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"Doom is supreme! There is no power on Earth, no intellect in all creation to equal mine!"
Examples of Big Bad in the Marvel Universe.

The following have their own pages:

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    Comic Books 

Comic Books

Recurring Big Bads
  • Doctor Doom has a big habit of being this, as does Magneto, and the Red Skull, in the wider Marvel Earth. The Kingpin is sometimes this when it comes to more purely criminal scales. They recur so much as local Big Bads in their respective corners of the Marvel Universe, that they eventually joined forces (manipulated by Trickster God Loki, obviously) during the Acts of Vengeance crossover (see below), along with the Mandarin and the Wizard.
  • Thanos, the Mad Titan: he alternates as the Big Bad in storylines from the original Captain Marvel, Silver Surfer and the Cosmic corner of the Marvel Universe:
    • He took Eternity's place. Twice. He had Mephisto kowtowing to him, and Mephisto is the Devil. He's Marvel's designated "Big Bad that other Big Bads worry about". The kicker: he does it all for love... of Death.
    • In one storyline, Thanos is in an Enemy Mine situation with Marvel's cosmic heroes to combat an even bigger Big Bad: the Fault. Which means the Big Bad of this event is essentially Life without Death.
  • Mephisto himself is nothing to snuff at, either. The nearest equivalent Marvel has to Satan, he has taken the time to torment nearly every hero in the Marvel Universe. Aside from giving Spider-Man fans One More Day (thus proving himself the epitome of evil), he has made efforts to take the souls of pure hearted heroes like Black Panther and the Silver Surfer, messed with the Fantastic Four on several occasions (one of which got him destroyed, leading to a convoluted chain of events that led to him accidently kicking off the process that drove the Scarlet Witch insane), and just generally causes havoc. He's strong enough to at least tussle with the likes of Odin and Galactus, created the demon Blackheart as a son who has proved to be every bit as evil as his dad, turned Johnny Blaze into the Ghost Rider, abducted the mother of Doctor Doom, and helped to create Daimon Hellstorm. There was also The Avengers (Jason Aaron), with his role in working with various alternate selves to create a Multiversal Masters of Evil, as well as creating simulacrums of the Squadron Supreme and orchestrating the Power Elite.
  • In the mini-crossover event "Chaos War", former Ares and Hercules baddie Amitsu Mikaboshi upgrades to the Chaos King, nominally the ultimate Marvel villain ever - he scares Eternity, has Death on the run and knocks Galactus on his ass. His beef: He is the darkness from before the universe was created and he wants to go back to that.
  • He's more of a Greater-Scope Villain because of his handful of actual appearances, but few forces are as responsible for as much evil as the Elder God Chthon. An ancient demon native to Earth and perhaps the first and oldest sorceror to ever live, Chthon is the creator of the race of demons known as the N'garai and the author of the Darkhold, the first and most powerful book of Black Magic on the Marvel Earth, which he left on the planet as a conduit for his eventual return and which is responsible for the creation of vampires and, by extension, the fall of Atlantis. A piece of his essence is sealed in Mount Wundegore in Eastern Europe, from where the Puppet Master gets his magical clay and where he encountered a young Wanda Maximoff, the Scarlet Witch. Chthon placed a piece of his power inside her so that he might one day use her as his host, so the reason she is so powerful, and therefore the reason she became such a threat to the universe, is entirely his fault. Being an Elder God, he carries some of the blame for the existence of Mephisto and the rest of The Legions of Hell as well.
  • Galactus had his turn of being this at times, often acting as the Big Bad for the Silver Surfer, the Fantastic Four and the cosmic corner of the Marvel Universe:
    • His first appearance was the FF arc The Coming of Galactus, where he faces the Fantastic Four as they try to stop him from consuming Earth.
  • Magneto, the Master of Magnetism: he is primarily a villain from the mutant corner of the Marvel Universe, but dips his feet in the water of other corners.
    • He is the main villain from the original 60's run of X-Men, coming into blows with Xavier's X-Men either alone or leading the Brotherhood of Evil Mutants.
    • In one early-70s storyline, he fights Namor and the Fantastic Four.
  • The Kingpin of Crime: Wilson Fisk's criminal enterprise cross paths with the street-level heroes of New York, namely, Spider-Man, Daredevil and the Punisher.
    • Whenever he crosses paths with Daredevil, he usually employs hired assassins to do his dirty work, such as Bullseye, Elektra and Typhoid Mary.
  • Ultron is the ultimate robotic Big Bad in Marvel. These days, when he pops up it's invariably on the final page of the build-up issue, usually after a few horrified whispers of the "Oh no - not him!" - "It can't be!" - variety.
  • HYDRA -as an organization- sometimes appears in this capacity for the Marvel Universe at large, but its leaders aren't slouches either:
    • One of its founders is Nazi Baron Strucker, who once upon a time contended with Captain America.
    • Madame Viper (sometimes Madame Hydra) leads the organization in Strucker's absence.

Big Bads for Individual Heroes

  • For Black Panther it's either Ulysses Klaw, the man who killed his father, who T'Challa injured the hand of in retaliation, or Erik Killmonger, his evil counterpart who tried to overthrow him in Wakanda.
  • In Kid Colt (2009) Sheriff McGreeley is behind almost all of the villainy. McGreeley's brother Joshua murdered Colt's family and Colt avenged them, killing Joshua in self-defence. After that, it was McGreeley, a Dirty Cop and Small-Town Tyrant, who framed Colt for murder and put a price on his head. He sets the plot of the 2009 series in motion by hiring Sherman Wilks and his Bounty Hunters to bring in Kid Colt, with no intention of letting Colt live long enough for a fair trial. All of this was part of a wider rewrite - prior to the 2009 series, Colt's family had been killed by an entirely different group of villains.
  • The Mandarin in the Iron Man series is one of Iron Man's most dangerous enemies, with his alien rings allowing him to fight evenly with Iron Man's suits of armor.
  • The Punisher has Jigsaw, one of his more persistent adversaries during his crusade against crime.
  • If someone is making the Hulk's life hell, it's The Leader, who was exposed to gamma radiation but with enhanced intelligence instead of strength, and often uses his intellect for various evil schemes.
  • The Inhumans have Maximus the Mad, who is the evil brother of their king, Black Bolt, and has manipulated conflicts to deal with the royal family.
  • Thor had his stepbrother Loki and the fire demon Surtur for the longest time serving as his main enemies, though with the dawn of the cinematic universe, and thus Loki's shift into a more morally ambiguous role as a result, as well as Surtur taking on a more consistently dead role, Malekith the Accursed rose up to compete for the role, which was cemented with storylines such as War of the Realms.
  • In the days before Kingpin made wrecking Daredevil's life his hobby, the Owl served this role for him.
  • The Big Bad of the Doctor Strange title tends to be Dormammu, a Dimension Lord Eldritch Abomination who is the source of most of the conflict in Dr. Strange's life, either directly or through minions like the treacherous Baron Mordo. If its not him then its likely to be Shuma-Gorath, who killed Strange's mentor the Ancient One and is an even more powerful demon than Dormammu himself, and ruled the Earth twice in the distant past.
  • In Runaways Alex's parents, Katherine and Geoffrey Wilder were the leaders of The Pride, and the major antagonists of the first arc, with The Gibborim in back of them. In the second arc, the writers go out of their way to imply that the Big Bad is Alex Back from the Dead; in reality it's a version of Geoffrey brought from 1985 to the present.
  • Captain America:
    • The Red Skull almost always plays the role of the Big Bad. Whenever there is an evil plot in the Captain America comic, there is 80% chance that the Red Skull is behind it.
    • And if it's not Red Skull, it's Baron Zemo, either the first, Baron Heinrich Zemo, or his son, Baron Helmut Zemo. The two Zemos have served as major Avengers villains as well due to their roles as the leaders of various incarnations of the Masters of Evil.
  • Spider-Man:
    • For about a year during Dark Reign, the biggest bad in Marvel was Norman Osborn, with Baron Strucker being a close second now that HYDRA has been upgraded to a full-on Ancient Conspiracy (ca. 2009-2010). Long before this, Norman was one of Spider-Man's main adversaries as the Green Goblin.
    • Another recurring Big Bad in the "Spider-Man" comics is Doctor Octopus. He was a recurring antagonist during the 60s and 70s, founded the Sinister Six (in 1964) and managed to take over Spider-Man's body for a while (2013) before Peter finally took it back.
    • Venom: he was introduced as Spider-Man's next great villain in 1988 (in "Amazing Spider-Man" #299-300), then returned as antagonist in ASM #315-317, #332-333, #346-347, and #374-375, after which he became a vigilante anti-hero.
      • Venom in his series has various archenemies like Crime Master and Lord Ogre as well as the Third Sin-Eater as well as his psychotic Antagonistic Offspring Carnage. Knull is also this for the venom franchise as a whole being the god of symbiotes (as well as being the original wielder of the Necrosword, which is used by Thor antagonist Gorr the God Butcher). Later Meridius for the 2021 series.
  • X-Men:
    • Mystique was introduced way back in the 70s as Ms. Marvel's arch enemy, and was later transplanted into the X-Men corner of the Marvel Universe. After her foster daughter Rogue joins the X-Men, Mystique becomes the latter's arch enemy. In storylines that involve an incarnaton of the Brotherhood of Mutants, she ofter appears as their leader, planning to kill an anti-mutant presidential candidate (e.g., Days of Future Past and Dream's End). Later loses this status to Master Mold and the Sentinels.
    • The X-Men usually have Enemy Mine moments with their main nemesis Magneto (and his followers, the Acolytes and/or Brotherhood of Evil Mutants) when confronting Apocalypse, who as one of the first and oldest mutants, aims to control the world, so he could count, too.
    • Mr. Sinister was the X-Men's Big Bad for a couple of years and quite a credible threat in the mid-to-late 1980s, being the Greater Scope Villain of the Mutant Massacre (1986) and taking on the Big Bad role in Inferno (1989) after main antagonist, Madelyne Pryor, dies. Later, he is demoted to a disciple of Apocalypse.
    • During the "Dark Phoenix Returns" arc, Mystique received horrible dreams about being hunted by Mastermind and Jean Grey (the titular Dark Phoenix), the Phoenix effect appeared in the sky over Tokyo, Wolverine's bride-to-be was hypnotised into saying "no" at the altar, and Emma Frost, White Queen of the Hellfire Club, was put in a coma. This all seemed to be the leadup for Phoenix to return, and culminated in Xavier being left in a coma and Phoenix's apparent resurrection. In reality, it was all a sham, orchestrated by Mastermind, the arc's real Big Bad. Mastermind was also one of the central antagonists of the original Dark Phoenix saga as well, with his membership in the Hellfire Club helping corrupt the Phoenix Force in the first place.
    • The biggest bad of Grant Morrison's much-beloved run on the book, although he personally didn't do much, was John Sublime. He created the Weapon Plus Program (which included the Weapon X Project, making him arguably Wolverine's Big Bad too), wrote the book that inspired the U-Men, gave Cassandra Nova her technology, and the drug Kick, which drove Xorn and Kid Omega insane, is made from his substance. He is partly responsible for the phenomenon of anti-mutant prejudice itself, subtly compelling humanity to be hostile to the emerging sub-species, making him arguably the Big Bad for the entire X-Men franchise.
    • Chris Claremont's X-Treme X-Men, which ran concurrently with Morrison's run, had Original Generation character Elias Bogan, a centuries-old disembodied mutant said to have been the original founder of the Hellfire Club. While he wasn't the main villain in every arc, he was the only villain to appear in more than one and was also the Final Boss.
    • Wolverine:
      • Romulus for most arcs being a prominent member of weapon x.
      • The Founder is the Big Bad of Jason Aaron's run for Wolverine.
      • In X-23 series Dr. Zander Rice is this until his death and later Kimura takes the role.

Crossover Big Bads

Alternate Universe Big Bads

    Films 

Films


  • Blade Trilogy
    • Blade (1998): Deacon Frost, an upstart vampire who wants to resurrect the Blood God so bloodsuckers can rule the Earth.
    • Blade II: Jared Nomak, the leader of a mutated strain of vampires who intends to usurp the main breed.
    • Blade: Trinity: Drake, who plans to eliminate Blade and lead the vampires in finalizing their dominance over humanity.
  • Captain America (1979): Lou Brackett, who kidnaps Steve's scientist friend and forces him to build a bomb in order to destroy the city of Phoenix.
    • Captain America II: Death Too Soon: Miguel, a notorious terrorist who ransoms Portland under the threat of killing the population with a serum that causes Rapid Aging.
  • Captain America (1990): Red Skull, whose attempt to launch a missile at Washington leads to Steve getting frozen, and come Cap's return decades later, plots to brainwash the President.
  • Daredevil (2003): The Kingpin, who controls all of the crime in Hell's Kitchen and sends Bullseye to kill Daredevil.
  • The Fantastic Four: Doctor Doom, Reed Richard's Evil Former Friend who's bent on killing him after an experiment of his nearly killed him; assembling a laser that he threatens to use to destroy New York City.
  • Fantastic Four (2005): Like in the previous film, Doctor Doom is the main villain; a billionaire who was caught in the same cosmic storm as the Fantastic Four and plans to use his new powers to achieve godhood.
  • Fantastic Four (2015): Victor von Doom is the villain yet again; this time wanting to destroy the world under the belief that humanity's a threat to Planet Zero.
  • Ghost Rider: Blackheart, the son of Mephisto who seeks to obtain the contract of San Venganza and gain the power of a thousand evil souls.
  • Hulk: David Banner, being responsible for destroying Bruce's life and creating the Hulk by experimenting on himself and his son out of an obsession with advancing humanity beyond its limits. He intends to drain Bruce's powers use them to get his revenge on the military.
  • Marvel Animation
  • The Punisher (1989): Lady Tanaka, the Dragon Lady Yakuza boss trying to take over New York's crime scene.
  • The Punisher (2004): Howard Saint, a mob boss who Frank wages war with after he has his family killed.
  • Punisher: War Zone: Billy Russoti/Jigsaw, a mob boss who sets out to kill Frank Castle as revenge for disfiguring him.
  • Spider-Man
  • X-Men Film Series:
    • X-Men: Magneto, who intends on sacrificing Rogue to power a machine capable of turning normal humans into mutants, but is unaware that the artificial mutations are unstable and will kill the affected.
    • X2: X-Men United: William Stryker, who intends to use a machine called Dark Cerebro to rid the world of mutants, although Magneto hijacks the role after he's killed and attempts to use the machine to kill all humans instead.
    • X-Men: The Last Stand: Magneto, again. This time, he builds an army and prepares to attack Alcatraz island, where a cure for mutations is being developed. His efforts lead him to recruit the unstable Phoenix, who goes on a rampage during the film's climax.
    • X-Men Origins: Wolverine: William Stryker, who Wolverine sets out to kill after making him undergo the horrific Weapon X procedure.
    • X-Men: First Class: Sebastian Shaw, the leader of the Hellfire Club who intends to start World War III by stirring the conflict between the US and the USSR, which leads to the X-Men joining together to put an end to his plan.
    • The Wolverine: Ichiro Yashida, who's responsible for bringing Logan to Japan as apart of an Evil Plan to steal his Healing Factor.
    • X-Men: Days of Future Past: Mystique and Bolivar Trask compete for the title of main villain; it's Trask's Sentinels that lead to the Bad Future, but it's Mystique killing him and being captured for experimentation that leads to the Sentinels getting approved by the government, making her the one whose Evil Plan needs to be stopped. That is, until Magneto hijacks both their plans.
    • Deadpool (2016): Ajax, the one responsible for Wade Wilson's scarring and insanity, and hunts Wade down for destroying his facilities and reneging on their deal.
    • X-Men: Apocalypse: Apocalypse is the main threat, given the film's Antagonist Title; assembling four mutants to act as his horsemen to aid him in conquering the world.
    • Logan: Dr. Zander Rice. He's the scientist responsible for the mass suppression of the Mutant gene and the one ordering Pierce to capture Laura.
    • Deadpool 2: The headmaster whose abusive treatment of mutant orphans is what set Russell Collins on the path to his Start of Darkness.
    • Dark Phoenix: Vuk, the leader of an Alien Invasion that seeks to seize control of the Phoenix Force and use it to wipe humanity off the face of the Earth.
    • The New Mutants: Cecelia Reyes, who keep the New Mutants captive to evaluate for the Essex Corporation's program where they'll be weaponized.

    Live-Action TV 

Live-Action TV

  • Blade: The Series: Marcus Van Sciver is portrayed as the main villain of the series.
  • The Gifted (2017):
    • Season 1: Dr. Roderick Campbell takes over as this for the first Season as soon as Jace goes to him for help, providing him with the means to continue the hunt for the Mutant Underground after being taken off the case and even going so far as to giving a Department of Justice officer a stroke to proceed with the operation.
    • Season 2: Reeva Payge for the second season, being the leader of the Hellfire Club with plans to annihilate both humans and opposing mutants.
  • Helstrom: Kthara, the demon possessing Victoria, is the most active antagonist and master of the demons the Helstrom siblings face. The siblings’ father, Marduk, is The Ghost and Greater-Scope Villain outside of flashbacks and the Sequel Hook, with his past actions having a huge impact on the backstories of a large majority of the cast. Not the least of which is that he's also the father of Kthara.
  • Legion (2017): The Shadow King was the primary antagonist of the first two seasons, although he ends up a Disc-One Final Boss in the Season 2 finale, with David Haller easing into the role of Villain Protagonist for the latter half of the episode.
  • Spider-Man (Japan): The main villain of the series is Professor Monster, who has laser-beam eyes but tends to sit around commanding things.

    Video Games 

Video Games

  • The Amazing Spider-Man: Alistaire Smythe, creator of the Spider-Slayers and the new head of scientific research at Oscorp after Curtis Connors was imprisoned.
  • Captain America and the Avengers: The Red Skull, who assembles various supervillains in a plot to takeover the world.
  • Deadpool (2013): Mister Sinister, who plots to take over the world with his clone army.
  • Guardians of the Galaxy (2021): Magus, the personification of Adam Warlock's dark thoughts and the one behind the Universal Church of Truth. Grand Unifier Raker is the public leader of the Universal Church of Truth, who sought to bring his son back to life. Having been lied to by Magus, he planned to feed "Faith Energy" to the Matriarch, who was Nikki being possessed by Magus, to complete the Fulfillment, which he falsely believed would bring back the dead for the Church's followers. Magus then planned to use the harnessed energy to consume the universe, before taking over Adam Warlock's body in order to destroy the universe when that failed.
  • Guardians of the Galaxy: The Telltale Series: Hala the Accuser, who seeks the Eternity Forge in order to revive the Kree, who had been eradicated by Thanos, so they can reestablish their galactic empire.
  • Hulk: Leader, who assembles several other villains to aid him in creating an army of gamma mutants to takeover the world.
  • The Incredible Hulk: Ultimate Destruction: Emil Blonsky and Devil Hulk make up the game's Big Bad Ensemble; with Devil Hulk spending the game trying to take control of Hulk and destroy the world, while Blonsky is the main obstacle for most of it due to his pursuit of Bruce Banner. After Devil Hulk's defeated, the focus of the game is stopping Blonsky, who has surrendered himself to the Abomination.
  • LEGO Marvel Super Heroes: A Big Bad Triumvirate of Loki, Magneto and Doctor Doom. However, Loki is the one behind the other villains teaming up and has the most plot significance out of all of them, due to Loki seeking to control Galactus and destroy Earth and Asgard.
  • Marvel Nemesis: Rise of the Imperfects: Niles Van Roekel, the alien creator of the Imperfects leading the invasion on Earth.
  • Marvel Ultimate Alliance series:
  • Marvel vs. Capcom and predecessors:
  • Marvel's Avengers: Monica Rappaccini. Five years ago, hoping to steal Terrigen Crystals, Monica hires Taskmaster to attack San Francisco, inadvertently causing A-Day and leading to the mass empowering of many Inhumans. In the present, Monica acts as second-in-command of A.I.M. to George Tarleton. In her position, Monica kidnaps and tortures Inhumans in order to replicate their powers through Adaptoids, as well as subjecting Tarleton to a regenerative serum derived from Captain America. When Tarleton, now calling himself M.O.D.O.K., finds out about Captain America, he kills Monica, and serves as the Final Boss. After M.O.D.O.K.'s defeat, Monica, who survived through a clone body, takes over A.I.M. as the new Scientist Supreme and continues her experiments.
  • Spider-Man (2000): Doctor Octopus, who breaks out several supervillains that Spidey must deal with and unleashes numerous symbiotes across New York to bond with and advance humanity.
    • Spider-Man 2 – Enter: Electro: The titular Electro, who seeks out a device that can harness and amplify human bio-electricity in order to enhance his electrical powers and become godlike.
  • Spider-Man (Insomniac):
    • Spider-Man (PS4): Doctor Octopus, the Evil Mentor of Spider-Man, who teams up with Mister Negative to form the Sinister Six and releases the Devil's Breath onto New York in an attempt to expose Norman Osborn's crimes.
    • The City That Never Sleeps DLC has Hammerhead try and take control of New York's criminal underworld after the absence of supervillains creates a power vacuum.
    • Spider-Man: Miles Morales: A Big Bad Ensemble between the Tinkerer/Phin Mason, Miles Morales' friend, the leader of the Underground whose vendetta against Roxxon threatens to destroy Harlem, and Roxxon President Simon Krieger, who distributes the deadly Nuform and plans on rebuilding Harlem in his own image. While Krieger is definitely the more evil of the two, he's a Non-Action Big Bad and so the Tinkerer serves as The Heavy and the Final Boss.
    • Marvel's Spider-Man 2: For the first half of the game, Kraven the Hunter is the main villain, as he captures several of Spider-Man's previous villains with the intent of hunting them, a threat that forces Spider-Man to use the Venom symbiote to stop him. However, Kraven is defeated just before the start of the third act, and killed by Venom, allowing the latter to take the stage as the main villain and Final Boss.
  • Spider-Man: Friend or Foe: Mysterio, who brainwashes various villains to bring him shards of the Venom symbiote to strengthen his army of P.H.A.N.T.O.M.s for him to takeover the world.
  • Spider-Man: Shattered Dimensions: Mysterio, who travels across dimensions to gather the fragments of the Tablet of Order and Chaos to become the most powerful being in existence and remake the multiverse in his own image.
    • Spider-Man: Edge of Time: The Alchemax CEO/Peter Parker 2099, who plans to gain the power to control time and change history.
  • Spider-Man vs. the Kingpin: The Kingpin himself, who frames Spider-Man for stealing a nuclear bomb, which he intends to use to destroy New York City in a bid to take over the world.
  • Spider-Man: Web of Shadows: Venom, who leads a symbiote army in taking over New York.
  • Ultimate Spider-Man (2005): Bolivar Trask, being the one who tricks Peter's father into selling the Venom suit over to his company, hires Silver Sable to hunt down Venom to be used as a bioweapon against his competitors. Venom takes over the position in the final level, going on a Roaring Rampage of Revenge and killing Trask.
  • X-Men (1992): Magneto, the leader of the Brotherhood of Mutants, who are reaking havoc.
  • X-Men (1993): Magneto, being responsible for infecting the main computer of the X-Men's Danger Room with a virus that traps them and makes the simulated danger lethal.
  • X-Men: Destiny: Bastion, an AI who creates hostilities between humans and mutants in a bid to destroy humanity.
  • X-Men Legends:
  • X-Men: Next Dimension: Bastion, who attempts to depower all mutants so he may kill them all.

    Western Animation 

Western Animation

  • Avengers Assemble:
    • Season 1 had the Red Skull, who assembles the Cabal to take down the Avengers and attempts to use the Tesseract the conquer the entire world.
    • Season 2 primarily had Thanos as the main villain. His search for the Infinity Stones causes them to crash land on Earth, and nearly uses the Infinty Gauntlet to take over the universe. After he's taken out midway through the season, Ultron and Nighthawk take turns as consecutive Arc Villains until Thanos returns for the season finale.
    • "Ultron Revolution" (Season 3) had Ultron take center stage as the main villain. His plans to wipe out humanity results in the massive influx of Inhumans seen throughout the season. He later disguises himself as Truman Marsh and attempts to have the Avengers round up the new Inhumans so he can weaponize them against humanity.
    • "Secret Wars" (Season 4) had Loki during the first half, having reformed the Cabal to get rid of the original Avengers and conquer the world in their absence. During the second half, the Beyonder takes his place as the main antagonist. He assembled Battleworld to satisfy his own curiosity, and the Avengers are forced to ally with Loki to return everything to normal. Sure enough, Loki betrays his new allies once he's taken care of.
    • "Black Panther's Quest" (Season 5) had Killmonger, who reformed the Shadow Council to overthrow T'Challa and use Wakanda's vast resources to conquer the rest of the world. His actions lead to increased tensions between Black Panther and the rest of the Avengers, and nearly lead to Atlantis declaring war on the surface world.
  • The Avengers: Earth's Mightiest Heroes:
    • Loki was the ultimate Big Bad of the first season. He was the one responsible for causing the massive breakout of supervillains across the various prisons and had the Enchantress form the Masters of Evil to keep Thor busy back on Earth. His ultimate goal was to conquer the Nine Realms using the Odinforce and nearly succeeded had it not been for the Avengers.
    • Queen Veranke, the leader of the Skrulls, was the main villain for the first half of Season 2. She leads her people in a secret invasion of Earth, and has her troops replace various key figures using their race's shapeshifting abilities. She personally disguises herself as Mockingbird, and one of her spies causes the Avengers to split up right before her invasion goes public. Galactus is the Greater-Scope Villain who caused the destruction of Skrullos, leading to the Skrulls' invasion of Earth. He comes to Earth in the finale as the Final Boss.
  • Iron Man: The Animated Series: The Mandarin is the main antagonist of the series. In Season 1, he launches various schemes with his henchmen that are stopped by Iron Man and Force Works. In Season 2, he spends the majority of it retrieving his scattered rings, and is the main antagonist of the Grand Finale.
  • Iron Man: Armored Adventures
    • Obadiah Stane serves as a central threat in the first season and the first part of the second season. He wants to turn Stark Industries into a weapons manufacturer and weaponize the Iron Man armor, having taken over the company following the presumed death of Howard Stark. Doing everything in his power to ensure Tony cannot take the company back when he is old enough for his birthright to demand it, he eventually hires the Ghost to steal designs from Tony, kicking off the show's version of "Armor Wars", and eventually becoming Iron Monger. Being the father of Tony's love interest Whitney, who later becomes Madame Masque, also complicates things between them.
    • In the second season, Justin Hammer steps up to the plate as a rival corporate executive vying for control over Tony's technology, eventually becoming Titanium Man, dethroning Stane by causing him to fall into a coma, and buying out Stark Industries outright.
    • Gene Khan is the antagonist of the Makluan Rings arc that runs throughout the show's two seasons, outlasting Stane and Hammer. He was searching for the Makluan rings, initially only seeking five but later learning there were ten, because he believed it was his destiny, and it was revealed that he was the one that caused the plane crash that lead to Howard being presumed dead and Tony nearly dying (requiring the Iron Man suit to save him). He usurps his manipulative stepfather Zheng Tong as the Mandarin and poses as Tony's friend, using his help to take several of the rings. In reality, Howard Stark was not dead, and Gene took him prisoner to use Howard’s expertise on the rings so he could get them. When he finally gets all ten rings, he brings the Makluan species to Earth in the finale, only for the Makluan Overlord to betray him and become the show's Final Boss, leading Gene to pull a Heel–Face Turn and become an ally of Tony.
  • The Marvel Super Heroes had some of the heroes' archenemies serve as the most frequently appearing or most prominent villain in the heroes' respective segments.
    • The Red Skull is established as the main threat in Captain America. While phased out after the series adapts Captain America ending up in modern times following his time as a Human Popsicle, the Red Skull does eventually come back in the final episodes, the very last segment being an adaptation of when he obtained the Cosmic Cube.
    • The Mandarin is the most frequently recurring antagonist in the Iron Man segments, each of his appearances having him try to kill Iron Man or his secret identity as Tony Stark.
    • Loki is the main villain in The Mighty Thor, most of his appearances having him scheme to find a way to defeat Thor in spite of Odin forbidding him from returning to Earth.
  • Spider-Man: The Animated Series: Wilson Fisk/The Kingpin acts as the main antagonist. He's the head of a vast criminal empire and The Man Behind the Man to many of the villains in the series, including all the incarnations of the Insidious Six and the Spider-Slayers.
  • Spider-Man Unlimited has Herbert Edgar Wyndham/The High Evolutionary, the dictator of Counter Earth, a tyrant who keeps humans oppressed under the heel of his creations, the Bestials.
  • The Spectacular Spider-Man: Lonnie Thompson Lincoln/Tombstone serves as the primary antagonist. Unlike his comic counterpart, Tombstone is a ruthless crime lord who nearly all of Spider-Man's rogues gallery answers to. He spends the series sending various super humans to kill Spider-Man so his criminal empire remains unopposed. However, come the Grand Finale, Green Goblin deposes Tombstone and becomes the show's Final Boss.
  • Ultimate Spider-Man (2012)
    • In season 1, Norman Osborn schemes to acquire the secrets of Spider-Man's powers, intending to make super soldiers with them (and leading to the creation of Venom). However, Doctor Octopus betrays him for his mistreatment and turns him into the Goblin at the end of the season.
    • In season 2, Doctor Octopus continues to menace Spider-Man by assembling the first two incarnations of the Sinister Six, before transforming the cured Norman Osborn back into the Goblin once more.
    • In season 3, Taskmaster races against Spider-Man to recruit potential assets for a plot to spring Goblin from SHIELD prison. This is followed by Goblin going through the Spider-Verse to encounter all the different versions of Spider-Man.
    • In season 4, Doctor Octopus forms a Big Bad Duumvirate with HYDRA, as lead by Arnim Zola, and combats Spider-Man's allies with the Sinister Six once more.
  • The Super Hero Squad Show:
    • Doctor Doom is the Big Bad in the first season, forming the Lethal Legion to help him recover the Infinity Fractals and reform the Infinity Sword, which was shattered during a fight between him and Iron Man prior to the series. The season finale would later see Galactus come to Earth, eclipsing the Lethal Legion as a much more powerful threat.
    • Thanos is the Big Bad in Season 2, tracking down the Infinity Gems so he can use the Infinity Gauntlet to take over the universe. Halfway through the season, Thanos is supplanted by the Silver Surfer, who has become corrupted by the Infinity Sword, and uses both the Sword and the Gauntlet to wreak havoc across the universe as the Dark Surfer.
  • X-Men: The Animated Series has Apocalypse in a more series-wide capacity, since Magneto's Heel–Face Revolving Door was played up. Mister Sinister clearly holds this status in Season 2, though.
  • In X-Men: Evolution, Magneto is the Big Bad for the first two seasons, and Apocalypse takes the role in the last two.
  • And in Wolverine and the X-Men (2009), Master Mold is the Big Bad of the Bad Future Xavier is stuck in, while Magneto and Senator Robert Kelly largely takes the role among several long-term villains though the Inner Circle also has a pretty good claim on driving a lot of the plot. The Sequel Hook set up Apocalypse as the Big Bad for an aborted second season.

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