- Surprisingly enough, Ganondorf went over this in There Will Be Brawl upon finding the pure evil that is Ness and Lucas. He questions how heroes can even exist when such evil does.
- As the end of Pokecapn's legendary Sonic the Hedgehog (2006) Let's Play approaches, the players themselves slowly slip towards and eventually cross the Despair Event Horizon; this is signified by Kung-Fu Jesus chanting song lyrics in monotone.
- "Because it's Thriller. Thriller night. And no one's gonna save you from..."
- In Dr. Horrible's Sing-Along Blog, Dr. Horrible crosses the Despair Event Horizon after his death ray backfires in Captain Hammer's hands and the shrapnel kills Penny.
- Happens a lot in Survival of the Fittest, more often than not later in the game, but given the premise, is it really that surprising?
- For example, Jacob Charles quickly shoots into this zone after his girlfriend is killed right in front of him, leading to him attempting suicide. Read it here.
- Happens to cup in Channel101's "2 girls, 1 cup the show". Unlike most of the cases in this page, the result is hilarious.
- Oancitizen of Brows Held High is driven to this in his Ken Park review. Genocide ensues.
- Discussed in Freeman's Mind."But yeah, I was expecting to look down there and see this giant eyeball looking up at me, angry at me because I blew off its eyelashes or something, then the whole building starts shaking and I guess I'd ball up and cry, because what do you do when something that big wants to kill you?"
- In Funny Business, Jeannette crossed this trope in a flashback after realizing that she had abused her Reality Warper powers as a toddler, to cause real harm to people and has remained in this state for more than seven years.
- In The Pirates Covered in Fur, Michum crosses this at the end shortly after Tully dies in his arms. Knowing he can't save the city, he goes back to the skate park his friends hung out at and calmly waits as several bombers destroy the city, and him as well.
- In Worm:
- Taylor crosses it after failing to prevent The End of the World as We Know It and witnessing the devastation caused by Scion's rampage, which killed her father. She would have killed herself if not for Tattletale.
- At the climax of the story, Taylor invokes this against Scion by taking away his hope of reuniting with his counterpart, and he allows himself to be killed.
- Scion also invokes it against Eidolon, by suggesting that Eidolon was responsible for creating the Endbringers. Whether this was true or not, the mere possibility was enough to utterly break Eidolon's will, and he ceases fighting back at all.
- Yahtzee was on the receiving end of this trope during his Spec Ops: The Line review. Unlike most of his foul mouthed, harsh and fast paced reviews, this one was restrained and it gave off the feeling that the game broke him.Yahtzee: *weary sigh* Remember when shooters were about killing demons from hell? Those were good days. Perhaps this is an inevitable part of gaming growing up as our childish fantasies are torn from us, and we are forced to confront consequences in an unfair, uncaring and unavoidable world of hatred, misery, and death. *Farting noises.*
- Atop the Fourth Wall's Jaeris crosses it when he discovers that You Can't Go Home Again. What followed was him Drowning His Sorrows for months on end.
- This was also parodied when 90s Kid saw a scene of Superboy Prime killing a pregnant Lana Lane in an alternate universe. That scene was so un-radical to him, that he didn't think he could ever be hardcore again after seeing something like that. Fortunately it just takes a comic by Rob Liefeld to get his spirits back up.
- The Angry Video Game Nerd crosses it after playing Desert Bus, and realizing that other people are playing it (and that someone even made an Atari 2600 version of it). He concludes that all the work he's done to warn people about shitty games has fallen on deaf ears, and that it's all been a huge waste of time, so he decides to retire. He soon changes his mind after playing a Simon's Quest romhack that did its best to fix all of the problems he had with the original, showing that at least someone out there is listening to him.
- The GameSpot video review of Big Rigs: Over the Road Racing is all about reviewer Alex Navarro being broken by an even more broken game (while not saying a word, no less!).
- In Takotsubo: The story of a superhero, the prologue is treated more like a Downer Beginning than a Superhero Origin. After the Chinese-American Cord Cai loses his fiance Roland Fujii in a carjacking, the police force utterly fail in dealing with it. After a suicide attempt, Cord tracks the murderer down through gang connections, shoots the murderer in the head, and becomes a gangster because he thinks this is his only choice. The worst part is that Cord and Roland were trying to leave the street life, and it's implied he views Roland's death as punishment for getting above his station. Being a Genre Deconstruction of superheroes—and specifically, the lack of Asian-American heroes—Cord's tangled up in Internalized Categorism, and the main script is stated to be Cord's journey of coming back from the horizon.
- Dreamscape: Dylan crosses it when Keela supposedly betrays him in the Unworld in the flashback in "Tale of the Unworld".
- He also crosses it in the flashback in "Over and Under" when he finds out about the Overlord of Evil's relation to Ethan and Curien, but his friends pull him out of it.
- Mahu: In "Second Chance" humanity itself goes through this as it tries to come up with a way to stop or at least survive the meteorite which will surely end all life upon Earth. Only the portal in Istanbul gives them any hopes of survival.
- The Onion: "Newborn Loses Faith in Humanity After Record 6 Days".
Despair Event Horizon / Web Original