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Leave it to a Scrooge to receive a Mickey.

"Kick the jukebox, slam the floor
Drink, drink, drink, drink some more
I can't think
Hey! What's in this drink?
It feels like somebody put something
Somebody put something in my drink
"
The Ramones, "Somebody Put Something In My Drink"

Tricking someone into drinking a drugged beverage although sometimes food can be spiked as well. One of the most common causes of Instant Sedation next to a Tap on the Head. Typically done to knock out a Mook, to capture a good guy for evil purposes (such as pressganging them onto a ship), or to rob or Date Rape the victim. If the other person suspects something, they may discreetly dispose of the drink or attempt a Poisoned Chalice Switcheroo. Attempting to do this to several different people at once can overlap with One Dose Fits All.

One of The Oldest Tricks in the Book. To the disappointment of many horny guys, it does not work for that purpose, so you're better not to attempt it.

The person who's been drugged (or is doing the drugging) may have some Parting-from-Consciousness Words. There's a good chance that the victim will have an Impairment Shot as they are losing or regaining consciousness.

Subtrope of Artistic License – Law. When this is done by adding a lethal drug to outright kill someone, see Tampering with Food and Drink. Especially in older works, a Poison Ring is used to dump the drug into the beverage. Compare Laxative Prank. Some cases may overlap with Forced Addiction.

Truth in Television: Read all about the original Mickey Finn on Wikipedia. In Real Life, safety advocates warn people to not accept drinks provided by strangers and keep their beverage cup with them at a party (including bringing the cup on bathroom breaks), so that would-be rapists and robbers can't spike it with Rohypnol or GHB.

As with all Sexual Harassment and Rape Tropes, No Real Life Examples, Please!


Examples:

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    Anime & Manga 
  • Sort of happens in Attack on Titan, where Zeke, the Beast Titan, has his spinal fluid mixed into wine by his followers, who then secretly get the Eldians of Paradis Island to drink said wine. To explain, if someone of Eldian descent ingests any amount of Zeke's spinal fluid, he can then turn them into a pure titan by screaming. Any pure titans created by Zeke are able to be controlled by him, and can move at night, unlike other pure titans. The plan is discovered when Nicolo, a captured Marleyan chef, tells the Survey Corps after Falco gets hit on the head with a bottle of wine and swallows some.
  • Happens often in Case Closed, where culprits tend to drug the food or the drinks of their prospective victims. i.e., Ran once gets pills slid in her coffee by a suspect who then tries to drown her to throw Kogoro and others off and much later Shiratori gets similarly drugged by a prospect murderess as a part of her plan to give herself an alibi while she kills her cheating boyfriend.
  • A comedic example occurs in Danganronpa 3: The End of Hope's Peak High School when Saionji spikes a stew Supreme Chef Hanamura made with his aphrodisiac soup as a prank, and the entire class ends up on the verge of Kissing Under the Influence.
  • In Denpa Teki na Kanojo, Miya drugs Juu's drink, and when the drug starts to kick in, she beat him with a baseball bat.
  • In an early episode of Dragon Ball, Oolong puts sleep medicine in the gang's drinks so he can molest Bulma. However, this also means that Goku is out cold when Yamcha comes around to rob their camper. In the Viz translated manga, Oolong even uses the term "slipped that mickey" when thinking about drugging Goku.
  • The Familiar of Zero:
    • The heroes do this to an entire detachment of Gallian soldiers during the third season. Since it's so dilute by that point, it takes longer for the effects to appear.
    • Also at the end of the second season where Saito slips a sleeping potion into Louise's glass of wine so he can get Julio to take her to safety while he sacrifices his life to delay an advancing army.
  • Freezing: Satellizer, of all people, tries to do this to Kazuya under the advice of Elizabeth. Fridge Brilliance comes out when you remember that Satellizer is a Broken Ace who has Rape as Backstory and thus has no experience in seducing boys and probably doesn't know that its such a bad idea to drug someone you like.
  • One episode of Hell Girl has a sleazeball of a guy drugging his girlfriend this way, so that another friend of his can "borrow" her for the evening in order to finally lose his virginity.
  • If Auguste Beau from Kaze to Ki no Uta offers you wine, drink it at your own risk. Rosemariné fell victim to this in the past, and later in the story, so does Serge. The results in both cases are... less than pleasant.
  • This happens often in The Kindaichi Case Files.
    • The killer in "Playing the Fool (Tarot Lodge Murder Case)" blackmails their victim to put sleeping drugs into Kindaichi's drink. This was done as one of the measures to let the killer slip between their room and the victim's room without anyone noticing since the killer, Kindaichi, Miyuki, and the victim's were next to each other and connected through doors. The killer used a different method for bypassing Miyuki to give themselves an alibi.
    • The culprit in "Murders from Silver Screen" drugged the entire remaining cast except themselves (but they drank the sedative later) during a discussion via drink to set up what others would see as a murder and suicide committed by the last victim.
      • In general, this method is often used by culprits who committed their killings as a precaution so that their intended victim couldn't escape and others couldn't find them snooping around, especially when the murder trick used to take a lot of time to execute like blowtorching and reattaching tin blocks on their victim's door in "Alchemy Murder Case."
  • In Mobile Suit Gundam Wing: Endless Waltz, this happens to Relena at a meeting concerning the L3 colonies. Her tea is drugged, and when she wakes up, she's being held hostage by the Mariemaia faction.
  • Monster Rancher: In "The Powerful Wondar Brothers", the titular brothers spike the Searchers' stew with a sleeping herb so they can steal Holly's Mystery Disk.
  • The Mysterious Cities of Gold: Ambrosius puts Gaspard to sleep by giving him some tempered wine.
  • Naruto: To keep Jiraiya from interfering with her plans to deal with Orochimaru, Tsunade pours Jiraiya a shot of sake and adds some unidentified white powder to it. The powder has the effect of putting Jiraiya to sleep and sapping his chakra; Jiraiya comments that Tsunade is the only person he knows that can design a drug that can be slipped into a drink and unnoticed by a ninja. He even uses the term in the English dub after coming to.
  • Negima! Magister Negi Magi has the Big Bad of the Mahorafest arc drugging Negi and Setsuna so that they'll be forced to use her time machine to get back on schedule.
  • From the same director, Penguindrum has several examples of it.
    • In episode 8 Ringo drugs a cake that Tabuki and Shouma eat and proceeds to try and rape an unconscious Tabuki. Luckily, an interruption stops anything from happening.
    • And then in episode 10 Shouma is given a spiked dessert when hospitalized, and the person who gave it to him (Masako) kidnaps him afterwards.
    • And in episode 14, Ringo is the one in the receiving end, when Yuri drugs her drink to rape her.
  • Happens twice to Fuutarou in The Quintessential Quintuplets, both times courtesy of Nino. The first time she does it to avoid studying, and the second because she's upset to discover that he is Kintarou, his "cousin" she fell in love with.
  • Ranma ½ has actually used this quite a few times in the manga, usually with Ranma just trying to end a date quicker. In an amusing example, female Ranma found herself roped into a date with a sickly boy who wouldn't take his medicine unless she gave it to him... personally. After several unsuccessful tries to just dump the stuff in his mouth, she quickly went "Look over there!" and poured it into his drink, exactly as he poured sleeping powder into her drink. When she woke up a long time later, he STILL hadn't taken the medicine.
  • In the movie of Revolutionary Girl Utena, a flashback shows that Akio did this to his sister Anthy and then took advantage of her sexually. This is icky enough, but it then goes on to show that afterwards he realized that she was awake and began to panic, and wound up stabbing her and then falling out a window to his death. Yikes. Worse still? Turns out they'd had each other's drinks. Partly contributing to the above-spoilered event.
  • Happens to Mugen (and maybe Jin) in Samurai Champloo, when they wake up they have no money. Earlier in the series, Mugen falls for a Tampering with Food and Drink involving sake and One-Night Mushroom.
  • Soul Eater: The Thompson Sisters managed to keep Giriko unconscious while his base was being infiltrated by pretending to be his maids, convincing him to go out with them for some drinks, and slipping drugs into his drink. Kid was quite curious as to why they had drugs on them, especially considering they probably hadn't come up with such a plan before they left home.
  • Sukisho sees this done to Sora and Nao, with Soushi drugging their tea and taking them in for a vaguely described medical exam.
  • In Tiger & Bunny, Maverick has a habit of drugging people's drinks before he wipes their mind.
  • Tower of God:
    • Tin gave Prince a can of special coffee claiming it would boost his abilities. Prince is suspicious and gives the drink to Ehwa instead, who drinks it and passes out since the drink was naturally drugged. That was exactly as planned, as she was now receptive to a Puppeteer Parasite.
    • Another case happens during in the Name Hunt Station, where if someone defeats another, either by beating them into submission or via a specific rule where touching the back of the opponent for a specific counts as defeating, the victor gains dominion over the loser (with all the implication that follows). A small-time villain drugs Khun Ran's team to claim easy win using the alternate method, but is later stopped by Ran's friends who suspect foul play.

    Asian Animation 
  • In Season 3 episode 14 of Happy Heroes, Big M. wants to take the place of the school doctor as part of an Evil Plan and tries to knock him unconscious by dropping a capsule into his drink. The doctor sees through the trick and makes Big M. drink the liquid he laced with the drug, but he is back to normal by the next scene and giving the Supermen fake checkups as a doctor himself.
  • Lamput: In "Shrunk Doc", the docs find their shrunken van in their boss's mustache. To keep the boss from scolding them for not catching Lamput (who is in the tiny car), Fat Doc laces the boss's drink with a sleeping serum.

    Comic Books 
  • In one Marvel Comics story that echoes ancient Egyptian myth, Sekhmet, the goddess of destruction, is defeated when Amadeus Cho force-feeds her chloral hydrate, turning her into Hathor, goddess of love... and apparently, goddess of LOLcats.
  • Shows up from time to time in the Disney Ducks Comic Universe, of all franchises:
    • In the Carl Barks-penned story "Back to the Klondike", saloon owner Glittering Goldie manages to steal young Scrooge's Goose Egg gold nugget after putting a drug in his coffee and dumping him outside of town after going through his pockets. He immediately goes back and roughs up everyone in the place before retrieving his record-size nugget, getting an I.O.U. out of Goldie for losing the rest of his gold in a card game, and kidnapping her to work on his claim in the mountains.
    • Paperinik New Adventures: Standard modus operandi whenever the superhero Paperinik has his secret identity exposed or needs someone to forget something is to trick them into eating a memory-erasing candy-an action made more egregious by Paperinik's identity being Donald Duck. Outside his comic, the only people who Paperinik trusts enough to not slip the candies are Gyro (who makes all his gadgets, including those candies) and Fethry (who is just too nice to betray him), and they actually decided to take the candies of their own initiative (Gyro because he doesn't trust himself with the secret, and Fethry because he realized he was making a mess and it was better for everyone if he forgot).
  • Maria does this to Gisburn to put him out of action so the Jesters can frame him for their plan in Sherwood, Texas #3.
  • The Smurfs:
    • Papa Smurf in the comic book story "The Smurfs and the Book That Tells Everything" was given a glass of smurfonade which was laced with a formula that the book gave to Lazy for curing insomnia. Afterwards he collapsed and was brought back to the village. While he was asleep, his little Smurfs locked him inside his own house.
    • Before that, in the comic book version of "The Astro Smurf" (and its Animated Adaptation), Papa Smurf had put a sleeping potion in the raspberry juice that he had Astro Smurf drink before he went into his spaceship to take off.
    • And the rebel Smurfs who break Jokey out of prison in "King Smurf" do the same thing with a Smurf guard and a bottle of raspberry juice that was offered to him.
  • Sensation Comics: Countess Draska Nishki drugged Steve Trevor into unconsciousness by slipping something into his drink at a Masquerade Ball and Steve was later rescued by Wonder Woman.
  • Superman: In Starfire's Revenge, the titular villain's mook Derek Marlowe pretends to be romantically interested in Supergirl until he manages to slip a power-nullifying pill into her drink. Then, when Supergirl has lost her powers, Starfire's henchmen attempt to gun her down.
  • Touch (2004): Knowing that Rory won't voluntarily give back his powers and will be wary if Coop tries, he drugs Rory to take them back.
  • The Warlord (DC): In #131, Rival Turned Evil Maddox feigns friendship with Morgan and the two of them spend the evening drinking and reminiscing about old times. Maddox takes the opportunity to drug Morgan's wine, and when Morgan wakes up he is in Maddox's dungeon.

    Comic Strips 
  • In the Conan the Barbarian newspaper comic, Conan is slipped a mickey by the tavern wench Renea, who sells him to slavers while he is unconscious.

    Fairy Tales 
  • In most if not all versions of the fairytale "The Twelve Dancing Princesses", the princesses prevent anyone from learning the secret of how their dancing shoes are worn out every night by giving their assigned watchers a drugged drink; the hero must perform a Discreet Drink Disposal in order to stay awake and solve the mystery. Robin McKinley's version of the story hangs a lampshade on the fact that nobody previous to the hero thought to do this but simply drank what they were given.

    Fan Works 
  • In Nobody Dies, Asuka's date attempts this in Chapter 11. Fortunately for her, though, Gendo had set up a sting operation, and shut down any date rape before they could even leave the restaurant, then threw the asshole to Rei.
  • In PMS Potions, a fanfiction of The Worst Witch, some students make a potion to cure Miss Hardbroom's PMS and slip it into her tea.
  • Shatterheart:
    • Another benign variant is when Kurogane laces Syaoran's food with pain medication to force the latter to take his medicine.
    • Healer Hinata also does this to Kurogane by lacing his food and tea with sedatives. Kurogane gets very angry at this.
  • Played for drama in the Laverne & Shirley Dark Fic Somebody to Lean On, where an evil OC Mike drugs Laverne's wine so he can rape her.
  • A more benign version in the Star Trek: The Original Series fanfic Step by Step: McCoy drugs Kirk's soup and drink to make sure he gets some sleep. He gets a double whammy because he actually drank both.
  • In Maleficent fanfic Your servant, Mistress, Stefan did this to Maleficent to be able to rape her.
  • A bartender tries to take advantage of Stormy's blindness in The Rainbow Connection and slips something into her drink. She notices right away.
  • Back to Zero: While at a Team Rocket party, the already drunk Cassidy is given a stun spore drug to snort. She takes it, not knowing that it's been laced with something else. Giovanni decides to take advantage of Cassidy and rape her during an orgy. The next day, Cassidy doesn't remember anything, but someone else tells her and later Giovanni decides to blackmail Cassidy.
  • Divorced: It's implied that Gerudo women frequently drug Hylian soldiers in order to get pregnant.
  • In A Peaceful Afterlife, Cherri Bomb drugs Kira's drink with MDMA to make it easier for his former allies to fetch him. They get a bit more than they bargained for when it turns out that high!Kira loses most of his inhibitions towards gruesome explodey murder.
  • Snow Blind: After he's kidnapped, the injured and (temporarily) blinded Donatello fears this trope happening when he's offered food, and taste-tests everything that the vigilante gives him (the fact that the vigilante keeps encouraging him to sleep doesn't help matters). Unbeknownst to him, his kidnapper (aka the Nightwatcher, aka Raphael) refuses to pull this trope even if he wants Don to sleep, considering the tactic underhanded.
  • The appropriately titled Roofie starts with a guy slipping Marinette a drug in her drink. Fortunately, Gabriel Agreste has the security keep an eye out for such things during his events. He notes that even before his Heel–Face Turn, this kind of action would have been an Even Evil Has Standards thing for him, but now, and with the guy not even pretending to feel remorse over that... he'll be lucky to find a job as a janitor.
  • In the Discworld of A.A. Pessimal, the very mature student Assassin Joan Sanderson-Reeves (she's forty-seven) is seen in a poisons class explaining things to her more-at-home-with-sharp-weapons peers Alice Band, Emmanuelle les Deux-Epées and Johanna Smith-Rhodes. Joan extols over the virtues of lithium hydroxide, one of the simplest sedatives possible, but which never fails to knock somebody out within minutes.
    The good old Mickey Finn, girls. One of these in somebody's bedtime cocoa and they are absolutely guaranteed a good night's sleep!
  • In The Lost Cause, Huaisang drugs Jin Guangyao's drink, partly to take him away for a private conversation, partly to show Guangyao that he is not to be messed with.
  • Things I Am Not Allowed to Do at the PPC: Rule 120 forbids slipping Love Potion into the meals of anyone living in PPC Headquarters.
  • In this Miraculous Ladybug fic, Lila spikes the punch to get her drunk and make her embarrass herself. Instead, Marinette loses her inhibitions and brings down Lila's castle of lies.
  • Witching Hour: Near the end of the story, Zim drugs Gaz's drinking water to make her fall into a deep sleep and then moves her to a large open field where he's set up a fake Satanic ritual, the final step in his plan to frame her as a witch.
  • My Hero Academia
    • Spiked Drink has Shouto get something put in his drink after he and the others are pro heroes. The villains think they'll get a hefty ransom for the number 3 ranked hero. Luckily Midoriya gets suspicious and investigates. Cue an Oh, Crap! for the villains who say they can’t fight the number 1 hero and Midoriya wrapping them in Blackwhip.
    • I’ll Carry You When Your Legs Can’t Hold The Weight Aizawa gets roofied and Hizashi interrupts the attacker before she can drag him out of the bar.
    • As Long as I’m Here Hizashi is drugged and it appears he was raped
    • Tense Silence has a variation with a villain with a paralyzing quirk in his spit. He slips that into Hizashi’s drink so he can drag him off and rape him. Turns into Rape and Revenge when it wears off enough for Hizashi to grab him and use so much Super-Scream that it kills the attacker and literally wrecks the guy’s face.

    Film — Animation 
  • In The Aristocats, the butler adds enough sleeping pills to kill a humannote  to the "creme de la creme a la Edgar" he serves the cats for dinner.
  • In Asterix Conquers America, the Indian medicine man tricks Asterix, Obelix, and Getafix into smoking a tainted peace pipe to knock them out. Getafix even anachronistically says "He's slipped us a Mickey."
  • In The Fantastic Adventures of Unico, the baron slips something into Katy's wine that makes her pass out. It's disturbingly clear what he plans to do after...
  • Basil and Dawson are given drugged drinks in The Great Mouse Detective. Basil is savvy enough about the pub to test his drink first, but Dawson is not so fortunate.
  • In The Nightmare Before Christmas, Sally typically knocks her creator Dr. Finkestein out by putting a plant called "Deadly Nightshade" into his food so she can sneak into the town. She's done this enough times that the doctor becomes suspicious when one of her meals is covered in an ingredient strong enough to cover the scent of anything.
  • In Shrek 2, the Fairy Godmother gives Harold a Love Potion to slip Fiona after it becomes clear to them that Fiona will not be with Charming on her own free will, something that bothers her father, but not Fairy Godmother or Charming. This is treated very much like a shallow breach of free will, and Harold refuses until the Fairy Godmother threatens him. Harold then, very reluctantly and feeling incredibly guilty about the situation, attempts to give Fiona the potion with a cup of tea. He then has a pang of conscience after Fiona expresses her love for Shrek and her terrible unhappiness with Charming (who was pretending to be Shrek at the time) and switches the cup for the untainted cup last minute.

    Film — Live-Action 
  • This is also an Abbott and Costello routine. Lou realizes his drink has been poisoned, so he distracts the bad guy ("HELLO! Steve, old boy!") so he can switch the glasses. Hilarity Ensues, especially when the move was faked.
  • In the 1956 film Around the World in Eighty Days, Fix drugs Passepartout's drink and knocks him out—in the book, he just gets him drunk and persuades him to smoke opium, with the same result.
  • In Asian School Girls, the two sleazeballs who abduct the girls from the club do so by feeding them whiskey sours laced with sedatives. Hannah only took a few sips of hers and so remains conscious while her friends pass out.
  • Asylum: In "Lucy Come to Stay", Lucy slips a sedative into George's tea to knock him out.
  • In The Awful Dr. Orloff, Dr. Orloff spikes Wanda's champagne when he is planning to abduct her. Wanda sees what he is doing in a Revealing Reflection and performs a Poisoned Chalice Switcheroo.
  • In Bad Times at the El Royale, Father Flynn slips several drops of what is probably chloral hydrate into Darlene's drink, so she can be got out of the way for a while. Suspecting that he was shady and up to something, Darlene actually snuck up behind him and knocked him out with a bottle while he was holding her drink.
  • In The Bank Dick, W.C. Fields labors to keep the bank examiner from doing his job - lures him into his regular saloon for a quick drink, and surreptitiously asks the bartender if "Michael Finn" has been in. The doctored drink leaves the examiner very ill.
  • In the 1959 version of The Bat, Davenport—the detective left on duty to watch the house—has his wine drugged, causing him to pass out.
  • In The Big Lebowski, Jackie Treehorn makes a "Hell of a Caucasian" for the Dude.
  • Done to Nina in Black Swan when she's at the bar with Lily. Maybe.
  • In A Blueprint for Murder, Cam surreptitiously drops the tablet he believes to be strychnine into Lynne's Bacardi cocktail.
  • In Circus, Leo slips Julius a mickey finn before dumping him on the side of the road to take the fall for Bruno's murder.
  • In Clegg, Suzy slips Lord Cruikshank a mickey, then lures him into the shower with her. She then strangles him and finishes the job by drowning him in the bath.
  • Clown Kill: Happens twice to Jenny in the movie. First in the prologue, and second at the night shift she's working.
  • In The Con is On, Harry tries to drug Jackie's drink at the party, but Jackie has a paradoxical reaction to the drug.
  • Contracted: It's revealed that the drink BJ gave Sam had rohypnol, which he used to inebriate and rape her, then she lost her memory mostly afterward.
  • In Copycat, Foley drugs the drink he buys for Andy in the nightclub.
  • Creepshow: In "The Crate", Henry slips sleeping pills into Dex's drink to knock him out so he can go to the lab, clean up the carnage, and set things up for his plan to dispose of his wife.
  • The Crime Doctor's Courage: Having invited Dr. Ordway back to their home to meet Kathleen, Miguel and Delores give him a glass of drugged wine; knocking him out to allow Kathleen to slip away again.
  • Rigby Reardon is given drugged drinks by two different women in Dead Men Don't Wear Plaid. In both cases, unconsciousness is preceded by a long and elaborate variation of Non Sequitur, *Thud*.
  • In Divine Secrets of the Ya-Ya Sisterhood, the titular sisterhood slips a roofie into Sidda's drink so they can take her to the old cabin and explain to her the secrets of her mother's past.
  • The point of the 1950 film, D.O.A.. The protagonist is told he's been poisoned and has only a couple of days to live. The film chronicles him trying to find out who poisoned him and why.
  • Invoked in Doctor Strange (2016): After Dr. Strange's first experience of extradimensional travel, he asks if the tea he'd been drinking was spiked with hallucinogens. The Ancient One assures him that it's just tea (with a little honey).
    • Ironically enough, in the sequel, Doctor Strange in the Multiverse of Madness, Doctor Strange and America Chavez are drugged, knocked out and taken in by the Illuminati after drinking Karl Mordo's tea without suspicion.
  • In Dracula vs. Frankenstein, Rico orders the waiter in the coffeehouse to drug Judith's coffee after mistaking her for a cop.
  • In Eat, the two guys that Novella and Candice are talking to at the club drug the womens' drinks to "loosen them up" (read: make them easier to overpower for nefarious purposes).
  • Eraser. Arnold Schwarzenegger takes a bottled water invitingly placed in a bucket in front of him. When one of the corrupt feds also goes to take one, The Mole quietly stops him and gives him a drink from the fridge, saying: "You'll like this better." Within moments Arnie's feeling the effects of the knockout drug — of course it doesn't slow him down much.
  • In Faster, Old Guy, one of the targets of the protagonist, Driver, drugs the drink of the teenage girl who helps him carry his shopping to his apartment. Given he is a sex offender who makes Snuff Films, and he has just pulled out his camera, her future is not looking bright when Driver saves her by kicking open the door and killing him.
  • In The Final, the outcasts drug the punch at the party, knocking out all of their tormentors.
  • Flower (2017): Erica and her friends roofie Will's beer before Erica's second seduction attempt.
  • In The Good, The Bad, The Weird, Tae-go is slipped a mickey by one of the girls in the brothel/opium den, so the pimp can steal the map and sell it to the Japanese.
  • Pretty much the primary plot point of The Hangover. One of the guys mistook Rohypnol for Ecstasy and slipped it into everyone’s drinks, causing amnesia. They later use the rest of the pills to knock out the tiger.
  • In Hard Candy, 32-year-old pedophile Jeff Kohlver learns the hard way that the rules about never letting someone else mix your drink applies both ways when his would-be victim, 14-year-old Hayley Stark, turns the tables and drugs him this way.
  • Hounds of Love: Evelyn invites Vicki inside while they're waiting for John to get her drugs, which lets them drug her drink, then take her prisoner.
  • Nicely avoided by the would-be victim in the '50s black-and-white film The House On Telegraph Hill. The husband brings a carafe of orange juice with one glass poured out. Due to the rest of the film, the wife is very suspicious. When the husband returns to the room he asks why she hasn't drunk her juice and she says that it tasted funny. He pours a glass from the jug, tells her it tastes fine, and makes her drink her own glass. Shortly afterwards, he admits the juice in the glass was poisoned and that she is dying. He's a bit upset when she tells him that she poured a fresh glass, poured the first glass back into the jug, and washed that glass.
  • Hustlers: A group of exotic dancers in Manhattan find that the 2006 financial crisis has caused their Wall Street customers to spend less freely. So they drug the men's drinks to make them insensible and then run up huge bills on their credit cards.
  • In the boarding school in If, one of the pupils says off-handedly that he's going bald, and wonders if it's something they put in the soup.
  • In Im Juli, a poison ring filled with LSD is used to drug and rob the hero.
  • In The Invisible Man (2020), Cecilia doses Adrian's water with diazepam the night she runs away from him.
  • James Bond
    • In Dr. No, Bond realises just a fraction too late that the coffee waiting in his room in Dr. No's "mink-lined prison" has been drugged. Through as Bond was already captive, one wonders why he bothered.
    • The Living Daylights: Kara gives James Bond a martini laced with chloral hydrate.
  • Johnny English Reborn: Simon Ambrose plans on drugging Pegasus this way.
  • In Kingsman: The Secret Service, while floundering on a test that involves seducing a specified target, a strange man suggests Rohypnol to the Kingsman candidates. Turns out it's already been done to their own drinks, setting them up for their real test - unexpected capture and interrogation.
  • Lust for Gold: When the salon owner wants Walz out of his bar, the bartender dumps a powder into his beer to knock him out.
  • Lycan: Kenny tries to spike Chrissy's Sprite when they're drinking out in the woods. It gets Irving instead though when he mixes up their cups.
  • In Maleficent the villain does this to the protagonist and cuts off her wings.
  • The Man from U.N.C.L.E. (2015). Napoleon Solo shows himself Properly Paranoid about this. When the female concierge turns up with a complimentary bottle of champagne, he insists that she join him in drinking it (as a fringe benefit she ends up in bed with him). Later Victoria Vinciguerra is able to drug Solo by lacing every bottle in her private bar with sedatives. When Solo realises he has been drugged, his response is to calmly lie down on a nearby sofa, explaining that last time this happened he fell badly and hurt his head.
  • In The Man with Nine Lives, Dr. Kravaal drugs the soup Judy serves the thawed Human Popsicles to knock them out so he can use them as guinea pigs for his experiments.
  • In Misery a kidnapped Paul tries it, but his captor accidentally knocks the glass over.
  • In Murder on the Orient Express (2017), Ratchett has his coffee spiked with barbital before he is murdered. When Poirot sniffs the coffee cup he remarks "a mickey has been slipped".
  • Done in The Naked Truth, at one point to someone who was Micky Finned the previous evening from the very same bottle. At the very same place.
  • In Pet Sematary (2019), Louis spikes Jud's whiskey to knock him out and prevent him from interfering with Louis' plan to steal Ellie's body from her grave.
  • The President's Analyst:
    • Affable Soviet spy Kropotkin rescues Dr. Schaefer and gives him a drink from a flask while appealing to his sense of reason to get him to defect to Russia... but to cover his bases, the drink is drugged to knock him out.
    • Earlier on, an agent of the Canadian Secret Service adds LSD to the ice supply of a nightclub, sending everyone who drinks (including several Federal agents) into a tripped-out orgy, and making it easy to abduct the doctor in the chaos.
  • Promising Young Woman: The vodka Cassie feeds to the guests at Al's Stag Party is drugged to render them all insensible for the night while she takes her revenge on Al.
  • Ricochet: Blake drugs Styles's nanny and his kids cocoa. Thankfully, he doesn't do anything to either.
  • Done both to and by the main character of The Rundown, using poisonous native fruit.
  • In Riot on Sunset Strip, Donnie slips an LSD sugar cube into Andy's soda pop, causing her to do a dance. Afterwards, he drags her upstairs, where he and four other boys rape her.
  • The Seventh Continent, the parents trick their daughter into drinking poison. The little girl comments on the bitterness of the beverage.
  • Irene Adler pulls a clever one on Holmes in Sherlock Holmes (2009) using an unopened bottle of wine. She uses a syringe to inject the drug through the cork and a match to re-melt the wax and conceal the hole. She then undresses him and leaves him to wake up Chained to a Bed.
  • In Sherlock Holmes and the Case of the Silk Stocking, Charles gives Roberta a glass of drugged champagne and then attempts to abduct her when she passes out.
  • In Shish O Besh Panis drugs the Amoral Attorney's juice so that the gang can break open his safe. Davood later drinks it as well.
  • In Shut In, it's revealed that Stephen has been drugging his mother the whole time, which caused her hallucinations.
  • In Small Soldiers, when the Commando Elite infiltrate the Fimple residence so they can take Christy hostage the moment she returns from her date, the first thing they must do is neutralize her parents and brother. The Commandoes put sleeping pills in Marion and Phil's drinks, and they're strong enough to make them heavy sleepers so they don't hear what's going on.
  • In Spy Kids 2: Island of Lost Dreams, during a party for the OSS elites, the adults' champagne turns out to be drugged and the party is attacked by a group of Magna Men trying to steal the Transmooker device and the children are forced to fight back.
  • Stonehearst Asylum: The staff was drugged this way by some of the inmates so they could take over the asylum. A couple of the nurses died, as they used too much it seems.
  • In Sunset, Michael is slipped a mickey at the Candy Store, leading him into a The Corpse Stops Here situation with Candy's body.
  • Tales from the Hood 2: In "Date Night", Ty and Kahad drug their dates and carry their unconscious bodies upstairs, planning to film and rape them.
  • Tales of Terror: In "The Black Cat", Montressor knocks Fortunato out by drugging his sherry.
  • Tamara: Shawn and Patrick habitually drug girls' drinks to then rape them.
  • The Terror of the Tongs: When Sale visits Lee Chung's, he is given a glass of drugged brandy. When he wakes up, he is in front of the tong head Chung King.
  • The Theatre Bizarre: It seems likely that the mulled wine Mere Antoinette feeds Martin in "The Mother of Toads" are laced with something to make him more susceptible to her seduction.
  • The Three Stooges also did several variations on the theme, often with a disgusting cocktail Moe would dub an "Icky-may". In "Pals and Gals", the recipient of the spiked drink actually died!
  • Twice-Told Tales: In "Rappaccini's Daughter", Rappaccini drugs Giovanni's drink to knock him out then, while he is unconscious, treats him with the same extract he gave Beatrice, turning Giovanni into a Poisonous Person as well.
  • In Viridiana, Don Jaime asks Viridiana, a novitiate nun, to stay with him at his mansion and marry him. When she refuses, he serves her drugged coffee and nearly rapes her.
  • In Vlog, the killer drops a roofie into Tony's drink to sedate him before dragging him off to be murdered.
  • In When Darkness Falls, Leyla's family uses this twice on her. First after Nina's death, then after Leyla reports her family to the police.
  • In The Woman Hunt, Psycho Lesbian Magda drugs Lori's wine, intending to rape her.
  • X-Men Film Series
    • In X2: X-Men United, Mystique slips a drug into Magneto's guard's drink in order to knock him out so she could inject enough metal in his body for Magneto to sense and manipulate to break out of prison.
    • Subverted in X-Men: First Class: The NATO general responds to the Hellfire Club's first display of mutant powers with "What the hell did you put in my drink?!", thinking that he must be hallucinating.
  • Superdome: To help her husband P.K. Jackson's team win the Super Bowl, Sonny pours a powder into McCauley's drink, which she says will leave him out of sorts for the next few days. Instead, his date Gail drinks it, reacts badly, and ends up in the hospital.

    Literature 
  • In the Callahan's Crosstime Saloon story "The Guy With the Eyes", Callahan saves the world by slipping an alien advance scout a Mickey Finn so he misses his check-in with his alien overlords. Said scout clued Callahan in on how to defeat him by giving the alias Michael Finn.
  • Dragonvarld: Ramone, a seasoned thief, drugs Ven's ale and robs him when he's down.
  • In The Famous Five book Five Go To Smuggler's Top, Uncle Quentin is kidnapped in his sleep, having been drugged and gagged. The Famous Five's friend Sooty happens to be in the room when this happens, and is kidnapped himself.
  • In the short story "The Fly-By-Night", a father attempts this on his daughter Celia, as he fears she's fallen under the titular creature's spell and wouldn't let him dispose of it if she was awake. To ensure she's knocked out, he uses eight ground-up sleeping pills. She notices the odd taste, but he forces her to drink anyway, completely destroying their relationship in the process. Not that it matters with the Mandatory Twist Ending calling in Diabolus ex Machina, anyway...
  • In The Gang That Couldnt Shoot Straight, the stupid Mafia gang needs a way to disable some bodyguards without killing them. Naturally, they have heard of a "Mickey Finn" and decide to try it. Of course, being who they are, they find out that once they put it in the drink and offer it to the bodyguards, the bodyguards immediately notice that their drink smells funny. A gang member has to force them to drink it under threat of shooting them.
  • In Hurog, this is Oreg's story of how he was Made a Slave. He was given some soup, drank it, and the next thing he knew, he was castle Hurog.
  • John Putnam Thatcher: In Going for the Gold, an athlete is slipped OTC cold medicines right before going down the ski run. Because she never takes medications, the "drowsiness" side effect hits her much harder than normal. Because she is an Olympic skier (the setting is the Lake Placid Olympics), she makes it down the ski run in one piece and can still provide important evidence.
  • Alistair Maclean:
    • This backfires in The Golden Gate. The police drug the food sent to feed the hostages and their captors, with the drugged plates secretly marked so their undercover agent can make sure the criminals get them. Unfortunately one of the hostages is so hungry he grabs a plate, scoffs it down, then dies of a heart attack. The hostage takers naturally think the food is poisoned and orders the hostages to eat all the food at gunpoint. The undercover agent eats from one plate, then when he's handed a drugged plate he throws it down and objects to this humiliation, getting the other hostages to join in. As the leader of the criminals is aiming to become a Villain with Good Publicity, he decides not to force the issue.
    • In The Golden Rendezvous, the crew of an ocean liner are being held prisoner. As it's a British liner, they brew some tea and the protagonist insists they send one out to their guard as well. The prisoners are outraged, but quickly realise he's setting the guard up for this trope if they need to use it in the future.
  • Harry Potter:
    • Attempted in Harry Potter and the Order of the Phoenix by Dolores Umbridge to Harry in the form of Veritaserum, a truth potion that would force Harry to tell her anything she asked. Harry, however, is wise enough not to drink something offered to him by a known enemy and does not drink the tea (and dumps it out at the first opportunity). In addition, the Veritaserum in question was fake, supplied to her by Snape to prevent this exact situation from occurring.
    • In Harry Potter and the Half-Blood Prince, Dumbledore theorizes that Voldemort's mother Merope Gaunt might have used this method to bewitch Tom Riddle Sr. into marrying her, slipping him a love potion in a glass of water during a hot day. Harry himself needs to be on the lookout for this, as his newfound popularity has attracted the attention of a girl named Romilda Vane, who bought some love potions in the Weasley twins' joke shop, and first tries to give him a glass Gillywater and later a box of Chocolate Cauldrons.
  • Helen and Troy's Epic Road Quest: At the dragon preserve, Peggy Truthstalker drugs the Wild Hunt gang with vision weed in their sandwiches so that they can all undergo a Vision Quest.
  • In the Katherine Kurtz novel High Deryni, Stefan Coram, who has been masquerading for several years as Rhydon of Eastmarch, breaks out a flask for a traditional toast at the start of a four-on-four arcane duel. He takes the first swig himself and lets his three colleagues drink before stopping King Kelson and his side from partaking. The flask was poisoned to ensure the outcome of the battle, but the poison was sufficiently slow-acting to allow for the Dénouement and the Coup de Grâce.
  • In The Impossible Virgin, a Modesty Blaise novel, Modesty and her team are captured by the villain after being served drugged coffee by someone they'd trusted.
  • Jaine Austen Mysteries:
    • Nina does this to Jaine in Shoes to Die For. She says she does it to her "tricks" to rob them.
    • The killer of Pampered to Death spikes everyone's tea with Valium so that they pass out during their seaweed wrap to give themselves the chance to choke her to death.
  • In the Jeeves and Wooster novel Jeeves and the Tie that Binds, Jeeves of all people resorts to using this to obtain the stolen Junior Ganymede club book. Among other motivations, the book contained potentially damaging information about just about every upper-class Londoner.
  • The Last Adventure of Constance Verity: When Tia refuses to "see reason" and not go with Connie into the Melpomene Apple Pie Factory like she tells her, she admits to having drugged her coffee so that she would have no choice in the matter.
  • In the Left Behind book Armageddon, Chloe Williams drank a milkshake with a drug in it that put her to sleep, enabling the GC to transfer her from San Diego to Illinois.
  • The Love and Lies of Rukhsana Ali: Rukhsana's mother drugs her tea after she's disobeyed by trying to flee so she can escape an unwanted arranged marriage, and keeps her there that way.
  • The title character of Mac Slade Private Dick: The Case of the Hardboiled Dicks mistakes "Mickey Finn" for a real person.
  • In The Mapmakers Race, Beckett tells a story in which an ogre drugs some travelers' wine so that they fall asleep in order for him to eat them. Thankfully, Tom, who didn't drink the wine, saved them.
  • In The Mental State, a prison inmate called Harry likes to do this to newcomers in order to manipulate them into joining his gang of addicts. He even attempts this on the main character.
    • Zack himself uses this to frame a sadistic prison guard and get him arrested.
  • In Myth-ing Persons, this is how the fugitives frame Aahz for murder, plying him with a drugged drink and planting fake evidence for him to get caught with, upon awakening. Skeeve's other friends tease Aahz about falling for such an old gimmick.
  • Nick Velvet: In "The Theft of the Venetian Window", Nick drugs the owner of the eponymous mirror by slipping sleeping pills into his coffee, then leaving and returning when the pills have had time to take effect. However, when he returns he discovers that someone has murdered the owner in the interval inside a locked room.
  • Paradise Rot: Thierry does this to Kyle when he starts being too loud about the zombies in his Tavern. Results in Instant Sedation.
  • Parker gets slipped a mickey by the middleman Brock when he shows up asking questions about Rosenstein and Uhl in The Sour Lemon Score. He is interrogated using Truth Serum and then wakes up in an alley with all of his valuables gone and doused in cheap wine to make him seem like a hobo.
  • Philo Vance: The Scarab Murder Case: Dr. Bliss' coffee is spiked with opium note  to keep him from hearing an Egyptian statue being dropped on top of Murder Victim #1. Bliss spiked the coffee himself, as an alibi.
  • In Phoenix Rising, Kyri is captured by an enemy this way. Played with; she's cautious enough to only pretend to drink from the glass, but it turns out the knock-out stuff isn't the drink, it's magically incorporated into the glass itself. (And to make sure he doesn't accidentally take the wrong glass, he explains, all the glasses in that set are identically enchanted, but the trigger is the touch of female lips — which prompts disquieting thoughts about why he would happen to own a set of glasses like that in the first place.)
  • In the Phryne Fisher novel Death by Water, Phyrne's companion Dot is slipped a mickey to keep her out of the way while Phryne's cabin is searched. Phryne is ready to inflict serious physical harm on the perpetrator when she finds out.
  • In Roald Dahl's autobiography Boy, he writes that his childhood friend Thwaites declared, with great authority, that sweets contained sedatives often fed to rowdy prisoners, saying that it was a grown-up plot to keep children quiet.
  • In Sunny Ella, wicked stepmother Mona brings Ella a cup of tea as a peace offering after an argument. Not surprisingly the tea was drugged, to ensure Ella didn't wake up while Mona performed a rather nasty surgery on her.
  • In A Tale of..., Mother Gothel planned on making Rapunzel's favorite hazelnut soup for her 18th birthday for this reason. She planned on lacing the soup with a sleeping potion so that her plans to revive her family using Rapunzel's powers would work. Unfortunately for her, Rapunzel rejects her attempts at making soup.
  • "A !Tangled Web (1981)": Lafitte drugs Navarro in an attempt to gain an advantage in the negotiations, and when accused later, claims it was just Navarro being unable to hold his liquor.
  • In Wicked, Melena doesn't remember Elphaba's conception because the man, the future wizard, gave her a drugged elixir. The elixir also caused Elphaba's green skin.
  • Chronicles of the Kencyrath. Jame has been captured by Lord Caineron who makes his intentions obvious. He's trying to soften her up with wine when she accuses him of trying to drug her, so Caineron drinks from her cup to prove otherwise. Turns out she's already slipped some Power Crystals into the wine, which Caineron discovers when he starts to hiccup and float in the air.
  • In the Bounders novel The Forgotten Shrine, the Alkalinians slip a drug, which turns out to be Alk venom, into the Earthlings' dinner to keep them unconscious while the Alkalinians examine them to decide which ones should be killed.
  • In The Society of Sylphs, Chuck roofies Pam's drink and drags her away from their friends to rape her. She resists and manages to get loose, and stumbles away from him. Unfortunately, there's nowhere to go but off a cliff, and when he pursues her, she falls to her death. As Chuck flees the scene, the bottle of roofies falls out of his pocket. Days later, Luranna helps Eddie find it, and it becomes key evidence in the case against Chuck.

    Live-Action TV 
  • In The Adventures of Superman episode "Drums of Death", the bad guy gives Perry White's sister Kate drugged tea, enabling him to brainwash her.
  • The A-Team:
    • The team often drugged B.A.'s milk so they wouldn't have to deal with his fear of flying.
    • In "Deadly Manuevers", one of the villains delivers milk to the A-Team. However, the milk is spiked with "a powerful sedative" that is meant to incapacitate them. (However, from the pain it causes the afflicted Hannibal and B.A., it seems more like poison than a sedative.)
    • In "Champ!", the antagonists drug the water in which B.A.'s mouthguard is rinsed when they realize that he has no intention of throwing the fight as ordered. Unfortunately for them, it makes him woozy but it doesn't stop him from beating his opponent.
  • Babylon 5:
    • Londo gets slipped a mickey in "Born to the Purple" by Adira. She uses this to get access to the Purple Files that could bring down almost any noble family in the Centauri Republic.
    • "Intersections in Real Time" uses a drugged sandwich. (That one is implied to cause extreme nausea, rather than sedation. The audience gets a massive Discretion Shot.)
  • Done by the title character of Blackadder II to the Baby-Eating Bishop of Bath and Wells, in order to get him into a compromising position for blackmail.
    Bishop: Drugged, by God!
    Blackadder: No, by Baldrick, actually, but the effect is much the same.
  • The Barrier: Alma is conducting experiments on children, whom she sometimes needs sedated. When that need arises, she usually has the sedative slipped into their food.
  • Breaking Bad: In the episode "Fly", Jesse is concerned Walt is going nuts trying to kill a fly that's gotten into the meth lab, coming in the next day seeing that Walt never left nor slept. He offers Walt some coffee which he secretly slipped a few sleeping pills in to force him to get some rest.
  • Hank is a victim of it in the Californication season 5 finale.
  • In Carnivàle, this happens to Ben in the episode "Old Cherry Blossom Road" via a cup of tea. Things get worse from there.
  • In one episode of Castle a bridesmaid at a wedding slips roofies into the drink of one of the groomsmen as part of a plan to seduce the groom in order to get the wedding called off.
  • Charmed: Aunt Gail and her friends need to slip the Charmed Ones a power-stripping potion before they can steal their powers. They do so via the iced tea they insistently serve the girls.
    Piper: Aunt Gail was Grams' best friend! She used to bake us cookies!
    Phoebe: (Deadpan) And now she's spiking our tea.
  • Columbo: In "Swan Song", Tommy Brown (Johnny Cash) hands his two victims a thermos of drugged coffee while they are flying. This puts them to sleep, and he bails out, leaving the plane to crash.
  • Copper: The Union army is contracting civilians to act as recruiters. A particularly unscrupulous group of them like to approach young men in taverns, drug their drinks, kidnap them and then hold them prisoner until they can be delivered as "volunteers" to the army.
  • CSI:
    • The series pilot involves a string of "trick rolls" in which a prostitute uses scopolamine on her nipples to knock out her Johns before robbing them.
    • One episode had Catherine wake up naked in a motel room after one of these. She wasn't raped, but photos taken were used to try and blackmail her casino mogul father.
  • In CSI: NY, a senator whose daughter was raped attempted to set up the rapist by having a woman get with him and then claim to have been drugged and raped by him. But the ploy backfired when the CSIs found the levels of GHB/Rophypnol would have been at lethal levels if she'd actually been given them by him at the time she said.
  • Death in Paradise:
    • In "La Murder Le Diablé", the killer gave their chosen patsy a spiked bottle of rum so that he would pass out and be unaware of his actions at the time of the murder. Then, when they planted the murder weapon back in his house, they swapped the spiked bottle for a normal one so there would be no evidence of a drugging.
    • In "Switcharoo", the killer drugs the Victim of the Week by putting sleeping pills in her champagne so she is passed out when they place her in an Electrified Bathtub.
    • In "Death in the Salon", the murderer spiked the Victim of the Week's iced tea, causing her to pass out before the actual murder occurred.
  • Doctor Who:
    • "The Edge of Destruction": The Doctor drugs Barbara and Ian's drinks to knock them out so he can investigate what is happening to the TARDIS without interference. Ian doesn't fall for it, however.
    • "The Tomb of the Cyberman": Kaftan drugs Victoria's coffee to knock her out.
    • "The Time Warrior": Sarah Jane drugs Irongron's men's food and drink withh a sleeping draught the Doctor prepared.
    • "The Brain of Morbius": Done quite cleverly when Solon offers the Doctor wine. After a short time away with other characters we return to a Doctor who is acting giddy and talkative and moving in an uncoordinated way. Nothing suspicious about that... until he suddenly passes out. The time skip was actually a lot shorter than it looked and he's actually drunk very little — he only appeared so out of it because he was drugged. Sarah was pouring her wine away, and as soon as she realizes what happened to the Doctor she quickly fakes passing out.
    • "The Name of the Doctor": Madame Vastra manages to do this to Clara Oswald from nearly 120 years in the past by arranging to have a letter infused with a knockout drug delivered to Clara in the year 2013.
    • "Empress of Mars": Jackdaw drugs Sergeant-Major Peach's tea so he can loot what he thinks is a tomb. Bad move.
  • On Ed, Shirley once suggested solving a problem by "slipping them a mickey". She didn't seem to know what it was.
  • In the Emergency! episode "Parade," a man puts chloral hydrate into his date's drink, but the drinks are switched by accident, so instead he passes out in the middle of the date. While he's out, some of the drug from his stomach ends up in his lungs, causing a much stronger reaction that almost kills him.
  • Father Brown: In "The Two Deaths of Hercule Flambeau", Lisandra drugs the thermos of tea she gives Father Brown. This knocks out both Father Brown and Flambeau and allows her to steal the key.
  • Gilligan's Island: In "Good Night, Sweet Skipper", the Castaways need the Skipper asleep because that's the only way he remembers how to turn a radio into a transmitter. When the Skipper is too wound up to get to sleep, Gilligan borrows some tranquilizers from Mr. Howell to put in his mango juice. Unfortunately, the girls and the Professor also add some and then the Skipper, seeing the tranquilizers, uses the juice to take a couple. He's too tranquilized even to remain upright.
  • Happy Days:
    • In one episode, Mr. C says that some punch at a party is "spiked" (with alcohol).
    • In "King Richard's Big Night", Richie is slipped a Mickey Finn by a college bully, causing him to completely lose control of his inhibitions and take Fonzie's motorcycle for a joyride. Fonzie is furious at him until he realizes that Ritchie legitimately has no idea what he did that night. Once he finds out that Ritchie's drink was drugged, his anger changes targets.
      Fonzie: You put something in your drink and that's stupid. You put something in somebody else's drink and that's pathetic.
  • In the Here Come the Brides episode "The Crimpers," the titular kidnappers pour something into Jeremy's whiskey that makes him feel woozy. He staggers out of the saloon to get some air. They grab him as he passes out.
  • Heroes:
    • Peter, Suresh, and Parkman do this to Noah's alcohol in order to kidnap and interrogate him. After he passes out, they carry him out of the bar by casually saying, "Looks like our friend had a few too many."
    • Which was a Hoist by His Own Petard moment, as Noah and the Haitian had done the same to Parkman early in the first season.
    • And Suresh had done this before; during the first season, he drugged Sylar's tea in order to interrogate him.
  • Happens a couple of times in House. Mainly between House, Wilson, and Cuddy.
  • I, Claudius: The wife of a Roman official is drugging his wine so she can have an affair with Serjanus while he's asleep. Serjanus convinces her they have to Murder the Hypotenuse instead, as he'll eventually become resistant to the drug.
  • I Love Lucy: In the first episode ever filmed, Lucy cuckoos out, believing Ricky is planning to murder her. Naturally, he responds, worried about her jumpiness, by spiking her drink with sleeping powder.
    Lucy: I got a Mickey from Ricky!
    • Why is Lucy so uptight? Simple, she had been reading a book called "The Mockingbird Murder Mystery". To make matters worse, she thinks Ricky is already lining up women to replace her even though she isn't dead. The women turn out to be dogs for Ricky's nightclub act.
  • An episode of It Ain't Half Hot, Mum was based around the Concert Party having Sergeant Major's drink spiked so he would act drunk and disorderly and be demoted. However, Graham (who's recently been appointed an acting NCO) takes the blame for Williams's actions and returns to the rank of Gunner.
  • I May Destroy You: Ava and Arabella were spiked by a member of their party, and it led to Arabella being sexually assaulted by an essential stranger (who they met on that night).
  • Jake and the Fatman: The M.O. of the organ-leggers in "Come Along With Me". The man chats up a woman in a bar. His female accomplice then distracts the victim while he spikes her drink.
  • L.A.'s Finest: Patrick's drink is drugged so he acts inappropriately and gets filmed as blackmail.
  • The Law According to Lidia Poët: The accused in 1x5 is a prostitute who gave her clients drugged alcohol, even calling it a mickey, and then robbed them as they lay unconscious.
  • Law & Order: Special Victims Unit, of course, has to deal with the aftermath of victims being slipped Mickeys. One example was in "Desire". April drugged multiple men with rohypnol and then raped them to get sperm.
  • Liar (2017): Laura accuses Andrew of doing this to her, though no evidence can be found in her blood test. It turns out he did drug her with GHB, and it's his M.O., which he learned from another serial rapist.
  • In Life on Mars (2006), this happens to Sam Tyler as part of a blackmail: the villain of the week (a nightclub owner and local gangster) hires one of his dancing-girls to seduce, drug, and date-rape Tyler (whilst he's Chained to a Bed) when he threatens to bring in her employer. She eventually relents and destroys the photographic evidence, leading to her murder.
  • Logan's Run: In "Stargate", the aliens give Logan and Jessica drugged drinks to render them unconscious.
  • Lost Girl. Our introduction to the protagonist Bo is when a businessman slips a roofie into her drink while she's working as a bartender. She's not allowed to drink while working so the man offers the drink to Kenzi instead, who picks his pocket and then gets as far as the elevator before the drug takes hold. Fortunately Bo follows them, kills the would-be rapist and takes the barely conscious Kenzi home. It's the beginning of a beautiful friendship.
  • M*A*S*H: In "White Gold", Hawkeye and Trapper slip a compound in Col. Flagg's coffee which causes a pain that the docs diagnose as appendicitis.
  • Happens in three episodes of Misfits. Played for laughs in the first case, as Nathan's brother spikes Simon's beer with ecstasy to get him to enjoy the party (and accidentally reversing his power in the process); most definitely not played for laughs when Mark spikes girls' drinks as a prelude to rape. In the fourth series opener, Rudy drugs Jess and Finn's drinks while under the influence of Michael's MacGuffin obsession power.
  • Miss Fisher's Murder Mysteries: Henry does this to Bert in "Death Do Us Part", drugging Bert's tea so he can escape from Phryne's house. To add insult to injury, he steals Bert's cab.
  • Motive: In "Foreign Relations", the killer slips the Victim of the Week a mickey so she can abduct and interrogate him. However, she miscalculates the dose needed, resulting in an Accidental Murder.
  • The Murders: In "Toxic", a young woman reveals a friend of hers slipped a date rape drug into her drink, waking up only after he was raping her.
  • In My Name Is Earl, Earl explains an item his dad brought up on his List of Transgressions. Back when Earl was a young boy, he didn't get along with his dad, who was often in a grumpy mood when he came home from work. Earl was envious of his friend Eric, who had a "cool" mom. Turns out the reason she was so "cool" was that she was mixing her prescription pills with alcohol. Earl swiped some pills from her and dropped them into his dad's whiskey at his parents' anniversary party. It resulted in Mr. Hickey goosing female guests, attempting to start a key party, and being Exiled to the Couch for a week (and very nearly divorced.)
  • Person of Interest:
    • The sociopathic Root grinds up a drug she's stolen from a chemist and slips it into a woman's drink (she's addicted to painkillers, so it's probably meant to look like an overdose). When the woman collapses, Root uses the distraction to steal her mobile phone, as she's The Mistress of her target, to whom she sends a text to lure him into a trap.
      Root: She'll be okay. In a few months.
    • In another episode, Harold's then-partner Dillinger finally brings Harold the correct type of tea; Harold barely registers this enough to be grateful, but does take a couple of sips while trying to work and talk at the same time. Halfway through realizing that Dillinger's got a different plan, Harold starts feeling the effects and glances at the teacup in horror. One has to wonder if Dillinger had been faking his failure to learn/remember the right tea brand, just to have this ace in the hole (expecting Harold to be too gratified to be suspicious). (Not to mention how much sedative was in the drink, given that two sips easily knocked Harold out within a couple of minutes — what would've happened if he had gulped it down instead?)
      Harold: Mr. Dillinger... what have you done?
  • In an early episode of The Practice, Lindsay can't figure out why she's so violently ill one morning. It turns out an ex she met up with the previous night drugged her in order to have sex with her. (When confronted, he actually defends himself by saying that Lindsay was always so uptight about sex, she needed help to "loosen up.")
  • In the Quantum Leap (2022) episode "Somebody Up There Likes Ben", Janis Calavicci drugs her mother Beth's tea. Janis does this so she can steal her late father Al's artifacts from the original Project Quantum Leap, including his old Ziggy handlink.
  • Played for Laughs in Seinfeld when George decides to poison his Bad Boss as payback for firing him:
    George: I'm gonna slip him a mickey.
    Jerry: What? In his drink? Are you out of your mind? What are you, Peter Lorre?
  • Special Ops: Lioness: Cruz's drink gets drugged by a man she meets at a bar then she's dragged away by him after it takes effect before the team saves her from his impending rape.
  • In the Starsky & Hutch episode "Discomania," a Serial Killer does this to a female cop who is trying to catch him.
  • In the Star Trek: The Original Series episode "Amok Time", McCoy gives Kirk a shot, saying that it would help Kirk breathe the thinner Vulcan air. He really gave Kirk a neural paralyzer that made it look like he was dead.
  • Strangers From Hell: Ms. Eom claims to be worried about Jong-woo's health, so she gives him drinks. Unknown to him, the drinks are drugged.
  • Tales of the Gold Monkey. American spy Sarah White drugs a man who's supposed to be a traitor in order to steal his MacGuffin, only to find out too late he's an American Double Agent. But she's given him too big a dose and can't wake him up. She has trouble convincing Jake Cutter that an unconscious man in her bed is Not What It Looks Like (then she has to get Jake to take the man's place).
    Jake: What'd you do, hit him over the head with a baseball bat?
    Sarah: I Mickey Finned him. I was supposed to use a thimble full. To make sure, I used a jigger.
  • Torchwood: Cardiff Branch has something they call "Retcon", which is given to unsuspecting people like a Mickey to give them Laser-Guided Amnesia.
  • The Twilight Zone (1959):
    • In "Queen of the Nile", Pamela Morris drugs Jordan Herrick's coffee so that she can use her scarab beetle on him and steal his Life Energy.
    • In "The Jeopardy Room", the Soviet commissar Vassiloff tricks the defector Major Ivan Kuchenko into drinking a glass of drugged wine with him to put him to sleep so Kuchenko can be placed in a Death Trap.
  • The Twilight Zone (1985): In "Cat and Mouse", Andrea Moffatt slips a sleeping pill into Guillaume de Marchaux's coffee. When he wakes up, he is once again in the form of a cat, and Andrea has brought him to the vet in order to have him fixed.
  • Veronica Mars: Played for Drama.
    • This is how Veronica was presumably assaulted because Dick drugged Madison with GHB like this but Madison swapped the glasses, and Logan drugged Duncan, which led to Duncan and Veronica having consensual sex under the influence and Veronica having no memory of it. Then it turns out that Veronica was raped by Cassidy Casablancas on the same night.
    • In Season 3, this is how the Hearst College rapist Mercer gets his victims. And if he doesn't, his co-conspirator Moe will snag them.
  • Walker, Texas Ranger:
    • The Season 4 episode "A Silent Cry", where the college-aged daughter of one of Walker's friends is raped by a group of guys after one of them places a GHB-like substance in her drink. The girl was one of several of the gang's victims (one of whom dies as a result), and Walker and Trivette spend the episode searching for the group.
    • This happens again in "Texas vs. Cahill", when Tony Seville, Alex's ex-boyfriend and the defending attorney in he current trial, visits her with evidence of her current case that would turn things around. Tony does this to Alex, then sets up a video camera in the air-conditioning vent where his client is Caught on Tape killing him, and is later used in court to prove that Alex was framed for killing him.
  • In the The Wayans Bros., Marlon gets a letter from a beautiful woman named Cynthia, and despite Shawn's advice to not go to her house, Marlon goes over to meet her. He's greeted by Cynthia's roommate, who offers Marlon a glass of Kool-Aid, as Marlon drinks it, she goes to get Cynthia. Marlon finds her Stalker Shrine, and comments that the chicken should be kept in the refrigerator, not the closet, and he suddenly gets dizzy, and right before he loses consciousness, the woman comes in and says she wrote the letter, and Cynthia doesn't exist.
  • In The West Wing, Zoey, the President's daughter, has agreed to take ecstasy but is getting cold feet. Her boyfriend decides to move things along by putting the drug in her drink. What he doesn't know is that GHB has been substituted for the drug he thought was E. (GHB is perhaps not as pernicious as popularly portrayed, but mixing it with alcohol is a very bad idea.) Thus begins a kidnapping plot which leads to a Constitutional crisis (the President—aware of the frightening implications of his willingness to do almost anything to get her back—agrees to temporarily give up his office under the 25th Amendment). She's found alive, eventually.
  • Whiplash: In "The Other side of the Swan", Cobb is abducted. His affable captors feed him a hearty breakfast, which they have secretly drugged so he can be delivered unconscious and in chains to a waiting ship.

    Music 
  • The video for Toby Keith's "As Good as I Once Was" shows Keith dropping a GHB pill in a young woman's drink. However, when one of Keith's other friends returns sooner than expected, Keith quickly gulps down the drugged drink.
  • In the second verse of the Eminem/Dr. Dre song "Guilty Conscience", Em, as the Bad Angel, has slipped something into a 15-year-old girl's drink and is pressuring the guy to take advantage of her. Dre, being the Good Angel, vehemently objects to this.
  • Subverted in Christmas song "Baby It's Cold Outside". It is about a man trying to convince a woman not to leave during a storm. It contains the line "What's in this drink?". That line, along with the man's aggressive attitude, leads modern viewers to view it as this. However, the original intention was that the woman really wants to stay longer but denies it. The "drink" line is supposed to be her simply asking what's in the drink, nothing morenote . Due to the Values Dissonance, many covers either replace or outright remove the line.
  • It's likely this happens to the protagonist of Ricky Martin's "Livin' la Vida Loca":
    Woke up in New York City
    In a funky cheap hotel
    She took my heart
    And she took my money
    She must've slipped me a sleepin' pill
  • An Italian folk song called "La Bevanda Sonnifera" has a nobleman proposing to pay a large sum of money to a peasant girl if she would sleep with him. Her mother agrees tells her to go with him, but gives her a sleeping potion that the girl slips him before they go to bed, thus preventing him from actually having sex with her. The next morning the nobleman doesn't remember anything, so he tries to buy another night with her. However, this time the mother forbids it, telling her daughter that while she won the last time, this time she might lose.
  • The Ramones song '"Somebody Put Something in My Drink,'' in which someone puts a tab of acid in Deedee's tangerine tonic for a giggle.
  • In Tone Loc's "Funky Cold Medina," Tone Loc tries a powerful aphrodisiac to get women. He first slips some into his dog's water, then attempts to try it on "Sheena," (but aborts the mission when he finds out Sheena is either a trans woman who has not (yet) had "the op" or a drag queen), then tries it on his date from a game show by slipping it into the drink he buys for her. It works on her...a little too well; she starts talking about marriage and such.
  • At the end of the video for Jonathan Coulton's "Skullcrusher Mountain", the girl who'd been kidnapped by a lovesick mad scientist spikes his wine with Narco-tonic, knocks him out, and flees his lab on Skullcrusher Mountain while he's unconscious.
  • the song U.O.E.N.O. by Rocko, Future and Rick Ross included the controversial bar:
    Put Molly all in her champagne, she ain't even know it
    I took her home and I enjoyed that, she ain't even know it
  • Erykah Badu's "Certainly" (Baduizim) has a few meanings. The most literal is that it's about a woman who is drugged by her date.
    You tried to get a little tricky
    Turned my back and then you slipped me a mickey

    Pro Wrestling 
  • In 2006, when legislation was proposed to require professional wrestling organizations to test their performers for drugs, a storyline was contrived and intertwined with the Vince McMahon-Shawn Michaels feud, whereby McMahon's daughter Stephanie placed a powdery substance in Michaels's water bottle before his match against Shane McMahon. Predictably, Michaels began to get woozy and eventually passed out from the powder's effects, leading to Shane's easy victory; Vince subsequently pinned an unconscious Michaels in an impromptu match immediately following — after which the Spirit Squad, a band of obnoxious male cheerleaders, beat down the prone Michaels.
  • The storyline continued on a later episode of WWE Raw, with Vince McMahon attempting to drug Triple H's water. Triple H, however, was wise to this trick and — when Vince walked out of the room — switched drinks.note  During the subsequent Triple H-Shane McMahon match, Triple H pretended to "pass out," but when Shane turned to taunt the audience, he went into a dazed state and fell unconscious. Vince realized what had happened... before turning to see an angry Triple H waiting to finish him off.

    Radio 
  • Dead Ringers: Dr. Michael Mosely's advice for Christmas 2023 is for his listeners to drug the family food with ketamine, then spend the rest of the day doing whatever the hell they feel like, rather than putting up with the usual holiday drama.

    Tabletop Games 
  • Dungeons & Dragons: Oil of Taggit seems to exist for this purpose, as it's the only poison that just knocks people out, as opposed to doing ability score damage/drain.
  • In Red Dragon Inn, you play as RPG explorers who are enjoying off time in an inn trying to get your rivals drunk, roughed-up or broke. Gerki The Rogue has one card that actually says Slipping a Mickey, whereas the other adventurers are (only slightly) more discreet (such as using holy magic to turn water into wine).

    Theatre 
  • In Arsenic and Old Lace, Aunt Abby and Aunt Martha poison lonely old men who have no family to put them out of their misery. They hold a prayer service for them, and the bodies end up in the "Panama Canal." (basement)
  • In Damn Yankees, Lola puts four pills into Applegate's drink the night before the last game of the season, intending to have him sleep while the Senators win the pennant.
  • Bullshot Crummond. Bullshot suggests one last drink before Count Otto von Bruno kills him, and slips knockout pills into his glass. First, he hides the doped glass and holds out the other to Otto, knowing he'll insist on swapping. Otto takes a sip and spits it out, then suggests they drink "Eastern European fashion" so Bullshot gets the doped glass. Both end up keeling over.
    Bullshot: You want to curse me von Bruno you can curse me now, for I have slipped you a deuced large Mickey Finn. You will shortly feel the effects. To begin with a crippling pain in your stomach. (Otto feels his stomach in alarm) Followed by slurred speeshhhh (breaks off into incoherence and keels over unconscious)

    Video Games 
  • In Fallout: New Vegas, you can spike the wine at the White Gloves' banquet with Med-X as part of the Beyond The Beef quest.
  • In Fallout 2, Myron would offer you a spiked drink if you played a female Chosen One with less than 4 Intelligence and more than 6 Charisma and rape your character.
  • In The Feeble Files, Feeble slips some expired Charisma X pills into the drink that he gives to the guy occupying the phone booth, just so the guy becomes uncharismatic enough to break up with the girl he was talking to. All just so he stops occupying the booth, allowing Feeble to finally use it.
  • The Mad Doctor in Heavy Rain tries to do this to Madison so that he can tie her up in his basement and vivisect her.
  • In Hopkins FBI, you have to slip a sedative into a scientist's drink so you can steal his laundry receipt. Bizarrely, Hopkins doesn't even try to distract the target before doing the deed; he just pours the substance into the man's drink right under his nose, and the scientist still falls for the trick and falls asleep after taking a sip.
  • The backstory of Infidel: The protagonist was leading an expedition to unearth a lost pyramid, but his cruelty and incompetence led his subordinates to decide they'd had enough. One of them slipped a drug in his drink, and when he woke up the entire expedition had packed up and gone home, leaving him alone in the desert.
  • I Was a Teenage Exocolonist: One of the characters who potentially dies can be saved by putting sleeping pills in their blep tea. Doing that promptly reveals that too many pills were used and gets them rushed to medbay, but it keeps them away from the circumstances of their death.
  • Parodied in Kingdom of Loathing. A roofie is a piece of the frat house roof that frat boys use to knock people out and do horrible things to them. You can use this against enemies:
    You slip your opponent the roofie. By which, of course, I mean you chuck it at his head (or head-analogue) as hard as you can. It makes a satisfying thud, and your opponent looks pretty dazed if those cartoon birds circling his head are any indication.
  • Done to Max Payne's title character by Mona Sax in the first game. Turns into Narm on repeated viewings. Sax offers to buy Payne a drink, and he says "As long as you don't try to slip me a mickey." We see him start to lose consciousness two panels later.
  • Pavel does this to Artyom in Metro: Last Light. It sets off a good part of the plot from here on then.
  • In Phantasmat 11: Deja Vu Matthew puts sleeping tonic in a cop's coffee so he can break into a grocery store.
  • In The Saboteur, the Femme Fatale Skylar drugs Sean in order to secret him away to her superiors in the British Intelligence. Bonus points for, upon realizing it, Sean says "You slipped me a Mickey."
  • In the Sam & Max episode What's New, Beelzebub?, the eponymous duo mess up Bosco's bachelor party by spiking the punch with the juice of the Forbidden Fruit. Detective Flint Paper uses this exact expression:
    Flint Paper: Somebody put a Mickey Finn in the happy juice and I'm gonna find out who!
  • In Season of Mystery: The Cherry Blossom Murders, the villain seems to have a line in killing people while making it look like suicide, and to make sure there isn't any fuss, he drugs them first. The powder he accidentally leaves near a victim's teacup is one piece of evidence found by the protagonist, and the discovery of his discarded pill bottle is another.
  • Ledon from Suikoden does this to the active party when they stop at his inn on the way up Mt. Tigerwolf by putting sedatives in their tea so he can take their belongings.
  • A substory from the first Yakuza and its remake features a woman innocently buying a drink for Kiryu. Depending on the player's choices, Kiryu will refuse the drink despite the forceful insistence of the bartender. On the third refusal, Kiryu will point out that his drink has pills in it, causing a fight to erupt. Of course, there's the option of taking the spiked drink... have fun with that.
  • Mutant Football League features inspirational speeches from your team captain during the pre-game, and they state they do this when the opposing team is favored to win.
    Team Captain: Hey, everyone in this building thinks we're going to lose, but GUESS WHAT - I roofied their Gatorade, so WHO'S LOST NOW!?

    Visual Novels 
  • In Nameless, Tei frequently drugs the heroine's "ZZZ" tea.
  • In Danganronpa 2: Goodbye Despair, Teruteru’s Free Time Events end with him giving Hajime a drugged riceball, most likely in an attempt to molest him. However, Hajime manages to stay awake long enough to make it back to his cottage unharmed.
  • Galaxy Angel: On Mint's route in the first game, her father's subordinates spike her tea with a sleeping agent and extract her from the Elsior hiding her inside one of her mascot costumes (an easy feat given that she's quite small).

    Webcomics 
  • In Erstwhile, the farmer's clever daughter does this to the king.
  • Girl Genius:
    • In the backstory of Girl Genius, Lucrezia does this to Klaus so she can get him out of the way while she marries Bill Heterodyne.
    • Aaronev Wilhelm Sturmvoraus slips Agatha a truth potion in her drink to find out if she's the one Lucrezia's followers have been waiting for.
    • It later happens to Lucrezia in Agatha's body as well as Klaus in Gil's body and various other characters, to get Lucrezia out of the picture and to help the protagonists escape without using force, except this time it's drugged cake. The two characters with Smoke Knight training both comment on how it's very good cake.
  • I Love Yoo:A guy does this to Shin-Ae's orange juice at the Masquerade Ball.
  • Attempted in Keychain of Creation during a short fight scene break. Ten Winds compliments the effort, but is otherwise unimpressed.
  • In Penny and Aggie, Cyndi has this done twice to Stan, her opponent in the student council presidential election, the first time successfully.
  • In The Last Days of FOXHOUND, Liquid's plan to nonviolently dissolve a Mexican Standoff in a drugstore is to have a psychic with Jedi Mind Trick powers convince everyone that they're very thirsty, and then give them drugged water. Everyone passes out within thirty seconds, because Liquid accidentally overdosed the pills, and everyone ends the night getting their stomachs pumped.
  • In Sequential Art, Hilary roofies Pip's drink to make him think they had sex.
  • In Sinfest, Slick is offered some. Even he rejects it.
  • In Nukees, Suzy Gee falsely (as it turns out) accuses Gav of doing this to her.
    Suzy: That was before you slipped me a goofy!
    Gav: I think you mean a roofie.
    Suzy: Actually, I think I meant a mickey.
  • This happens to Sarah in Think Before You Think.
  • In Wizard School, Goatsie is excited at a summoned pile of drugs because he wants to slip someone a roofie.
  • In Questionable Content, a rather drunk Marten is invited to play Scrabble with a girl he just met. Hannelore jokes about having roofied his drink so he'll spell things like "murmule" and "burngsu" and "rmnxtw" and won't remember it in the morning.

    Web Original 
  • In The Adventures of The League of S.T.E.A.M. episode "Two for Dinner", a vampire tries this with the classical ring containing powdered drug on his guests, Crackitus Potts and vampire hunter Sir Conrad.
  • Occurs in Epic Rap Battles of History "George Carlin vs. Richard Pryor". Bill Cosby tries to cut in as the battle's third rapper, but Joan Rivers won't let him try and get away from his deserved reputation as a Serial Rapist and spikes his pudding, knocking him out before he's even finished his second verse.
  • The Onion: I Think the Leader of the World's Tenth-Largest Economy Put Something in My Drink.
  • In Shadowrun Storytime, an obviously untrustworthy man offers Dervish an almost certainly drugged drink. Despite knowing better, Dervish gets dared into drinking and wakes up later half-naked and chained in the basement. And the booze wasn't even good.
  • Revenge Films: This story has one of the most revolting examples: the protagonist's sister's husband ground up his sleeping pills and slipped them into their baby daughter's milk to keep her from crying and interrupting his sleep. Thankfully, the baby survived, but her mother divorced him afterward.
  • Stampy's Lovely World: Veeva Dash poisons a cake with a sleeping potion and Hit The Target leaves it out as a trap in Episode 320, "Sleepy Stampy", dragging our protagonist off to a Drowning Pit while he's unconscious and kidnapping his favourite dog off-camera. This is foreshadowed a couple of episodes before that, with some of Stampy's friends consuming similarly spiked foodstuffs and falling asleep as well, but Stampy wrote it off as exhaustion until it also happened to him.
  • At Halloween in the Whateley Universe, Whateley Academy student G-Force (one of the Cape Squad, but with homophobic issues) is given a mickey, but it's a deviser drug that amps up his powers and lessens his inhibitions. After that, a telepath aims at a student with known gender issues. Badness happens.

    Western Animation 
  • American Dad!
    • In "The Vacation Goo" When the family finds out that all the vacations they have taken over the years were fake via being simulated though the goo chambers from the CIA, Stan reveals that every year when he cooks the pre vacation pancakes, he spikes them and when Francine, Hayley, and Steve are out cold, he hooks them up to the chambers and programs a vacation to simulate in their minds.
    • In "I Ain't No Holodeck Boy", after Stan gets frustrated with Steve and his friends hogging the TV instead of going outside and playing, he decides to subject the boys to his own experiences in the woods by using the CIA's latest invention: the hologramdeck. In order to get Steve and company in the hologramdeck, he gives them hamburgers laced with knockout pills.
  • In one Animaniacs (1993) episode spoofing Film Noir, Yakko is slipped a Mickey, meaning there's a mouse in red shorts in his drink. He declines, saying, "Nice try, bub, but I work for Warners."
  • Double subverted in Beavis and Butt-Head when the title characters slip a vial of "Spanish Fly" into what they think is a girl's milk — moments before her boyfriend drinks it.
  • In BoJack Horseman, in a misguided attempt to get Hollyhock to lose weight, Beatrice slips amphetamines into the coffee she continuously makes for her.
  • In Disenchantment, Luci slips two shots of Dankmirian Schnapps into Bean's soda so that she'll mess up the speech she's supposed to give at the banquet. Keep in mind that, according to Chazzzzz, "One shot is all you need".
  • Happens to Goofy in the Classic Disney Short How to Be a Detective.
  • Subverted in Drawn Together where Captain Hero slips himself the roofie for the purpose of getting himself date raped, passes out, only to have Xandir point out it was candy. He gets annoyed when they don't take advantage of his faux-drugged state.
  • Family Guy:
    • Quagmire likes getting his dates Roofie Coladas.
    • "Friends Without Benefits" had Meg attempting to drug Chris with roofies (courtesy of Quagmire) to get close to her gay crush. When she has second thoughts about it, she throws them away and they get eaten by Stewie, thinking they were candy.
  • Garfield's Babes and Bullets: How O'Felix killed Professor O'Tabby, by spiking his coffee with sleeping pills.
  • Hey Arnold!: Implied in "The Flood". Oskar offers to help Grandpa blow up his rescue raft, and he makes him some warm milk. Grandpa is suspicious, but he drinks the milk anyway. When Oskar sees Grandpa fast asleep, he takes off with the raft. Thankfully, Grandpa stops him from getting too far when he realizes what's going on.
  • Looney Tunes: The use of GHB substances and similar "mickeys" was a common gag used by the antagonists, in an attempt to gain the upper hand. Examples:
    • The Fair Haired Hare: In a cartoon where Bugs Bunny and Yosemite Sam are battling over property rights, Sam drops a poisonous powder in Bugs's carrot juice. Bugs is immediately wise to the trick and tries to switch glasses, but when an irritated Sam tries to get the upper hand, Bugs spins the table around à la a roulette wheel. Sam loses his patience and forces Bugs (at gunpoint) to drink, but only after he agrees to drink his glass. Of course, Bugs drinks the pure carrot juice... and Sam blasts off like a rocket and lands several miles away.
    • The WWII-era short Plane Daffy has spy Hata Mari slipping a courier a drink from a bottle labelled "Mickeyblitz Finnkrieg" (complete with a lemon slice and cherry on a toothpick straight from the bottle) — the courier promptly starts babbling secrets like an auctioneer.
    • Witch Hazel does this in her first cartoon, Bewitched Bunny, in an attempt to knock out Bugs so she can cook and eat him.
      Witch Hazel: Double, double, pour it in, for the rabbit's Mickey Finn.
    • In Hare Remover, when Elmer is preparing to make Bugs test his scientific formula, Bugs tells the audience that he thinks Elmer's trying to slip him one.
  • In Mike Tyson Mysteries, "Mite Tyson", Pigeon one time slipped a roofie into Yung's soda without her knowledge but she didn't drink it. And after Pigeon was kicked out of Mike's home, he waited at a bus stop and took a roofie to pass the time.
    Pigeon: Maybe I'll get date-raped. Huh. Meh, better than sitting on this bus bench.
  • My Little Pony: Friendship Is Magic: "Hearts and Hooves Day" sees the Cutie Mark Crusaders working on what they believe to be a love potion for Cheerilee and Big Mac. Only well after the effects kick in do they realize that they've actually created the equivalent of a date rape drug.
  • Popeye, in an attempt to have Nurse Olive Oyl care for him, force-feeds spinach to Bluto to make Bluto beat him up so Popeye'll end up in the hospital.
  • Parodied in Regular Show. A giant coffee bean and his translator provide Mordecai and Rigby with coffee so they can work overtime to pay for concert tickets. After Mordecai and Rigby buy the tickets, they're offered more coffee - but realize too late they've been served chamomile tea. They pass out, and the bean and translator steal the tickets.
  • Parodied in a Rugrats (1991) episode when the babies imitate a Noir Episode after listening to an old radio show. Tommy goes into a juice bar and meets Lil, who is a mook for Angelica, pretending to have made a Heel–Face Turn. They drink bottles of juice, only for Tommy to realize too late that she had slipped him a bottle of warm milk. Tommy then passes out for a nap.
  • Done in Columbia's The Schooner the Better by a Buzz Buzzard expy trying to conscript a Chilly Willy-esque penguin, only to have the tables literally turned on him.
  • The Simpsons:
    • Lisa assumes this in "Cape Feare" when Homer is passed out while the family is at the mercy of Sideshow Bob.
      Lisa: Oh no, dad's been drugged!
      Marge: (annoyed) No, he hasn't.
    • In "Bart Gets a Z", after Mrs. Krabappel confiscates everyone's cell phones, Bart gets the rest of the class to gather liquor to slip into her coffee to get her to loosen up. However, it works too well and she ends up losing her job.
  • Papa Smurf's "Christmas spirit" in The Smurfs: A Christmas Carol slips itself into the smurfberry nog that Grouchy drinks to make him fall asleep on the floor. Or so he thinks.
  • J.G. Quintel's short film 2 in the AM PM mentions this trope by name when two gas station workers - one played by Quintel himself - are talking about candy. One of them insists on it and eventually the other takes it, only to find that it tastes funny. The first one eventually admits that he slipped weed into it...then remembers it was actually acid.
    Second worker: "I've never done acid before, I didn't WANT to do acid, but even if I did, I'd much rather be told about it than slipped some stupid milk-chocolate mickey!"
  • Tiny Toon Adventures: During a school dance, Gogo Dodo slips a literal spike in the punch.


 
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Drugging Angel Dust

One of the gangsters slips some kind of drug into Angel's drink. Husk intervenes and drags Angel out.

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