A skinless boy who looks like a hunk of meat. He's on a mission to save Bandage Girl, his girlfriend, from Dr. Fetus, despite the many dangers (and deaths) he'll have to face along the way.
- Badass: Not surprising, seeing all the crap he has to go through over the course of the game.
- Bi the Way: Assuming his secret character status in the console release of Spelunky is anything to go by.
- Body Horror: For whatever reason he lacks skin, but never dies of blood loss.
- Determinator: Things might slow him down, but they never stop him. Not buzzsaws, syringes, salt, hell, the rapture, or even really hard platforming and boss battles.
- Distressed Dude: During Cotton Alley.
- Overdrawn at the Blood Bank: Just moving around coats the area surrounding him in blood.
- Toothy Issue: Part of his look whenever he is drawn in detail.
- Weaksauce Weakness: Salt, due to him having no skin. Ouch.
A pink wad of gauze who loves Meat Boy. She spends most of the game suffering abuse at the hands of Dr. Fetus while waiting for Meat Boy to save her.
An evil fetus in a jar with a suit and monoclue. He serves as the Big Bad
of the game and sets off the plot by beating up Meat Boy and kidnapping Bandage Girl.
- Brainy Baby: Well, fetus. It still counts.
- Determinator: Just like Meat Boy, he refuses to give up. Even when his jar gets broken, he still jumps on and attacks Bandage Girl; of course, by that point, she's had enough of his crap...
- Flipping the Bird: Does this several times over the course of the game.
- Kick the Dog: Every time he appears!
- Luke, You Are My Father: After Bandage Girl stomps him to death, it's revealed that he's been re'born' as her unborn son.
- Why Don't You Just Shoot Him?: Tries this in the last level, but it fails due to Meat Boy's ability to reform himself.
- Would Hit a Girl: Oh yes. He beats the crap out of Bandage Girl at the end of every single level!
A robot suit made by Dr. Fetus that is equipped with a large chainsaw.
- Chainsaw Good: Though not for the player...
- Humongous Mecha: Or at least giant compared to the characters.
- Non-Indicative Name: You'd think he was some sort of small baseball-themed boss judging by his name, but no, he's a giant mech with a chainsaw.
A strange fish-like thing that Meat Boy fights at the end of the hospital level.
- Adorable Abomination: Initially he's far from this, but once exposed to sunlight, he shrinks, and this trope comes into full effect.
- Bloody Murder: In addition to the rising level of lethal blood during his boss stage, C.H.A.D. himself seems to be made out of deadly blood... or at least coated in a shell of solidified blood. In any case, touching him is (like everything else) an instant kill.
- Weakened by the Light: The entire boss fight has Meat Boy running around collecting keys that eventually unlock the roof, which was blocking out the sun. Once it gets opened, C.H.A.D. shrinks to a weaker, smaller form of himself.
A giant poo who "fights" Meat Boy in the salt factory by attempting to outrun him and leave him at the mercy of a rising pile of salt.
- Disney Death: Appears to die by falling to his death after Dr. Fetus tosses bricks at his head to prevent Meat Boy from pulling him to safety. Apparently, he survived this and was able to return at the last second and save Meat Boy from dying in Dr. Fetus's collapsing lair.
- Heel-Face Turn: After Meat Boy attempts to save him from falling to his (supposed) death.
- Heroic Sacrifice: Saves Meat Boy in the ending at the cost of being left behind.
- Talking Poo: Okay, he doesn't actually talk, but he IS a giant living poo...
- Toilet Humor: Ewwww...
A massive monster made up of all the dead Meat Boys that fell into hell.
- Body of Bodies: Its body is made up of all the dead meat boys.
- Hard Head: MASSIVELY averted, after just 3 hits he goes down for the count.
- Hoist by His Own Petard: The only thing its headbutts end up hurting is itself.
- Non-Indicative Name: Similar to the first boss. He doesn't have horns and is most certainly NOT little.
- Use Your Head: Attempts to use this form of attack, only to end up injuring itself in the process.
Three giant maggots that battle with Meat Boy at the end of the rapture level.