The main protagonist of the film. He is a chameleon with aspirations for the stage and stardom, but most of all desires companionship. After being accidentally thrown out of his owner's car, he starts his journey towards his destiny.
Voiced by: Johnny Depp
BeansA ranch owner, this desert iguana found Rango and brought him to Dirt. She suspects that something has happened to the water supply of the town, that someone is throwing the water out into the desert.
Voiced by: Isla Fisher
PriscillaA young cactus mouse (or, if you believe Verbinski, an aye-aye) in the town of Dirt. At first she dismisses Rango as "funny-lookin'", she grows to admire him near the end. She has her own pair of revolvers, seems a little too excited about violence and death, and likes to make fun of strangers.
Voiced by: Abigail Breslin
Tortoise JohnHe is the mayor of the town of Dirt, who appoints Rango as the sheriff after killing the hawk. He is the wealthiest citizen in Dirt, and is a polite gentleman to the townsfolk, supporting their wishes of a better life. Early in the film, he is the only character with access to the town's supply of water, which makes Beans particularly suspicious. He's also responsible for sealing the water from getting it to the town, which is part of his grand plan to construct a more modern city outside the borders of Dirt (implied to be inspired by seeing the Las Vegas cityscape), which would eventually make it obsolete and the townsfolk forced to move or to face death.
Voiced by: Ned Beatty
"You got killer in your eyes, son? I don't see it."A fearsome, ferocious desert rattlesnake with a gatling gun for a tail and the secondary antagonist. He is called the Grim Reaper and lauded by many as a ruthless killer who "doesn't leave a town without taking a soul." He secretly worked for the Mayor until near the end when the Mayor turned on Jake.
Voiced by Bill Nighy.
WafflesPart of the posse. A horned toad with a simpleton personality and less than appropriate amount of teeth. Regarding to his official information, he writes "surprisingly bad haiku."
Voiced by James "Jim" Ward Byrkit
Wounded BirdPart of the posse and Rango's deputy. A Native American raven who is a quiet bystander and uses a crutch of some sort to help himself walk. His general information from the movie's website states that his tracking skills are legendary and that he's big in Finland for reasons unknown.
Voiced by Gil Birmingham
AmbrosePart of the posse. An owl of some sort, dresses like a gentleman and, according to his official information, is a professional gambler and can speak in 12 languages.
Voiced by Ian Abercrombie
The Mariachi Owls
Rock-Eye the Toad
Mr. Johannes "Fluffy Joe" Merrimack III