Superman Unbound: Brainiac, an alien conqueror who steals cities and blows up the planets they're from.
Batman: Assault on Arkham: Amanda Waller and Joker share the role; Waller being behind the Suicide Squad, which Batman aims to take down, and Joker, being the squad's primary obstacle.
Justice League: Gods and Monsters: Will Magnus, who helped create the Metal Men which frame the Justice League and plans to use Superman's ship to power the device necessary for his Assimilation Plot.
Batman vs. Two-Face: Two-Face himself, who goes on a crime spree that culminates in him using a gas to try and make the citizens of Gotham evil like him.
Batman: Soul of the Dragon: The Naga demon is who Jeffrey Burr answers to and who Batman and co. must stop from getting released from his home dimension.
Injustice (2021): While Superman is the main antagonist throughout much of the narrative, he's joined by Ra's Al Ghul, who gradually corrupts the Man of Steel.
Batman And Superman Battle Of The Super Sons: Starro, an alien parasite invading Earth who takes control most of the world's heroes, forcing Damian and Jon to put aside their differences and defeat him.