend a school for cartoon characters.
- Total Drama Island: Kovu (with help from Chef Maurice) gathers these teenagers: Giselle, Edward Scissorhands, Tadashi Hamada, Claire, Good Will Hunting, Yang, Sokka (later Kevin Levin), Oscar, Riley Daring, Hermione Granger, Monique, Blossom, Mulan, Jessica Day (later Unikitty), Huey Freeman (later Tsukiyomi), Stephen Hawking, Charlotte, Yakko Warner, season 2 winner Timmy Turner, Ted, Puck, and eventual season winner Bartok; onto an island, where they compete for money. The world tour introduces two new contestants named Coop and Princess Kida, plus TV show host Vicky. Blossom manages to fight Coop and win Season Three.
- Kovu and Maurice return for season 4 with 13 new contestants: B, Lois Lane, Margo, Ben Tennyson, Death the Kid, Hiccup, Kagome, Andrea Beaumont, Brick, season winner Ferb, Rekuta, Steve Smith, and Rachel Berry.
- Rachel Berry wins the All-Star season. For season 6, Kovu brings twin sisters Katie and Aggie, Beardo, Gumball Watterson, Haley Long, Velma Dinkley, Scott Pilgrim, Greg Heffley, Joe Kido, Alex Mack, Deadpool, Laney Penn, Molly, and young Simba onto a new island. It's down to Deadpool and Laney in the finale.
- Totally Spies!: Princess Toadstool, Nami and Sandy Cheeks are three spies working for Lucario's agency. At high school, they have to deal with Angelica.
- The Transformers: Autobots, led by Lobo (later Huggy Bear), fight the evil Decepticons led by Uncle Jesse (later Herbert).
- Transformers Animated: An Autobot team formed by Drago, Tokageroh, Johnny Test, Kaiba and Roy Mustang lands on Earth, where they meet Dawn, daughter of Kogoro Mouri. The Autobots fight evil Decepticons led by Captain Hero and including Magmion, Tamama and Brook.
- Transformers Prime: Shredder leads the Autobots, with Commander Shepard, Mai Valentine, The Tick, a mute guy and Sanji, fighting evil Decepticons led by Mario, Vegeta, another mute guy, Giroro, Butters, Queen Chrysalis and an army of drones. The Autobots befriend human kids Parco Folgore, Hikari and Nobita, Folgore's mom Apple Bloom, and Agent Kilowog. Also, another bad guy is Escargoon.
- TRON: Uprising: Tombo is a computer program mentored by Megatron to fight the evil Count Dooku.
- T.U.F.F. Puppy: Angol Mois and Tintin work for the T.U.F.F. agency, which is run by Chief Discord and Koza the inventor.
- In one episode, Mabel Pines guest stars as an ice skater (the one in the carrot suit).
- Ultimate Spider-Man: Cleveland Junior is a teen with spider powers who attends school with Izzy Fuentes. Daffy Duck goes undercover as the school principal, while Biff Tannen assigns Cleveland onto a team with Mello, Zak Saturday, Troy Bolton and Ren Mikihara.
- Uncle Grandpa: Tantor, Pinky, Wolverine, and Leeron ride on a tiger as they entertain kids.
- Walter Melon: Chief Thunderhooves and his assistant Shun replace various heroes in their adventures. In every adventure, Gaz is the female lead and Starscream is the villain.
- Wander over Yonder: Robocop rides on BMO as he fights Principal Lewis and his henchman Pizza Steve.
- The Weekenders: Wasabi, Fred, Stacey, and Azula are California teens making plans for the weekend.
- What's New, Scooby-Doo?: Obi-Wan Kenobi, Marie Kanker, Rogue the bat, and Quackerjack are teenage detectives who travel with Chef Remy in their van, the "Mystery Machine".
- The Wild Thornberrys: Barbie discovers that she can talk to animals, such as her best friend Hunk. She travels the world with her sister Misty, adopted brother Jingle, and their parents Scarecrow and Hawkgirl.
- Winx Club: Ally Dawson, Lizzie McGuire, Topanga Lawrence, Maddie Fitzpatrick and Bridget Hennessy have magical powers and live their adventures in a Magical Dimension.
- W.I.T.C.H.: Pinkie Pie, Libby Folfax, Bu-ing Huang, Quinn Morgendorffer and Susan Test are chosen to be the new Guardians of Kandrakar. Alongside Superman the warrior, the Magical Girls go on a quest to fight an emperor and a sorceress.
- Wonder Pets: Numbuh 4, Austin and Tweety rescue baby animals.
- Wow! Wow! Wubbzy! : Sharpay Evans, Tai, and Pixel have adventures.
- Wunschpunsch: Mr. Sulu and Granny Smith are two wizards who are trying to bring chaos in their town under Squidward's orders. Link and Ganon have to stop them.
- Xiaolin Showdown: Bugs Bunny, Bubbie, Buena Girl, and Bloo are monks in training under Maximus IQ and his pet dragon Jabberjaw. They often fight Uncle Jimbo and his ghost Miss Endive.
- X-Men: Evolution: Jiraiya starts a school for mutants.
- Yin Yang Yo: Jinx and Max are trained as Woo Foo Knights from Optimus Prime. Dr. Nefario is an evil wizard.
- Young Justice: Rigby, Vector, Shinji Ikari, Anakin Skywalker, Nia, and an archer form a superteam.