Originally the Deputy Director of Special Weapons in charge of Project Noah, Guilder was dying of Lou Gehrig's Disease when the outbreak occurred. By abducting Grey, he was able to prolong his life and the lives of a few select others. Over the next 100 years, he gradually emerges as the dictator of a large society called 'Homeland' which he rules with an iron fist.
- The Ageless: Due to a diet of Grey's blood, Guilder becomes a sort of semi-'familar' much like Jude Cripp. As a result, he doesn't age for almost 100 years.
- Ax-Crazy: Ends up as this due to his Villainous Breakdown, when he begins executing people left and right for spurious reasons.
- Bad Boss: Even his longest and closest friends aren't safe from him if he's caught in a bad mood. He executes Fred Wilkes, his most competent and loyal comrade, for basically no reason. Even he comes to regret it.
- Big Bad: Of The Twelve.
- Character Death: After Lila kills herself along with Grey, the effects of Grey's blood come to a halt. Guilder begins ageing rapidly and is then torn to pieces by the Twelve.
- Character Development: But not for the better. Guilder goes from a well-intentioned (if weak and self-serving) man desperate for love and approval to a monstrous tyrant responsible for thousands of deaths.
- Les Collaborateurs: With the Virals; he even plans a longer partnership.
- Determinator: You have to hand it to Guilder: When he wants something, absolutely nothing will stand in his way. Even a helicopter crash which kills his men, injures him and strands him in a post-apocalyptic wasteland with hungry monsters rushing about doesn't stop him from creating an entire society/dictatorship.
- Dying Alone: His greatest fear and ultimate fate.
- Evil Is Petty: Guilder becomes increasingly petty and just plain obnoxious as his sanity slips.
- Evil Overlord: Of the Homeland.
- Freudian Excuse: He led a friendless, loveless life and worked tirelessly to gain the approval of his cold father, who never acknowledged any of his many achievements. He then saw his father ravaged by illness, and knew the same fate was in store for him.
- Hidden Villain: His existence is barely alluded to in The Passage, but he was responsible for the loss of the Colony and the deaths of most of the characters inside it.
- Humiliation Conga: Guilder's whole life was one of these, from getting ignored by his father to falling in love with a prostitute who didn't even like him.
- I Just Want to Be Loved: He has no friends, never married, his parents were distant, and the most 'loving' relationship he ever had was with a prostitute. Guilder desperately wants some kind of acknowledgement and love, but is too crazy to ever get it.
- Immortality Seeker: His motivation for going ahead with Project Noah; he wanted to save himself from a long, painful death of Huntington's.
- Jumping Off the Slippery Slope: His murder of Masterson is something of a turning point; it's when he begins to truly do anything it takes to survive.
- Karmic Death: After the 'source' is destroyed by the woman he imprisoned, Guilder falls to pieces as his moment of seeming victory falls apart before his eyes.
- Mercy Kill: Does this to his father.
- Large Ham: Becomes this as part of his Sanity Slippage.
- Life Drinker: He has to keep drinking Grey's blood, or he begins to rot.
- Older Than They Look: He's over 100 years old, but stays looking like he's in his 40s/50s.
- Sanity Slippage: He's practically a different person from who he was pre-apocalypse. He's paranoid, delusional, impulsive and violent.
- The Unfettered: Following the Time Skip, he's become this. He kills hundreds of people, tortures others and engages in numerous sadistic hobbies.
- Villainous Breakdown: His unnaturally long life has degraded his sanity, and the threat of Sergio has turned him into an angry, paranoid man.
- "Well Done, Son!" Guy: He didn't have a good relationship with his father, who was never impressed or interested in Guilder's many impressive achievements.
- Woobie, Destroyer of Worlds: His backstory is pretty tragic; all he wanted was not to die alone.
- 0% Approval Rating: Guilder is absolutely despised by everyone in the Homeland. Even his 'friends' like Suresh and Wilkes are scared of him.
Dr. Lila Kyle
An orthopedic surgeon and the ex-wife of Bradford Wolgast. After the outbreak, she has a psychotic break and labours under a complex delusion.
- Ascended Extra: She only really appears during a phone call in The Passage, but in The Twelve she gets a great deal more pagetime and serves a crucial role.
- Broken Bird: Her infant daughter dies, her marriage falls apart, she sees her co-worker horribly killed and then she has a miscarriage during the apocalypse.
- Character Death: She blows herself up along with Grey.
- Cloud Cuckoo Lander: Following her psychotic break.
- Heroic Sacrifice: It's unclear how 'heroic' it was, but her decision to blow herself up along with Grey led to the destruction of the Homeland.
- Heel Realisation: She eventually comes to realize what a monster she's become.
- Hospital Hottie: Wolgast certainly thought so.
- Odd Friendship: With Grey.
- Redemption Equals Death: Lila comes to the realization that she's a monster, and decides to end the Homeland by blowing herself and Grey up.
- Replacement Goldfish: She starts doing this in the Homeland with a succession of children that Guilder gives her to keep her placated. She re-names them and uses them to feed her delusion until they reach a certain age, after which she loses interest and the child is subsequently replaced.
- Sanity Slippage: After a Viral attack, Lila's grasp on reality breaks and she spends the next 100 years in a state of delusion.
- Together in Death: She and Grey die together.
- Woobie, Destroyer of Worlds: Lila goes through all kinds of pain, but she's ultimately the real power of the Homeland and as Guilder's secret weapon, she's responsible for the deaths of thousands, among them her own Replacement Goldfish children and staff.
A convicted paedophile who works as a 'sweep' in the Colorado facility, he slowly becomes subject to manipulations by Subject Zero.
- And I Must Scream: For 100 years he was kept locked up, unable to move and fed on a dropper of blood.* The Atoner: He tried his best to keep on the straight and narrow, but circumstances conspire against him. For what it's worth, he never does lapse into his 'old ways'.
- Butt-Monkey: Hoo, boy, let's see:
- Witnesses his father's suicide;
- Endures a long history of horrible sexual abuse as a child;
- Struggles with depression and OCD;
- He's bullied by the likes of Paulson in the Colorado facility;
- Mind-raped by Zero into releasing the Virals;
- Locked up by Guilder, unmoving for 100 years so his blood can be harvested, during which he's taunted and tortured.
- Brainwashed and Crazy: By Zero, who manipulates him through thoughts, dreams and visions.
- Character Death: Grey dies in an explosion with Lila.
- Death Equals Redemption: Grey's final death destroys the Homeland, essentially rdeeming him.
- Fat Slob: Grey is pretty overweight and messy. This gets averted after the destruction of the Colorado facility and he feels the beneficial effects of Zero's blood.
- Heroic Sacrifice: He and Lila blow themselves up, and his death causes the effects of Guilder's immortality to halt.
- Punch-Clock Villain: Literally. He's a janitor for Project Noah.
- Mind Rape: He's a victim of it, from Zero.
- Rape as Backstory: Numerous times, often at the hands of 'stepfathers' and 'cousins'.
- Unwitting Instigator of Doom: Grey is the one who, while mind-controlled, releases Zero and dooms the world.
- Unwitting Pawn: He's unwittingly controlled by Zero.
- Trauma Conga Line: His entire backstory.
An older man who eventually meets up with Horace Guilder, who gifts him immortality. Wilkes helps to create and govern the Homeland, acting as Guilder's closest advisor and only friend.
- The Ageless: Like Guilder and the other founders of the Homeland.
- Boom, Headshot!: Guilder kills him like this.
- Character Death: Guilder shoots him in the head for daring to defy him.
- Les Collaborateurs: He works with the Virals, under Guilder's eye.
- Even Evil Has Standards: He's barely 'evil', but is willing to do plenty of terrible things for the Homeland. However, he draws the line at pointlessly murdering innocent civilians.
- Fat and Skinny: Wilkes was the skinny to his wife's fat. The physical difference between the two didn't seem to matter remotely to either of them.
- Happily Married: To his wife, until her death from a heart attack in the aftermath of the Viral attack.
- HeelFace Door-Slam: Wilkes finally realizes just how truly evil Guilder is, and refuses to gun down an innocent person for no reason. Guilder instantly kills him.
- Honest Advisor: Part of what makes him so valuable to Guilder, and also what kills him.
- Just Following Orders: His rationalisation.
- Life Drinker: Like Guilder.
- Older Than They Look: He's over 100 years old, but looks much younger.
- Only Friend: To Horace Guilder, but eventually even Wilkes can't stand beside him any longer. Guilder kills him for refusing an order, but later regrets it.
A scientist who works for Horace Guilder and the Homeland.
- Les Collaborateurs: Like Guilder, Wilkes and other Homeland higher-ups, he works with the Virals.
- The Dragon: Ends up being an ineffective one to Guilder.
- The Evil Genius: He's a scientist who ends up being Guilder's top man regarding the study of the Virals and how to control them.
- Life Drinker: Like Guilder and Wilkes.
- Older Than They Look: He's over 100 years old but doesn't look it.
- What Happened to the Mouse?: It isn't entirely clear what happened to him following the destruction of the Homeland and the Twelve. It's likely he died in the same manner as Guilder.
A former advertising executive now working as Minister of Propaganda for Horace Guilder and the Homeland.
- Character Death: Guilder executes him pretty much to prove a point.
- Les Collaborateurs: Like Guilder, Wilkes and other Homeland higher-ups, he works with the Virals.
- Flat Character: He doesn't have much personality, existing mostly to die at Guilder's hands.
- Life Drinker: Like Guilder and Wilkes.
- Older Than They Look: He's over 100 years old, but looks like he's in his 30s.
A 'human resources officer' working for the Homeland. Although stern and complicit in the Homeland's brutality, he's considered to be a relatively fair-minded Col.
- Character Death: He kills himself in a suicide attack.
- Les Collaborateurs: It's even in the nickname 'Col' given to the profession of 'human resources officer'.
- Heroic Sacrifice: He detonates a suicide bomb for the Homeland.
- Hidden Depths: He's one of the more fair-minded 'Cols' who treats the citizens of the Homeland without any disdain or abuse.
- The Mole: For Sergio.
- Suicide Attack: He kills himself by blowing himself up.
- Token Good Teammate: Of the Cols.
- Walking Spoiler: It's hard to talk about him without giving a lot away.
A 'human resources officer' who is infamous in the Homeland for his sadistic sexual appetites. His penchant for rape earned him his name.
- Anything That Moves: Sod will rape anything: man, woman, child, animal.
- The Brute: What Guilder considers him to be. He's not wrong.
- Character Death: He gets a much-deserved neck-snapping at Alicia's hands.
- Les Collaborateurs: He's a 'col', a step below Red Eyes.
- Karmic Death: Sod is killed by his rape victim in his rape shed.
- Neck Snap: At the hands of Alicia.
- No Name Given: Like Whistler, 'Sod' isn't his real name but just a nickname given by the flat-landers. His birth name is never revealed.
- Rape Is a Special Kind of Evil: He's widely known for his love of rape, be it man, woman or child.
- Sadist: Sod is the worst kind of psychopath, taking pleasure in the pain of others.
- Slimeball: He's a crass, vulgar rapist.
- Torture Technician: What he is when it comes to interrogating Alicia.
A brutal and sadistic Col nicknamed 'Whistler' due to her congenital deformity that affects her voice.
- The Brute: Like many other Cols.
- Character Death: She dies in a suicide bombing.
- Les Collaborateurs: She's a 'col', a step below Red Eyes.
- No Name Given: Like Sod, 'Whistler' isn't her real name but just a nickname given by the flat-landers due to a deep cleft in her upper lip that gives her voice a reedlike quality. Her birth name is never revealed.
A Homeland doctor with a seemingly kindly disposition, Verlyn is responsible for processing new arrivals including Sara Fisher.
- Asshole Victim: Verlyn processes new arrivals into the Homeland, and performs highly invasive tests to do this. It's hard to feel sorry for him after Lila takes him out.
- Character Death: Lila kills him during her HeelFace Turn.
- Les Collaborateurs: Another 'col' working with the Virals.
- Evil Old Folks: Verlyn is one of the older cols, and he's just as ruthless as his younger comrades.
- Faux Affably Evil: He acts like a kindly grandfather, but is still fine with putting people through utter hell for the benefit of the Homeland.
- Four Eyes, Zero Soul: His glasses make him look more grandfatherly, but he's still a monster working for the Homeland.
- Surrounded by Idiots: Verlyn expresses some frustration at working with other Cols who are not as educated or intelligent as him, some of whom can barely read or write.
A member of the Expeditionary who was kidnapped by the Homeland along with Sara Fisher at Roswell. He's beaten badly after standing up to his captors, but survives and goes on to found the Insurgency, a rebel group that uses the alias 'Sergio'.
- Death Faked for You: Part of what the Insurgency does.
- Happily Married: To Nina following the fall of the Homeland.
- La Résistance: He even created La Résistance.
- Rebel Leader: He's the leader of the Insurgency within the Homeland.
- Scars Are Forever: His face is horribly scarred and deformed from a brutal beating during his 'orientation' at the Homeland.
- Suicide Attack: Attempted, but it turned out to be unnecessary.
- Well-Intentioned Extremist: He's very willing to organise suicide bombings and even kill himself to take down the Homeland.
A high-ranking member of the Insurgency fighting the Homeland from within, and the second-in-command to Eustace.
- Action Girl
- Death Faked for You: Part of what the Insurgency does. She can't even remember what she died from.
- Good Is Not Nice: She's pretty stand-offish and aggressive, but is on the side of the angels.
- Happily Married: After the fall of the Homeland, she marries Eustace.
- Number Two: To Eustace within the Insurgency.
- La Résistance: A high-ranking member and second-in-command to the leader, Eustace.
- Well-Intentioned Extremist: She's perfectly willing to go along with suicide bombings and other acts of violence. Considering who Guilder is and what the Homeland does, it's tough to blame her.
- Who's Your Daddy?: It's Tifty, although she's unaware of this until Tifty tells her on his deathbed.