How many Academy Awards does Clint Eastwood have? Five. How many 'golden guardians' does the Spirit of the West, an expy of The Man With No Name, have? Five.
Rango's name, despite being Durango without the Du, is most likely a refference to Ringo, the main character of A Pistol For Ringo, an Spaghetti Western staring Giuliano Gemma.
Appearing as Lotso in Toy Story 3 and the Mayor in this film means that Ned Beatty was in two Academy Award-winning animated films in a row. In both cases, he plays the Big Bad.
Album cover artist Roger Deakins was the responsible for the film's unique look.
Actor Allusion: Many, but the most obvious one is when Rango is flying through the air on the highway, he smacks into the windshield of a car driven by Raoul Duke and Dr. Gonzo. (It doesn't hurt Rango himself wears Duke's Hawaiian shirt.)