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  • 009-1 anime's first episode: Ivan Godunov is the ruthless deputy chief of security of the Eastern Block. Kidnapping a scientist, Godunov tortures him for information on his new weapon, later murdering him after he has what he needs. When the 009 corps is sent after him, it is revealed Godunov intends to use nuclear weapons on the Western Bloc, killing countless people to ignite a bloody, genocidal war where he can come out on top.
  • 17-sai., by Seiji Fujii and Youji Kamata: Miyamoto is a vicious, brutal thug of a teenager who uses his ties to the Yakuza to get away with any violent impulse that he wishes. Though starting out simply assaulting and nearly killing people for their cash or just for fun, Miyamoto soon escalates his depravity until the point that he kidnaps the teenage girl Sachiko and holds her hostage in his house for 12 days. Regularly raping and beating the girl while keeping her starved and dehydrated, Miyamoto allows other gangs to rape the girl in exchange for their loyalty, and later sets parts of Sachiko's body aflame when she tries to escape. After beating one of his friends to death for being clumsy, Miyamoto tries to murder Sachiko and her twin sister with a baseball bat to eliminate all evidence of his crimes, and, even when caught, Miyamoto expresses zero remorse for his crimes, cracking a smug grin upon learning Sachiko has recovered from his torment simply because he now cannot receive the death penalty.
  • 20th Century Boys: Both versions of Friend are absolute monsters of different varieties.
    • In the original manga, the first Friend—Fukubei Hattori—grew up ignored by his classmates, with their attention often focused on hero Kenji Endō. Thus, Fukubei developed a craving for attention, and a disproportionate hatred for Kenji. Already wicked as a child, Fukubei psychologically abused his so-called "best friends," regularly tried to terrify people with his tricks, and ruined the childhood of one of his classmates—who would later become the second Friend thanks in part to the Fukubei's cruelty. Forming the "Friendship Party" as an adult, Fukubei began developing a virus that painfully killed anyone it infected, all while silencing anyone who got his way. Unleashing the virus, Fukubei framed Kenji and his group for the ensuing 150,000 deaths, took over much of the world as a "hero", and ruled it with an iron fist, sending people to reeducation camps for even minor crimes. Fukubei's master plan is then revealed: Use a new virus to wipe out 99% of the human race, then rule over the remaining 1% of "true believers". Sociopathic, egomanical, and petty, Fukubei Hattori set the bar for wickedness in this manga.
    • The second Friend—Katsumatagrew up unliked and bullied, in particular by Fukubei, and this resulted in a hatred for all humanity. Taking over after Fukubei's death, Katsumata destroys much of human civilization with a new virus and rules what's left even harsher than Fukubei, spreading tales of "aliens" invading to keep innocents terrified in the process. To further cause chaos, Katsumata regularly sends out small doses of vaccines to groups of potential rebels, knowing they will tear themselves apart trying to acquire the antidote. Revealing he plans to destroy all of humanity with an incurable virus, Katsumata tries to make Kenji watch as he kills Kenji's niece, Kanna—Kanna's mother is Kenji's sister, while her father is Fukubei—as revenge for a transgression Kenji committed against him as a child, and, when finally defeated, it is revealed he left an Anti-Proton bomb to be detonated by his followers, which will destroy the entire world when activated. In the alternate Perfect Edition, Katsumata is revealed to have been both Friends all along, having masqueraded as Fukubei and carried out all the initial atrocities himself.
  • 8.1 Yamada Yuusuke Gekijou, by Yamada Yuusuke & U.G.E: The unnamed organizer is a sadist who oversees many deadly games to enjoy the suffering of his victims and comment about it to his subordinates while he eats. In the first chapter, "Jet Ride", his organization kidnaps a roller coaster wagon and forces its six passengers into a game where they have to hang to the metal bars or fall to their death until only one remains, with the first victim being a child. In the chapter "Soccer", the Organizer is shown to be involved in deadly soccer matches where the players are routinely murdered, with many of the players being indebted people. In the final chapter, "Brake", the Organizer kidnaps a young man named Takanobu and threatens his girlfriend to force him to participate on a race of obstacles where any mistake would result on his death. When Takanobu proves his skills and overcomes all the obstacles, including outright sabotage, the Organizer ignores his victory and decides to start a "second game" to force Takanobu to choose between his girlfriend or his own life.
  • 91 Days: Fango is the homicidal enforcer of the Orco Family who introduces himself by beating Tigre to near-death, then causing a shootout in a bar. Later Fango has a teenage boy killed and shoots right through a prostitute to kill Avilio Bruno, who was hired to kill him. When Don Orco refuses to declare war on the Vanettis for putting a hit on him, Fango stabs one of Orco's men with a fork and works with Avilio and Nero to overthrow Orco, ending with him killing Orco and feeding him to his men. Taking over Orco's crime syndicate, Fango starts a gang war which kills countless people, and nearly kills the wife and daughter of prohibition agent Murphy to force him to back down. Fango also forces Corteo to make his booze for him only to sell Corteo out to be killed by Vanettis after Fango got Corteo's recipe from a prohibition agent he killed; Fango also intends to betray the Vanettis.
  • Acid Town has these two pedophile rapists:
    • Ashiei is a member of the Yakuza, like many characters in this manga, but what distinguishes him is the fact that he raped his stepson Yuki and sold him into being a Sex Slave when Yuki was only 12. Years later, he shows up again, stalking his stepson. When a friend of Yuki's tracks him down to confront him, Ashiei brags about his stepson's "talents" as a slave and about raping him. He reveals that he's stalking Yuki out of revenge for being left with burns from a fire that Yuki set to escape him, because his looks were ruined and he's in pain, despite the fact that Yuki showed mercy by not killing him. When he finds out Yuki is still alive during their confrontation, he gloats about how he wants to rape him again, and tries to do so until Yuki escapes. He was a Stalker with a Crush on Yuki's mother, took the opportunity when her husband died, possibly raped her as well, and was a factor in her suicide. He's unable to work with pretty much any gang other than Wang's triad, because of his behavior that ranges from unstable at best to purely sociopathic. Even the other Yakuza reject him.
    • Wang shows up upon the scene of Ashiei and Yuki fighting years later. He reveals himself to be a False Friend of Ashiei's, offers Yuki a loaded gun to finish him off, then, when Yuki hesitates, shoots Ashiei himself. However, it turns out he was the slaveholder/pimp that bought Yuki from Ashiei. He is an owner/seller of child prostitutes. He didn’t help his former victim out of any noble cause, but instead wants Yuki, now seventeen-years-old, for himself as his personal "pet," as well as using him as The Mole against an opposing mob boss that's actually treating Yuki with some degree of respect and caring. By kidnapping Yuki and holding him hostage, along with his previous actions to consolidate power, he's also managed to turn the heat up on a Mob War that had grown somewhat cold after the first round of deaths.
  • Agent Aika: Rudolf Hagen created the Delmo for one purpose: to serve as his own personal harem after the apocalypse. An egomaniac who views himself as the pinnacle of perfection, Hagen abducts and brainwashes women he deems worthy to join the Delmo. Researching the volatile material called the Lagu, Hagen intends to use it to cause a chain reaction on Earth to exterminate all life, allowing him to repopulate the world with the Delmo, creating a new race with his "superior genes". Not even Hagen's own sister and lover Nina is safe, as Hagen happily attempts to sacrifice her when he judges her usefulness to him is done.
  • Air Bound, by Shirogumi: Winston the White Weasel is the bloodthirsty leader of the weasels. Reveling in the fear he instills in his victims, Winston led wave after wave of assaults on Dream Island, one of which involved massacring several of the island's seagulls and crushing the eggs. Under the guise of inviting the Dream Island mice to a peaceful celebration, Winston hypnotizes the mice into walking towards the water, fully intent on devouring them all when they crossed over. After coldly murdering the leader of the Dream Island mice, Winston corners the remaining mice in the water, giddily admitting that he hadn't thoroughly enjoyed himself since he was a child. Refusing to take his defeat gracefully, Winston tries to drag Gavin into the depths of the ocean when the tide returned.
  • Ajin:
    • Manga:
      • "Satō", real name Samuel T. Owen, is a bold, brilliant, and charismatic, yet utterly amoral Ajin. A skilled soldier, Satō awakened as an Ajin after being caught and killed by a criminal syndicate following his own murder of hundreds in the underworld. Seeking the ultimate challenge, Satō frees other Ajin to challenge the whole Japanese government, forming a resistance movement while incapacitating any Ajin uninterested in his cause. Threatening to decapitate protagonist Kei Nagai when the latter refuses to join him and make Kei watch as a new head regrows to take his body, Satō begins planning to throw the whole country into turmoil under the guise of revolution. Personally killing hundreds in a plane crash to destroy a pharmaceutical company testing on Ajin, Satō proceeds to murder a list of targets before aiming to take control of Japan altogether. Tricking his way into a military base, Satō swiftly takes control of it, using the jets for Suicide Attacks he revives from repeatedly to murder Japanese officials, seeking to murder his way to escape Japan and make his way to a new country to seek more entertainment.
      • Minister Yuuwa Tokui uses his position in the Ajin Control Commission to line his pockets. Cutting a deal with a pharmaceutical company, the Minister allows Ajin to be tortured through experimentation to develop new drugs, with one suffering for years. Capturing more Ajin to continue the cruel experiments, the Minister only relents to negotiate for peace with Satō after his own life is threatened, and when double-crossed, furiously tries to torture and encase Satō's unarmed former subordinate in cement.
    • Anime: "Satō", real name Samuel T. O'Brian, is an even more vicious version of the cunning Ajin terrorist. Once a soldier discharged for his trigger-happy brutality, Satō discovers his immortality and chooses to entertain himself by forming an Ajin extremist group claiming to fight for Ajin rights. Toppling a building to destroy a pharmaceutical company as part of his plan, Satō kills countless before stealing canisters of nerve gas and capturing a military base, from which he threatens to fire them with missiles and destroy Japan lest the government yield to his demands. Rejecting the offered peaceful compromise as "boring", Satō fires one of his missiles upon the Prime Minister's office, the blast killing many in such a brutal attack that causes many of his own subordinates to defect out of horror.
  • Akame ga Kill!:
    • Prime Minister Honest is the self-indulgent de facto ruler of The Empire, manipulating their young Emperor to maintain his hedonistic lifestyle. Regularly ordering the execution and torture of innocents, Honest uses his position to sexually assault women as he pleases and terrorizes his population with his military, allowing his twisted son Syura to form Wild Hunt to rape, torture and kill as they please. Launching devastating campaigns to secure his grip of power, when the capital is attacked by rebel forces, Honest convinces the Emperor to activate the Supreme Teigu, risking the city's entire population just to avoid giving up power. Having poisoned the previous Emperor to stay in power, Honest's only hope is that his twisted corruption lives on even after he dies through the current Emperor and when beaten, cowardly flees for his life.
    • Syura, Honest's equally-sadistic son, is the leader of Wild Hunt who hopes to outdo his father in evil. Taking his band of psychopaths to indulge in the same depravities of himself, Syura sees attacks where innocents are butchered and women and children raped before being slaughtered, even having a mother and her daughter violated and killed atop her soldier-husband's grave. Capturing a member of Night Raid, Syura horrifically tortures him for information, enjoying every moment of doing so.
    • Champ is a pedophile, Serial Killer and rapist, and the most depraved member of Wild Hunt alongside Syura. Murdering a woman for trying to stop him from raping a young boy during one of Wild Hunt's raids, Champ goes on to force himself on the young daughter of a dead Imperial soldier before killing her. When confronted by the former teacher of a classroom full of children he had raped and murdered, Champ struggles to recall the event due to the sheer volume of his victims.
    • Zero: "Uncle Bill", real name unknown, is the leader of the Empire's assassination squad, Group of Terror. Using the children that weren't skilled enough to be part of the Elite Seven, Bill uses drugs to enhance their skills in a painful process that also includes indoctrination into absolute loyalty. Training children with inhuman methods that weren't far from tortures, including leaving them without needed drugs as punishment, Bill didn't care if they died during missions, and even "euthanized" one of them after considering her the weak link of the team. A cold man that doomed many children to painful lives, including Akame's sister Kurome, Bill's "training" affected her for years.
  • Akashic Records of Bastard Magic Instructor: Former Imperial Court Mage Guard Jatice Lowfan was stripped of his position for using Angel's Dust—a drug which horrifically turned its user into an easily controlled, zombie-like creature—to control innocents into assassinating rivals in the Imperial Court Corps and nobles. Discovered by Glenn Radars, Jatice has his puppets murder Glenn's only friend out of spite, which he later taunts him about. Murdering a man, Jatice takes his identity and coerces Glenn's student Sistine into marrying him, while continuing to taunt Glenn.
  • Akudama Drive: In a Crapsack World filled with violent criminals and corrupt cops, the following stand far above in terms of their sheer vileness:
    • Doctor makes a habit of finding people who need medical aid and brutally dissecting them alive, killing any civilians around the area who bother her during her work. Upon being hired for a heist job, Doctor sabotages the stitches of her injured teammate Brawler so that his wound would reopen, causing Brawler to die from blood loss just because he was immune to her drugs. Doctor later sells out the team to the Executioners in order to have her status as an Akudama cleared. Despite having a clean slate, Doctor wastes no time in continuing her criminal ways, slaughtering a group of lab workers so that she can analyze the blood of the immortal Brother and Sister. She later forces Hoodlum to aid her in her goal to kidnap and dissect the two children so that she can discover how to have full control over death.
    • Cutthroat is an eccentric Serial Killer who beheaded over 1,000 victims. After being rescued from his execution by the team, Cutthroat develops an obsession with Swindler, acting as her bodyguard solely so that he can kill her for himself later on. After the team gets split up, Cutthroat heads towards the Kansai region to find Swindler, killing every person he comes across along the way. Upon reaching Kansai, Cutthroat invades the Executioners' headquarters and slaughters hundreds of workers to form a pile of their corpses to greet Swindler with. When he chases her down to a storage closet, Cutthroat attempts to slowly strangle her to death, taking glee at her agony.
  • Alderamin on the Sky: Lt. General Tamutsukusuku Safida is the top commander of the Northern Border Regiment with a devious scheme for glory. An incompetent general who's looked down upon, Safida intends to start a war with the Sinack tribe, a ethnic group of civilians, both out of personal disdain and to look like a victorious general. To that end, he imposed poor conditions to the Sinack tribe, leaving them in great poverty and stealing their spirits, considered sacred to them. Once the Sinack tribe retaliates in a bloody crusade, Safida showed no mercy, burning their villages and trying to have all of them killed, including innocent bystanders. He even abused his authority, sending soldiers without a care to near certain death, resulting in thousands of casualties. When the Sinack tribe's main village was taken over, Safida allowed his men to Rape, Pillage, and Burn it while glorifying himself. Once he's charged for his crime by the royal court, Safida tried to throw his own followers under the bus to save himself, knowing it will result to the death penalty.
  • Amalgam of Distortion: Sara Warren, SAI's head scientist, experiments on countless people, turning them into horrific monstrosities to sell on the black market, even eating one alive. Becoming obsessed with high-schooler Rokumichi Kusaba, Sara creates a lifelike hologram of a child to jump on a train track, forcing Rokumichi to risk his own life to save the fake child. When Rokumichi escapes her laboratory, Sara sends her other experiments to hunt him down while kidnapping his Love Interest, Yayoi Hina. Sara is also revealed to have manipulated one of her follower's memories to make him think she was his savior from the harm she had put him in, and also manipulates another young man into becoming a Serial Killer. Ever obsessed with her own god complex, Sara also subjected her own unborn children the same procedures as Rokumichi, hoping to create a race of immortal being while turning the other five billion people on the planet into more monsters. Beautiful and sadistic, Sara cements herself as Rokumichi's most dangerous enemy.
  • Amon Saga: Tsuki no Miko: Momotarō, aka Yotendoji, is the eldest child of the demonic Princess Kaguya. Having taken over a large base of operations, Momotaro terrorizes the populace and betrays one of his old allies by selling out his clan's location to fearful humans, resulting in the shapeshifters being almost exterminated. Momotaro frequently enjoys the taste of human flesh, having women cooked and fed to him. When he discovers an arrowhead in one meal, he proceeds to force-feed it to the cook before crushing her head. Upon hearing of Kaguya's arrival, Momotaro goes to a village and eats a noblewoman alive to "sample" the goods for a feast. Upon finding her too oily, he orders all the children abducted and cooked for the feast, killing any who try to stop him.
  • Android Kikaider: The Animation: Saburo/Hakaider, lacking any of the redeeming qualities of his original counterpart, is instead concerned solely with fighting his "brother" Kikaider and having fun while doing so. Created by Dr. Komyoji and repurposed by Professor Gill, Saburo's introduction sees him murdering a fellow android who showed mercy to Jiro and Mitsuko. He later takes control of Jiro and forces him to commit a series of obscene acts to break him so he'll show his true power, starting with stopping Jiro from saving Mitsuko's mother from committing suicide. Saburo then forces Jiro go on a rampage through the city, killing a police officer in the process. When all that doesn't work, Saburo makes Jiro strangle Mitsuko. When Jiro defeats Saburo but refuses to kill him, Saburo attempts to shoot Dr. Komyoji's brain out of spite.
  • Angel Cop:
    • Governor Maisaka of Tokyo is the true Big Bad of the series. Seeking to get rich, Maisaka forms the Red May terrorist group and has them bomb Japan's infrastructure and civilians, killing innocent people by the truckload, before creating the monstrous Hunters to slaughter their way through the terrorists and many civilians. When the special forces begin investigating, Maisaka has the Hunters attempt to exterminate them, even torturing one horribly to keep his plan to use nukes against manufactured enemies secret, all so he can grow richer.
    • Lucifer is the leader of the Hunters, a group of psychics out to stop terrorism. A self-righteous sadist, Lucifer doesn't care who stands in her way, viewing everyone who tries to stop her brutal murders as an accomplice to the Red May. When Hacker and Peace take Tachihara with them, Lucifer tortures a scientist for information, causes a massive pile-up on a highway, and kills Peace in front of Hacker to torment him. When Asura and Freya refuse to partake in her murders, Lucifer labels them as traitors and kills Freya. Participating in an attack at the Special Forces base, she kills Ichihara and Asura before trying to drain Raiden of his energy.
  • Angels of Death: Catherine "Cathy" Ward, the B3 floor master, was once a manipulative girl who strung Lucy into killing her school rivals, before growing up to become a sadistic prison warden who punished the "sinners" under her charge, forcing Lucy into helping her, later killing Lucy herself. Helping Danny Dickens recruit killers for the Tower, when Ray Gardner and Zack Foster encounter her, Cathy tortures both of them, and also makes Zack relive traumatizing memories from his past, before drugging him to force him to kill Ray. Additionally, Cathy keeps several Tower prisoners withered and trapped to enjoy their unending pain.
  • Apocalypse Zero: Shiro Hagakure, grandfather of Kakugo and Lord Harara, is a fanatical scientist of Imperial Japan that performed horrible experiments on prisioners during the Second World War, creating the Tactical Fiends after mutating his victims and sacrificing thousands of Chinese soldiers after subjecting them to extreme agony, leaving their souls in constant pain to create the Zero Armor. Doing the same process with the newborn baby of a loyal Japanese soldier, this would turn the baby's mother Mei into a grieving spirit that would haunt the Kasumi Armor. Seemingly executed in the last days of the war, Shiro would reveal his survival decades later after Mei's spirit gets exorcised before killing Harara's servant to take control of the G Bodhisattva and test his machine by stomping over a Chinese city. Realizing the limits of his body, Shiro forces Kakugo's girlfriend to drink anesthesia to take over her body and continue his plan to crown himself Emperor of Japan and Take Over the World. When Kakugo is resurrected by a surviving Harara, Shiro would appeal to his family ties before trying to cause a potentially apocalyptic explosion to kill his grandchildren after Kakugo rejects his murderous ideals.
  • Appare-Ranman!: Gil T. Cigar, better known as Gil The Butcher, disguises himself as racer Richard Riesman while hired to sabotage the big race. Murdering his employer when he grows sick of taking orders, Gil proceeds to try to slaughter everyone about before kidnapping a woman named Sophia and several others, threatening to have Sophia gang-raped by his men should she prove problematic. To amuse himself, Gil has two hostages given one gun with a promise to release who kills the other, even killing any of his subordinates who fail him after torturing them with multiple non-fatal gunshots. Plotting to send Sophia along in a train packed full of dynamite into Chicago station, Gil plans on a massive loss of life to brand his personal "Might Makes Right" philosophy into America.
  • AR∀GO: City of London Police's Special Crimes Investigator: The Patchman is a vicious Serial Killer initially dubbed "this era's Jack the Ripper" for his depraved and random murders. The Patchman murdered Arago's parents and later his brother Ewan in the future. The Patchman is later revealed to kill people so he can take pieces of them to keep his own rotting body mobile. He is also responsible for empowering his servants, the Four Horsemen, after taking advantage of their pain and despair to enlist them in ending the world and destroying humanity. He reanimates Ewan as a corpse with his consciousness trapped in his mind to mess with Arago, and at the final battle he possesses Ewan so Arago can know the despair of his own brother killing him.
  • Ar tonelico ~arpeggio manga: Masticus is a seemingly-kind scientist who aimed to non-humans like the Reyvateils, as he blamed them for two apocalyptic disasters in the past, despite humans playing a strong role. Unleashing the Reveris virus, causing Reyvateils to go berserk and comatose, Masticus plans to perfect it with the Hymn Crystal "Soporific", having Espada's parents killed to get it. Once Sonnet manages to retrieve it from Espada, Masticus began to show his true colors, revealing to Sonnet she's the latest version of the virus, transforming her into the perfect version of the virus and ordering her to kill her friends Espada and Adagio. Once Sonnet was able to break free, the virus manifests itself into a physical form, and under his command Masticus orders it to kill everyone. Once the virus is dealt with, he laughed at the heroes for their ideals before throwing himself to his death as one last attack. A hateful scientist, Masticus pretends he fights for humanity, but in actuality just wants to satisfy his discrimination.
  • Arifureta: From Commonplace to World's Strongest anime: Ehitorujue is the god who rules Tortus. Slowly growing bored and lonely due to his immortal life, Ehito develops a cruel and sadistic personality after seeing his people suffering. To that end, Ehito manipulated several races to fight brutal wars and has his worshippers commit countless atrocities. Attempting to manifest himself in Tortus, Ehito attempts to bodyjack a powerful Vampire Princess, Yue. When that failed, he then set his sights towards a highschool student who has a misguided sense of justice which resulted on him and his classmates being summoned into another world. After Yue was released from her seal, Ehit successfully possessed Yue while torturing her inside out. After being expelled from Yue's body, he absorbs all of his creations in order to finish the heroes once and for all. It was soon revealed that Ehit's master plan was to destroy Tortus and attempts to find a new sandbox to play with in other worlds solely to satiate his boredom.
  • The Aristocrat's Otherworldly Adventure (anime adaptation): Aaron was once the eighth member of the Pillar Gods presiding over the Kingdom of Esfort. The God of Amusement, Aaron grew bored of providing humans with entertainment and decides to instead brainwash mankind into sadistic death games. Having plunged dozens of kingdoms into endless wars, Aaron personally kills the parents of Kazuya Shiina, aka Cain von Silford, before getting sealed away. With his imprisonment weakening, Aaron takes possession of a dragon, driving the monsters of the forest into a crazed frenzy, with the intent of using them to raze the Kingdom of Esfort to the ground as an act of spite for the "Old Geezers".
  • Armitage III: René D'anclaude is an anti-robot bigot who helped to develop the Third series of robots. Secretly working for a Government Conspiracy and despising the Thirds, D'anclaude designs a host of assassin robots in his image to murder them. Starting a serial killing spree of Third women, D'anclaude intends to inspire a wave of anti-Third violence, even resorting to suicide bombers to enhance the anti-robot sentiment.
  • Armored Trooper VOTOMS: Colonel Yoran Pailsen is a ruthless Mad Scientist who crafted an experiment on the world of Sunsa that involved burning hundreds of children alive to determine who had a unique "survivalist" trait. Obsessed with creating the "perfect soldier", Pailsen directs his private unit, the Red Shoulder Battalion, to commit wartime atrocities and even fight to the death among themselves. In order to test his theories, Pailsen even manipulates the head of the military, Fedok Wockam, into starting a pointless battle that leaves 120 million people dead, obsessed with furthering his research no matter the human cost.
  • Artificial Maiden: Kai is a 240-year-old alchemist who runs a business that specializes in cloning. Kai places the clones in a virtual paradise before harvesting their bodies for his clients. Realizing that his assistant had given a clone of Satonaka to a married couple, Kai murders him and sends the Crow to retrieve the body; the Crow murders Musumi's parents, and reduces him to a brain. Learning that Musumi was still alive, Kai kidnaps him, and schemes to marry Nakahara for the family fortune, uncaring if she died should her brain not be transferred. An apathetic man, Kai isn't above murdering his own Jinzous if they were to inconvenience him, and not even Satonaka is immune to his wrath; Kai tricks Satonaka into releasing him from a trap by appealing to his sensitive nature, only to stab him to death. Desiring only to make a profit, Kai cares nothing on the effect his illegal acts have on those whose lives he creates.
  • Assassination Classroom:
    • Shiro, real name Kotaro Yanigasawa, was a Mad Scientist focused on utilizing Antimatter in a human body, and the reason Koro-sensei may destroy the world. To this end, he used the famed assassin the God Of Death as a human guinea pig in painful experiments, using his own fiancée as their liaison since Yanagisawa figured she was worthless as a hostage. When the God of Death escaped, destroyed the lab and took Yanigasawa's eye, the scientist formed the identity of Shiro and plotted his vengeance. He implanted a boy named Itona with the same tentacles and later abandoned him to die when he'd served his purpose. Mutating the assassin's former protege into a monstrosity, he tested his new success by having him annihilate a giant building—and anybody inside—before attacking Koro-sensei and his students. Having the second God of Death attack Koro-sensei, Yanagisawa opted to then have the students attacked, gloating how he'd kill every single one of them painfully and Koro-sensei would be forced to watch his class die before dying in despair. When his former fiancée's sister attempted to help Korosensei, Yanagisawa had her impaled through the chest and gloated how he'd intended to use her as a "replacement" for her sister.
    • Akira Takaoka is a brutal military trainer known for torturing his students with sadistic relish while he breaks them mentally. During his brief stint as Class E's trainer, he is willing to brutalize any unruly student, regardless of gender. After being ousted, Takaoka devotes himself to revenge. After stealing money to buy a bio-weapon and hire hitmen, he infects Class E with a virus to cause a horrifyingly painful death as they slowly suffocate under the weight of tumors. The few students who escape this fate are targeted for even worse fates as Takaoka intends on burying a girl named Kayano alive in cement in a bathtub full of material lethal to the kids' teacher Korosensei, which would force him to sacrifice his life to save her. To drive in his victory, he even destroys the antidote while gloating he might use the money to purchase middle-school aged kids to murder on a regular basis as some twisted celebration.
  • Astra Lost in Space: Doctors Jed Walker and Olive Raffaeli lead a conspiracy of Immortality Seekers responsible for the events of the series. Having perfected a method of transferring a person's mind into a clone body, the two doctors and the project's various wealthy backers raise clones of themselves as their children, with the ultimate aim of eventually killing them and transplanting their own brains into the younger clones; the fact that the children are effectively their own people means nothing to them. When laws against cloning intensify, Jed and Olive callously lead their cabal in attempting to have all of them killed in a space travel accident to save themselves from incrimination.
  • Attack on Titan's chapter 122—"From You, 2,000 Years Ago": Fritz, the first King of Eldia and the mythical Devil of All Earth, was a cruel tyrant who ran an empire on conquest, with countless slaves endlessly abused out of their very sense of self, many having their tongues removed. When the young slave Ymir was accused of freeing pigs, the King tried to have her hunted for sport, whereupon she found the power of the Titans. Using her to exterminate and kill all in his path, the King raped her to produce children to inherit her power and upon her death (taking a spear meant for Fritz), forced his daughters to eat her corpse raw, unleashing the new Titans on all his enemies to found an empire on genocide and blood.
  • Aura Battler Dunbine: Lady Luuza Luft manipulates her powerful husband, Lord Drake Luft, so she can conquer Byston Well. Encouraging Drake's war, Luuza cares nothing for the people massacred, as long as it secures her power. Angered by her daughter, Riml, attempting to stop the war, Luuza has her beaten and imprisoned, later threatening Riml's life to make a group of rebels back down. Believing King Bishott Hale to be a better puppet than Drake, Luuza cheats on her husband with the king. When Drake becomes aware of Luuza's treachery, he sends Riml to arrest her, only for Luuza to murder her daughter in cold blood.
  • Ayakashi: Samurai Horror Tales:
    • Yotsuya Kaidan arc: Tamiya Iemon, while initially more sympathetic than his theatre counterpart, quickly becomes just as evil. When the father of his fiancée Oiwa breaks off their marriage due to his Ronin status, Iemon murders the man in order to have Oiwa return to him and pretends to seek vengeance. After the Time Skip, Iemon tortures a servant for stealing his medicine to save his ailing father and kidnaps him. After the birth of Oiwa's child, Iemon loses all affection for her and agrees to marry the woman who poisoned and disfigured her solely for her wealth. Iemon then instructs one of his friends to rape Oiwa in order to get her thrown out for infidelity, and to murder her if she fights back. After the man informs Oiwa of the scheme, Oiwa is so mortified she kills herself, to which Iemon has no remorse. Iemon then murders his kidnapped servant even after he offers to not spill the truth in exchange for the medicine, in order to frame him as Oiwa's illicit lover, and has his infant son killed with them. When Oiwa returns as a ghost and kills his new family, Iemon shows no grief.
    • Bakeneko Mononoke Pilot Arc: Lord Yoshiyuki is the pathetic, geriatric patriarch of the Saika family, and the cause of the Bakeneko's existence. Decades ago, Yoshiyuki kidnapped a young woman named Tamaki, imprisoning her in a tiny cage and regularly raping her with his family's knowledge for decades, which drove her to attempt suicide by starvation. After his son Yoshikuni rapes Tamaki out of curiosity, Yoshiyuki is driven into a rage for her "seducing" his son and beats her to death in front of her beloved pet cat, causing it to be twisted into the Bakeneko as a result of grief. In the present, Yoshiyuki lies about the truth as the Bakeneko threatens the lives of others, claiming to have treated Tamaki in a loving fashion before the Bakeneko reveals the truth.
    • Mononoke Episodes 8-9—Nue arc: The Zue Mononoke is in truth a narcissistic Ayakashi possessing a rotten piece of wood known as the Toudaiji, and is the only of its kind completely lacking in sympathetic qualities or tragedy. Developing into a Mononoke from people's blind admiration of it, it drove two of Lady Ruri's original suitors to murder her and another suitor in obsession before killing the three suitors and her maid, and trapped them in a "Groundhog Day" Loop. Not content with this, it killed hundreds of others, including a young girl, before attempting to lure the Medicine Peddler himself, forcing him to brutally "kill" the suitors to free them. When snapped in half, the graveyard of its victims is revealed to stretch dozens of yards around the house property.
  • Azumi:
    • Bishamonten, named after the Japanese War God, is the leader of the "nobuseri," or ronin-turned-bandits who have taken to preying on the populace. Occupying a post town, Bishamonten massacres whoever stands against him and makes the town his personal kingdom, where women are regularly raped or kept as sex slaves for him and his men. One son of a former samurai, who attempts to kill Bishamonten for raping his sister, is easily disabled by Bishamonten, who then thanks the man for his sister's body before killing him and having his corpse defiled. Kidnapping high-ranking officials in the province, Bishamonten uses them as hostages after slaughtering most of the province's military, and has said hostages dropped onto sharpened bamboo stakes later. Bishamonten captures Azumi's comrade Kiku, and upon learning Kiku is a transgender woman, Bishamonten breaks his word to not harm her by allowing one of his lieutenants Seiryu, to rape and beat Kiku to death.
    • Konishi Shizune and Tadane are a pair of Creepy Twins who pose as a single "Shizune" in a small province. Pretending to be a devout Christian and the son of God, Shizune slowly manipulates the land's new administrator, the peasants and the samurai, laying the groundwork for a brutal war between them. When tensions are high, he then gives a speech to the peasants to declare the conflict a "holy war" that God himself has decreed. The twins proceed to drug Azumi herself, keeping her captive in their home where they torture her, starve her and deprive her of sleep to break her mind and make her their new servant, while also involving their old nursemaid Naka in the "games" as well, by forcing Azumi to choose between eating or sleeping and Naka's life. The twins proceed to enjoy the bloody war they have created while planning to have the noncombatants take refuge in a mine before trapping them there and burning them all alive. When a young woman whose family has been killed in the conflict offers herself to one of the twins, he proceeds to torture her to death while mocking her. Hiding their utter depravity behind a veil of gentle serenity, Shizune and Tadane end up being two of Azumi's most vile and deeply personal enemies.

    B 
  • Babylon (2015): Ai Magase, a wicked temptress and the biblical Whore of Babylon, uses her voice alone to bend her victims to her will. Later hired by Kaiku Itsuki to push the suicide law, Magase kills Shin Inaba when he was conducting research in the "Nyux" drug, and Fumio Atsuhiko when he went to investigate. After driving over sixty people to suicide, Magase dwindles down the number of Zen Seizaki's team, and kidnaps Hiasa Sekuro so she could film her grisly murder to further torment Seizaki. Setting her sights on US President Alexander W. Wood, Magase corrupts his mind in a bid of making him jump off a roof to legitimize the suicide law.
  • Baki the Grappler's "Most Evil Death Row Convicts" saga:
    • Spec is one of the escaped Death Row convicts, and easily the most deranged of the group. Sentenced to death row for several homicides, Spec makes his appearance by brutally murdering a man right before ripping his gold tooth from his mouth. After escaping prison, Spec goes on a killing spree in Japan in his quest to "taste defeat", killing numerous cops and a task force who tries to stop Spec's homicidal rampage. Spec violently attacking Hanayama while using various objects from rocks to park benches to maul him, until permanently scarring Hanayama with bullets on his mouth. After his previous battle, Spec reawakens and slaughters many within the police station, before shooting Hanayama in the legs to finish him off. A psychopathic killer, Spec expresses glee when committing violent acts of murder and assault.
    • Jeff Mark(son) is a former corrupt NYPD officer who extorts hippies through intimidation before he was brutally attacked by Biscuit Oliver. Returning years later, out for revenge, Markson sets up a bomb within a building killing 15 people, taking over the building and holding 20 hostages. Markson murders the rest of the hostages once they try to escape, having killed nine of them, all to lure Oliver so he'll have his revenge.
  • Bakugan: These are the worst villains the Bakugan Battle Brawlers have had the displeasure of facing:
    • New Vestroia: King Zenoheld is the ruthless leader of an alien race known as the Vestals, who enslaved the Bakugan to use them as entertainment against their will, passing them off as inanimate playthings. After they were freed and revealed as sapient beings, something which horrified most of his followers, Zenoheld designed the Bakugan Extermination System to commit genocide against them. His own son, Prince Hydron, fares no better as Zenoheld treats him as a disposable pawn, abusing and torturing him to take out his frustrations at losing. After his genocide attempt is foiled, Zenoheld loses it and decides to wipe out all life in the universe, including his home world of Vestal, out of petty spite for being defied.
    • Gundalian Invaders & Mechtanium Surge Arc 1: Emperor Barodius is the sadistic leader of an alien race known as the Gundalians and hero Dan Kuso's Arch-Enemy. Barodius invaded and planned to eventually destroy the peaceful world of Neathia in order to capture a powerful artifact known as the Sacred Orb, which would allow him to control all Bakugan and conquer all of reality. Barodius cares nothing for his men, and treats them as expendable pawns to use and abuse, having them tortured for failing him or having them killed in order to gain an advantage. Eventually defeated by the heroes and imprisoned in an alternate universe for eternity by Code Eve for his attempted genocide, he was mutated there into Mag Mel. As Mag Mel, he formed a psychic link with Dan Kuso and Drago, which he used to torment Dan with terrible visions of the destruction he intends to cause on Earth. Barodius, now as Mag Mel, declares war on his homeworld of Gundalia, intending to wipe it and his people off the map before being stopped. His newly created Co-Dragons Mistress Sellon and Anubius are expendable as well, Mag Mel killing the former despite her begging him to stop and the latter for living out his use. Mag Mel, after being fully revived, has all humans transferred to the dark dimension where he plans on torturing them. At full power, he sends monsters to the five biggest cities on Earth in order to drill to the Earth's core and blow it up, releasing a large amount of energy which he will use to wipe out the entire universe.
    • Mechtanium Surge Arc 2: Coredegon/Mechtavius Destroyer is a rogue Mechtogan obsessed with wiping out all the Bakugan so he can't be summoned to do battle. Introduced by destroying his progenitor Fury, Coredegon and his entourage then travel to Bakugan City on Earth to wipe out all the Bakugan living there, along with their human partners. Defeated, Coredegon abducts the human Gunz Lazar and copies his appearance to become Wiseman, a guise he uses to become empowered under the pretence of attacking humans to force them to give up their Bakugan. He then uses Gunz's likeness to infiltrate the Brawlers' HQ to steal a Bakumeter that allows him to summon Battle Suits for the Nonets, making the Brawlers, including Gunz's partner Reptak, think their friend has betrayed them in the process. Managing to defeat the Brawlers, Coredegon offers to spare Bakugan City from destruction if the Brawlers kill their own partners. Regaining his full power, Coredegon murders the Nonet Balista for suspecting his true operation, before revealing himself to both sides by attacking them. Banishing the Brawlers to spend an eternity in the Doom Dimension, Coredegon then slaughters the Nonets for standing up to him, and in one Bad Future, murders all the Bakugan throughout the dimensions along with their partners and people living with them.
    • Battle Planet: Viloch is an Aurelus Bakugan and member of the Supreme Council whose veneer of refinement clouds an intense hatred towards humanity and lust for power. Enlisting Gregorius Reed and his team of brawlers to fight on his behalf in the Battle Judgment tournament to decide whether Earth and Vestroia should be separated, Viloch plots behind Reed's back to betray him when the moment arises. Causing several Geogan agony as he merges with them against their will, Viloch becomes immensely powerful before turning on Reed and revealing his true plan to destroy the Earth and everyone on it once it's separated from Vestroia. When his fellow Council members and the Awesome Brawlers try to stop him, Viloch simply steals the power of the Faction Crystals to augment his own and knocks them down with ease. When it seems that he is on the brink of defeat against a similarly-empowered Drago, Viloch tosses his own ally Spartillion in the path of one of his opponent's attacks, callous and uncaring towards his well-being.
  • Banana Fish anime:
    • Abraham Dawson is the scientist who, prior to the main story, found a dangerous drug-like substance known as Banana Fish along with his brother Alexis. After this, Abraham then experimented on his friend by using Banana Fish on him, resulting in the friend's death. Bullied by other soldiers when he went to The Vietnam War-—Iraq War in the anime-—he then uses Banana Fish against other soldiers, including Ash Lynx's half-brother, Griffin Callenreese, in order to pit them against each other. Returning from the war, he then tries to improve Banana Fish and sells them to the Corsican Mafia, led by Dino Golzine for more profit. After finding out that Griffin is still alive, Abraham shoots him in a fit of paranoia. His worst act is when he experiments on one of Ash's friends, Shorter Wong, by brainwashing him with the Banana Fish in order to kill Ash's Morality Pet, Eiji Okumura, while taking a personal delight from all of this.
    • Eduardo L. Fox, aka Edward Foxx, is a ruthless mercenary who faked his own death to escape prosecution for war crimes. Returning under the employ of Dino Golzine, Foxx begins killing at will, wiping out the allies of Ash, taking Ash hostage and raping him to place him under Foxx's control. When Ash escapes, Foxx is only too happy to torture his friends to find out where he is before pursuing Ash to the Foundation. Intending on seizing control and keeping Ash as a broken figurehead slave, Foxx betrays and guns down Golzine while trying to kill all of Ash's allies, intending on ruling over the Foundation with no regard to the misery he spreads.
  • Basilisk:
    • Original manga: Tenzen Yakushiji, the Number Two of the Iga Clan and the true Big Bad, absolutely leaps heads and shoulders over any of his fellow ninja for sadism, cruelty, greed and monstrosity. Secretly a centuries old former Koga himself, Tenzen has nothing but loathing for the Koga and little use for his own Clan. When Princess Oboro seals away her mystic eyes, Tenzen attempts to rape her before being stopped by a Koga attack. Engaging the Koga ninja, Gyobu Kasumi, Tenzen hears how Gyobu's father was murdered by Iga and in their duel, tricks Gyobu into striking at a child, forcing the boy's father to take a fatal blow, solely so the child's pain rattles Gyobu enough for Tenzen to win. Tenzen sadistically toys with other ninja and abandons his loyal student Koshiro because Koshiro had objected to his actions with Oboro. When Tenzen captures the beautiful Koga shinobi, Kagero, because her powers make raping her impossible, he brutally tortures her by impaling her with needles, before attempting to rape Oboro with intent of forcing her to dispel Kagero's powers to force himself on her as well. When he faces off with the young Koga leader Gennosuke, Tenzen reveals his intent to destroy all in his path, end the war victoriously and force Oboro to be his bride while he rules Japan from the shadows through the young shogun.
    • The Ouka Ninja Scrolls: Joujin has the Treasures of Koga and the Flowers of Iga massacred to show off the abilities of his team, the Joujinshu. Seeking to turn the world into a living hell to satisfy his desires, Joujin attempts to implant the soul of Oda Nobunaga in the bodies of others, a process which kills them, and seeks to use Tadanaga Tokugawa as a host, later having him eliminated when he proves troublesome. He then attempts to force Hibiki Iga and her twin brother Hachiro Koga into incest for his plot, trying to kill them when they refuse and having their friends killed. In a different timeline, Joujin happily has Edo turned into an inferno, before trying to kill Hachiro and Hibiki again, before trying to rape Hibiki to create a new bloodline with which to send the world to hell.
  • Bastard!! (1988): Anthrasax, God of Destruction, is the soul of a rogue angel drawn into a demon body. Upon awakening, Anthrasax wreaked horrific destruction on the land, destroying kingdoms and murdering countless people. Manipulating its own freedom centuries later, Anthrasax takes over Dark Schneider's old general Kal-su and unleashes horrible destruction to annihilate all mankind before releasing more demons to consume the entire world.
  • Battle Angel Alita:
    • Manga: The Super Nova incarnation of Desty Nova, in his introduction, betrayed the main characters and the other two clones of himself to Aga Mbadi. He then proceeds to gleefully tell Alita how LADDER is going to send down an army after the Z.O.T.T. to wipe out The Scrapyard and capture all people on Tiphares for their brains, just before destroying Alita physically and mentally by telling her her brain was replaced with a chip and deconstructing her body, causing her remains to fall down a shaft all while maniacally laughing about it and celebrating over her despair and sadness, disturbing even his other clones. When he asks if the clones would like to work together with him and they politely decline, stating that their methods have grown too different, he uses his power to kill NovaPod and would have killed Nova X if he didn't unplug communication.
    • Battle Angel OVA: Stripped of all his redeeming qualities from of the manga, Vector is a cruel crime lord who reigns over Iron City. Stringing along young Yugo with promises to send him to Zalem, Vector has Yugo and others illegally remove the spines of cyborgs in a black market trade to enrich himself, while also funding highly illegal operations. Vector even executes a victim himself to prove a point to Yugo about witnesses. When Yugo is caught, Vector calmly sells him out to be killed. Not content with this, Vector also keeps the scientist Chiren under his thumb with promises to return her to Zalem, extorting sex from her in the process. Vector later reveals what going to Zalem truly means: murdering people and harvesting them for their organs, which he does on a monthly basis, uncaring why so long as he profits.
  • Battle Royale (manga): Yonemi Kamon is the administrator of the Battle Royale Program, where high school students are forced to kill one another. His hobbies are watching students kill each other, killing students and joking about said students' deaths. After taking a school bus full of students including Shuuya and Yoshio to be transported into the Program, he later mentions that he also went and raped an orphanage director Shuuya and Yoshio had grown close to. Unlike the movie portrayal of the Director, Yonemi doesn't even pretend to buy into the crap about maintaining order or protecting the honor of the Empire. He enjoys raping and killing, and is a huge fan of the Program because he gets to see teenagers deal with gut-wrenching emotions before dying horribly. Even soldiers are visibly nervous around him.
  • Beautiful Bones: Sakurako's Investigation anime: The mysterious painter Hanabusa, known as "The Sphenoider", is the shadowy mastermind behind many of the cases. Obsessed with the sphenoid bone, Hanabusa's modus operandi is to get close to potential accomplices and corrupt them. Once he gains their full trust as some type of angel, he abuses them for pleasure, such as giving them a scar shape like a butterfly, before convincing them to commit heinous crimes for him such as murder or suicide, claiming this will give the victims butterfly wings to be "free". Once the crime is done, Hanabusa takes the sphenoid bone from the corpses and adds it to his collection. By the time of the story, he's responsible for countless cold cases which he orchestrated and sets his eyes on Sakurako and Shoutaro after they foiled a number of his plans. A twisted man, Hanabusa is a criminal genius who will stop at nothing to fulfill his dark obsession.
  • Beastars' "Meteor Festival" arc: The unnamed chief lion of the Shishigumi, favoring the taste of white-furred herbivores, has ordered the abduction of countless victims to serve as his meals over the years, resulting in Haru being captured by his men. The chief lion believes that feelings of shame promote blood flow, improving the flavor of the meat, so he would psychologically torment his prey by forcing them to strip and bathe in front of him before looking over every inch of their body in order to humiliate them. During this process, the chief lion seems to have a polite demeanor, even stopping his men from brutalizing Haru, but this is proven to be nothing more than a façade which quickly crumbles when she starts showing signs of defiance, as he threatens to violate her and attempts to tear her apart while she's still alive. After being defeated and spared by Legoshi, the chief lion proves how utterly dishonorable he is by attempting to shoot him In the Back.
  • Beyblade: Metal Saga:
    • Doji, the leader of the Dark Nebula, aims to sow darkness across the world. Invading Koma Village with Ryuga to steal the forbidden Beyblade, L-Drago, Doji seemingly causes Gingka's father to die. In the present, Doji forces Kyoya to work with him and puts him through a life-threatening training program so he can use him to defeat Gingka. Upon failure, Doji injures Kyoya and invites the heroes to challenge him at the Dark Nebula Castle, awakening Ryuga and L-Drago. Recruiting more Bladers into the Dark Nebula, Doji feeds their souls to L-Drago if they fail him. Doji opens Battle Bladers, allowing powerful Bladers to enter so L-Drago can absorb their power. Though Doji himself eventually suffers the same fate, he is revived along with everyone else killed by L-Drago and lays low until Metal Fury, where he assembles the Nemesis Bladers and reveals his ultimate goal—to awaken Nemesis. Provoking Ryuga into the battle that would cause his death, Doji sadistically mocks him all throughout for having been his pawn, right up until his death.
    • Metal Masters: Dr. Ziggurat is the CEO of Hades Inc. and the financial backer for the Dark Nebula. Running the prestigious HD Academy, Ziggurat puts his students through the Arrangement System, improving their blading skills at the cost of their physical and mental well-being, and takes the most successful products into Team Star Breaker, which he leads as the American representatives for the world championship. When Gan Gan Galaxy wins the tournament, Ziggurat crashes the celebration to reveal he was collecting data on the Bladers, using it to invent Spiral Force, and brainwashed Toby, Masamune and Zeo's friend, into Faust, the Blader who would generate and wield Twisted Tempo. Demonstrating the destructive potential of his energy source on innocent settlements, Ziggurat then announces his wish to sell it to the highest bidder, and is revealed to have forced Julian to join him by ruining the Konzern family name. As he is confronted by the heroes, Ziggurat boasts about his smarts and his plan's success, only for the generated Spiral Force to go into meltdown levels, leading him to realise he has failed and flee the scene, insisting the entire time that he is not to blame.
    • Metal Fury:
      • Pluto is one of the two leaders of the Nemesis Bladers, a cult that desires to use the God of Destruction, Nemesis, to destroy the world so that they can rebuild the kingdom of the ancient King Hades. Initially running the Nemesis Bladers alone, Pluto keeps his organization and himself to the shadows as he masterminds the creations of both Dark Nebula and Hades Inc., hoping to use both L-Drago and Spiral Force for the purpose of reviving Nemesis. When both Dark Nebula and Hades Inc. fail, Pluto and the Nemesis Bladers enter the fray themselves, attempting to recruit the Legendary Bladers to use their power to awaken Nemesis, luring in those willing with false rewards and by hiding the Nemesis Bladers' true goal of world annihilation. No slouch with a Beyblade himself, Pluto assists in the world's destruction and personally provides backup for Rago during the Nemesis Bladers's endgame, attempting to defeat Kenta before he can put his newly inherited power as a Legendary Blader to use.
      • Rago is the second leader of the Nemesis Bladers. Known as the Child of the Black Sun, Rago is the one who wields Nemesis and commands it to undertake the task of bringing ruin to the world. Appearing only once Nemesis's revival is at hand, Rago is utterly brutal and merciless to anyone who would stand in the way of the Nemesis Bladers's goal of omnicide. When challenged by Ryuga on his lonesome, Rago crushes him with ease, beating Ryuga down physically while Doji beats him down verbally. Annoyed by Kenta's persistence despite not even being a Legendary Blader, Rago declares his intent to kill Kenta next, and is only interrupted by Ryuga's final act of passing on his Star Fragment to Kenta. Merging into Nemesis along with Pluto for the final battle, Rago spreads darkness and destruction over the entire world, taunting Gingka to defeat Nemesis before the world is completely destroyed.
  • The Big O:
    • Alan Gabriel is a terrorist, Serial Killer, thrill-seeking psychopath and traitorous agent of the group the Union. Carrying out the assassination missions of Alex Rosewater, Alan delights in hurting others and particularly enjoys targeting cyborgs. Regularly organizing destructive terrorist attacks on Paradigm City, Alan frequently casually adjusts his allegiance between the Union and Rosewater, basing it on whichever side is currently partaking in attempted devastation. Ultimately choosing to serve under Rosewater when he offers Alan a giant robot "Megadeus", Alan breaks a death row inmate out of prison and oversees an attack on hero Roger Smith's manor, capturing the android Dorothy Wainwright for Rosewater while enjoying the destruction his robots bring upon the city. Piloting his Megadeus to combat Roger, Alan goes on a rampage, intending on slaughtering and massacring everyone he can.
    • "Missing Cat": Eugene Grant is a truly despicable Mad Scientist convinced that he is a god due to his recent discoveries in transmutation. To constantly improve his alchemic transmutations, Eugene kidnaps innocents by the dozens and transforms them into pain-stricken abominations that he keeps alive and on display for no particular reason. When many of his old partners abandon him because of his depravity, Eugene has one mauled by one of his monsters, and kidnaps two of his former compatriots' son Roy before turning the boy into a cat, following this up by murdering said couple in front of their son. Eugene proceeds to transform Roy into a monstrous chimera, then sics it on Roger Smith while he holds Smith's partner Dorothy at gunpoint, ordering Roy to destroy first Smith, then all else in his path. Despite being a Villain of the Week, Eugene Grant handily stood out as the most wicked and irredeemable monster in the series alongside Alan Gabriel.
  • Big Order: Hanzo Hattori, a seemingly-polite member of the U.N. Providential Government Security Council, is revealed to be a willing accomplice of Gennai Hoshimiya's plan to cause the Second Great Destruction. Hattori kidnaps Sena Hoshimiya for their plans, with their failure causes entire cities to be obliterated. After Gennai dies and Sena lies about her intention of causing a new Great Destruction out of sadist misanthropy, Hanzo admires her apparent sadism and becomes her right-hand man. He helps her to overthrow the government and tries to prevent the protagonists from stopping God from swallowing the world, all of which is motivated because the idea of causing pain at a massive scale amuses him.
  • Bio-Meat: Nectar: Jean Cloche is a silly-seeming but sinister man who manipulates a violent general to ensure he gets control over production of the world's food source in a time of mass starvation. When the titular monsters threaten the only Japanese island not overrun by them, Cloche engineers their invasion and flees. Responsible for the prior outbreak of the bio-meat creatures in Japan and the deaths of 100 million innocent civilians, when called out for his actions, Cloche shows nothing but smug indifference to his crimes.
  • Biomega: Niardi, also known as Nyaldee, is the Overlord of the DRF, and is responsible for all of their crimes throughout the manga. Developing a god complex due to her tremendous "empathy" powers, Niardi spread a virus across the Earth that turned all it infected into ravenous zombies. After decimating much of humanity with this virus, Niardi created her own world, which she named The Recreator, and populated it with numerous bio-androids, all with human-like emotions. Centuries later, Niardi first razes an entire village of innocent bio-androids to the ground, then rips out the lone survivor's womb in order to use it to perpetrate the birth of Niardi's daughter. Niardi then tries to murder and absorb the powers of her own daughter in order to wipe out the remains of humanity, along with the bio-androids, then start over and create another world which she will reign over as sovereign. Convinced of her own superiority above all else, Niardi is a genocidal psychopath who saw all other living things as insects to be crushed under her boot.
  • Birdy the Mighty:
    • OVA: Seichiro Hikawa is an amoral biologist seeking to forcibly evolve the human race solely so his genius can be recognized. Originally an Imperial Japan war criminal responsible for heinous experiments, Hikawa faded into exile following World War II. When the enigmatic alien terrorist Christella Revi sought his expertise for her own ends, Hikawa saw this as an opportunity to revive his failed dreams. Through Revi's resources, Hikawa enacts a plot to contaminate Japan's water supply with an experimental serum to mutate its citizens into psychic metahumans enslaved to his will. When confronted with the fact his plan will undoubtedly fail and kill everyone in Japan instead, Hikawa in a rage unleashes the serum into the sewers anyways.
    • Birdy the Mighty II/Evolution:
      • Bacillus, a parasitic alien who is originally a tenuous ally of Christella Revi, would prove to be far worse than he seemed. Investigating Birdy Cephon following the death of fellow smuggler Geega, Bacillus develops an obsession with taking her body for himself. After being repelled in a battle, Bacillus is consumed by rage and abandons Revi for his own self-serving interests. Murdering a police detective to assume a cover, Bacillus quickly forgoes any subtlety and massacres many policemen before instigating a high school shooting to draw Birdy out into the open.
      • Shogo, ultimately revealed to be Seichiro, Hikawa may be human but proves to be the worst of his kind and among the most wicked adversaries Birdy Cephon ever faced. An enigmatic World War II biologist whose youth was restored by Christella Revi's aid, Hikawa, under the guise of being a grandson to himself, plots to restore Imperial Japan and Take Over the World. Financed by a multi-governmental conspiracy to produce Super Soldiers, Hikawa happily abuses his supposed invulnerability to maximize suffering upon anyone unfortunate enough to fall into his clutches, often only for his amusement. No one is safe from Hikawa's cruelty, not even children or whole families, which he abducts and slaughters in droves to the disgust of everyone around him. A narcissistic madman with delusions of grandeur, in the end Hikawa accomplishes nothing but spreading suffering and turning all his allies against him.
      • Bishop Mace proves that even in the Federation's sinister department of worship. a whole new low can be reached. An insecure man who prizes his given authority above all else, Mace was assigned captain of the assassination squad dispatched to kill Christella Revi after Birdy Cephon reported her location to her superiors. His subordinate Nechla Geeze, worried over Mace's general incompetence and bloodlust, misleads him to kill or detain Revi personally before his arrival. After failing in her mission and being captured, Mace, incensed by her subverting his authority, declares Nechla's lack of response as proof of her death and claims to his subordinates they must "honor" her death by fulfilling their mission. To the shock of everyone around him, Mace unleashes an Orbital Bombardment directly upon Japan, hoping to kill both Revi and Nechla, who he knows is alive, single-handedly ruining any chances of diplomacy between Earth and spacefarers. Upon missing his intended target, Mace attempts to launch another bombardment, openly not caring if he kills everyone on Earth.
      • Satyajit Shyamalan is the CEO of Playmaker Industries, a corrupt neuroscience organization that weaponizes A.I. development to fuel regional conflicts across the globe. Murdering Sayaka Nakasugi's father to gain full control of the Nakasugi family research, Shyamalan tries to recruit Sayaka for her talents so he can achieve his goals of becoming a god on Earth. In the Alternate Universe where he succeeded, Shyamalan inadvertently wiped out all life in the universe in his avaricious desire to discover the multiverse and expand his power.
    • Decode Season 1: Satyajit Shyamalan has a philosophy of only the "Chosen" deserving life. Locating an alien weapon called the Ryunka, Shyamalan seeks to use it to "cleanse" the world. Murdering those in his way, Shyamalan later strangles the host of the Ryunka's grandfather to death and hooks the Ryunka up to a device of his own making to amplify its powers, killing many, many people with the intention of completely annihilating humanity save those he deems worthy of life.
  • Black Bird (2006): Kuzunoha Shuhei stands out as the most vicious, misogynist bastard around. The leader of the Kitsune Demon Clan who sets his sights on the magical heroine Misao Harada, Shuhei attempts to rape her after disguising himself as her love interest and the leader of the Tengu Clan. After being foiled by Kyo and the rest of the Tengu clan, Shuhei manipulates a member of the snake demon clan into having Kyo poisoned before invading the Tengu territory, before attempting to injure Misao badly to abduct her. Shuhei gleefully states he doesn't care how badly he hurts her as long as he can force her to bear his heir.
  • Black Butler: Dark and twisted as the world Ciel Phantomhive and Sebastian Michaelis inhabit may be, some inhabitants can manage to disgust even a demon:
    • Manga:
      • Baron Kelvin, once a kindly philanthropist, became obsessed with young Ciel Phantomhive and steadily went deeper into darkness. Founding his own circus known as the Noah's Ark, Kelvin would recruit children from orphanages to serve as performers, with many killed performing dangerous stunts, to Kelvin's amusement. Those injured or killed were sacrificed for the experiments of "The Doctor," Kelvin's right-hand man. Worse still, Kelvin used the performers of the Noah's Ark Circus as his personal army and kidnappers by threatening the safety of the children from the work houses they came from. After meeting Ciel, Kelvin revealed he had constructed a replica of the day Ciel was sacrificed, with multiple children tortured into empty shells of their former selves. It was soon revealed that Kelvin had long since broken his word to his subordinates: the work house they came from was long since burnt and abandoned, with the children having been dead for years.
      • The Doctor, Kelvin's number two, is a man who only cares for his experiments in prosthetic limbs. Fashioning new limbs from the bones of children, the Doctor takes those who are injured or killed by the circus and harvests them for "spare parts," with Ciel surmising that he had long ago killed the work house children. After Ciel kills Kelvin, the Doctor seems entirely unconcerned with anything but continuing his work and attempts to sacrifice a child on the makeshift altar to prove to Ciel why Ciel should hire him.
    • Anime:
      • Angela Blanc/Ash Landers are a dual-gendered, shapeshifting Fallen Angel who are disgusted with what they see as mankind's "uncleanliness". Ostensibly loyal to the Queen of England, the angel killed Ciel's parents are part of their plan to "purify" the world and regain favor in God's eyes. The angel horrifically turns multiple girls into dolls, using their bodies as an army of puppets. During a curry contest, the angel gives a spice to a contestant which causes those who eat it to go into a berserk rage. When Ciel goes to investigate their cult, the angel fuses the bodies of both of his parents together to torment him. When the Queen fails to live up to the angel's standard of "purity" by refusing to lose a part of her late husband which had been implanted into her, the angel leaves her to die before using a demon dog it had corrupted to burn London as part of its insane mission. Not even holding itself to the demands it puts on humans, the angel's devotion to purity is a hypocritical one, as the female personality, Angela, is a sadist who shows arousal when torturing Sebastian.
      • Lord Trancy, the former head of House Trancy, has a creepy taste for little boys. He refers to his boys as "dolls" and subjects them to beatings and abuse while holding them as sex slaves for his pleasure. We see Lord Trancy have multiple boys brought to him at one point, his intention to pick the "best" out so he can sexually abuse them. In the first episode of Season 2, we see Alois Trancy, his adopted son, naked near Lord Trancy sleeping in bed, with a cold, vacant look in his eyes.
  • Black Cat: Doctor Kosuke Kanzaki sadistically conducts a number of awful experiments over the course of the series, including transforming a man into a werewolf; brainwashing captured bounty hunters into fighting their friends; and trapping Train in a illusory world where the very people he cares about most are trying to kill him. Fascinated by ten-year old Eve's power to shapeshift, the Doctor kidnaps her towards the end of the series, planning to vivisect her in order to discover how her abilities work. Loyal only to himself and driven by his need to know, the Doctor outshines even Creed Diskenth when it comes to villainy.
  • Black Lagoon ("Fujiyama Gangster Paradise" arc): Chaka is a childishly violent Yakuza thug who introduces himself by beating Rokuro "Rock" Okujima in an attempt to impress Rebecca "Revy" Lee. When the Mob War between the Yakuza and Russian mob goes badly for his faction, Chaka kidnaps and brutalizes the teenage daughter of the Yakuza head, Yukino Washimine, threatening to sell her to a sexual sadist to be raped and tortured. Intending to take control of the Washimine clan with Yukino and her father out of the way, when Revy and Yukino's bodyguard come for him, he hides behind his own men, shooting through them and killing one for trying to run while fleeing himself.
  • The Black Museum: The Ghost and the Lady: Sir John Hall is a revolting old man who manages Scutari Army Field Hospital during The Crimean War. Intentionally mismanaging his hospital due to his extreme hatred towards the soldiers, who he views as nothing but fodders for war, his negligence resulted in the wounded soldiers dying a slow, painful death, with the mortality rate reaching 52%. He also mistreated the patients during his tenure as the hospital director during the Battle of Waterloo. Haunted by Le Chevailer D'Eon's ghost since he was a child, he conspires with D'Eon to eliminate his own enemies. When Florence Nightingale attempts to improve the conditions in Scutari Army Field Hospital, Hall attempts to get rid of her by any means necessary, such as ordering D'Eon to murder her or sending slanderous reports towards the England government regarding Florence's management at Scutari Hospital. During Florence's tenure at Balaklava Hospital, Hall tricks her by inviting her to become a nurse of Transport Corp so that he could murder her, and when Florence's supernatural guardian got critically wounded by D'Eon, Hall mocked Florence.
  • Black★Rock Shooter manga adaptation: White★Rock Shooter is the catalyst of mankind's extinction. Posing as an alien idol singer, W★RS has herself cloned by a scientist named Gibson while her forces attack the Earth. Gibson makes a failed attempt to kill W★RS after finding out about her appetite for her progeny, prompting W★RS to call for the destruction of the human race. She proceeds to kill all but two of the clones and beat one of the surviving clones, Nana, before falsely telling her that Gibson never loved any of them. Sensing that the remaining humans have found the final clone, Stella, W★RS orders her enforcers to kill them. She soon kills two defectors, along with their new human allies, and plots the destruction of the Earth just to spite a third defector. Afterwards, she forces another enforcer to kill Stella and Nana, promising her death should she fail or succeed. Confronted by the two surviving clones, W★RS strips Nana, fakes her death, beats Stella to near-death, mutilates her arm, and taunts her by spitting out the apparent remains of Nana. As their fight nears its end, W★RS asks Stella to help her conquer another planet and crush its people's wishes so she can rule over them for the rest of time. Cruel and self-centered, White★Rock Shooter would without hesitation or remorse kill anyone who she felt wronged her.
  • Black Tiger, by Osamu Akimoto: "The Boss" and Black Jaguar are Human Traffickers. With the prohibition of slavery, the Boss turns to Natives to profit, killing through their villages and taking the women and young girls to sell as sex slaves. Black Jaguar eagerly assists in this endeavor, killing a multitude of innocent US Marshals, while being a client of the girls himself. After he betrays and guns down heroine Black Tiger, Black Jaguar is interrupted attempting to rape a slave, when Black Tiger comes to save the slaves, prompting the duo to decide to burn a native village to the ground in retribution. Even when caught, Black Jaguar betrays and murders the Boss to pass himself off as having infiltrated the Boss's operation—an excuse that fools Black Tiger for not even a second.
  • Blade of the Immortal: Shira is a sadistic, misogynistic Serial Killer and the most depraved member of the Mugai-Ryu. When hunting the Itto-Ryu, Shira rapes, tortures and mutilates a kind prostitute named O-Ren, leaving her to die after he's done. When he initially teams up with Manji and Rin, Shira puts on a facade of acting like a human being, only to torture and attempt to rape another prostitute serving a decoy for the Itto-Ryu leader, trying to murder Rin when she attempts to stop him. Losing a hand to Manji as a result, Shira grows more and more unhinged with dreams of vengeance to the point he willingly submits to twisted immortality experiments to combat Manji. Raping a woman to death and keeping a boy with a grudge against Manji named Renzo as a helper and Sex Slave who he violently abuses on a regular basis, Shira proceeds to massacre the Shogunate's forces sent after him and kidnaps Rin. Tying her to a dock, half submerged with a boulder tied to her feet in the dead of winter, Shira attempts to force Manji to choose to drown saving her or leave her to die to face Shira himself. Shira proceeds to attempt to murder his other nemesis, O-Ren's beloved Magatsu, while trying to cripple and rape a Shogunate kunoichi assisting him. When finally defeated, Shira uses his last words to implore Renzo to abandon his revenge, only to crush his spirit even further by spitefully telling him to never listen to men like him.
  • Blade Runner: Black Lotus: Niander Wallace Sr. is the initial head of the Wallace Corporation. Corrupt to the bone and interested in designing Replicants as a disposable slave race, Wallace engineers submissive Replicants to be used in "Doll Hunts", where wealthy men pay to hunt them down, abuse them, and murder them to their hearts' content. Unlike his icy son who fancies himself a god over Replicants, Wallace Sr. delights in pain and when he learns Replicants can feel suffering, his only response is "perfect."
  • Blaster Knuckle: While all the beasts that our protagonist—the African-American Victor Freeman—hunt and eat humans, this duo stands out as notoriously cruel.
    • "Coffin for the Weak" arc: The Major is a beast disguised as the Major of a racist rural town. Having eaten humans from all races, the Major decided to focus on African descendants due to considering them easy prey. Taking advantage of the racism of his time, the Major allies with The Klan and other racists to execute all whites sympathetic to the black population, and is then free to abuse them, with him personally eating the corpses of victims of lynchings. Capturing a unlucky black girl with the help of racists, the Major proudly confesses having eaten her sister befor locking her in a room filled with the bones of his victims, with the intention of enjoying her fear before eating her as he already has done with other victims.
    • The Unnamed Beast from the town of White Rock Valley is beast with the power of taking over the control of his descendants. Using said power, the beast annihilates a entire town of African-Americans and takes control of their bodies, with the intention of forcing Victor to kill black children. Sending his descendants to attack both Victor and the cops hunting him, the Beast later receives the former in his human disguise, setting a trap in the town—whose original inhabitants were slaughtered—to let his descendants kill and torture them, with Alex MacGregor as the Sole Survivor due to his extreme skill. Realizing that both Alex and Victor were members of a beast slaying organization, the Beast sends all his descendants to attack them while taking control of the body of a Alex's friend to guilt trip him.
  • BlazBlue: Alter Memory: Hazama/Yūki Terumi continues to be a monstrous sadist. He burned down the church taking care of the young Ragna, Jin, and Saya, and dismembered Ragna by possessing his younger brother. Using his high position in the NOL, he orders Tsubaki Yayoi to assassinate her best friend Noel. Maniuplating Tsubaki's jealousy, he goads her in the fight proper despite the Izayoi's hurtful side effects. After having an entire military branch killed to supply life-force energy to the Monolith, Hazama/Terumi encounters Noel and Makoto Nanaya and severely tortures the latter in order to top off a Mind Rape of the former. Having threatened the world through his own failed experiment, the Black Beast, and planning to do it again for his selfish designs with the Kusanagi, Hazama/Terumi still proves to be an irredeemable monster despite the Compressed Adaptation.
  • Blood+:
    • Original series: Amshel Goldsmith is a researcher obsessed with Chiropterans, The Man in Front of the Man to Diva, and responsible for all the chaos in the setting. Since her birth, Amshel twisted Diva to become a Psychopathic Womanchild easy for him to control, while he used her resulting appetite for death and destruction to profit and increase his own power at the expense of her victims. Living for hundreds of years, Amshel now has the public persona of the CEO of pharmaceutical company Cinque Flèches, and uses his wealth to create a group of artificial Chiropterans known as The Schiff, raising them as Child Soldiers and treating them like equipment, as shown by his indifference to their deaths when they escape his clutches and their shortened lifespans begin to expire. A man with loyalty to none, Amshel even kills his own brother, Solomon, for falling in love with Saya. His false loyalty to Diva is an obvious ruse which even she can see through but chooses to go along with out of loneliness, and when she's killed, Amshel reacts with only irritation and demands to be given her children so he can continue his insane experiments.
    • Manga adaptation, by Asuka Katsura:
      • Amshel Goldsmith is no less vile in this abridged retelling of the anime. Back in the 19th century, Amshel devoted himself to Diva by becoming her Chevalier, manipulating her sister Saya into releasing her and having her slaughter an entire banquet to his delight. Securing Diva for his own selfish needs, Amshel spent the centuries concocting schemes to fulfill Diva's dream of a world infested with Chiropeans, establishing the pharmaceutical company Cinq Fleches to conduct countless human experiments and massacres to achieve said dream. Seeking to have Diva mate with the Chevalier Riku, Amshel organizes an attack on a Red Shield ship to slaughter everybody onboard. With his care for Diva nothing more than possessive obsession, Amshel uses the Red Shield attack to reveal his secret project, the Corpse Corps, child Chiropean soldiers created for the sole purpose of wiping out all of Diva's Chevaliers so that only he can rule beside her. Spreading the Chiropean virus with his D67 drugs, Amshel organizes an opera performance by Diva to be broadcasted worldwide, with her singing activating the drugs' effects and creating a massive Chiropean infestation.
      • Solomon Goldsmith, lacking the redeeming qualities of his anime version, is a sadistically gleeful scientist and Amshel's brother who assists him in his plans. A Chevalier of Diva's who indulges in his scientific curiosities as a way to encourage him to continue living, Solomon oversees numerous human experiments and Chiropteran massacres, even having an entire village turned to test out Saya's capabilities. Assisting Amshel in his plan to claim Riku as Diva's "bridegroom" to see if a Chiropteran can give birth, when Diva goes against his wishes, Solomon bails on his brother's plans. Obsessed with making Saya his bride, Solomon feigns a change of heart to get Saya and Red Shield to help him kill Amshel, even hoping to use Diva to continue his experiments.
  • Blood Blockade Battlefront Season 1: Blank, the "King of Despair", is an otherworldly entity that has caused countless tragedies for thousands of years. Possessing the body of a teenage boy, Blank manipulates the boy's sister into bringing him the hero, Leonardo "Leo" Watch, so his can use Leo's magical eyes for his master plan, promising to leave her brother's body if she does so. As soon as she does, Blank goes back on his promise, fatally shooting her and revealing that he intends to use Leo's eyes to destroy the barrier around the city of Hellsalem's Lot that keeps Earth from being torn apart by an alternate dimension. When his ally accuses Blank's apocalypse of being too dull, Blank responds by telepathically throwing around buildings and summoning a horde of zombies, looking on with delight as the terrified citizens are slaughtered.
  • Blue Blood Gear, by Kohei Hanao: The unnamed overseer of a mine that uses the slave labor of captured Red Blood People is the symbol of the worst aspects of the Blue Blood Clan. A firm believer in the superiority of his people and the need to annihilate the Red Blood Clan, the overseer reacts to the arrival of Prince Kodo by ordering his men to activate the Watari, destroying a mine in the launch and endangering the slaves to earn a promotion after personally murdering Kodo for his "tradition" of showing empathy for the enemies. When Kodo tries to reason with him, the overseer mocks his kindness and declares the Red Blood to be "bloodsucking worms". Chasing Kodo, the Watari's march throws debris that crushes fleeing slaves and when Kodo falls to the ground, the overseer slows down to play with a injured Kodo trying to run. After the Watari is ruined for Kodo's trap, a enraged overseer orders his men to murder everyone in the mine.
  • Blue Comet SPT Layzner: The monstrous Gosterro is a sadistic, brutal Gradosian officer whose only joy is in murder. Gleefully leading his forces in the Gradosian invasion of Earth, murdering soldier and civilian alike, Gosterro cheerfully catches his own men in his attacks, enjoying the deaths of his own soldiers while referring to those he hunts down as "prey" or "meat". Utterly without honor, Gosterro sets up a duel, only to use hidden snipers on his enemies so he can have the joy of murdering them after. With a body count of innocent and soldier alike that eclipses many Gradosians, Gosterro is later made into a cyborg and escapes after committing several more murders, intending on returning to kill all in his path just to satisfy his thirst for blood.
  • Blue Exorcist:
    • Anime: Ernst Frederik Egin is a member of the True Cross Order who, despite his claims, is entirely motivated by his racism against demons. Ernst would send men to kill demons and those associated with them, regardless of innocence. When he learns that his daughter Yuri is pregnant with Satan's children, he has her put on the stake to be burned to death, something he had done to many other women before. He even has people watch, but when Satan comes to rescue her, he abandons them all while he escapes. Many years later, Ernst finds one of Yuri's children, Yukio, whom he persuades to his side. He then murders The Order's leadership, becoming its new leader, with his first command issuing all True Cross Academy students weapons forcing them to fight demons, despite many being inexperienced. He also tasks Yukio to bring him his brother Rin Okumura saying he will spare Rin, only to admit he lied once Yukio does this. Ernst proceeds to torture Rin, knowing it would open the Gate to Gehanna where he will drop his nuclear bomb, The Messiah, onto the world, destroying it and eradicating every last demon there. When Yukio offers to take Rin's place, Ernst allows it, but tries to kill Rin anyway. When Satan finally appears and foils Ernst's plans by revealing to Yukio what Ernst did to Yuri, he responds that Yuri was not his daughter for loving a demon and her children are just disgraces to him. Sacrificing all those he see, family members included, Ernst proves that humans can become more evil than demons.
    • Manga's "Izumo Rescue" arc: Dr. Michael (Mihaeru) Gedouin, the resident Mad Scientist of the Illuminati, spends the entirety proving himself to be the most selfish and utterly depraved villain in that arc. In flashbacks, Gedouin and his team abduct Izumo, her sister Tsukumo, and her mother to use as subjects in his research on the elixir of immortality. He subjects their mother to horrific experiments that reduced her to a broken, bloody shell of a person, while threatening to use Tsukumo (who was two years old at the time) next if Izumo did not follow his demands. When the heroes storm his laboratory, they discover that he has been brainwashing people who visit the town near the lab and using them as disposable fodder for his experiments, turning them into shambling, semi-conscious zombies. When called out on his atrocities, he actually employs a Humans Are the Real Monsters argument to defend himself, considering himself to be above the people he uses as guinea pigs. Further, it is repeatedly show that his only motivation for his evil is to earn approval from Lucifer. An immature, self-centered bastard who relishes the suffering of others, Gedouin stands head and shoulders above most previous villains in terms of monstrosity, with his actions even disgusting Lucifer.
  • Blue Heaven, by Tsutomu Takahashi: "Papa" Jyunou is a pharmaceutical company owner who knowingly let thousands die from faulty medicine until a vengeful group burned and crippled him. Raising his son, Galph, into a Serial Killer, Jyunou boards the Blue Heaven with him and, learning of an Asian assassin onboard, has Galph round up all the Asians on the ship, killing first the men, then women and children as well. Setting explosives throughout the ship, Jyunou intends to flee with Galph while the rest of the passengers are killed. Using a machine gun to kill any passengers attempting to escape on lifeboats, while proclaiming his supremacy over the "Asian filth", Jyunou even attempts to abandon Galph to "adopt" the assassin, intending to extend his killing spree indefinitely.
  • Blue Reflection Ray: Shino Mizusaki's mother was the leader of the Saint Inés Religion and abusive to both Shino and her twin sister Kano. She used them as the figurehead of her movement to eliminate the weak people of society—the sick, poor, elderly, and uneducated. However, she forced Kano to be Shino, denying her a sense of self and beating her whenever she acknowledged herself as an individual. Whenever Shino made a mistake, she would beat Kano in her place, saying that her mistakes are why her sister is suffering. Eventually, this culminated in her performing a ritual to make Shino a true god by draining Kano's blood and force-feeding it to Shino. Her actions are in part what led to Shino's current misanthropy.
  • Blue Seed: Murakumo Yagami in the anime is a ruthless member of the Aragami monsters who seeks power at any cost. Introduced killing any stray Aragami to "purify the herd", Murakumo leads a number of attacks to kill humans and awaken the Aragami ruler Susano-oh. Draining the life energy from an entire town for Susano-oh, Murakumo, later flying into a rage when he learns Susano-oh wishes to turn the Earth into a garden paradise, betrays Susano-oh and threatens to kill the heroine Momiji Fujimiya in front of his former partner and Susano-oh's closest subordinate, Momiji's twin sister Kaede. When this fails, Murakumo later returns to drain Susano-oh's power, assuming his true form as the Yamata no Orochi to kill every human in the city and exterminate the entire human race save for a few he will rule over, with only the Aragami he deems strong enough serving him.
  • BNA: Brand New Animal: Alan Sylvasta is a pure-blood beastman seeking to eliminate all of the half-blood beastmen within Anima City. Posing as a benevolent human supporter of beastmen, Alan convinced Nazuna Hiwatashi, a human teenager who recently turned into a beastman, to become the leader of the Silver Wolf Order in order to pacify the beastmen in Anima City. To test the effects of the Nyrvasil Syndrome, he had one of his lackeys subjected to the illness, causing him to destroy a police station with rage and subsequently wound or kill various prisoners and police officers. Alan later tries to convince Nazuna to tell her followers during a concert that she's really human so thousands would unknowingly give in to the Nyrvasil Syndrome. When she backs out of the plan, Alan reveals the information himself, resulting in hundreds of beastmen succumbing to the illness and rioting in the streets. While claiming he wants to save the beastmen, Alan intended on using anti-beastmen robots to turn them all into humans he would rule over, not caring if thousands were killed in the riots and Anima City was destroyed in the process.
  • Bomberman Jetters Jetters:
    • Dr. Mechadoc (renamed Dr. Mechard), while initially appearing to be working under Bagura, is actually far more sinister. Bitter at Bagura for stealing his work, even when Bagura told him it didn't work, he had been plotting behind the scenes to overthrow him, and ultimately, he planned to use his work to cause two planets to collide, which would kill an unimaginable amount of people. Despite seemingly being The Dragon, he usurps the role from Bagura of Big Bad and is the only character in Jetters with no redeeming qualities to speak of.
    • MAX, Mechard's final creation and also known as MA-10, manages to be nearly as bad as his creator. Willingly going along with his plan of colliding two planets, killing millions of people, he develops a strong hatred and rivalry to one of Mechard's old prototypes, MA-0. This comes to a head at the end of the series, where he abandons his creator to kill Zero. At the end of this fight, MAX performs his worst deed of his own accord: once he and Zero are dying, he writes his own data into Zero so he can hijack Zero's body, forcing Shirobon to kill Zero, one of his friends, to permanently eliminate MAX. Despite not coming close to Mechard in his resources, he makes a name for himself in the series and manages to be nearly as vile.
  • Booty Royale: Never Go Down Without a Fight!: Dr. Ikezaki Gensuke is a celebrity surgeon who uses his public image, wealth, and connections to shield his sexual sadism from both the police and the Yakuza. Ikezaki is first introduced having savagely beaten Akihoshi Leia after hiring her as a call girl and then bribing her to keep quiet; Yashiki Kurisu heard of him similarly beating a worker at an extreme S&M club so badly that they banned him for life. After Misora breaks his left hand for the assault on Leia, Ikezaki first hires a hitman to attack her with a sword, then has her kidnapped and attempts to make a Snuff Film where he first rapes her, then watches as she's vivisected—and he admits to there being many prior victims buried on the mountain behind the studio. Throughout it all, Ikezaki remains unrepentant and utterly convinced he'll get away with all of his crimes.
  • Bosco Adventure: Scorpion is the leader pf a race of Planet Eaters who have devoured countless planets in the past. Scorpion manipulated Lady Damia into helping him take over Fountain Land in order to destroy the Water of Life and dry out the planet to make it edible. Killing Princess Apricot's parents, Scorpion sends his minions to capture her so he can kill her. He has Fountain Land's inhabitants enslaved in order to block the source of the Water of Life and sends his offspring to raze the now-dry land. When Apricot is ready to sit on the throne and bring back the Water of Life, Scorpion tries to kill her one last time, betraying Damia and killing most of her soldiers in the process.
  • Brave Series:
    • Exkaiser: Dino Geist is the universe's most infamous Space Pirate, having ravaged and plundered planets across the universe with his crew, the Geisters. Dino Geist would endanger countless human lives to either gain as much treasure as he can, or simply to spite the Kaisers, to the point of attempting to detonate Mt. Fuji and put the 8 million people in the surrounding area in danger, purely to harm the humans the Kaisers cared so much about. On several occasions, Dino Geist takes hostages, both human or Kaiser, to gain an advantage, then tries to kill them without a second thought once he got his way, in some cases even indulging in torture while waiting. Even his own allies aren't safe from his ruthlessness, as both Trader and his own crew are ultimately abandoned to the Kaisers without a second thought when it suits the pirate's goals. Near the end, Dino Geist attempts to kidnap young hero Kouta and take him off world as a trophy solely to spite Exkaiser for getting in his ways, and when that fails, threatens his life get an advantage over his archenemy. Dino Geist eventually casts himself into the sun, taking his own life to insult Exkaiser's belief that all life is a treasure rather than allowing the Kaiser to arrest him.
    • The Brave Fighter of Sun Fighbird: Dr. Jango is a rival to Professor Hiroshi Amano and has an unhealthy obsession towards evil and the ambition to rule over other humans and make them suffer to prove his superiority. Not content with just stealing Amano's works, modifying them for evil purposes, and using them for destructive pettiness, he willingly partnered with Draias and enabled all of Draias's evil acts with glee, having Draias enable his evil acts, trampling fellow humans, and delighting in their suffering; he would even try to usurp Draias if the opportunity presented itself. Absolutely shameless and lacking excuses about his atrocities against his own kind and only selfishly concerned of having him stand on the top of everyone else, Dr. Jango is a prime example of a thoroughly despicable human being in the entire franchise.
    • Command Dagwon:
      • Ark/Arc(h) Seijin is the most vicious of the escaped Sargasso prisoners. The self-proclaimed Emperor of Space, Ark Seijin once wiped out the Kein Seijin, leaving only a single survivor in the warrior Lian. Arriving on Earth, Ark Seijin initiates a series of brutal attacks that leave multiple civilians dead while taking a special interest in torturing Lian. After he decides Earth has resisted him too much, Ark Seijin uses his technology to freeze the entire Earth, which will kill every living thing on the planet, on nothing more than a spiteful whim.
      • Super Lifeform Genocide, the self-proclaimed ultimate perfection in the universe, is the ultimate Big Bad of the entire series, having been revealed to be behind the Sargasso Space Prison takeover from the beginning of the series. Throughout the series, Genocide regularly released deadly prisoners from Sargasso and subtly pushed them to attack Earth, where they carried out various plans that involved the mass slaughter of humans across the planet. Once arriving near the Earth's orbit, Genocide controls the Dagwon group to fight each other to the death for his own amusement, and then attempts to merge with the entire Earth, turning each and every living thing on the planet into a copy of himself and having them butcher any humans who manage to escape his merging wave.
  • Brynhildr in the Darkness: Loki is a member from an ancient and extinct alien race that created humans as food—and is strongly implied to have caused the extinction of said race. Faking unconsciousness for thousands of years, Loki waits until he is "awakened" to fulfill the plans of Takachiho, leader of Vingulf, before starting a massacre, devouring every human in his way and taking a human form, enjoying the horror that he induces in his victims. After fulfilling his goal of eating a Valkyria class Magician to recover his complete form, his first action is swallowing an entire city with the intention of doing the same to the entire human race.
  • B: The Beginning: Gilbert Ross is the coroner for the Royal Investigation Service, and a Serial Killer who proves that sometimes Humans Are the Real Monsters. In a flashback, Gilbert resents his father's growing sympathy for children being raised to be super soldiers in the Jaula Blanca Institute and kills him. Seeking to destroy his father's legacy, he lies to Minatsuki that he'd used as spare parts for Koku (one of two perfect progenitor clones). This lie led Minatsuki to betray the school and kill Heath Flick (Keith Flick's father and the headmaster of Jaula Blanca) as well as almost every child in the institute. After this, he goes to college with Keith and becomes obsessed with Keith's adoptive sister Erika. When he finds out she loves her adopted brother romantically, he vivisects and slices her into bits before tossing her remains over the mountain and framing a Reggie (a demihuman bred to kill) for the crime. He proceeds to kills 37 women who look similar to Erika, and covers up crimes committed by Market Maker (a corrupt Black Ops organization led by Minatsuki) to the point of having Jean Henry Richard brainwashed to attack Bran and then commit suicide in front of Keith. Eager to break Keith and make him stoop to his level of brutality, he lures Keith into the institute and mocks him over Erika's death. There, Gilbert reveals his involvement in the institute's destruction and Erika's death before he tries to kill Lily, forcing Keith to kill him.
  • Bubblegum Crisis: The original incarnation of Brian J. Mason seeks a weaponized satellite to spy on and kill his rivals. Kidnapping a "Boomer" child to locate the satellite, Mason later purposefully has a Boomer of his own go berserk as an excuse to unleash the satellite's laser in a populated area. A heartless businessman, Mason also has a tenant killed by his demolition crew and even mocks heroine Priscilla "Priss" S. Asagiri over the civilian's death. Remade as the Boomer "Largo" after his seeming death, he manipulates a group of Sexaroids to their deaths before setting the last against Priss by lying that the latter is responsible for her best friend's death. Mason also destroys multiple cities with his satellite to eradicate his former superiors and personally kills the final Sexaroid, sneering at her death to Priss before declaring his intent to rule the planet like a god with none to stand against him.
  • Buddy Complex: Evgeni Gedar is a 90-something year-old Bizon Gerafil, a Zogilian pilot sent to the past, revealed in the final three episodes of the show to have become the new leader of the Zogilian Empire under a new name. Even back under his old name, he already had an obsession with his childhood friend, Hina Ryazan, and tried to seek vengeance against his personal enemy, Watase Aoba, because he saw Aoba interacting with Hina. At one point, he then forces Hina to do Coupling, causing Hina physical pain. After his time-traveling experience, it was revealed that he was the pilot who tries to kill Aoba during the first episode, and is planning to seek revenge against Aoba after more than seventy years. To this end, Evgeni then overtakes the Zogilian Empire through a Military Coup and orders his soldiers to build a large cannon in space. After Aoba and his companions tries to stop his plans, Evgeni then sacrifices his own men so that he could use the cannon as a test drive, and also to lure in the Alliance members. After one of his subordinates is disgusted by his actions and tries to arrest him, Evgeni then spitefully tries to obliterate the Earth using his cannon in his last moments. Whatever redeeming qualities Bizon might've originally had are obliterated by Evgeni, who ultimately was a spiteful, cruel and petty individual that tries to satiate his vengeance for his wounded ego and pride.
  • Buddy Daddies: Ryo Ogino is a sociopathic Professional Killer obsessed with recording the final words of his targets. Introduced massacring a kingpin and his bodyguards, Ogino is responsible for several tragedies in the series, having indirectly killed Kazuki Kurusu's pregnant wife in an explosion, and torturing the girlfriend of Rei Suwa's mentor to death. When Shigeki Suwa assigns him with eliminating Kazuki and the young Miri Unakasa, Ogino murders Miri's birth mother while gloating to Kazuki that he would write down the last words of him and his adopted daughter before killing them both.

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